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  1. Article ; Online: Epidemiological characteristics and disease burden of senile dementia death in Jing’an District, Shanghai from 2016 to 2020

    WAN Qiuping / YANG Xiaoming / CHU Xiaoting / YIN Xiaolie / ZHANG Guohui / WANG Yunhui / XIONG Jianjing / FANG Jialie

    Shanghai yufang yixue, Vol 34, Iss 8, Pp 736-

    2022  Volume 742

    Abstract: ObjectiveTo analyze the epidemiological characteristics of senile dementia death in Jing ... in the senile dementia death cases from 2016 to 2020 in Jing’an District. The YLL, YLD, DALY and their rates ... of the residents of Jing’an District from 2016 to 2020 were calculated by using Global Burden of Disease (GBD 2019 ...

    Abstract ObjectiveTo analyze the epidemiological characteristics of senile dementia death in Jing’an District from 2016 to 2020, as well as the trends of mortality, standardized mortality, years of life lost (YLL) due to early death, years lived with disability (YLD), and disability-adjusted life year (DALY), and to provide scientific basis for the prevention and control of senile dementia.MethodsThe distribution of senile dementia in terms of gender, age, marital status and education level was investigated in the senile dementia death cases from 2016 to 2020 in Jing’an District. The YLL, YLD, DALY and their rates of the residents of Jing’an District from 2016 to 2020 were calculated by using Global Burden of Disease (GBD 2019) research method and results in combination with the corresponding population data.ResultsCompared to those without dementia, deaths with dementia were more likely to be female, more likely to be over 80 years old, less likely to be married, and more likely to have education level under middle school. Among the deaths with dementia, only 27.70% of the primary cause of death was dementia, and the other main causes were cerebrovascular disease, coronary heart disease and diabetes mellitus, which accounted for 25.54%, 17.81% and 7.28%, respectively. There was a significant gender difference in the burden of disease on senile dementia in Jing’an District. Mortality, standardized mortality, YLL, YLD and DALY rates of females were higher than those of males. The burden of disease on senile dementia increased with age. The change trend of mortality and YLL rate from 2016 to 2020 was not statistically significant, while the YLD rate and DALY rate showed an upward trend, which was statistically significant.ConclusionAs the life span of residents in Jing’an District increases and the population aging deepens, the burden of disease on senile dementia is still heavy. This requires extensive attention of the whole society, and active exploration of prevention and control strategies and measures for senile ...
    Keywords senile dementia ; mortality ; disability adjusted life year ; burden of disease ; annual percentage change ; Medicine ; R
    Subject code 360
    Language Chinese
    Publishing date 2022-08-01T00:00:00Z
    Publisher Shanghai Preventive Medicine Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: [Control Models and Effect Evaluation of Air Pollution in Jing-Jin-Ji Urban Agglomeration].

    Wang, Zhen-Bo / Liang, Long-Wu / Lin, Xiong-Bin / Liu, Hai-Meng

    Huan jing ke xue= Huanjing kexue

    2018  Volume 38, Issue 10, Page(s) 4005–4014

    Abstract: Controlling air pollution in the Jing-jin-ji urban agglomeration (JJJUA), the most seriously ...

    Abstract Controlling air pollution in the Jing-jin-ji urban agglomeration (JJJUA), the most seriously polluted area in China, is related to the integrated development strategy for the region. Based on the national and regional implementation of air pollution control measures in recent years, the hierarchical cross-regional multi-directional linkage (HCML) air pollution prevention and control model was applied in this study. The effect of air pollution control was evaluated by monitoring the pollutants, SO
    Language Chinese
    Publishing date 2018-07-02
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 0250-3301
    ISSN 0250-3301
    DOI 10.13227/j.hjkx.201701007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Research on Herb Pairs of Classical Formulae of ZHANG Zhong-Jing Using Big Data Technology

    Huang Xin-Di / Ding Chang-Song / Liang Hao / Xiong Shi-Wei / Li Li-Song

    Digital Chinese Medicine, Vol 2, Iss 4, Pp 195-

    2019  Volume 206

    Abstract: ... Lve, 《金匮要略》) by ZHANG Zhong-Jing. Formulae were then preprocessed with all herb names standardized ...

