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Article ; Online: Reply to J.M. Snaman et al.

Hui, David / Finlay, Esmé / Buss, Mary K / Prommer, Eric / Bruera, Eduardo

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2016 Volume 34, Issue 3, Page(s) 289

MeSH term(s)	Adenocarcinoma/therapy ; Female ; Humans ; Medical Oncology ; Palliative Care ; Pancreatic Neoplasms/therapy ; Patients/psychology ; Specialization
Language	English
Publishing date	2016-01-20
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2015.64.4799
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article ; Online: GPCR kinase subtype requirements for arrestin-2 and -3 translocation to the cannabinoid CB

Manning, Jamie J / Finlay, David B / Glass, Michelle

Biochemical pharmacology

2024 Volume 224, Page(s) 116190

Abstract: Arrestins are key negative regulators of G Protein-Coupled Receptors (GPCRs) through mediation of G protein desensitisation and receptor internalisation. Arrestins can also contribute to signal transduction by scaffolding downstream signalling effectors ... ...

Abstract	Arrestins are key negative regulators of G Protein-Coupled Receptors (GPCRs) through mediation of G protein desensitisation and receptor internalisation. Arrestins can also contribute to signal transduction by scaffolding downstream signalling effectors for activation. GPCR kinase (GRK) enzymes phosphorylate the intracellular C-terminal domain, or intracellular loop regions of GPCRs to promote arrestin interaction. There are seven different GRK subtypes, which may uniquely phosphorylate the C-terminal tail in a type of 'phosphorylation barcode,' potentially differentially contributing to arrestin translocation and arrestin-dependent signalling. Such contributions may be exploited to develop arrestin-biased ligands. Here, we examine the effect of different GRK subtypes on the ability to promote translocation of arrestin-2 and arrestin-3 to the cannabinoid CB
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2024.116190
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Zs.A 19: Show issues

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Article: Determination of the Cannabinoid CB1 Receptor's Positive Allosteric Modulator Binding Site through Mutagenesis Studies.

Green, Hayley M / Fellner, Daniel M J / Finlay, David B / Furkert, Daniel P / Glass, Michelle

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 2

Abstract: Positive allosteric modulators (PAMs) of the cannabinoid CB1 receptor ( ... ...

Abstract	Positive allosteric modulators (PAMs) of the cannabinoid CB1 receptor (CB
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17020154
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Article ; Online: "Please don't let me become a statistic in this grocery store": Civic engagement among older Americans since the COVID-19 pandemic onset.

Finlay, Jessica / Eastman, Marisa / Kobayashi, Lindsay

Social science & medicine (1982)

2023 Volume 337, Page(s) 116267

Abstract: The COVID-19 pandemic disrupted civic life and upended daily routines. Coffee shops, restaurants, recreation centers, parks, and other 'third places' that facilitate communal gathering, interpersonal connection, and meaningful activity closed or operated ...

Abstract	The COVID-19 pandemic disrupted civic life and upended daily routines. Coffee shops, restaurants, recreation centers, parks, and other 'third places' that facilitate communal gathering, interpersonal connection, and meaningful activity closed or operated under tight restrictions. Little is known about longer-term impacts on older adults' civic life since the pandemic's onset. The COVID-19 Coping Study conducted semi-structured interviews in April-July 2021 with 57 adults aged ≥55 across the United States (mean age 71). Reflexive thematic analysis identified heightened sociopolitical tensions and complex community experiences since the pandemic's onset. Participants shared nuanced perceptions of greater physical and emotional distancing, siloed communities, politicized public health adherence, fears of gun violence, and experiences of racial discrimination in shared spaces. Hopeful efforts to re-engage in civic life involved cautious social activities post-vaccination, altered daily routines, and finding a "new normal." The novel results explore how a large sample of racially and socioeconomically diverse older adults perceive and experience American sociopolitical tensions anchored in shared everyday spaces. Results may inform practical opportunities for policymakers and community service providers to strengthen social infrastructure, support wellbeing, and bolster civic life.
MeSH term(s)	Humans ; United States/epidemiology ; Aged ; COVID-19/epidemiology ; Pandemics ; Supermarkets ; Social Behavior ; Life Style
Language	English
Publishing date	2023-10-06
Publishing country	England
Document type	Journal Article
ZDB-ID	4766-1
ISSN	1873-5347 ; 0037-7856 ; 0277-9536
ISSN (online)	1873-5347
ISSN	0037-7856 ; 0277-9536
DOI	10.1016/j.socscimed.2023.116267
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Zs.A 625: Show issues

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Article ; Online: Post-Activation Performance Enhancement of Punch Force and Neuromuscular Performance in Amateur Boxing: Toward a More Individualized and "Real-World" Approach.

