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Article ; Online: Frontal Sinus Balloon Sinuplasty-Patient Satisfaction and Factors Predicting Reoperation.

Sainio, Sara / Blomgren, Karin / Koskinen, Anni / Lundberg, Marie

OTO open

2023 Volume 7, Issue 1, Page(s) e23

Abstract: Objective: To explore predictive factors of postoperative outcome of frontal sinus balloon dilation.: Study design: Retrospective questionnaire study.: Setting: Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital ... ...

Abstract	Objective: To explore predictive factors of postoperative outcome of frontal sinus balloon dilation. Study design: Retrospective questionnaire study. Setting: Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Finland. Methods: We reviewed electronic records of all patients who underwent frontal sinus balloon dilatation (successful or attempted) in our clinic from 2008 to 2019. We documented patient characteristics, preoperative imaging results, intraoperative factors, possible complications, and reoperations. Those who underwent frontal sinus balloon sinuplasty were sent a questionnaire regarding their current symptoms and long-term satisfaction with surgery. Results: In total, 258 operations (404 frontal sinuses) were reviewed, with a technical success rate of 93.6% (n = 378). The revision rate was 15.7% (n = 38). Previous sinonasal surgery predicted a higher revision rate ( Conclusion: Technical success rate and patient satisfaction after frontal sinus balloon sinuplasty are high. Balloon sinuplasty seems insufficient in reoperations. A hybrid approach appears to result in fewer reoperations than a balloon only approach.
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article
ISSN	2473-974X
ISSN (online)	2473-974X
DOI	10.1002/oto2.23
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Article: The effect of single kinetic oscillation stimulation treatment on nonallergic rhinitis.

Sainio, Sara / Blomgren, Karin / Laulajainen-Hongisto, Anu / Lundberg, Marie

Laryngoscope investigative otolaryngology

2023 Volume 8, Issue 2, Page(s) 373–379

Abstract: Objective: Kinetic oscillation stimulation (KOS) is a new treatment method for nonallergic rhinitis (NAR), usually delivered twice with a 2- to 4-week interval, and thought to stabilize autonomous dysregulation in the nasal mucosa. We aimed to assess ... ...

Abstract	Objective: Kinetic oscillation stimulation (KOS) is a new treatment method for nonallergic rhinitis (NAR), usually delivered twice with a 2- to 4-week interval, and thought to stabilize autonomous dysregulation in the nasal mucosa. We aimed to assess the long-term (1 year) results following one KOS treatment amongst patients with NAR. Methods: KOS was administered through a latex balloon placed in the patient's nasal cavity. The balloon is connected to a device that fills the balloon with air pulses, thus vibrating the balloon for 10 min per side. Outcomes were evaluated through patient-reported outcome measures (Sino-Nasal Outcome Test 22 [SNOT-22], Total Nasal Symptom Score [TNSS], Nasal Obstruction Symptom Evaluation [NOSE], and 15D) and measures of patency (rhinomanometry, acoustic rhinometry, peak nasal inspiratory flow [PNIF], and clinical inferior turbinate size). Pre-treatment actions were repeated at 1, 3, 6, and 12 months. Results: In all 49 patients, we found significant improvement in the SNOT-22, NOSE, and TNSS scores. At 12 months, SNOT-22 improved from 44 to 34, NOSE from 60 to 45, TNSS from 8 to 7, and PNIF from 80 to 100 L/min ( Conclusion: One KOS treatment appears to provide NAR patients with a subjective symptom improvement for at least 1 year, thus possibly decreasing the need for invasive treatment methods. Level of evidence: III.
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.1048
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Article ; Online: Recovery of Ammonium from Biomass-Drying Condensate Via Ion Exchange and Its Valorization as a Fertilizer

Jianzhi Song / Jari Heinonen / Tuomo Sainio

Processes, Vol 11, Iss 815, p

2023 Volume 815

Abstract: ... removal. K 3 PO 4 was used for regeneration to produce a liquid compound fertilizer containing nutrient ... elements (N, K, and P) as a byproduct. The N/K ratio in the byproduct was found to be adjustable by varying ... the operating parameters. Regeneration with 2 mol/L K 3 PO 4 gave a higher regeneration efficiency (97.67% at 3 BV and ~100 ...