    Abstract Objective: To analyze various herbal combinations in Treatise on Exogenous Febrile Diseases (Shang Han Lun,《伤寒论》) and Synopsis of Prescriptions of the Golden Chamber (Jin Gui Yao Lve, 《金匮要略》), seeking to identify fundamental rules dictating the selection of herbal combinations through probability models and big data technology. Methods: A total of 252 formulae were collected from Treatise on Exogenous Febrile Diseases (Shang Han Lun, 《伤寒论》) and Synopsis of Prescriptions of the Golden Chamber (Jin Gui Yao Lve, 《金匮要略》) by ZHANG Zhong-Jing. Formulae were then preprocessed with all herb names standardized. The concepts of candidate herb pair and candidate herb pair probability were proposed to analyze the rules of combinations in classical formulae based on probability statistics. MapReduce parallel computing framework of distributed big data technology was adopted to analyze large data samples combined with inverted index algorithm. Results: The results showed that the core herbs were Glycyrrhizae Radix Rhizoma (Gan Cao, 甘 草 ), Cinnamomi Ramulus (Gui Zhi, 桂 枝 ), Zingiberis Rhizoma Recens (Sheng Jiang, 生姜), Jujubae Fructus (Da Zao, 大枣), Paeoniae Radix Alba (Bai Shao, 白 芍 ), etc. 43 high-frequency pairs co-occurring 10 times or above were extracted, and 35 of these combinations were recognized as traditional herb pairs, such as Cinnamomi Ramulus (Gui Zhi, 桂枝) - Glycyrrhizae Radix Rhizoma (Gan Cao, 甘草), Zingiberis Rhizoma Recens (Sheng Jiang, 生姜) - Jujubae Fructus (Da Zao, 大枣), and Cinnamomi Ramulus (Gui Zhi, 桂枝) - Ginseng Radix Et Rhizoma (Ren Shen, 人参). The other 8 pairs of combinations, such as Paeoniae Radix Alba (Bai Shao, 白芍) - Zingiberis Rhizoma Recens (Sheng Jiang, 生姜), Paeoniae Radix Alba (Bai Shao, 白 芍 ) - Jujubae Fructus (Da Zao, 大 枣 ), and Zingiberis Rhizoma Recens (Sheng Jiang, 生姜) - Ginseng Radix Et Rhizoma (Ren Shen, 人参), were not defined traditionally, but in connection with commonly used herbs. Classical formulae took the core herbs as principles, focusing on tonifying deficiency, strengthening the ...
    Keywords Medicine ; R ; Other systems of medicine ; RZ201-999
    Subject code 006
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Assessment of Sediment Impact on the Risk of River Diversion during Dam Construction: A Simulation-Based Project Study on the Jing River, China

    Song, Zida / Hu, Zhigen / Li, Huian / Liu, Quan / Xiong, Jianqing

    Water. 2018 Feb. 17, v. 10, no. 2

    2018  

    Abstract: ... diversion project on the Jing River in China with a clear water contrast, the risk values ...