Finlay, Mitchell James / Greig, Matt / Bridge, Craig Alan / Page, Richard Michael

Journal of strength and conditioning research

2024

Abstract: Abstract: Finlay, MJ, Greig, M, Bridge, CA, and Page, RM. Post-activation performance enhancement ... world" approach. J Strength Cond Res XX(X): 000-000, 2023-Previous research on post-activation ...

Abstract	Abstract: Finlay, MJ, Greig, M, Bridge, CA, and Page, RM. Post-activation performance enhancement of punch force and neuromuscular performance in amateur boxing: Toward a more individualized and "real-world" approach. J Strength Cond Res XX(X): 000-000, 2023-Previous research on post-activation performance enhancement has been applied in several sporting settings, although this is lacking in a boxing setting. This study explored the effectiveness of 2 upper-body conditioning activities in improving punch-specific performance during an amateur boxing-simulated bout. On 3 separate occasions, 10 male senior elite amateur boxers performed the following conditioning activities before a boxing-specific simulation protocol: isometric (ISO) punch, elastic resistance (ER) punch, and a control trial. Boxers performed maximal punches against a vertically mounted force plate, and countermovement jumps (CMJ) at baseline, before round 1, after each round, and 4 minutes after the simulation. Both conditioning activities, but not the control trial, produced small worthwhile increases (effect size ≥ 0.20; equal to or greater than the smallest worthwhile change) in punch force, although worthwhile increases in rate of force development were limited to the cross during the ISO trial. No group-based improvements in CMJ performance were observed. Individual analysis revealed that 6 boxers improved punch-specific performance to the greatest extent in the ISO trial; in contrast, only 1 boxer did so in the ER trial. Three boxers exhibited similar performance increases across trials. In conclusion, both conditioning activities may be applied to an amateur boxer's warm-up to acutely enhance punch-specific performance. The ISO conditioning activity seems most effective; however, the interindividual variability suggests a need for protocols to be individualized to each athlete. The conditioning activities in the present study may be applied to sparring, competitive bouts, or to other combat sports.
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1156349-7
ISSN	1533-4287 ; 1064-8011
ISSN (online)	1533-4287
ISSN	1064-8011
DOI	10.1519/JSC.0000000000004740
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Zs.A 6263: Show issues

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Article ; Online: Citrobacter rodentium

Krekhno, Z / Woodward, S E / Serapio-Palacios, A / Peña-Díaz, J / Moon, K M / Foster, L J / Finlay, B B

Gut microbes

2024 Volume 16, Issue 1, Page(s) 2308049

Abstract: Infectious diarrheal diseases are the third leading cause of mortality in young children, many of which are driven by Gram-negative bacterial pathogens. To establish successful host infections these pathogens employ a plethora of virulence factors ... ...

Abstract	Infectious diarrheal diseases are the third leading cause of mortality in young children, many of which are driven by Gram-negative bacterial pathogens. To establish successful host infections these pathogens employ a plethora of virulence factors necessary to compete with the resident microbiota, and evade and subvert the host defenses. The type II secretion system (T2SS) is one such conserved molecular machine that allows for the delivery of effector proteins into the extracellular milieu. To explore the role of the T2SS during natural host infection, we used
MeSH term(s)	Child ; Humans ; Animals ; Mice ; Child, Preschool ; Citrobacter rodentium/genetics ; Type II Secretion Systems ; Gastrointestinal Microbiome ; Virulence Factors/genetics ; Virulence Factors/metabolism ; Enterohemorrhagic Escherichia coli ; Enterobacteriaceae Infections/microbiology
Chemical Substances	Type II Secretion Systems ; Virulence Factors
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2575755-6
ISSN	1949-0984 ; 1949-0984
ISSN (online)	1949-0984
ISSN	1949-0984
DOI	10.1080/19490976.2024.2308049
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Article ; Online: Mapping of Family Reported Outcome Measure (FROM-16) scores to EQ-5D: algorithm to calculate utility values.

