LIVIVO - Search results -

Search results

Result 1 - 10 of total 162

Search options

Article ; Online: Evaluation of cycloplegic and noncycloplegic performance of spot vision screener in detection of amblyopia risk factors using 2021 AAPOS guidelines.

Bulut, Erkan / Dayi, Ozlem / Celik, Yusuf / Bulut, Hatice / Başar, Emel

2024 Volume 46, Page(s) 104073

Abstract: Purpose: This research evaluates the effectiveness of the Spot Vision Screener (SVS) before and after cycloplegia to detect amblyogenic refractive errors in children.: Methods: Children ages 3 to 10 years old were screened by the SVS before and after ...

Abstract	Purpose: This research evaluates the effectiveness of the Spot Vision Screener (SVS) before and after cycloplegia to detect amblyogenic refractive errors in children. Methods: Children ages 3 to 10 years old were screened by the SVS before and after cycloplegia. Sensitivity, specificity, positive and negative predictive value, paired t-test, Bland-Altman plot and receiver operating characteristic area under the curve were evaluated by comparing the results of the SVS (v3.0.05) measurements with the results of the cycloplegic Topcon autorefractometer according to the 2021 guidelines of the American Association for Pediatric Ophthalmology and Strabismus. Results: Both eyes of 211 patients aged 3 to 10 years old were included. Regarding the amblyopia risk factors, the noncycloplegic SVS had 65.7 % sensitivity, 94.9 % specificity, 81.2 % positive predictive value and 89.3 % negative predictive value. The SVS's sensitivity increased from 65.7 % to 81.9 % with cycloplegia compared to noncycloplegic SVS results. The sensitivity detection of hyperopia was improved from 4.2 % to 100 % after cycloplegia. Areas under the receiver operator characteristic curve for noncycloplegic SVS and cycloplegic SVS were 0.506 (95 % CI, 0.395 to 0.646, p = 0737) and 0.905 (95 % CI, 0.915 to 0.971, p < 0.001) for hyperopia, respectively. Using the +1.64 D revised cutoff criteria for hyperopia increased sensitivity from 4.2 % to 78 %. Conclusion: Noncycloplegic SVS measurements showed relatively high specificity in detecting amblyopia risk factors. The fact that noncycloplegic measurements have a very low sensitivity for hyperopia is an important weakness of the SVS, especially because hyperopia is the most frequently encountered refractive error in very young children. It should be noted that amblyogenic hyperopia may be overlooked by an SVS without cycloplegia.
Language	English
Publishing date	2024-04-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2149918-4
ISSN	1873-1597 ; 1572-1000
ISSN (online)	1873-1597
ISSN	1572-1000
DOI	10.1016/j.pdpdt.2024.104073
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Clinical Relevance of Choroidal Thickness in Obese and Healthy Children: A Machine Learning Study.

Bulut, Erkan / Köprübaşı, Sümeyra / Dayi, Özlem / Bulut, Hatice

Turkish journal of ophthalmology

2023 Volume 53, Issue 3, Page(s) 161–168

Abstract: Objectives: To analyze the effect of macular choroidal thickness (MCT) and peripapillary choroidal thickness (PPCT) on the classification of obese and healthy children by comparing the performance of the random forest (RF), support vector machine (SVM), ...

Abstract	Objectives: To analyze the effect of macular choroidal thickness (MCT) and peripapillary choroidal thickness (PPCT) on the classification of obese and healthy children by comparing the performance of the random forest (RF), support vector machine (SVM), and multilayer perceptrons (MLP) algorithms. Materials and methods: Fifty-nine obese children and 35 healthy children aged 6 to 15 years were studied in this prospective comparative study using optical coherence tomography. MCT and PPCT were measured at distances of 500 μm, 1,000 μm, and 1,500 μm from the fovea and optic disc. Three different feature selection algorithms were used to determine the most prominent features of all extracted features. The classification efficiency of the extracted features was analyzed using the RF, SVM, and MLP algorithms, demonstrating their efficacy for distinguishing obese from healthy children. The precision and reliability of measurements were assessed using kappa analysis. Results: The correlation feature selection algorithm produced the most successful classification results among the different feature selection methods. The most prominent features for distinguishing the obese and healthy groups from each other were PPCT temporal 500 μm, PPCT temporal 1,500 μm, PPCT nasal 1,500 μm, PPCT inferior 1,500 μm, and subfoveal MCT. The classification rates for the RF, SVM, and MLP algorithms were 98.6%, 96.8%, and 89%, respectively. Conclusion: Obesity has an effect on the choroidal thicknesses of children, particularly in the subfoveal region and the outer semi-circle at 1,500 μm from the optic disc head. Both the RF and SVM algorithms are effective and accurate at classifying obese and healthy children.
MeSH term(s)	Humans ; Child ; Prospective Studies ; Clinical Relevance ; Reproducibility of Results ; Cross-Sectional Studies ; Pediatric Obesity/diagnosis ; Tomography, Optical Coherence/methods
Language	English
Publishing date	2023-06-16
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2586160-8
ISSN	2149-8709 ; 2147-2661 ; 2149-8709 ; 1300-0659
ISSN (online)	2149-8709
ISSN	2147-2661 ; 2149-8709 ; 1300-0659
DOI	10.4274/tjo.galenos.2022.36724
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: When platelets meet candidalysin: "We just Wnt to have fun".