Abstract	In this study, an industrial biomass-drying wastewater condensate containing > 3200 mg/L NH 4 + and >8900 mg/L CH 3 COO − was treated in ion-exchange columns for the recovery of NH 4 + . Two commercial resins (CS12GC and CS16GC) were studied on laboratory and pilot scales. CS16GC outperformed CS12GC by achieving better separation at the condensate temperature (60 °C), which was energy-efficient regarding NH 4 + removal. K 3 PO 4 was used for regeneration to produce a liquid compound fertilizer containing nutrient elements (N, K, and P) as a byproduct. The N/K ratio in the byproduct was found to be adjustable by varying the operating parameters. Regeneration with 2 mol/L K 3 PO 4 gave a higher regeneration efficiency (97.67% at 3 BV and ~100% at 4 BV). The stability tests performed on a laboratory scale showed that the cyclic runs of the column separation process were steady and repeatable. Based on the outcomes of the laboratory-scale tests, the pilot-scale tests applied a loading volume of 7 BV. The pilot column purified the feed and achieved the target NH 4 + level in the treated effluent within the seven tested cycles, revealing that the industrial application of the cation ion-exchange resin CS16GC is worth further study.
Keywords	ammonium acetate ; ion-exchange column ; pilot scale ; industrial condensate ; fertilizer byproduct ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	333
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: A randomized controlled trial protocol for persistent physical symptoms associated with indoor environment or chronic fatigue: Effectiveness of video-based functional case conceptualization and web-program for improving quality of life.

Selinheimo, Sanna / Keinonen, Katariina / Vuokko, Aki / Liesto, Sanna / Sainio, Markku / Lappalainen, Raimo / Paunio, Tiina

Frontiers in psychology

2023 Volume 13, Page(s) 923532

Abstract: Introduction: Persistent physical symptoms (PPS) refer to symptoms that cannot be fully explained by structural bodily pathology or by environmental factors. Their impact on daily functioning varies from mild to severe disability. So far, evidence-based ...

Abstract	Introduction: Persistent physical symptoms (PPS) refer to symptoms that cannot be fully explained by structural bodily pathology or by environmental factors. Their impact on daily functioning varies from mild to severe disability. So far, evidence-based treatments for PPS have resulted in only small to moderate effects. Treatment protocols with a stronger orientation toward personalized approaches are needed to improve the efficacy and applicability of treatment. In this study, we aim to assess the effect of an online individual case conceptualization with web-based program for PPS. This study is conducted among two focus groups: patients with indoor air-related symptoms and patients with chronic fatigue syndrome. Methods and analyses: Using a randomized controlled design (RCT) with two parallel groups in a 1:1 ratio, we will compare individual video-based case conceptualization with a web-based program based on Acceptance and Commitment Therapy (ACT), combined with treatment as usual, with treatment as usual only. The web-based program consists of ten modules, each lasting 1 week and including training. The planned sample size is 124 eligible patients without attrition. The primary outcome will be the health-related quality of life as measured by the 15D questionnaire. The secondary outcome measures will include questionnaires on psychiatric and physical symptoms, illness perceptions, psychological flexibility, and work ability. We will also use national registers to obtain information on the use of healthcare and social benefits to complete patient-reported outcomes. Data collection began in August 2020 and will continue until 2023. Discussion: This trial will provide information on the effects and usefulness of an online administrated individual case conceptualization and an ACT-based web-program on PPS. Ethics and dissemination: The Ethics Committee of the Hospital District of Helsinki and Uusimaa, Finland, has granted approval for the study. The results will be published in peer-reviewed journals. Clinical trial registration: Clinicaltrials.gov, identifier NCT04532827 preresults.
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.923532
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Article ; Online: Use of O RhD-negative red blood cells: A nationwide, prospective audit.

Ilmakunnas, Minna / Salmela, Katja / Kivipuro, Tiia / Sareneva, Hannele / Sainio, Susanna

Vox sanguinis

2022 Volume 117, Issue 11, Page(s) 1279–1286

Abstract: Background and objectives: Despite declining transfusion rates, overuse of O RhD-negative red blood cells (RBCs) risks the secure supply of this limited resource. A nationwide prospective audit was performed in Finland to understand the clinical use and ...

Abstract	Background and objectives: Despite declining transfusion rates, overuse of O RhD-negative red blood cells (RBCs) risks the secure supply of this limited resource. A nationwide prospective audit was performed in Finland to understand the clinical use and inventory management of O RhD-negative units. Our aim was to identify areas where policy changes could help alleviate the shortage of O RhD-negative RBCs. Materials and methods: The use of every O RhD-negative unit in Finland during a period of 1 month was reviewed. For each issued unit (n = 1105), unit age, urgency of transfusion, hospital and patient demographics, and specific reasons for issuing O RhD-negative units were recorded. Results: Almost half of the O RhD-negative units (n = 529, 47.9%) were issued to non-O RhD-negative patients. Only 22.3% (n = 118) were issued for females under the age of 50. Of the units for ABO-nonidentical transfusion, one-third (32.5%, n = 172) were issued for emergency transfusion, two-thirds (67.5%, n = 357) for non-urgent transfusions. The most common reason for issuing an O RhD-negative unit was inventory management (n = 172, 48.2% of units issued for non-urgent transfusion). Most of these units were issued close to the unit expiry date. Conclusion: This nationwide audit revealed that a significant proportion of O RhD-negative RBCs are used inappropriately. Clinicians should be educated on the appropriate use of O RhD-negative RBCs, and blood banks should develop strategies for inventory management to avoid issuing O RhD-negative units purely to prevent outdating.
MeSH term(s)	Female ; Humans ; Erythrocyte Transfusion ; Erythrocytes ; Blood Banks ; Blood Transfusion ; Erythrocyte Count
Language	English
Publishing date	2022-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	80313-3
ISSN	1423-0410 ; 0042-9007
ISSN (online)	1423-0410
ISSN	0042-9007
DOI	10.1111/vox.13357
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Article: Imaging-based internal body temperature measurements: The journal

