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  1. Article ; Online: COVID-19

    Fatima A Saleh / Aleen Sleem

    Medical Sciences, Vol 9, Iss 1, p

    Test, Test and Test

    2021  Volume 1

    Abstract: A new virus was identified in late December 2019 when China reported the first cases of pneumonia in Wuhan, and a global COVID-19 pandemic followed. The world was not late to respond, with a number of sweeping measures ranging from social distancing ... ...

    Abstract A new virus was identified in late December 2019 when China reported the first cases of pneumonia in Wuhan, and a global COVID-19 pandemic followed. The world was not late to respond, with a number of sweeping measures ranging from social distancing protocols, stringent hygienic practices, and nation-wide lockdowns, as well as COVID-19 testing campaigns in an attempt to prevent the transmission of the disease and contain the pandemic. Currently, different types of diagnostic testing have been adopted globally, such as nucleic acid detection tests, immunological tests and imaging approaches; however, real-time reverse transcriptase–polymerase chain reaction (RT-PCR) remains the “gold standard” for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pre-analytical factors, such as specimen selection and collection, are crucial for RT-PCR, and any suboptimal collection may contribute to false-negative results. Herein, we address some of the specimen types that have been used in molecular detection methods for COVID-19. However, the pandemic is still evolving, and information might change as more studies are conducted.
    Keywords COVID-19 ; RT-PCR ; diagnostic testing ; sampling methods ; nasopharyngeal swabs ; false-negative results ; Medicine ; R
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: COVID-19: Test, Test and Test.

    Saleh, Fatima A / Sleem, Aleen

    Medical sciences (Basel, Switzerland)

    2020  Volume 9, Issue 1

    Abstract: A new virus was identified in late December 2019 when China reported the first cases of pneumonia in Wuhan, and a global COVID-19 pandemic followed. The world was not late to respond, with a number of sweeping measures ranging from social distancing ... ...

    Abstract A new virus was identified in late December 2019 when China reported the first cases of pneumonia in Wuhan, and a global COVID-19 pandemic followed. The world was not late to respond, with a number of sweeping measures ranging from social distancing protocols, stringent hygienic practices, and nation-wide lockdowns, as well as COVID-19 testing campaigns in an attempt to prevent the transmission of the disease and contain the pandemic. Currently, different types of diagnostic testing have been adopted globally, such as nucleic acid detection tests, immunological tests and imaging approaches; however, real-time reverse transcriptase-polymerase chain reaction (RT-PCR) remains the "gold standard" for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pre-analytical factors, such as specimen selection and collection, are crucial for RT-PCR, and any suboptimal collection may contribute to false-negative results. Herein, we address some of the specimen types that have been used in molecular detection methods for COVID-19. However, the pandemic is still evolving, and information might change as more studies are conducted.
    MeSH term(s) COVID-19/diagnosis ; COVID-19 Testing ; Humans ; Nasopharynx/virology ; Pandemics ; Saliva/virology ; Specimen Handling
    Language English
    Publishing date 2020-12-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2754473-4
    ISSN 2076-3271 ; 2076-3271
    ISSN (online) 2076-3271
    ISSN 2076-3271
    DOI 10.3390/medsci9010001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mesenchymal stem cells in the fight against viruses: Face to face with the invisible enemy.

    Sleem, Aleen / Saleh, Fatima

    Current research in translational medicine

    2020  Volume 68, Issue 3, Page(s) 105–110

    Abstract: The relative ease of isolation of mesenchymal stem cells (MSCs) from different tissues coupled with their culture expansion in vitro and their differentiation capacity to mesodermal, endodermal and ectodermal lineages have made these cells attractive for ...

    Abstract The relative ease of isolation of mesenchymal stem cells (MSCs) from different tissues coupled with their culture expansion in vitro and their differentiation capacity to mesodermal, endodermal and ectodermal lineages have made these cells attractive for a large number of therapeutic applications. In recent years, there has been remarkable progress in the utilization of MSCs in diverse clinical indications both in animal models and human clinical trials. However, the potential of MSCs to control or treat viral diseases is still in its infancy. In this study, we report quantitative data on the MSC-based clinical trials over the last ten years as they appear on the online database of clinical research studies from US National Institutes of Health. In particular, we provide comprehensive review of either completed or ongoing clinical trials using MSCs for virus-associated diseases focusing on HIV, hepatitis B virus and COVID-19 virus.
    MeSH term(s) Animals ; Betacoronavirus/physiology ; COVID-19 ; Cell Culture Techniques ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; HIV/physiology ; Hepatitis B virus/physiology ; Humans ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cell Transplantation/trends ; Mesenchymal Stem Cells/physiology ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Virus Diseases/epidemiology ; Virus Diseases/immunology ; Virus Diseases/therapy ; Virus Physiological Phenomena ; Viruses/pathogenicity
    Keywords covid19
    Language English
    Publishing date 2020-05-01
    Publishing country France
    Document type Journal Article ; Review
    ISSN 2452-3186
    ISSN (online) 2452-3186
    DOI 10.1016/j.retram.2020.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Mesenchymal stem cells in the fight against viruses: Face to face with the invisible enemy

    Sleem, Aleen / Saleh, Fatima

    Curr Res Transl Med

    Abstract: The relative ease of isolation of mesenchymal stem cells (MSCs) from different tissues coupled with their culture expansion in vitro and their differentiation capacity to mesodermal, endodermal and ectodermal lineages have made these cells attractive for ...

    Abstract The relative ease of isolation of mesenchymal stem cells (MSCs) from different tissues coupled with their culture expansion in vitro and their differentiation capacity to mesodermal, endodermal and ectodermal lineages have made these cells attractive for a large number of therapeutic applications. In recent years, there has been remarkable progress in the utilization of MSCs in diverse clinical indications both in animal models and human clinical trials. However, the potential of MSCs to control or treat viral diseases is still in its infancy. In this study, we report quantitative data on the MSC-based clinical trials over the last ten years as they appear on the online database of clinical research studies from US National Institutes of Health. In particular, we provide comprehensive review of either completed or ongoing clinical trials using MSCs for virus-associated diseases focusing on HIV, hepatitis B virus and COVID-19 virus.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #631298
    Database COVID19

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