    Abstract Dams are vital for water resource utilization, and river diversion is key for dam construction safety. As sandy river basins are important exploitation areas that have special diversion features, the impact of sediment on the risk of river diversion during dam construction should be assessed. Diversion uncertainty is the origin of diversion risk, and sediment uncertainty changes the storage and discharge patterns of the diversion system. Two Gumbel–Hougaard (GH) copula functions are adopted to couple the random variables of flood and sediment, so that the sediment impacts on diversion storage and discharge can be obtained by the sampling of flood peaks. Based on variable coupling and sediment amendment, a method of Monte Carlo simulation (MCS) with a water balance calculation can quantitatively assess the risk of sandy river diversion, by evaluating the probability of upstream cofferdam overtopping. By introducing one diversion project on the Jing River in China with a clear water contrast, the risk values of dam construction diversion with or without sediment impacts can be obtained. Results show that the MCS method is feasible for diversion risk assessment; sediment has a negative impact on the risk of river diversion during dam construction, and this degradation effect is more evident for high-assurance diversion schemes.
    Keywords dams (hydrology) ; Monte Carlo method ; risk ; risk assessment ; rivers ; sediments ; uncertainty ; watersheds ; China
    Language English
    Dates of publication 2018-0217
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2521238-2
    ISSN 2073-4441
    ISSN 2073-4441
    DOI 10.3390/w10020217
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Prevalence of hypertension and associated risk factors in Chinese Jing compared with Mulao populations.

    Xie, Rui-Bin / Liao, Pei-Juan / Yin, Rui-Xing / Hu, Xi-Jiang / Huang, Jian / Wei, Dai-Xun / Li, Hui / Huang, Feng / Yao, Li-Mei / Pan, Shang-Ling / Yang, De-Zhai / Lin, Wei-Xiong

    The Journal of international medical research

    2015  Volume 43, Issue 6, Page(s) 819–833

    Abstract: ... and associated risk factors between the Chinese Jing and Mulao populations.: Methods: Subjects ... of Jing and Mulao ethnicities were surveyed using stratified randomized sampling. Demography, diet and ... blood pressure (BP) levels and serum lipid concentrations were obtained.: Results: Data from 915 Jing and 911 ...

    Abstract Objective: *These authors contributed equally to this work. At present, they work at the Hezhou People's Hospital, Hezhou, China.To retrospectively compare differences in the prevalence of hypertension and associated risk factors between the Chinese Jing and Mulao populations.
    Methods: Subjects of Jing and Mulao ethnicities were surveyed using stratified randomized sampling. Demography, diet and lifestyle data were collected using standardized questionnaires. Several anthropometric parameters, blood pressure (BP) levels and serum lipid concentrations were obtained.
    Results: Data from 915 Jing and 911 Mulao subjects aged ≥ 35 years were included. Diastolic BP levels and prevalence of hypertension were lower, but prevalence of isolated systolic hypertension was higher, in the Jing compared with the Mulao population. Prevalence of hypertension in the age 60-69 years, body mass index (BMI) > 24 kg/m(2), and smoker subgroups was lower in the Jing compared with the Mulao populations. Prevalence of hypertension correlated with age, cigarette smoking, triglyceride level, waist circumference, sodium intake and total dietary fibre in the Jing population; hypertension prevalence also correlated with age, triglyceride level, BMI, total fat, sodium intake and total dietary fibre in the Mulao population (unconditional logistic regression analyses).
    Conclusions: Prevalence of hypertension and associated risk factors were different between the two ethnic minorities, which might result from the combined effects of differences in their geographic, dietary, lifestyle, and genetic backgrounds.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alcohol Drinking/epidemiology ; Asian Continental Ancestry Group ; Blood Pressure ; Body Mass Index ; China/epidemiology ; Demography ; Ethnic Groups ; Humans ; Hypertension/epidemiology ; Hypertension/physiopathology ; Life Style ; Lipids/blood ; Middle Aged ; Prevalence ; Risk Factors ; Young Adult
    Chemical Substances Lipids
    Language English
    Publishing date 2015-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 184023-x
    ISSN 1473-2300 ; 0300-0605 ; 0142-2596
    ISSN (online) 1473-2300
    ISSN 0300-0605 ; 0142-2596
    DOI 10.1177/0300060515587579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association of the ARL15 rs6450176 SNP and serum lipid levels in the Jing and Han populations.

    Sun, Jia-Qi / Yin, Rui-Xing / Shi, Guang-Yuan / Shen, Shao-Wen / Chen, Xia / Bin, Yuan / Huang, Feng / Wang, Wei / Lin, Wei-Xiong / Pan, Shang-Ling

    International journal of clinical and experimental pathology

    2015  Volume 8, Issue 10, Page(s) 12977–12994

    Abstract: ... lipid levels in the Jing and Han populations. Genotypes of the SNP were determined in 726 unrelated ... subjects of Jing nationality and 726 participants of Han nationality. The genotypic and allelic frequencies ... of the SNP in Jing but not in Han were different between males and females (P < 0.001 and P < 0.05 ...

    Abstract The association of ADP-ribosylation factor-like 15 (ARL15) rs6450176 single nucleotide polymorphism (SNP) and serum lipid profiles has never been studied in the Chinese population. The present study was undertaken to detect the association of ARL15 rs6450176 SNP and several environmental factors with serum lipid levels in the Jing and Han populations. Genotypes of the SNP were determined in 726 unrelated subjects of Jing nationality and 726 participants of Han nationality. The genotypic and allelic frequencies of the SNP in Jing but not in Han were different between males and females (P < 0.001 and P < 0.05; respectively). The G allele carriers in Han had lower serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein (Apo) B levels, and higher ApoA1/ApoB ratio than the G allele non-carriers (P < 0.05-0.01). The G allele carriers in Jing had lower serum TC, high-density lipoprotein cholesterol (HDL-C), ApoA1, ApoB levels and higher ApoA1/ApoB ratio than the G allele non-carriers (P < 0.05 for all). Subgroup analyses showed that the G allele carriers had lower TC and LDL-C levels in Han males; lower LDL-C and ApoB levels in Han females; lower ApoB levels and ApoA1/ApoB ratio in Jing males; and lower LDL-C levels in Jing females than the G allele non-carriers (P < 0.05-0.01). Multiple linear regression analysis showed that serum TC, LDL-C, ApoB levels and the ApoA1/ApoB ratio in Han; and TC, HDL-C and ApoA1 levels in Jing were correlated with the genotypes of the ARL15 rs6450176 SNP (P < 0.05-0.001). Serum lipid parameters were also associated with several environmental factors in both ethnic groups. These findings indicated that there may be a racial/ethnic- and/or sex-specific association of the ARL15 rs6450176 SNP and serum lipid levels.
    MeSH term(s) ADP-Ribosylation Factors/genetics ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group/genetics ; Female ; Genetic Association Studies ; Genotype ; Humans ; Lipids/blood ; Male ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide/genetics ; Sex Characteristics ; Young Adult
    Chemical Substances Lipids ; ADP-Ribosylation Factors (EC 3.6.5.2) ; ARL15 protein, human (EC 3.6.5.2)
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2418306-4
    ISSN 1936-2625 ; 1936-2625
    ISSN (online) 1936-2625
    ISSN 1936-2625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ultra-high performance liquid chromatography coupled with quadrupole/time of flight mass spectrometry based chemical profiling approach for the holistic quality control of complex Kang-Jing formula preparations.

    Yang, Xiao-Huan / Cheng, Xiao-Lan / Qin, Bing / Cai, Zhuo-Ya / Cai, Xiong / Liu, Shao / Wang, Qi / Qin, Yong

    Journal of pharmaceutical and biomedical analysis

    2016  Volume 124, Page(s) 319–336

    Abstract: The Kang-Jing (KJ) formula is a compound preparation made from 12 kinds of herbs. So far, four ...