Bulut, Ozlem / Geckin, Büsranur / Domínguez-Andrés, Jorge

Allergy

2022 Volume 77, Issue 6, Page(s) 1927–1928

MeSH term(s)	Blood Platelets ; Candida albicans ; Fungal Proteins ; Humans
Chemical Substances	ECE1 protein, Candida albicans ; Fungal Proteins
Language	English
Publishing date	2022-01-31
Publishing country	Denmark
Document type	News ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15228
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.150: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 125: Show issues

Order via subito

Details ▾

Article ; Online: Epithelial ingrowth as a rare complication of nonpenetrating traumatic corneal injury.

Bulut, Okyanus / Yaman, Banu / Barut Selver, Ozlem

Clinical & experimental optometry

2022 Volume 106, Issue 4, Page(s) 449–451

MeSH term(s)	Humans ; Cornea ; Corneal Diseases/diagnosis ; Corneal Diseases/etiology ; Corneal Injuries/etiology ; Corneal Injuries/complications ; Epithelium, Corneal ; Keratomileusis, Laser In Situ ; Postoperative Complications
Language	English
Publishing date	2022-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	639275-1
ISSN	1444-0938 ; 0816-4622
ISSN (online)	1444-0938
ISSN	0816-4622
DOI	10.1080/08164622.2022.2048175
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 3168: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Clinical Relevance of Choroidal Thickness in Obese and Healthy Children

Erkan Bulut / Sümeyra Köprübaşı / Özlem Dayi / Hatice Bulut

Türk Oftalmoloji Dergisi, Vol 53, Iss 3, Pp 161-

A Machine Learning Study

2023 Volume 168

Abstract: Objectives:To analyze the effect of macular choroidal thickness (MCT) and peripapillary choroidal thickness (PPCT) on the classification of obese and healthy children by comparing the performance of the random forest (RF), support vector machine (SVM), ... ...

Abstract	Objectives:To analyze the effect of macular choroidal thickness (MCT) and peripapillary choroidal thickness (PPCT) on the classification of obese and healthy children by comparing the performance of the random forest (RF), support vector machine (SVM), and multilayer perceptrons (MLP) algorithms.Materials and Methods:Fifty-nine obese children and 35 healthy children aged 6 to 15 years were studied in this prospective comparative study using optical coherence tomography. MCT and PPCT were measured at distances of 500 μm, 1,000 μm, and 1,500 μm from the fovea and optic disc. Three different feature selection algorithms were used to determine the most prominent features of all extracted features. The classification efficiency of the extracted features was analyzed using the RF, SVM, and MLP algorithms, demonstrating their efficacy for distinguishing obese from healthy children. The precision and reliability of measurements were assessed using kappa analysis.Results:The correlation feature selection algorithm produced the most successful classification results among the different feature selection methods. The most prominent features for distinguishing the obese and healthy groups from each other were PPCT temporal 500 μm, PPCT temporal 1,500 μm, PPCT nasal 1,500 μm, PPCT inferior 1,500 μm, and subfoveal MCT. The classification rates for the RF, SVM, and MLP algorithms were 98.6%, 96.8%, and 89%, respectively.Conclusion:Obesity has an effect on the choroidal thicknesses of children, particularly in the subfoveal region and the outer semi-circle at 1,500 μm from the optic disc head. Both the RF and SVM algorithms are effective and accurate at classifying obese and healthy children.
Keywords	choroidal thickness ; feature selection ; machine learning ; obese children ; optical coherence tomography ; Medicine ; R ; Ophthalmology ; RE1-994
Subject code	006
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A rare cause of microcephaly, thin corpus callosum and refractory epilepsy due to a novel SLC1A4 gene mutation.

