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  1. Article: Advancing Cancer Immunotherapy: From Molecular Mechanisms to Clinical Applications.

    Zhao, Xianda / Starr, Timothy / Subramanian, Subbaya

    Cancers

    2023  Volume 15, Issue 16

    Abstract: In recent years, cancer immunotherapy research has made remarkable progress, completely transforming the cancer treatment landscape [ ... ]. ...

    Abstract In recent years, cancer immunotherapy research has made remarkable progress, completely transforming the cancer treatment landscape [...].
    Language English
    Publishing date 2023-08-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15164197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cancer Immunology and Immunotherapies: Mechanisms That Affect Antitumor Immune Response and Treatment Resistance.

    Zhao, Xianda / Subramanian, Subbaya

    Cancers

    2021  Volume 13, Issue 22

    Abstract: The past decade has seen immunotherapy rise to the forefront of cancer treatment [ ... ]. ...

    Abstract The past decade has seen immunotherapy rise to the forefront of cancer treatment [...].
    Language English
    Publishing date 2021-11-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13225655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Allogeneic tumor cell-derived extracellular vesicles stimulate CD8 T cell response in colorectal cancer.

    Gates, Travis J / Wangmo, Dechen / Zhao, Xianda / Subramanian, Subbaya

    Molecular therapy oncolytics

    2023  Volume 31, Page(s) 100727

    Abstract: Most colorectal cancer (CRC) patients present with a microsatellite-stable phenotype, rendering them resistant to immune checkpoint inhibitors (ICIs). Among the contributors to ICI resistance, tumor-derived extracellular vesicles (TEVs) have emerged as ... ...

    Abstract Most colorectal cancer (CRC) patients present with a microsatellite-stable phenotype, rendering them resistant to immune checkpoint inhibitors (ICIs). Among the contributors to ICI resistance, tumor-derived extracellular vesicles (TEVs) have emerged as critical players. Previously we demonstrated that autologous transfer of TEVs without miR-424 can induce tumor antigen-specific immune responses in CRC models. Therefore, we postulated that allogeneic TEVs, modified to lack miR-424 and derived from an MC38 cells, could induce CD8
    Language English
    Publishing date 2023-09-16
    Publishing country United States
    Document type Journal Article
    ISSN 2372-7705
    ISSN 2372-7705
    DOI 10.1016/j.omto.2023.100727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Allogeneic Tumor Cell-Derived Extracellular Vesicles Stimulate CD8 T Cell Response in Colorectal Cancer.

    Gates, Travis J / Wangmo, Dechen / Zhao, Xianda / Subramanian, Subbaya

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Colorectal Cancer (CRC) is the second leading cause of cancer-related death in the United States. Most CRC patients present with a microsatellite stable (MSS) phenotype and are highly resistant to immunotherapies. Tumor extracellular vesicles (TEVs), ... ...

    Abstract Colorectal Cancer (CRC) is the second leading cause of cancer-related death in the United States. Most CRC patients present with a microsatellite stable (MSS) phenotype and are highly resistant to immunotherapies. Tumor extracellular vesicles (TEVs), secreted by tumor cells, can contribute to intrinsic resistance to immunotherapy in CRC. We previously showed that autologous TEVs without functional miR-424 induce anti-tumor immune responses. We hypothesized that allogeneic modified CRC-TEVs without miR-424 (mouse homolog miR-322) derived from an MC38 background would effectively stimulate CD8
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.17.537250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Centrosomal Protein 55 (CEP55) Drives Immune Exclusion and Resistance to Immune Checkpoint Inhibitors in Colorectal Cancer.

    Wangmo, Dechen / Gates, Travis J / Zhao, Xianda / Sun, Ruping / Subramanian, Subbaya

    Vaccines

    2024  Volume 12, Issue 1

    Abstract: Colorectal cancer (CRC) currently ranks as the third most common cancer in the United States, and its incidence is on the rise, especially among younger individuals. Despite the remarkable success of immune checkpoint inhibitors (ICIs) in various cancers, ...

