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  1. Book ; Online: Diabetic Foot

    Raghav, Alok

    Recent Advances

    2023  

    Keywords Endocrinology ; diabetes ; inflammation ; machine learning ; epigenetics ; diabetes mellitus ; quality of life
    Language English
    Size 1 electronic resource (162 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030380861
    ISBN 9781838808167 ; 1838808167
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Basics of Hypoglycemia

    Raghav, Alok

    2022  

    Keywords Endocrinology ; Clinical & internal medicine
    Language English
    Size 1 electronic resource (144 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030378584
    ISBN 9781803558998 ; 1803558997
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Fundamentals of Glycosylation

    Raghav, Alok / Ahmad, Jamal

    2022  

    Keywords Biochemistry
    Language 0|e
    Size 1 electronic resource (100 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021613562
    ISBN 9781839691362 ; 1839691360
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Nanoquercetin and Extracellular Vesicles as Potential Anticancer Therapeutics in Hepatocellular Carcinoma.

    Raghav, Alok / Jeong, Goo Bo

    Cells

    2024  Volume 13, Issue 7

    Abstract: Despite world-class sophisticated technologies, robotics, artificial intelligence, and machine learning approaches, cancer-associated mortalities and morbidities have shown continuous increments posing a healthcare burden. Drug-based interventions were ... ...

    Abstract Despite world-class sophisticated technologies, robotics, artificial intelligence, and machine learning approaches, cancer-associated mortalities and morbidities have shown continuous increments posing a healthcare burden. Drug-based interventions were associated with systemic toxicities and several limitations. Natural bioactive compounds derived nanoformulations, especially nanoquercetin (nQ), are alternative options to overcome drug-associated limitations. Moreover, the EVs-based cargo targeted delivery of nQ can have enormous potential in treating hepatocellular carcinoma (HCC). EVs-based nQ delivery synergistically regulates and dysregulates several pathways, including NF-κB, p53, JAK/STAT, MAPK, Wnt/β-catenin, and PI3K/AKT, along with PBX3/ERK1/2/CDK2, and miRNAs intonation. Furthermore, discoveries on possible checkpoints of anticancer signaling pathways were studied, which might lead to the development of modified EVs infused with nQ for the development of innovative treatments for HCC. In this work, we abridged the control of such signaling systems using a synergetic strategy with EVs and nQ. The governing roles of extracellular vesicles controlling the expression of miRNAs were investigated, particularly in relation to HCC.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Artificial Intelligence ; Extracellular Vesicles/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; MicroRNAs
    Language English
    Publishing date 2024-04-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13070638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A systematic review on the modifications of extracellular vesicles: a revolutionized tool of nano-biotechnology.

    Raghav, Alok / Jeong, Goo-Bo

    Journal of nanobiotechnology

    2021  Volume 19, Issue 1, Page(s) 459

    Abstract: Background: Tailoring extracellular vesicles (EVs) can bequeath them with diverse functions and efficient performance in nano-biotechnology. Engineering and modification of EVs improves the targeted drug delivery efficiency. Here, we performed ... ...

    Abstract Background: Tailoring extracellular vesicles (EVs) can bequeath them with diverse functions and efficient performance in nano-biotechnology. Engineering and modification of EVs improves the targeted drug delivery efficiency. Here, we performed systematic review of various methods for EVs modifications.
    Methods: PubMed, Scopus, ISI Web of Science, EMBASE, and Google Scholar were searched for available articles on EVs modifications (up to March 2021). In total, 1208 articles were identified and assessed, and then only 36 articles were found eligible and included.
    Results: Six studies demonstrate the application of click chemistry, seven studies used co-incubation, two studies used chemical transfection, four studies implicated electroporation and sonication approach for modification of EVs. Moreover, two studies utilized microfluidics as suitable approach for loading cargo into EVs, while eight studies showed freeze-thaw method as feasible for these biological nanoparticles.
    Conclusion: Freeze-thaw approach is found to be convenient and popular among researchers for performing modifications in EVs for the purpose of targeted drug delivery loading. Clinical-grade EVs production with good clinical practices (GCPs) is challenging in the current scenario. More studies are needed to determine the best suitable approach for cargo loading of EVs that may be exploited for research and therapeutic use.
    MeSH term(s) Click Chemistry ; Cryopreservation ; Drug Delivery Systems ; Electroporation ; Extracellular Vesicles/chemistry ; Extracellular Vesicles/metabolism ; Genetic Engineering ; Liposomes/metabolism ; Microfluidics ; Nanoparticles/chemistry ; Nanoparticles/metabolism ; Sonication
    Chemical Substances Liposomes
    Language English
    Publishing date 2021-12-30
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2100022-0
    ISSN 1477-3155 ; 1477-3155
    ISSN (online) 1477-3155
    ISSN 1477-3155
    DOI 10.1186/s12951-021-01219-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Engineered Extracellular Vesicles in Treatment of Type 1 Diabetes Mellitus: A Prospective Review.