Sarigecili, Esra / Bulut, Fatma Derya / Anlas, Ozlem

Clinical neurology and neurosurgery

2022 Volume 218, Page(s) 107283

Abstract: L-serine is an important amino acid that ensures neuronal differentiation and development. The SLC1A4 gene encodes proteins that transport amino acids such as serine, alanine, threonine and glutamate into neurons. Pathogenic variants in SLC1A4 gene ... ...

Abstract	L-serine is an important amino acid that ensures neuronal differentiation and development. The SLC1A4 gene encodes proteins that transport amino acids such as serine, alanine, threonine and glutamate into neurons. Pathogenic variants in SLC1A4 gene interneuron transport of L-serine impaired and a severe global developmental delay occurs, characterized by microcephaly and refractory seizures. In this article, we would like to describe the demographic, clinical, electroencephalography (EEG) and magnetic resonance imaging (MRI) features of a patient with a novel pathogenic variant in the 6th exon of the SLC1A4 gene (p.Gly374Arg) detected by whole-exome sequencing, which is extremely rare (there have been twenty patients reported in the literature). It is emphasized that SLC1A4 gene variants should be kept in mind if the patients have microcephaly, global developmental delay, refractory seizures, and there are no abnormalities in basal metabolic investigations, and the thin corpus callosum and myelination delay is seen on the MRI.
MeSH term(s)	Amino Acid Transport System ASC/genetics ; Corpus Callosum/diagnostic imaging ; Drug Resistant Epilepsy/diagnostic imaging ; Drug Resistant Epilepsy/genetics ; Humans ; Microcephaly/complications ; Microcephaly/diagnostic imaging ; Microcephaly/genetics ; Mutation/genetics ; Seizures/genetics ; Serine/genetics
Chemical Substances	Amino Acid Transport System ASC ; SLC1A4 protein, human ; Serine (452VLY9402)
Language	English
Publishing date	2022-05-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2022.107283
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui I Zs.53: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Impact of adjuvant amniotic membrane transplantation in infectious ulcerative keratitis.

Bulut, Okyanus / Musayeva, Gunel / Selver, Ozlem Barut

International ophthalmology

2022 Volume 43, Issue 3, Page(s) 915–923

Abstract: Purpose: To evaluate the effectiveness of cryopreserved human amniotic membrane transplantation (hAMT) in patients with infectious ulcerative keratitis.: Methods: A retrospective cohort study based on medical records of patients who underwent hAMT ... ...

Abstract	Purpose: To evaluate the effectiveness of cryopreserved human amniotic membrane transplantation (hAMT) in patients with infectious ulcerative keratitis. Methods: A retrospective cohort study based on medical records of patients who underwent hAMT procedure over a 2-year period (2020-2021) was conducted at Ege University Hospital, Turkey. Cryopreserved hAM was used. Best corrected visual acuity (BCVA) was measured with the Snellen chart. Detailed ophthalmological examination was performed at all visits. Treatment success was defined as complete healing including disappearance of corneal infiltrates, epithelial defect closure, reduction in anterior segment reaction. Results: A total of 13 eyes of 12 patients were diagnosed with ulcerative keratitis between 2020 and 2021. hAMT was performed in severe keratitis patients in which corneal infiltrates extending to middle to deep stromal and patients with neurotrophic component, in other words, having trouble for wound healing. The mean age was 60.9 ± 18.7 years, and 66.6% of the patients were male. Average ulcer horizontal diameter was 9.7 ± 2.8 mm. A single-layer human amniotic membrane (hAM) was transplanted 92.3% of eyes. Overlay technique was used in all patients for hAMT. The mean residence time of the amniotic membrane on the ocular surface was 14.1 ± 10.2 days. The mean time from the first presentation to the hAM transplantation was 9.7 ± 6.8 days. The average hospitalization time of all patients was 15 ± 12.1 days, pre-hAMT was 10.2 ± 7.3 days and post-hAMT was 4.8 ± 9.1 days. The mean follow-up time was 3 months. Recovery response was positive in 76.9%. Average healing time was 32.1 ± 14.04 days. Conclusions: hAMT was effective in the treatment of infectious ulcerative keratitis by accelerating and supporting wound healing. Performing hAM transplantation at the early stages of the disease and prolonged residence of membrane on the ocular surface increase the success of the treatment and moreover shortens hospitalization time.
MeSH term(s)	Humans ; Male ; Adult ; Middle Aged ; Aged ; Female ; Corneal Ulcer/diagnosis ; Corneal Ulcer/surgery ; Amnion/transplantation ; Retrospective Studies ; Keratitis ; Cornea ; Corneal Diseases
Language	English
Publishing date	2022-09-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-022-02493-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1479: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: The Relationship Between Anthropometric Z-Score Measurements and Ocular Structures in Turkish Children.