Shah, R / Salek, M S / Finlay, A Y / Kay, R / Nixon, S J / Otwombe, K / Ali, F M / Ingram, J R

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

2024 Volume 33, Issue 4, Page(s) 1107–1119

Abstract: Objective: Although decision scientists and health economists encourage inclusion of family member/informal carer utility in health economic evaluation, there is a lack of suitable utility measures comparable to patient utility measures such those based ...

Abstract	Objective: Although decision scientists and health economists encourage inclusion of family member/informal carer utility in health economic evaluation, there is a lack of suitable utility measures comparable to patient utility measures such those based on the EQ-5D. This study aims to predict EQ-5D-3L utility values from Family Reported Outcome Measure (FROM-16) scores, to allow the use of FROM-16 data in health economic evaluation when EQ-5D data is not available. Methods: Data from 4228 family members/partners of patients recruited to an online cross-sectional study through 58 UK-based patient support groups, three research support platforms and Welsh social services departments were randomly divided five times into two groups, to derive and test a mapping model. Split-half cross-validation was employed, resulting in a total of ten multinomial logistic regression models. The Monte Carlo simulation procedure was used to generate predicted EQ-5D-3L responses, and utility scores were calculated and compared against observed values. Mean error and mean absolute error were calculated for all ten validation models. The final model algorithm was derived using the entire sample. Results: The model was highly predictive, and its repeated fitting using multinomial logistic regression demonstrated a stable model. The mean differences between predicted and observed health utility estimates ranged from 0.005 to 0.029 across the ten modelling exercises, with an average overall difference of 0.015 (a 2.2% overestimate, not of clinical importance). Conclusions: The algorithm developed will enable researchers and decision scientists to calculate EQ-5D health utility estimates from FROM-16 scores, thus allowing the inclusion of the family impact of disease in health economic evaluation of medical interventions when EQ-5D data is not available.
MeSH term(s)	Humans ; Quality of Life/psychology ; Cross-Sectional Studies ; Surveys and Questionnaires ; Algorithms ; Patient Reported Outcome Measures
Language	English
Publishing date	2024-02-25
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1161148-0
ISSN	1573-2649 ; 0962-9343
ISSN (online)	1573-2649
ISSN	0962-9343
DOI	10.1007/s11136-023-03590-z
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Zs.A 3796: Show issues

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Article: Scoping review of military veterans involved in the criminal legal system and their health and healthcare: 5-year update and map to the Veterans-Sequential Intercept Model.

Singh, Kreeti / Timko, Christine / Yu, Mengfei / Taylor, Emmeline / Blue-Howells, Jessica / Finlay, Andrea K

Health & justice

2024 Volume 12, Issue 1, Page(s) 18

Abstract: Background: A previous scoping review of legal-involved veterans' health and healthcare (1947-2017) identified studies and their limitations. Given the influx of literature published recently, this study aimed to update the previous review and map ... ...

Abstract	Background: A previous scoping review of legal-involved veterans' health and healthcare (1947-2017) identified studies and their limitations. Given the influx of literature published recently, this study aimed to update the previous review and map articles to the Veterans-Sequential Intercept Model (V-SIM) - a conceptual model used by key partners, including Veterans Health Administration, veteran advocates, criminal justice practitioners, and local governments to identify intercept points in the criminal legal system where resources and programming can be provided. Developing an updated resource of literature is essential to inform current research, discover gaps, and highlight areas for future research. Methods: A systematic search of 5 databases identified articles related to legal-involved veterans' health and healthcare published between December 2017 through December 2022. The first and senior authors conducted abstract reviews, full-text reviews, and data extraction of study characteristics. Finally, each article was sorted by the various intercept points from the V-SIM. Results: Of 903 potentially relevant articles, 107 peer-reviewed publications were included in this review, most related to mental health (66/107, 62%) and used an observational quantitative study design (95/107, 89%). Although most articles did not explicitly use the V-SIM to guide data collection, analyses, or interpretation, all could be mapped to this conceptual model. Half of the articles (54/107, 50%) collected data from intercept 5 (Community Corrections and Support Intercept) of the V-SIM. No articles gathered data from intercepts 0 (Community and Emergency Services Intercept), 1 (Law Enforcement Intercept), or 2 (Initial Detention and Court Hearings Intercept). Conclusions: There were 107 articles published in the last five years compared to 190 articles published in 70 years covered in the last review, illustrating the growing interest in legal-involved veterans. The V-SIM is widely used by front-line providers and clinical leadership, but not by researchers to guide their work. By clearly tying their research to the V-SIM, researchers could generate results to help guide policy and practice at specific intercept points. Despite the large number of publications, research on prevention and early intervention for legal-involved veterans is lacking, indicating areas of great need for future studies.
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2740401-8
ISSN	2194-7899
ISSN	2194-7899
DOI	10.1186/s40352-024-00274-9
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Article ; Online: Postactivation Performance Enhancement of Amateur Boxers' Punch Force and Neuromuscular Performance Following 2 Upper-Body Conditioning Activities.