Raiko, Juho / Koskensalo, Kalle / Sainio, Teija

Temperature (Austin, Tex.)

2020 Volume 7, Issue 4, Page(s) 363–388

Abstract: Noninvasive imaging methods of internal body temperature are in high demand in both clinical medicine and physiological research. Thermography and thermometry can be used to assess tissue temperature during thermal therapies: ablative and hyperthermia ... ...

Abstract	Noninvasive imaging methods of internal body temperature are in high demand in both clinical medicine and physiological research. Thermography and thermometry can be used to assess tissue temperature during thermal therapies: ablative and hyperthermia treatments to ensure adequate temperature rise in target tissues but also to avoid collateral damage by heating healthy tissues. In research use, measurement of internal body temperature enables us the production of thermal maps on muscles, internal organs, and other tissues of interest. The most used methods for noninvasive imaging of internal body temperature are based on different parameters acquired with magnetic resonance imaging, ultrasound, computed tomography, microwave radiometry, photoacoustic imaging, and near-infrared spectroscopy. In the current review, we examine the aforementioned imaging methods, their use in estimating internal body temperature in vivo with their advantages and disadvantages, and the physical phenomena the thermography or thermometry modalities are based on.
Language	English
Publishing date	2020-05-29
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2332-8940
ISSN	2332-8940
DOI	10.1080/23328940.2020.1769006
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Article: Complications and number of follow-up visits after using septal stapler in septoplasty.

Sainio, S / Blomgren, K / Lundberg, M

Rhinology

2019 Volume 57, Issue 4, Page(s) 273–278

Abstract: Background: Septoplasties have traditionally been closed with transseptal sutures, silicone splints, or packing with nasal tamponade. In 2015, our clinic began to employ a septal stapler. The stapler adheres the mucosa to the septal cartilage with ... ...

Abstract	Background: Septoplasties have traditionally been closed with transseptal sutures, silicone splints, or packing with nasal tamponade. In 2015, our clinic began to employ a septal stapler. The stapler adheres the mucosa to the septal cartilage with bioresorbable staples, replacing both sutures and silicone splints and limiting the use of nasal tamponade for bleeding cases. The complications of stapler versus other methods have not been reported on previously. Thus, the aim of this study was to investigate whether the use of stapler in septoplasties makes a difference in complication rates, operation time, or number of follow-up visits when compared to the traditional closure or filling methods. Methodology: Patient records from 101 septoplasties in which the stapler had been used, and a reference group of 356 septoplasties in which the stapler had not been used, were retrospectively reviewed and analysed. Results: No significant difference was seen in the complication rate between the stapler and the control group. Overall follow-up visits were fewer in the stapler group when compared to the control group, however there was no significant difference in the number of unplanned follow-up visits between the groups. Conclusions: By using the stapler in septoplasty, the number of postoperative follow-up visits might be reduced. Neither complication rate, nor operation time differed when using the stapler as compared to the traditional methods of closure.
MeSH term(s)	Follow-Up Studies ; Humans ; Nasal Septum/surgery ; Retrospective Studies ; Rhinoplasty/adverse effects ; Rhinoplasty/methods ; Suture Techniques ; Sutures
Language	English
Publishing date	2019-04-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80336-4
ISSN	0300-0729
ISSN	0300-0729
DOI	10.4193/Rhin18.142
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Article ; Online: Ultrafast photoresponse of vertically oriented TMD films probed in a vertical electrode configuration on Si chips.

Järvinen, Topias / Hosseini Shokouh, Seyed-Hossein / Sainio, Sami / Pitkänen, Olli / Kordas, Krisztian

Nanoscale advances

2022 Volume 4, Issue 15, Page(s) 3243–3249

Abstract: Integrated photodetectors based on transition metal dichalcogenides (TMDs) face the challenge of growing their high-quality crystals directly on chips or transferring them to the desired locations of components by applying multi-step processes. Herein, ... ...