Bulut, Erkan / Sakallioğlu, Ahmet Kürşad / Dayi, Özlem / Alacamli, Goksu

Romanian journal of ophthalmology

2024 Volume 67, Issue 4, Page(s) 374–380

Abstract: Objective (Aim): ...

Abstract	Objective (Aim):
MeSH term(s)	Child ; Humans ; Myopia ; Refraction, Ocular ; Cornea ; Body Mass Index ; Anthropometry ; Biometry
Language	English
Publishing date	2024-02-09
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2842202-8
ISSN	2501-2533 ; 2457-4325
ISSN (online)	2501-2533
ISSN	2457-4325
DOI	10.22336/rjo.2023.59
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Exploiting epigenetic targets to overcome taxane resistance in prostate cancer.

Cevatemre, Buse / Bulut, Ipek / Dedeoglu, Beyza / Isiklar, Arda / Syed, Hamzah / Bayram, Ozlem Yedier / Bagci-Onder, Tugba / Acilan, Ceyda

Cell death & disease

2024 Volume 15, Issue 2, Page(s) 132

Abstract: The development of taxane resistance remains a major challenge for castration resistant prostate cancer (CR-PCa), despite the effectiveness of taxanes in prolonging patient survival. To uncover novel targets, we performed an epigenetic drug screen on ... ...

Abstract	The development of taxane resistance remains a major challenge for castration resistant prostate cancer (CR-PCa), despite the effectiveness of taxanes in prolonging patient survival. To uncover novel targets, we performed an epigenetic drug screen on taxane (docetaxel and cabazitaxel) resistant CR-PCa cells. We identified BRPF reader proteins, along with several epigenetic groups (CBP/p300, Menin-MLL, PRMT5 and SIRT1) that act as targets effectively reversing the resistance mediated by ABCB1. Targeting BRPFs specifically resulted in the resensitization of resistant cells, while no such effect was observed on the sensitive compartment. These cells were successfully arrested at the G
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Taxoids/pharmacology ; Taxoids/therapeutic use ; Docetaxel/pharmacology ; Docetaxel/therapeutic use ; Epigenesis, Genetic ; Drug Resistance, Neoplasm/genetics ; Cell Line, Tumor ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/pathology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Bromodomain Containing Proteins ; DNA-Binding Proteins/genetics ; Adaptor Proteins, Signal Transducing/genetics ; Protein-Arginine N-Methyltransferases/genetics ; Bridged-Ring Compounds
Chemical Substances	taxane (1605-68-1) ; Taxoids ; Docetaxel (15H5577CQD) ; Antineoplastic Agents ; BRPF1 protein, human ; Bromodomain Containing Proteins ; DNA-Binding Proteins ; Adaptor Proteins, Signal Transducing ; PRMT5 protein, human (EC 2.1.1.319) ; Protein-Arginine N-Methyltransferases (EC 2.1.1.319) ; Bridged-Ring Compounds
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-024-06422-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Identification of Normal Fornix Depth Dataset Generated with a Validated Fornix Meter in Healthy Turkish Population.

Bulut, Okyanus / Kaplan, Anil / Furundaoturan, Onur / Kose, Timur / Barut Selver, Ozlem

Ocular immunology and inflammation

2023 , Page(s) 1–5

Abstract: Purpose: To provide an age and sex-classified reference dataset for normal fornix depth by measuring the lower and upper conjunctival fornix depth (FD) in healthy volunteers.: Methods: An epidemiological, prospective, cross-sectional study evaluates ... ...

Abstract	Purpose: To provide an age and sex-classified reference dataset for normal fornix depth by measuring the lower and upper conjunctival fornix depth (FD) in healthy volunteers. Methods: An epidemiological, prospective, cross-sectional study evaluates conjunctival FDs in 301 healthy Turkish volunteers aged 20-83. Fornix measurements were made using a validated fornix depth measurer (FDM). Results: The mean age was 49.2 ± 19 in males and 48.6 ± 16.2 in females. The mean upper and lower conjunctival FDs were 15.9 (12-21) mm and 10.1 (6-13) mm, respectively. The mean upper and lower FDs were 15.4 (13-20) mm and 9.7 (6-13) mm in females, and 16.3 (12-21) mm and 10.5 (8-13) mm in males, respectively. . Conclusion: When the normative dataset created in healthy Turkish volunteers, it was observed that both the upper and lower FDs were shallower in females and that they gradually became shallower with age. Accordingly, when an evaluation for conjunctival pathology is to be made, the expected normal FD value for both age and sex should be considered.
Language	English
Publishing date	2023-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2023.2199055
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4004: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito