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  1. Article ; Online: Mesenchymal stem cells and management of COVID-19 pneumonia.

    Metcalfe, Su M

    Medicine in drug discovery

    2020  Volume 5, Page(s) 100019

    Abstract: Human coronavirus, hCoV-19, is highly pathogenic with severe pneumonia associated with rapid virus replication. Arising in Wuhan China December 2019, the current COVID-19 epidemic has rapidly grown with person-to-person infection expanding to become a ... ...

    Abstract Human coronavirus, hCoV-19, is highly pathogenic with severe pneumonia associated with rapid virus replication. Arising in Wuhan China December 2019, the current COVID-19 epidemic has rapidly grown with person-to-person infection expanding to become a global health emergency now on pandemic scale. Governments will not be able to minimise both deaths from COVID-19 and the economic impact of viral spread in mitigation of this current COVID-19 pandemic, according to Anderson et al. 2020 [1], Keeping mortality as low as possible will be the highest priority for individuals; hence governments must put in place measures to ameliorate the inevitable economic downturn. The current global picture shows small chains of transmission in many countries and large chains resulting in extensive spread in a few countries, such as Italy, Iran, South Korea, and Japan. Most countries are likely to have spread of COVID-19, at least in the early stages, before any mitigation measures have an impact. The scale of the problem is massive. Here I consider new approaches to improve patient's biological resistance to COVID-19 using stem cells, and how benefit might be scaled and simplified using synthetic stem cells to meet logistical needs within a short time frame.
    Keywords covid19
    Language English
    Publishing date 2020-03-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-0986
    ISSN (online) 2590-0986
    DOI 10.1016/j.medidd.2020.100019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mesenchymal stem cells and management of COVID-19 pneumonia

    Metcalfe, Su M.

    Medicine in Drug Discovery

    2020  Volume 5, Page(s) 100019

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2590-0986
    DOI 10.1016/j.medidd.2020.100019
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: LIF and multiple sclerosis: One protein with two healing properties.

    Metcalfe, Su M

    Multiple sclerosis and related disorders

    2018  Volume 20, Page(s) 223–227

    MeSH term(s) Humans ; Leukemia Inhibitory Factor/physiology ; Multiple Sclerosis
    Chemical Substances LIF protein, human ; Leukemia Inhibitory Factor
    Language English
    Publishing date 2018-01-31
    Publishing country Netherlands
    Document type Editorial ; Comment
    ISSN 2211-0356
    ISSN (online) 2211-0356
    DOI 10.1016/j.msard.2018.01.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: COVID-19 lockdown

    Metcalfe, Su M.

    Medicine in Drug Discovery

    de-risking exit by protecting the lung with leukaemia inhibitory factor (LIF)

    2020  Volume 6, Page(s) 100043

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2590-0986
    DOI 10.1016/j.medidd.2020.100043
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

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  5. Article ; Online: LIF and the lung’s stem cell niche: is failure to use LIF to protect against COVID-19 a grave omission in managing the pandemic?

    Metcalfe, Su M

    Abstract: What tips the SARS/COVID-19 balance into severe pneumonia, rather than recovery? Is it insufficient LIF – the lung’s own protective growth factor at the blood–air barrier? ...

    Abstract What tips the SARS/COVID-19 balance into severe pneumonia, rather than recovery? Is it insufficient LIF – the lung’s own protective growth factor at the blood–air barrier?
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.2217/fvl-2020-0340
    Database COVID19

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  6. Book ; Online: LIF and the lung’s stem cell niche

    Metcalfe, Su M

    is failure to use LIF to protect against COVID-19 a grave omission in managing the pandemic?

    2020  

    Abstract: Tweetable abstract: What tips the SARS/COVID-19 balance into severe pneumonia, rather than recovery? Is it insufficient LIF – the lung’s own protective growth factor at the blood–air barrier? ...

    Abstract Tweetable abstract: What tips the SARS/COVID-19 balance into severe pneumonia, rather than recovery? Is it insufficient LIF – the lung’s own protective growth factor at the blood–air barrier?
    Keywords Editorial ; alveolus ; blood–air barrier ; COVID-19 ; LIF ; covid19
    Language English
    Publishing date 2020-11-09T16:14:11Z
    Publisher Future Medicine Ltd
    Publishing country uk
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  7. Book ; Online: LIF and the lung’s stem cell niche

    Metcalfe, Su M

    is failure to use LIF to protect against COVID-19 a grave omission in managing the pandemic?

    2020  

    Abstract: Tweetable abstract: What tips the SARS/COVID-19 balance into severe pneumonia, rather than recovery? Is it insufficient LIF – the lung’s own protective growth factor at the blood–air barrier? ...

    Abstract Tweetable abstract: What tips the SARS/COVID-19 balance into severe pneumonia, rather than recovery? Is it insufficient LIF – the lung’s own protective growth factor at the blood–air barrier?
    Keywords Editorial ; alveolus ; blood–air barrier ; COVID-19 ; LIF ; covid19
    Language English
    Publishing date 2020-11-09T16:18:45Z
    Publisher Future Medicine Ltd
    Publishing country uk
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Mesenchymal stem cells and management of COVID-19 pneumonia

    Metcalfe, Su M.