    Abstract The Kang-Jing (KJ) formula is a compound preparation made from 12 kinds of herbs. So far, four different methods (M1-M4) have been documented for KJ preparation, but the influence of preparation methods on the holistic quality of KJ have remained unknown. In this study, a strategy was proposed to investigate the influence of different preparation methods on the holistic quality of KJ using ultra-high performance liquid chromatography coupled with quadrupole/time of flight mass spectrometry (UHPLC-QTOF-MS/MS) based chemical profiling. A total of 101 compounds mainly belonging to flavonoids, tanshinones, monoterpene glycosides, triterpenoid saponins, alkaloids, phenolic acids and volatile oils, were identified. Among these compounds, glaucine was detected only in M3/M4 samples, while two dehydrocorydaline isomers merely detected in M2/M3/M4 samples. Tetrahydrocolumbamine, ethylic lithospermic acid, salvianolic acid E and rosmarimic acid were only detected in M1/M3/M4 samples. In the subsequent quantitative analysis, 12 major compounds were determined by UHPLC-MS/MS. The proposed method was validated with respect to linearity, accuracy, precision and recovery. It was found that the contents of marker compounds varied significantly in samples prepared by different methods. These results demonstrated that preparation method does significantly affect the holistic quality of KJ. UHPLC-QTOF-MS/MS based chemical profiling approach is efficient and reliable for comprehensive quality evaluation of KJ. Collectively, this study provide the chemical evidence for revealing the material basis of KJ, and establish a simple and accurate chemical profiling method for its quality control.
    MeSH term(s) Chromatography, High Pressure Liquid/methods ; Mass Spectrometry/methods ; Medicine, Chinese Traditional ; Quality Control
    Language English
    Publishing date 2016-05-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2016.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Spatiotemporal variation and driving forces of reference evapotranspiration in Jing River Basin, northwest China

    Xu, Lihong / Shi, Zhongjie / Wang, Yanghui / Zhang, Shulan / Chu, Xinzheng / Yu, Pengtao / Xiong, Wei / Zuo, Haijun / Wang, Yunni

    Hydrological processes. 2015 Nov. 15, v. 29, no. 23

    2015  

    Abstract: ... water resources. In this study, ETₒ was estimated by the FAO‐56 Penman–Monteith method in the Jing River Basin ... of agricultural production and water resources, which could improve the ecological environment in Jing River Basin. Copyright ...

    Abstract Evapotranspiration is an important component of the hydrological cycle, which integrates atmospheric demands and surface conditions. Research on spatial and temporal variations of reference evapotranspiration (ETₒ) enables understanding of climate change and its effects on hydrological processes and water resources. In this study, ETₒ was estimated by the FAO‐56 Penman–Monteith method in the Jing River Basin in China, based on daily data from 37 meteorological stations from 1960 to 2005. ETₒ trends were detected by the Mann–Kendall test in annual, seasonal, and monthly timescales. Sensitivity coefficients were used to examine the contribution of important meteorological variables to ETₒ. The influence of agricultural activities, especially irrigation on ETₒ was also analyzed. We found that ETₒ showed a decreasing trend in most of the basin in all seasons, except for autumn, which showed an increasing trend. Mean maximum temperature was generally the most sensitive parameter for ETₒ, followed by relative humidity, solar radiation, mean minimum temperature, and wind speed. Wind speed was the most dominant factor for the declining trend in ETₒ. The more significant decrease in ETₒ for agricultural and irrigation stations was mainly because of the more significant decrease in wind speed and sunshine hours, a mitigation in climate warming, and more significant increase in relative humidity compared with natural stations and non‐irrigation stations. Changes in ETₒ and the sensitivity coefficient of meteorological variables in relation to ETₒ were also affected by topography. Better understanding of ETₒ response to climate change will enable efficient use of agricultural production and water resources, which could improve the ecological environment in Jing River Basin. Copyright © 2015 John Wiley & Sons, Ltd.
    Keywords autumn ; basins ; evapotranspiration ; global warming ; hydrologic cycle ; irrigated farming ; irrigation ; relative humidity ; solar radiation ; spatial variation ; temperature ; temporal variation ; topography ; water resources ; watersheds ; wind speed ; China
    Language English
    Dates of publication 2015-1115
    Size p. 4846-4862.
    Publishing place Wiley
    Document type Article
    ZDB-ID 1479953-4
    ISSN 1099-1085 ; 0885-6087
    ISSN (online) 1099-1085
    ISSN 0885-6087
    DOI 10.1002/hyp.10541
    Database NAL-Catalogue (AGRICOLA)

