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  1. Article: The Spatial Organization of Sister Chromatids.

    Gregan, Juraj

    Trends in biochemical sciences

    2021  Volume 46, Issue 4, Page(s) 255–257

    Abstract: Understanding how genomes are spatially organized is central to many aspects of cell biology. However, it has been difficult to study the relationships between sister chromatids because sequencing-based techniques such as Hi-C could not distinguish ... ...

    Abstract Understanding how genomes are spatially organized is central to many aspects of cell biology. However, it has been difficult to study the relationships between sister chromatids because sequencing-based techniques such as Hi-C could not distinguish identical sister DNAs. Here, I discuss recent developments that provide insights into sister chromatid organization.
    MeSH term(s) Cell Cycle Proteins/metabolism ; Chromatids/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; DNA ; DNA Replication
    Chemical Substances Cell Cycle Proteins ; Chromosomal Proteins, Non-Histone ; DNA (9007-49-2)
    Language English
    Publishing date 2021-02-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2021.01.010
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    Zs.A 1207: Show issues Location:
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  2. Article ; Online: SILAC-Based Proteomic Analysis of Meiosis in the Fission Yeast Schizosaccharomyces pombe.

    Anrather, Dorothea / Polakova, Silvia Bagelova / Cipak, Lubos / Gregan, Juraj

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2603, Page(s) 19–29

    Abstract: Stable isotope labeling by amino acids in cell culture (SILAC) provides a powerful tool to quantify proteins and posttranslational modifications. Here we describe how to apply SILAC for protein identification and quantification in synchronous meiotic ... ...

    Abstract Stable isotope labeling by amino acids in cell culture (SILAC) provides a powerful tool to quantify proteins and posttranslational modifications. Here we describe how to apply SILAC for protein identification and quantification in synchronous meiotic cultures induced by inactivation of the Pat1 kinase in the fission yeast Schizosaccharomyces pombe.
    MeSH term(s) Schizosaccharomyces/metabolism ; Proteomics ; Meiosis ; Proteins/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism
    Chemical Substances Proteins ; Schizosaccharomyces pombe Proteins
    Language English
    Publishing date 2022-11-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2863-8_2
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  3. Article: Cohesin Biology: From Passive Rings to Molecular Motors.

    Mayerova, Nina / Cipak, Lubos / Gregan, Juraj

    Trends in genetics : TIG

    2020  Volume 36, Issue 6, Page(s) 387–389

    Abstract: The loop extrusion hypothesis postulated that extrusion of DNA loops through cohesin rings organizes genomes. Recent findings suggest that cohesin itself is a molecular motor that extrudes DNA. This has important implications not only for the ... ...

    Abstract The loop extrusion hypothesis postulated that extrusion of DNA loops through cohesin rings organizes genomes. Recent findings suggest that cohesin itself is a molecular motor that extrudes DNA. This has important implications not only for the organization of interphase chromatin but also for other processes where cohesin plays vital roles.
    MeSH term(s) Animals ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Nucleus/genetics ; Chromatin Assembly and Disassembly ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; DNA Packaging ; DNA Replication ; Humans ; Meiosis ; Cohesins
    Chemical Substances Cell Cycle Proteins ; Chromosomal Proteins, Non-Histone
    Language English
    Publishing date 2020-03-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2020.03.001
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  4. Article ; Online: Probing Mechanical Properties in Biology Using Brillouin Microscopy.

    Elsayad, Kareem / Polakova, Silvia / Gregan, Juraj

    Trends in cell biology

    2019  Volume 29, Issue 8, Page(s) 608–611

    Abstract: Brillouin microscopy can be used to map the mechanical properties of samples in a noncontact and label-free manner, with potential applications in cell biology. Here, we provide an overview of the underlying principles and technology as well as the ... ...

    Abstract Brillouin microscopy can be used to map the mechanical properties of samples in a noncontact and label-free manner, with potential applications in cell biology. Here, we provide an overview of the underlying principles and technology as well as the current challenges and outlook.
    MeSH term(s) Biomechanical Phenomena ; Cell Biology ; Humans ; Microscopy/methods
    Language English
    Publishing date 2019-05-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2019.04.002
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  5. Article ; Online: Tandem affinity purification protocol for isolation of protein complexes from

    Cipak, Lubos / Selicky, Tomas / Jurcik, Jan / Cipakova, Ingrid / Osadska, Michaela / Lukacova, Veronika / Barath, Peter / Gregan, Juraj

    STAR protocols

    2022  Volume 3, Issue 1, Page(s) 101137

    Abstract: Many cellular processes require the activities of complex molecular machines composed of several protein subunits. Insights into these systems can be gained by isolation of protein complexes followed ... ...

