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Article ; Online: Dachshund and C-terminal Binding Protein bind directly during

Banerjee, Surya Jyoti / Curtiss, Jennifer

microPublication biology

2024 Volume 2024

Abstract: The transcription factor Dachshund (Dac) and the transcriptional co-regulator C-terminal Binding Protein (CtBP) were identified as the retinal determination factors ... ...

Abstract	The transcription factor Dachshund (Dac) and the transcriptional co-regulator C-terminal Binding Protein (CtBP) were identified as the retinal determination factors during
Language	English
Publishing date	2024-03-10
Publishing country	United States
Document type	Journal Article
ISSN	2578-9430
ISSN (online)	2578-9430
DOI	10.17912/micropub.biology.001106
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Article ; Online: Evinacumab Reduces Triglyceride-Rich Lipoproteins in Patients with Hyperlipidemia: A Post-Hoc Analysis of Three Randomized Clinical Trials.

Rosenson, Robert S / Rader, Daniel J / Ali, Shazia / Banerjee, Poulabi / McGinniss, Jennifer / Pordy, Robert

Cardiovascular drugs and therapy

2024

Abstract: Purpose: Natural selection (Mendelian randomization) studies support a causal relationship between elevated triglyceride-rich lipoproteins (TRLs) and atherosclerotic cardiovascular disease (ASCVD). This post-hoc analysis assessed the efficacy of ... ...

Abstract	Purpose: Natural selection (Mendelian randomization) studies support a causal relationship between elevated triglyceride-rich lipoproteins (TRLs) and atherosclerotic cardiovascular disease (ASCVD). This post-hoc analysis assessed the efficacy of evinacumab in reducing TRLs in patient cohorts from three separate clinical trials with evinacumab. Methods: Patients with homozygous familial hypercholesterolemia (HoFH) and low-density lipoprotein cholesterol (LDL-C) ≥ 70 mg/dL were enrolled in a phase III trial (R1500-CL-1629; NCT03399786). Patients diagnosed with refractory hypercholesterolemia, with LDL-C ≥ 70 mg/dL or ≥ 100 mg/dL for those with or without ASCVD, respectively, were enrolled in a phase II trial (R1500-CL-1643; NCT03175367). Patients with severe hypertriglyceridemia (fasting TGs ≥ 500 mg/dL) were enrolled in a phase II trial (R1500-HTG-1522; NCT03452228). Patients received evinacumab intravenously (5 or 15 mg/kg) every 4 weeks, or subcutaneously (300 or 450 mg) every week or every 2 weeks. Efficacy outcomes included change in TRLs (calculated as total cholesterol minus high-density lipoprotein cholesterol minus LDL-C) and other lipid parameters from baseline to 12, 16, or 24 weeks for trial 1522, 1643, and 1629, respectively. Results: At baseline, TRL levels were higher for patients with severe hypertriglyceridemia entering the 1522 trial vs. other cohorts. Reductions in TRLs were observed across all studies with evinacumab, with > 50% reduction from baseline observed at the highest doses evaluated in patients with HoFH or refractory hypercholesterolemia. Within all three trials, evinacumab was generally well tolerated. Conclusions: Despite limitations in direct comparisons between study groups, these data indicate that TRL levels could be a future target for lipid-lowering therapies.
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	639068-7
ISSN	1573-7241 ; 0920-3206
ISSN (online)	1573-7241
ISSN	0920-3206
DOI	10.1007/s10557-024-07567-z
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Article ; Online: Association of Healthy Lifestyle and Incident Polypharmacy.

Koren, Melanie J / Kelly, Neil A / Lau, Jennifer D / Jonas, Chanel K / Pinheiro, Laura C / Banerjee, Samprit / Safford, Monika M / Goyal, Parag

The American journal of medicine

2024 Volume 137, Issue 5, Page(s) 433–441.e2

Abstract: Background: Polypharmacy, commonly defined as taking ≥5 medications, is an undesirable state associated with lower quality of life. Strategies to prevent polypharmacy may be an important priority for patients. We sought to examine the association of ... ...