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  9. Book: Dian han xun yan jin shu nai mi shen jing du xing diao cha yan jiu

    Xiong, Yingmei

    A study of neuronal toxicity on metal nanoparticles in metal fume

    (Lao gong an quan wei sheng yan jiu bao gao)

    2013  

    Title variant Study of neuronal toxicity on metal nanoparticles in metal fume
    Author's details yan jiu zhu chi ren Xiong Yingmei, Liu Peishan
    Series title Lao gong an quan wei sheng yan jiu bao gao
    MeSH term(s) Nervous System Diseases/chemically induced ; Metals, Heavy/toxicity ; Occupational Exposure
    Language Chinese ; English
    Size vii, 77 pages :, illustrations.
    Edition 1 ban.
    Document type Book
    Note In Chinese; abstract also in English.
    ISBN 9789860366839 ; 9860366837
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article: [Association of HLA-DQA1 loci with Helicobacter pylori infection in children of Guangxi Zhuang, Mulam nationalities, China and central Jing nationality, Vietnam].

    Wang, Lin-Lin / Tran, Dinh Binh / Lin, Wei-Xiong / Jiang, Hai-Xing / Shan, Qing-Wen / Xie, Xiang-Zhi / Liang, Dan-Mei

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2004  Volume 42, Issue 8, Page(s) 577–580

    Abstract: ... and Mulan ethnic groups, Guangxi Luocheng county, China and in children of Jing ethnic group, Central ... VacA and urease antibodies by immunoblotting were performed for 54 Zhuang, 76 Mulan and 109 Jing ... infection were 39% in Vietnamese Jing nationality, which was significantly lower than that in children ...

    Abstract Objective: To compare the prevalence of Helicobacter pylori (Hp) infection in children of Zhuang and Mulan ethnic groups, Guangxi Luocheng county, China and in children of Jing ethnic group, Central Vietnam and to analyze the association of HLA-DQA1 alleles of these ethnic groups' children with Hp infection.
    Methods: Serodiagnosis by determining Hp antibody with ELISA and determination of serum CagA, VacA and urease antibodies by immunoblotting were performed for 54 Zhuang, 76 Mulan and 109 Jing children. Polymerase chain reaction-single strand polymorphism (PCR-SSP) technique was applied to determine the polymorphism of the HLA-DQA1 locus of these children and then the association of HLA-DQA1 alleles of these minority children with Hp infection was analyzed by SAS software.
    Results: The prevalence of Hp infection were 39% in Vietnamese Jing nationality, which was significantly lower than that in children of Guangxi Luocheng county (65% in Zhuang nationality and 58% in Mulan nationality) (P < 0.01). The distribution of HLA-DQA1 locus was not significantly different among the 3 groups. The frequency of HLA-DQA1 * 0104 allele was significantly higher in children with Hp infection than in children without Hp infection in each of the 3 groups (P < 0.01).
    Conclusion: The results indicated that the prevalence of Hp infection in Zhuang and Mulan minority ethnic groups in Guangxi, China was higher than that in Vietnamese Jing ethnic group children. HLA-DQA1 * 0104 allele may be associated with susceptibility to Hp infection.
    MeSH term(s) Alleles ; Child ; China/epidemiology ; HLA-DQ Antigens/genetics ; HLA-DQ alpha-Chains ; Helicobacter Infections/epidemiology ; Helicobacter Infections/genetics ; Helicobacter Infections/microbiology ; Helicobacter pylori ; Humans ; Polymorphism, Genetic ; Prevalence ; Vietnam/epidemiology
    Chemical Substances HLA-DQ Antigens ; HLA-DQ alpha-Chains ; HLA-DQA1 antigen
    Language Chinese
    Publishing date 2004-08
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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