Abstract	Integrated photodetectors based on transition metal dichalcogenides (TMDs) face the challenge of growing their high-quality crystals directly on chips or transferring them to the desired locations of components by applying multi-step processes. Herein, we show that vertically oriented polycrystalline thin films of MoS
Language	English
Publishing date	2022-07-05
Publishing country	England
Document type	Journal Article
ISSN	2516-0230
ISSN (online)	2516-0230
DOI	10.1039/d2na00313a
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Article ; Online: Effect of alar nasal valve stent on nasal breathing.

Sainio, Sara / Lundberg, Marie / Hammarén-Malmi, Sari / Pietarinen, Petra / Blomgren, Karin

American journal of otolaryngology

2022 Volume 43, Issue 4, Page(s) 103473

Abstract: Purpose: Lateral nasal wall insufficiency has previously been a surgical challenge. In 2018, the Alar Nasal Valve Stent (Medtronic) was taken into use at Helsinki University Hospital. The alar cartilages are repositioned and locked into position with ... ...

Abstract	Purpose: Lateral nasal wall insufficiency has previously been a surgical challenge. In 2018, the Alar Nasal Valve Stent (Medtronic) was taken into use at Helsinki University Hospital. The alar cartilages are repositioned and locked into position with the Alar Nasal Valve Stent on the mucosa. The stent gives support and widens the alar valve while cartilages scar into their new position presumably facilitating breathing after removal of the stent. The aim of this prospective, observational study was to investigate whether the Alar Nasal Valve Stent has an effect on nasal breathing in patients with lateral nasal wall insufficiency. Materials and methods: Symptom questionnaires (Sino-Nasal Outcome Test-22, Nasal Obstruction Symptom Evaluation, five-step symptom score) were analyzed preoperatively and at 3, 6, and 12 months postoperatively. Acoustic rhinometry, rhinomanometry, and peak nasal inspiratory flow were analyzed preoperatively and 3 months postoperatively. The patients performed a stress ergometry preoperatively and 3 months postoperatively, with their noses being photographed and filmed. Results: In a series of 18 patients, a significant positive difference was seen in subjective symptom scores preoperatively versus postoperatively. The difference remained stable throughout the follow-up. No difference in objective symptom measurements was observed. Conclusions: Patients suffering from lateral nasal wall insufficiency experience a significant subjective improvement in nasal breathing after Alar Nasal Valve Stent surgery.
MeSH term(s)	Humans ; Nasal Cartilages/surgery ; Nasal Obstruction/diagnosis ; Nasal Obstruction/etiology ; Nasal Obstruction/surgery ; Nose/surgery ; Prospective Studies ; Rhinoplasty ; Stents
Language	English
Publishing date	2022-05-02
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2022.103473
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Article ; Online: Variants in tropomyosins TPM2 and TPM3 causing muscle hypertonia.

Wallgren-Pettersson, Carina / Jokela, Manu / Lehtokari, Vilma-Lotta / Tyynismaa, Henna / Sainio, Markus T / Ylikallio, Emil / Tynninen, Olli / Pelin, Katarina / Auranen, Mari

Neuromuscular disorders : NMD

2023 Volume 35, Page(s) 29–32

Abstract: Patients with myopathies caused by pathogenic variants in tropomyosin genes TPM2 and TPM3 usually have muscle hypotonia and weakness, their muscle biopsies often showing fibre size disproportion and nemaline bodies. Here, we describe a series of patients ...

Abstract	Patients with myopathies caused by pathogenic variants in tropomyosin genes TPM2 and TPM3 usually have muscle hypotonia and weakness, their muscle biopsies often showing fibre size disproportion and nemaline bodies. Here, we describe a series of patients with hypercontractile molecular phenotypes, high muscle tone, and mostly non-specific myopathic biopsy findings without nemaline bodies. Three of the patients had trismus, whilst in one patient, the distal joints of her fingers flexed on extension of the wrists. In one biopsy from a patient with a rare TPM3 pathogenic variant, cores and minicores were observed, an unusual finding in TPM3-caused myopathy. The variants alter conserved contact sites between tropomyosin and actin.
MeSH term(s)	Humans ; Female ; Muscle, Skeletal/pathology ; Tropomyosin/genetics ; Muscular Diseases/pathology ; Muscle Hypertonia/pathology ; Phenotype ; Myopathies, Nemaline/genetics ; Myopathies, Nemaline/pathology ; Mutation
Chemical Substances	Tropomyosin ; TPM3 protein, human ; TPM2 protein, human
Language	English
Publishing date	2023-12-15
Publishing country	England
Document type	Case Reports
ZDB-ID	1077681-3
ISSN	1873-2364 ; 0960-8966
ISSN (online)	1873-2364
ISSN	0960-8966
DOI	10.1016/j.nmd.2023.12.006
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