Abstract	Background: Polypharmacy, commonly defined as taking ≥5 medications, is an undesirable state associated with lower quality of life. Strategies to prevent polypharmacy may be an important priority for patients. We sought to examine the association of healthy lifestyle, a modifiable risk factor, with incident polypharmacy. Methods: We performed a secondary analysis of the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study, including 15,478 adults aged ≥45 years without polypharmacy at baseline. The primary exposure was healthy lifestyle at baseline as measured by the Healthy Behavior Score (HBS), a cumulative assessment of diet, exercise frequency, tobacco smoking, and sedentary time. HBS ranges from 0-8, whereby 0-2 indicates low HBS, 3-5 indicates moderate HBS, and 6-8 indicates high HBS. We used multinomial logistic regression to examine the association between HBS and incident polypharmacy, survival without polypharmacy, and death. Results: Higher HBS (i.e., healthier lifestyle) was inversely associated with incident polypharmacy after adjusting for sociodemographic and baseline health variables. Compared with participants with low HBS, those with moderate HBS had lower odds of incident polypharmacy (odds ratio [OR] 0.85; 95% confidence interval [CI], 0.73-0.98) and lower odds of dying (OR 0.74; 95% CI, 0.65-0.83). Participants with high HBS had even lower odds of both incident polypharmacy (OR 0.75; 95% CI, 0.64-0.88) and death (OR 0.62; 95% CI, 0.54-0.70). There was an interaction for age, where the association between HBS and incident polypharmacy was most pronounced for participants aged ≤65 years. Conclusions: Healthier lifestyle was associated with lower risk for incident polypharmacy.
MeSH term(s)	Humans ; Polypharmacy ; Male ; Female ; Middle Aged ; Aged ; Healthy Lifestyle ; Cohort Studies ; Risk Factors ; United States/epidemiology ; Incidence
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2023.12.028
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Ua VI Zs.289: Show issues

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Article ; Online: Association between dexamethasone exposure and visually significant cataracts in multiple myeloma.

Banerjee, Rahul / Hurtado Martínez, Jorge Arturo / Flores Pérez, Patricia Alejandra / Porras, Nolan / Hydren, Jay / Ahlstrom, Jennifer M / Taravati, Parisa / Cowan, Andrew J

American journal of hematology

2023 Volume 99, Issue 1, Page(s) E12–E14

MeSH term(s)	Humans ; Multiple Myeloma/complications ; Multiple Myeloma/drug therapy ; Bortezomib/therapeutic use ; Dexamethasone/adverse effects ; Cataract/chemically induced ; Antineoplastic Combined Chemotherapy Protocols
Chemical Substances	Bortezomib (69G8BD63PP) ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Letter
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.27133
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Zs.A 1251: Show issues

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Article ; Online: Author Correction: The Drosophila melanogaster Neprilysin Nepl15 is involved in lipid and carbohydrate storage.

Banerjee, Surya / Woods, Christine / Burnett, Micheal / Park, Scarlet J / Ja, William W / Curtiss, Jennifer

Scientific reports

2021 Volume 11, Issue 1, Page(s) 5093

Language	English
Publishing date	2021-02-25
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-84100-4
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Article ; Online: Accountable Care Organization Attribution and Post-Acute Skilled Nursing Facility Outcomes for People Living With Dementia.

Bynum, Julie P W / Montoya, Ana / Lawton, Emily J / Gibbons, Jason B / Banerjee, Mousumi / Meddings, Jennifer / Norton, Edward C

Journal of the American Medical Directors Association

2023 Volume 25, Issue 1, Page(s) 53–57.e2

Abstract: Objectives: Under the Accountable Care Organization (ACO) model, reductions in healthcare spending have been achieved by targeting post-acute care, particularly in skilled nursing facilities (SNFs). People with Alzheimer disease and related dementias ( ... ...