    Med. Drug Disc.

    Abstract: Human coronavirus, hCoV-19, is highly pathogenic with severe pneumonia associated with rapid virus replication. Arising in Wuhan China December 2019, the current COVID-19 epidemic has rapidly grown with person-to-person infection expanding to become a ... ...

    Abstract Human coronavirus, hCoV-19, is highly pathogenic with severe pneumonia associated with rapid virus replication. Arising in Wuhan China December 2019, the current COVID-19 epidemic has rapidly grown with person-to-person infection expanding to become a global health emergency now on pandemic scale. Governments will not be able to minimise both deaths from COVID-19 and the economic impact of viral spread in mitigation of this current COVID-19 pandemic, according to Anderson et al. 2020 [1], Keeping mortality as low as possible will be the highest priority for individuals; hence governments must put in place measures to ameliorate the inevitable economic downturn. The current global picture shows small chains of transmission in many countries and large chains resulting in extensive spread in a few countries, such as Italy, Iran, South Korea, and Japan. Most countries are likely to have spread of COVID-19, at least in the early stages, before any mitigation measures have an impact. The scale of the problem is massive. Here I consider new approaches to improve patient's biological resistance to COVID-19 using stem cells, and how benefit might be scaled and simplified using synthetic stem cells to meet logistical needs within a short time frame.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #9529
    Database COVID19

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: COVID-19 lockdown: de-risking exit by protecting the lung with leukaemia inhibitory factor (LIF)

    Metcalfe, Su M.

    Medicine in Drug Discovery

    Abstract: There are two key needs in COVID-19 management: (i) to reduce SARS-CoV-2 viral infection rate;and (ii) to reduce death rate of those infected - the subject of this commentary The current WHO estimated global mortality rate is 3 4% (March 2020) and the ... ...

    Abstract There are two key needs in COVID-19 management: (i) to reduce SARS-CoV-2 viral infection rate;and (ii) to reduce death rate of those infected - the subject of this commentary The current WHO estimated global mortality rate is 3 4% (March 2020) and the global death toll has now past 200,000 (April 2020) Without therapy the COVID-19 pandemic is escalating exponentially: from the first reported death in Wuhan China 10th January 2020, it took 91 days for the global death toll to pass 100,000 - then a further 16 days to reach 200,000 A vaccination program will take 1–2 years to roll out, once safety and efficacy is proven Anti-virals are being sought mainly amongst repurposed drug candidates but also with combinatorial screening of libraries, for example to block virus binding angiotensin converting enzyme 2 (ACE2) - ACE2 providing the receptor on cells that allows viral entry Cell-based approaches include stem cells and exosomes but these will never meet scale of need whilst also carrying risk of viral transmission if contaminated Countries have introduced Population control with social distancing and lockdown to isolate individuals: this has reduced infectivity rate - “R” - where R denotes the average number of people an infected person will spread the illness to But, after lockdown, the virus remains: the probability of R increasing again is high The new danger is exit from lockdown Here, leukaemia inhibitory factor (LIF) represents an untapped resource to boost the lung's own resistance to developing COVID-19 - reducing risk of severe disease as nations cautiously leave lockdown to return to normality
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #276398
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Mesenchymal stem cells and management of COVID-19 pneumonia.

    Metcalfe, Su M

    nlmid: 101765689 ; essn: 2590-0986

    2020  

    Abstract: Human coronavirus, hCoV-19, is highly pathogenic with severe pneumonia associated with rapid virus replication. Arising in Wuhan China December 2019, the current COVID-19 epidemic has rapidly grown with person-to-person infection expanding to become a ... ...

    Abstract Human coronavirus, hCoV-19, is highly pathogenic with severe pneumonia associated with rapid virus replication. Arising in Wuhan China December 2019, the current COVID-19 epidemic has rapidly grown with person-to-person infection expanding to become a global health emergency now on pandemic scale. Governments will not be able to minimise both deaths from COVID-19 and the economic impact of viral spread in mitigation of this current COVID-19 pandemic, according to Anderson et al. 2020 [1], Keeping mortality as low as possible will be the highest priority for individuals; hence governments must put in place measures to ameliorate the inevitable economic downturn. The current global picture shows small chains of transmission in many countries and large chains resulting in extensive spread in a few countries, such as Italy, Iran, South Korea, and Japan. Most countries are likely to have spread of COVID-19, at least in the early stages, before any mitigation measures have an impact. The scale of the problem is massive. Here I consider new approaches to improve patient's biological resistance to COVID-19 using stem cells, and how benefit might be scaled and simplified using synthetic stem cells to meet logistical needs within a short time frame.
    Keywords Corona virus ; Leukaemia inhibitory factor ; Mesenchymal Stem Cells ; Cytokine Storm ; Synthetic Stem Cells ; covid19
    Language English
    Publishing date 2020-05-18T00:22:36Z
    Publisher Medicine in drug discovery
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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