    Abstract Many cellular processes require the activities of complex molecular machines composed of several protein subunits. Insights into these systems can be gained by isolation of protein complexes followed by
    MeSH term(s) Mass Spectrometry ; Proteins/metabolism ; Schizosaccharomyces/genetics ; Tandem Affinity Purification
    Chemical Substances Proteins
    Language English
    Publishing date 2022-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101137
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  6. Article ; Online: The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol.

    Kotora, Peter / Šeršeň, František / Filo, Juraj / Loos, Dušan / Gregáň, Juraj / Gregáň, Fridrich

    Molecules (Basel, Switzerland)

    2016  Volume 21, Issue 1, Page(s) E127

    Abstract: Resveratrol (3,5,4'-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their ... ...

    Abstract Resveratrol (3,5,4'-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their antioxidant activity. All prepared resveratrol analogs were able to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR) and 2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The antioxidant activity efficiency correlated with the number and position of hydroxyl groups. The most effective antioxidants were resveratrol analogs containing three hydroxyl groups in the benzylidene part of their molecules. These results provide new insights into the relationship between the chemical structure and biological activity of resveratrol analogs.
    MeSH term(s) Benzhydryl Compounds/antagonists & inhibitors ; Benzothiazoles/antagonists & inhibitors ; Biphenyl Compounds/antagonists & inhibitors ; Free Radical Scavengers/chemistry ; Free Radical Scavengers/pharmacology ; Molecular Structure ; Picrates/antagonists & inhibitors ; Resveratrol ; Stilbenes/chemistry ; Stilbenes/pharmacology ; Sulfonic Acids/antagonists & inhibitors
    Chemical Substances Benzhydryl Compounds ; Benzothiazoles ; Biphenyl Compounds ; Free Radical Scavengers ; Picrates ; Stilbenes ; Sulfonic Acids ; 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (28752-68-3) ; 1,1-diphenyl-2-picrylhydrazyl (DFD3H4VGDH) ; Resveratrol (Q369O8926L) ; galvinoxyl (W07Q6T5546)
    Language English
    Publishing date 2016-01-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules21010127
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  7. Article ; Online: Sexual Reproduction: Preventing Re-fertilization in Fission Yeast.

    Huraiova, Barbora / Pozgajova, Miroslava / Gregan, Juraj

    Current biology : CB

    2018  Volume 28, Issue 22, Page(s) R1300–R1303

    Abstract: During sexual reproduction, two haploid cells fuse to produce a diploid cell called a zygote. A new study describes how fission yeast prevents a zygote from being formed by the fusion of more than two cells. ...

    Abstract During sexual reproduction, two haploid cells fuse to produce a diploid cell called a zygote. A new study describes how fission yeast prevents a zygote from being formed by the fusion of more than two cells.
    MeSH term(s) Diploidy ; Haploidy ; Oocytes/metabolism ; Reproduction/physiology ; Schizosaccharomyces/growth & development ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/metabolism ; Zona Pellucida/metabolism ; Zona Pellucida/physiology ; Zygote/physiology
    Chemical Substances Schizosaccharomyces pombe Proteins
    Language English
    Publishing date 2018-11-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2018.09.048
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    Zs.A 3208: Show issues Location:
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  8. Article ; Online: Promoter interactions direct chromatin folding in embryonic stem cells.

    Sanyal, Swastika / Molnarova, Lucia / Gregan, Juraj

    Nature structural & molecular biology

    2017  Volume 24, Issue 6, Page(s) 494–495

    MeSH term(s) Cell Differentiation ; Chromatin ; Embryonic Stem Cells ; Promoter Regions, Genetic
    Chemical Substances Chromatin
    Language English
    Publishing date 2017--06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/nsmb.3421
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  9. Article ; Online: The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol

    Peter Kotora / František Šeršeň / Juraj Filo / Dušan Loos / Juraj Gregáň / Fridrich Gregáň

    Molecules, Vol 21, Iss 1, p

    2016  Volume 127

    Abstract: Resveratrol (3,5,4′-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their ... ...

    Abstract Resveratrol (3,5,4′-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their antioxidant activity. All prepared resveratrol analogs were able to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR) and 2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The antioxidant activity efficiency correlated with the number and position of hydroxyl groups. The most effective antioxidants were resveratrol analogs containing three hydroxyl groups in the benzylidene part of their molecules. These results provide new insights into the relationship between the chemical structure and biological activity of resveratrol analogs.
    Keywords resveratrol analogs ; iminophenols ; antioxidant activity ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Disadvantages for families.

    Gregan, Juraj

    EMBO reports

    2006  Volume 7, Issue 1, Page(s) 2–3

    MeSH term(s) Education, Graduate ; Family ; Fellowships and Scholarships ; Humans ; Research Personnel
    Language English
    Publishing date 2006-01-04
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.1038/sj.embor.7400610
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