    Abstract Colorectal cancer (CRC) currently ranks as the third most common cancer in the United States, and its incidence is on the rise, especially among younger individuals. Despite the remarkable success of immune checkpoint inhibitors (ICIs) in various cancers, most CRC patients fail to respond due to intrinsic resistance mechanisms. While microsatellite instability-high phenotypes serve as a reliable positive predictive biomarker for ICI treatment, the majority of CRC patients with microsatellite-stable (MSS) tumors remain ineligible for this therapeutic approach. In this study, we investigated the role of centrosomal protein 55 (CEP55) in shaping the tumor immune microenvironment in CRC. CEP55 is overexpressed in multiple cancer types and was shown to promote tumorigenesis by upregulating the PI3K/AKT pathway. Our data revealed that elevated CEP55 expression in CRC was associated with reduced T cell infiltration, contributing to immune exclusion. As CRC tumors progressed, CEP55 expression increased alongside sequential mutations in crucial driver genes (APC, KRAS, TP53, and SMAD4), indicating its involvement in tumor progression. CEP55 knockout significantly impaired tumor growth in vitro and in vivo, suggesting that CEP55 plays a crucial role in tumorigenesis. Furthermore, the CEP55 knockout increased CD8
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12010063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Changing Oncology Treatment Paradigms in the COVID-19 Pandemic.

    Lou, Emil / Subramanian, Subbaya

    Clinical colorectal cancer

    2020  Volume 19, Issue 3, Page(s) 153–155

    MeSH term(s) COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Delivery of Health Care/organization & administration ; Gastrointestinal Neoplasms/pathology ; Gastrointestinal Neoplasms/therapy ; Humans ; Medical Oncology/organization & administration ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Risk
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2112638-0
    ISSN 1938-0674 ; 1533-0028
    ISSN (online) 1938-0674
    ISSN 1533-0028
    DOI 10.1016/j.clcc.2020.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5798: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 435: Show issues

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  8. Article ; Online: Changing Oncology Treatment Paradigms in the COVID-19 Pandemic

    Lou, Emil / Subramanian, Subbaya

    Clinical Colorectal Cancer

    2020  Volume 19, Issue 3, Page(s) 153–155

    Keywords Gastroenterology ; Oncology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2112638-0
    ISSN 1533-0028
    ISSN 1533-0028
    DOI 10.1016/j.clcc.2020.05.002
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5798: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 435: Show issues

    Order via subito

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  9. Article: Special Issue: MicroRNA Regulation in Health and Disease.

    Subramanian, Subbaya / Steer, Clifford J

    Genes

    2019  Volume 10, Issue 6

    Abstract: Our understanding of non-coding RNA has significantly changed based on recent advances in genomics and molecular biology, and their role is recognized to include far more than a link between the sequence of DNA and synthesized proteins [ ... ]. ...

    Abstract Our understanding of non-coding RNA has significantly changed based on recent advances in genomics and molecular biology, and their role is recognized to include far more than a link between the sequence of DNA and synthesized proteins [...].
    MeSH term(s) Genomics ; Humans ; MicroRNAs/genetics
    Chemical Substances MicroRNAs
    Keywords covid19
    Language English
    Publishing date 2019-06-15
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes10060457
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  10. Article: Differential landscape of immune evasion in oncogenic RAS-driven primary and metastatic colorectal cancers.

    Lou, Emil / Xiu, Joanne / Baca, Yasmine / Saeed, Anwaar / Prakash, Ajay / Gholami, Sepideh / Subramanian, Subbaya / Starr, Timothy K / Fontana, Elisa / Pandey, Ritu / Lenz, Heinz-Josef / Shields, Anthony F / Nabhan, Chadi / Oberley, Matthew / Seeber, Andreas / El-Deiry, Wafik

    Molecular therapy. Oncology

    2024  Volume 32, Issue 1, Page(s) 200786

    Abstract: Oncogenic drivers such ... ...

    Abstract Oncogenic drivers such as
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ISSN 2950-3299
    ISSN 2950-3299
    DOI 10.1016/j.omton.2024.200786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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