Abstract	Objectives: Under the Accountable Care Organization (ACO) model, reductions in healthcare spending have been achieved by targeting post-acute care, particularly in skilled nursing facilities (SNFs). People with Alzheimer disease and related dementias (ADRD) are frequently discharged to SNF for post-acute care and may be at particular risk for unintended consequences of SNF cost reduction efforts. We examined SNF length of stay (LOS) and outcomes among ACO-attributed and non-ACO-attributed ADRD patients. Design: Observational serial cross-sectional study. Setting and participants: Twenty percent national random sample of fee-for-service Medicare beneficiaries (2013-2017) to identify beneficiaries with a diagnosis of ADRD and with a hospitalization followed by SNF admission (n = 263,676). Methods: Our primary covariate of interest was ACO (n = 66,842) and non-ACO (n = 196,834) attribution. Hospital readmission and death were measured for 3 time periods (<30, 31-90, and 91-180 days) following hospital discharge. We used 2-stage least squares regression to predict LOS as a function of ACO attribution, and patient and facility characteristics. Results: ACO-attributed ADRD patients have shorter SNF LOS than their non-ACO counterparts (31.7 vs 32.8 days; P < .001). Hospital readmission rates for ACO vs non-ACO differed at ≤30 days (13.9% vs 14.6%; P < .001) but were similar at 31-90 days and 91-180 days. No significant difference was observed in mortality post-hospital discharge for ACO vs non-ACO at ≤30 days; however, slightly higher mortality was observed at 31-90 days (8.4% vs 8.8%; P = .002) and 91-180 days (7.6% vs 7.9%; P = .011). No significant association was found between LOS and readmission, with small effects on mortality favoring ACOs in fully adjusted models. Conclusions and implications: Being an ACO-attributed patient is associated with shorter SNF LOS but is not associated with changes in readmission or mortality after controlling for other factors. Policies that shorten LOS may not have adverse effects on outcomes for people living with dementia.
MeSH term(s)	Humans ; Aged ; United States ; Skilled Nursing Facilities ; Medicare ; Accountable Care Organizations ; Cross-Sectional Studies ; Patient Readmission ; Patient Discharge ; Dementia
Language	English
Publishing date	2023-12-08
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2023.10.031
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Zs.A 5971: Show issues

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Article ; Online: Pathways to care for Long COVID and for long-term conditions from patients' and clinicians' perspective.

Turk, Fidan / Sweetman, Jennifer / Allsopp, Gail / Crooks, Michael / Cuthbertson, Dan J / Gabbay, Mark / Hishmeh, Lyth / Lip, Gregory Y H / Strain, W David / Williams, Nefyn / Wootton, Dan / Banerjee, Amitava / van der Feltz-Cornelis, Christina

Journal of evidence-based medicine

2023 Volume 16, Issue 4, Page(s) 435–437

MeSH term(s)	Humans ; Post-Acute COVID-19 Syndrome ; COVID-19 ; Attitude of Health Personnel
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Letter
ZDB-ID	2474496-7
ISSN	1756-5391 ; 1756-5383
ISSN (online)	1756-5391
ISSN	1756-5383
DOI	10.1111/jebm.12563
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Article ; Online: Molybdenum(III) Amidinate: Synthesis, Characterization, and Vapor Phase Growth of Mo-Based Materials.

Shaw, Thomas E / Ali, Zahra / Currie, Taylor M / Berriel, S Novia / Butkus, Brian / Wagner, J Tyler / Preradovic, Konstantin / Yap, Glenn P A / Green, Jennifer C / Banerjee, Parag / Sattelberger, Alfred P / McElwee-White, Lisa / Jurca, Titel

ACS applied materials & interfaces

2023 Volume 15, Issue 29, Page(s) 35590–35599

Abstract: The synthesis, characterization, and thermogravimetric analysis of tris( ...

Abstract	The synthesis, characterization, and thermogravimetric analysis of tris(
Language	English
Publishing date	2023-07-14
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c04074
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Article ; Online: Genome-scale and pathway engineering for the sustainable aviation fuel precursor isoprenol production in Pseudomonas putida.

Banerjee, Deepanwita / Yunus, Ian S / Wang, Xi / Kim, Jinho / Srinivasan, Aparajitha / Menchavez, Russel / Chen, Yan / Gin, Jennifer W / Petzold, Christopher J / Martin, Hector Garcia / Magnuson, Jon K / Adams, Paul D / Simmons, Blake A / Mukhopadhyay, Aindrila / Kim, Joonhoon / Lee, Taek Soon

Metabolic engineering

2024 Volume 82, Page(s) 157–170

Abstract: Sustainable aviation fuel (SAF) will significantly impact global warming in the aviation sector, and important SAF targets are emerging. Isoprenol is a precursor for a promising SAF compound DMCO (1,4-dimethylcyclooctane) and has been produced in several ...

