Article ; Online: Mesenchymal stem cell alongside exosomes as a novel cell-based therapy for COVID-19: A review study.
Clinical immunology (Orlando, Fla.)
2021 Volume 226, Page(s) 108712
Abstract: In the past year, an emerging disease called Coronavirus disease 2019 (COVID-19), caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been discovered in Wuhan, China, which has become a worrying pandemic and has challenged the ... ...
| Abstract | In the past year, an emerging disease called Coronavirus disease 2019 (COVID-19), caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been discovered in Wuhan, China, which has become a worrying pandemic and has challenged the world health system and economy. SARS-CoV-2 enters the host cell through a specific receptor (Angiotensin-converting enzyme 2) expressed on epithelial cells of various tissues. The virus, by inducing cell apoptosis and production of pro-inflammatory cytokines, generates as cytokine storm, which is the major cause of mortality in the patients. This type of response, along with responses by other immune cell, such as alveolar macrophages and neutrophils causes extensive damage to infected tissue. Newly, a novel cell-based therapy by Mesenchymal stem cell (MSC) as well as by their exosomes has been developed for treatment of COVID-19 that yielded promising outcomes. In this review study, we discuss the characteristics and benefits of MSCs therapy as well as MSC-secreted exosome therapy in treatment of COVID-19 patients. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | B-Lymphocytes/immunology ; COVID-19/immunology ; COVID-19/pathology ; COVID-19/therapy ; Drug Carriers/metabolism ; Drug Delivery Systems/methods ; Exosomes/metabolism ; Humans ; Mesenchymal Stem Cell Transplantation/adverse effects ; Pandemics ; Precision Medicine/methods ; SARS-CoV-2/pathogenicity ; T-Lymphocytes/immunology ; COVID-19 Drug Treatment | |||||
| Chemical Substances | Drug Carriers | |||||
| Language | English | |||||
| Publishing date | 2021-03-06 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 1459903-x | |||||
| ISSN | 1521-7035 ; 1521-6616 | |||||
| ISSN (online) | 1521-7035 | |||||
| ISSN | 1521-6616 | |||||
| DOI | 10.1016/j.clim.2021.108712 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 880: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.