    Raghav, Alok / Ashraf, Hamid / Jeong, Goo-Bo

    Biomedicines

    2022  Volume 10, Issue 12

    Abstract: Insulin replacement is an available treatment for autoimmune type 1 diabetes mellitus (T1DM). There are multiple limitations in the treatment of autoimmune diseases such as T1DM by immunosuppression using drugs and chemicals. The advent of extracellular ... ...

    Abstract Insulin replacement is an available treatment for autoimmune type 1 diabetes mellitus (T1DM). There are multiple limitations in the treatment of autoimmune diseases such as T1DM by immunosuppression using drugs and chemicals. The advent of extracellular vesicle (EV)-based therapies for the treatment of various diseases has attracted much attention to the field of bio-nanomedicine. Tolerogenic nanoparticles can induce immune tolerance, especially in autoimmune diseases. EVs can deliver cargo to specific cells without restrictions. Accordingly, EVs can be used to deliver tolerogenic nanoparticles, including iron oxide-peptide-major histocompatibility complex, polyethylene glycol-silver-2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester, and carboxylated poly (lactic-co-glycolic acid) nanoparticles coupled with or encapsulating an antigen, to effectively treat autoimmune T1DM. The present work highlights the advances in exosome-based delivery of tolerogenic nanoparticles for the treatment of autoimmune T1DM.
    Language English
    Publishing date 2022-11-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10123042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Role of the circulatory interleukin-6 in the pathogenesis of gliomas: A systematic review.

    Singh, Manish / Raghav, Alok / Gautam, Kirti Amresh

    World journal of methodology

    2022  Volume 12, Issue 5, Page(s) 428–437

    Abstract: Background: Glioma is the most common primary tumor in the brain originating from glial cells. In spite of extensive research, the overall survival rate is not enhanced. A number of published articles observed differentially circulating levels of ... ...

    Abstract Background: Glioma is the most common primary tumor in the brain originating from glial cells. In spite of extensive research, the overall survival rate is not enhanced. A number of published articles observed differentially circulating levels of cytokines in glioma. Interleukin-6 (IL-6) protein coded by IL-6 gene is regulated by the immune system and it has been found to have a significant role in progression and apoptosis resistance of glioma.
    Aim: To review the role of circulatory IL-6 in the development and progression of glioma and its utility as a biomarker.
    Methods: Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were applied to filter the relevant studies based on inclusion and exclusion criteria. We used a combination of keywords and the
    Results: The published results were inconsistent; however, most studies showed a significantly higher IL-6 level in glioma cases as compared to controls. Comparative IL-6 level among the different grades of glioma showed a higher level with low-grade gliomas and lower level with high-grade gliomas.
    Conclusion: IL-6 level significantly differed between cases and controls, and among different cancer stages, which shows its potential as a diagnostic and prognostic marker.
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Journal Article
    ISSN 2222-0682
    ISSN 2222-0682
    DOI 10.5662/wjm.v12.i5.428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Genetic Polymorphisms of Gene Methionine Synthase Reductase (MTRR) and Risk of Urinary Bladder Cancer.

    Gautam, Kirti Amresh / Raghav, Alok / Sankhwar, S N / Singh, Rajender / Tripathi, Prashant

    Asian Pacific journal of cancer prevention : APJCP

    2023  Volume 24, Issue 4, Page(s) 1137–1141

    Abstract: Methionine synthase reductase (MTRR) gene involved in the signaling for production of enzyme called methionine synthase reductase that use for the synthesis of methionine, which further used in DNA replication and repair. Genetic variation in MTRR gene ... ...

    Abstract Methionine synthase reductase (MTRR) gene involved in the signaling for production of enzyme called methionine synthase reductase that use for the synthesis of methionine, which further used in DNA replication and repair. Genetic variation in MTRR gene may alter the susceptibility of developing urinary bladder cancer. The present study undertaken to identify the contribution of genetic polymorphisms in the MTRR gene on the selected polymorphic sites including c.66A>G and c.524C>T towards urinary bladder cancer risk. Direct-DNA sequencing method was applied for the observation of genotyping distribution of MTRR c.66A>G and c.524C>T polymorphisms in 232 histopathological confirmed cases of transitional cell carcinoma (TCC) of urinary bladder cancer and 250 age-, sex- and ethnicity-matched cancer free controls. With significant difference (p = 0.05) of genotype analysis further corresponding Odds ratio (OR) and 95% confidence interval (CI) were calculated. Multivariable logistic regression analysis was applied for adjusting significant confounder variables. Haploview software (version 4.2) was used to perform pairwise Linkage Disequilibrium (LD) analysis. Age (p = 0.01), Habit of smoking (p = 0.05), tobacco consumption (p = 0.001) and diet (p = 0.02) were significantly differed between cases and controls. Both the MTRR substitution showed higher risk of developing urinary bladder cancer (p = <0.001), although this effect alters in multivariable logistic regression analysis in a protective association for both the substitution. No LD observed between the c.66A>G and c.524C>T substitutions. In conclusion, MTRR c.66A>G and c.524C>T substitutions showed a joint effect with the other associated risk factors. Further studies with a greater number of subjects of different ethnicity and polymorphisms are recommended for the better understanding urinary bladder cancer etiology and to screen the population who are at higher risk of developing urinary bladder cancer.
    MeSH term(s) Humans ; Genotype ; Polymorphism, Genetic ; Ferredoxin-NADP Reductase/genetics ; Risk Factors ; Urinary Bladder Neoplasms/genetics ; Case-Control Studies ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Genetic Predisposition to Disease ; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/genetics
    Chemical Substances methionine synthase reductase (EC 1.18.1.-) ; Ferredoxin-NADP Reductase (EC 1.18.1.2) ; Methylenetetrahydrofolate Reductase (NADPH2) (EC 1.5.1.20) ; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (EC 2.1.1.13)
    Language English
    Publishing date 2023-04-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2023.24.4.1137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evaluation of Micronutrients and Pro-Inflammatory Cytokines Levels in Nutritionally Deprived Children-A Tertiary Care Hospital-Based Study.

    Mishra, Malvika / Raghav, Alok / Tripathi, Prashant / Rao, Yashwant Kumar / Singh, Desh Deepak

    Nutrients

    2023  Volume 15, Issue 23

    Abstract: Background: Severe acute malnutrition (SAM) is a significant public health problem in developing countries, including India, where a significant proportion of children suffer from malnutrition.: Objective: This research aims to investigate the ... ...

    Abstract Background: Severe acute malnutrition (SAM) is a significant public health problem in developing countries, including India, where a significant proportion of children suffer from malnutrition.
    Objective: This research aims to investigate the factors contributing to severe acute malnutrition (SAM). Additionally, the study seeks to explore the relationship between micronutrient levels and pro-inflammatory cytokines in SAM children with and without clinical complications. Furthermore, the effectiveness of antibiotic treatment in SAM children without complications is evaluated.
    Methods: The study involved three groups comprising 66 subjects each: a healthy control group, SAM children with complications, and SAM children without complications. Blood samples were collected, and various analyses were conducted, including biochemical, hematological, micronutrient, and pro-inflammatory marker quantification. The data were analyzed using SPSS version 22.0.
    Results: The results indicate that the levels of IL-6, CRP, and TNF-α were significantly higher in the SAM group with complications compared to both the control group and the SAM group without complications. Zinc and copper levels were significantly lower in both SAM groups compared to the control group, and a negative correlation was observed between zinc levels and inflammatory markers. The study also assessed the efficacy of antibiotic treatment in SAM children without complications by comparing their weight, height, weight-for-height, and weight-for-age at baseline and after a 15-day follow-up period. Significant improvements in these parameters were observed in both the group receiving antibiotic treatment and the group not receiving antibiotic treatment.
    Conclusion: The findings suggest that a combination of antibiotic treatment and nutritional support can lead to significant clinical improvements in SAM children without complications. This study has important implications for the management and treatment of SAM in India and other developing countries.
    MeSH term(s) Child ; Humans ; Infant ; Micronutrients ; Cytokines ; Tertiary Care Centers ; Severe Acute Malnutrition/therapy ; Anti-Bacterial Agents/therapeutic use ; Zinc
    Chemical Substances Micronutrients ; Cytokines ; Anti-Bacterial Agents ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2023-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15234865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: FE-SEM/EDX Based Zinc Mobilization Analysis of

    Upadhayay, Viabhav Kumar / Singh, Ajay Veer / Khan, Amir / Singh, Jyoti / Pareek, Navneet / Raghav, Alok

    Frontiers in microbiology

    2022  Volume 13, Page(s) 852192

    Abstract: The experimental study was contrived to characterize two zinc-solubilizing bacteria (ZSB), namely BMRR126 and BMAR64, and their role in zinc (Zn) biofortification of rice. These bacteria solubilized Zn profoundly, determined qualitatively by halo-zone ... ...

    Abstract The experimental study was contrived to characterize two zinc-solubilizing bacteria (ZSB), namely BMRR126 and BMAR64, and their role in zinc (Zn) biofortification of rice. These bacteria solubilized Zn profoundly, determined qualitatively by halo-zone formation on a solid medium and quantitatively in a liquid broth by AAS and SEM-EDX. The lowering of pH and contact angle assessment of the liquid broth unveiled the establishment of the acidic conditions in a medium suitable for Zn solubilization. The characterization of both isolates on the basis of 16S rRNA gene analysis was identified as
    Language English
    Publishing date 2022-05-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.852192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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