Abstract	Sustainable aviation fuel (SAF) will significantly impact global warming in the aviation sector, and important SAF targets are emerging. Isoprenol is a precursor for a promising SAF compound DMCO (1,4-dimethylcyclooctane) and has been produced in several engineered microorganisms. Recently, Pseudomonas putida has gained interest as a future host for isoprenol bioproduction as it can utilize carbon sources from inexpensive plant biomass. Here, we engineer metabolically versatile host P. putida for isoprenol production. We employ two computational modeling approaches (Bilevel optimization and Constrained Minimal Cut Sets) to predict gene knockout targets and optimize the "IPP-bypass" pathway in P. putida to maximize isoprenol production. Altogether, the highest isoprenol production titer from P. putida was achieved at 3.5 g/L under fed-batch conditions. This combination of computational modeling and strain engineering on P. putida for an advanced biofuels production has vital significance in enabling a bioproduction process that can use renewable carbon streams.
MeSH term(s)	Pseudomonas putida/genetics ; Pseudomonas putida/metabolism ; Carbon/metabolism ; Metabolic Engineering
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2024-02-16
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	1470383-x
ISSN	1096-7184 ; 1096-7176
ISSN (online)	1096-7184
ISSN	1096-7176
DOI	10.1016/j.ymben.2024.02.004
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Zs.A 6288: Show issues

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Article ; Online: Pulmonary embolism response teams. A description of the first 36-month Australian experience.

Roy, Bapti / Cho, Jin-Gun / Baker, Luke / Thomas, Liza / Curnow, Jennifer / Harvey, John J / Geenty, Paul / Banerjee, Ashoke / Lai, Kevin / Vicaretti, Mauro / Erksine, Odette / Li, Jane / Alasady, Rafid / Wong, Vanessa / Tai, Jian E / Thirunavukarasu, Caitlin / Haque, Imran / Chien, Jimmy

Internal medicine journal

2024

Abstract: Background: High/intermediate-risk pulmonary embolism (PE) confers increased risk of cardiovascular morbidity and mortality. International guidelines recommend the formation of a PE response team (PERT) for PE management because of the complexity of ... ...

Abstract	Background: High/intermediate-risk pulmonary embolism (PE) confers increased risk of cardiovascular morbidity and mortality. International guidelines recommend the formation of a PE response team (PERT) for PE management because of the complexity of risk stratification and emerging treatment options. However, there are currently no available Australian data regarding outcomes of PE managed through a PERT. Aims: To analyse the clinical and outcome data of patients from an Australian centre with high/intermediate-risk PE requiring PERT-guided management. Methods: We performed a retrospective observational study of 75 consecutive patients with high/intermediate-risk PE who had PERT involvement, between August 2018 and July 2021. We recorded clinical and interventional data at the time of PERT and assessed patient outcomes up to 30 days from PERT initiation. We used unpaired t tests to compare right to left ventricular (RV/LV) ratios by computed tomography criteria or transthoracic echocardiogram (TTE) at baseline and after interventions. Results: Data were available for 74 patients. Initial computed tomography pulmonary angiography RV/LV ratio was increased at 1.65 ± 0.5 and decreased to 1.30 ± 0.29 following PERT-guided interventions (P < 0.001). TTE RV/LV ratio also decreased following PERT-guided management (1.09 ± 0.19 vs 0.93 ± 0.17; P < 0.001). 20% of patients had any bleeding complication, but two-thirds were mild, not requiring intervention. All-cause mortality was 6.8%, and all occurred within the first 7 days of admission. Conclusion: The PERT model is feasible in a large Australian centre in managing complex and time-critical PE. Our data demonstrate outcomes comparable with existing published international PERT data. However, successful implementation at other Australian institutions may require adequate centre-specific resource availability and the presence of multispeciality input.
Language	English
Publishing date	2024-03-18
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.16363
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Zs.A 792: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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