Finlay, Mitchell J / Bridge, Craig A / Greig, Matt / Page, Richard M

International journal of sports physiology and performance

2022 , Page(s) 1–13

Abstract: Purpose: The purpose of this study was to assess the efficacy of upper-body punch-specific isometric (ISO) and elastic resistance (ER) conditioning activities (CAs) on the punch force and neuromuscular performance of amateur boxers.: Methods: Ten ... ...

Abstract	Purpose: The purpose of this study was to assess the efficacy of upper-body punch-specific isometric (ISO) and elastic resistance (ER) conditioning activities (CAs) on the punch force and neuromuscular performance of amateur boxers. Methods: Ten male senior elite amateur boxers (19.7 [1.2]\| y; height 180.9 [7.0] cm; mass 78.7 [9.6] kg) visited the laboratory on 4 separate occasions. Initially, the participants performed baseline physical tests comprising bench-press 1-repetition maximum and countermovement jumps. On the other 3 occasions, the boxers performed maximal punches against a vertically mounted force plate and maximal countermovement jumps prior to and following an ISO or ER CA, as well as a control trial. Results: No interactions between CA × time were found in all performance variables. As observed by mean changes, effect sizes, and signal:noise ratio, both the ISO and ER, but not the control trial, consistently produced small to moderate, worthwhile increases in punch force and rate of force development, with the greatest increases in performance typically observed in the ISO trial. No meaningful improvements were observed in countermovement jump performance in all trials, indicative of a localized postactivation performance enhancement effect. Conclusion: In conclusion, the ISO and ER CAs may be implemented in an amateur boxers' warm-up to acutely enhance punch-force variables, although the ISO punch appears to be the superior CA to improve punch-specific performance. The CAs used in the present study may also be relevant to other combat sports inclusive of a striking element.
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article
ISSN	1555-0273
ISSN (online)	1555-0273
DOI	10.1123/ijspp.2022-0159
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Article ; Online: Acute physiological, endocrine, biochemical and performance responses associated with amateur boxing: A systematic review with meta-analysis.

Finlay, Mitchell J / Greig, Matt / Page, Richard M / Bridge, Craig A

European journal of sport science

2022 Volume 23, Issue 5, Page(s) 774–788

Abstract: Previous research has explored the demands of amateur boxing-specific activity; however, no holistic review of the acute responses to such activity currently exists. This paper aimed to provide a systematic review of the available literature on the acute ...

Abstract	Previous research has explored the demands of amateur boxing-specific activity; however, no holistic review of the acute responses to such activity currently exists. This paper aimed to provide a systematic review of the available literature on the acute physiological, endocrine, biochemical, and performance responses to amateur boxing-specific activity. Following a search of EBSCOhost, SPORTDiscus, PubMed and Google Scholar databases, 25 studies were identified as meeting the inclusion criteria for the review. The methodological quality of the included studies was assessed via a modified Downs and Black checklist. Random-effects meta-analysis of standardised mean differences (SMD) revealed large (SMD = 4.62) increases in pre-post blood lactate (BLa), cortisol (SMD = 1.33), myoglobin (Mb) (SMD = 1.43), aspartate transaminase (AST) (SMD = 1.37), and alanine aminotransferase (ALT) (SMD = 0.97), in addition to moderate increases in creatine kinase (CK) (SMD = 0.65). Small pre-post increases in counter-movement jump (CMJ) height (SMD = 0.33) were observed. Consistently greater pre-post alterations were observed in competitive bouts, followed by sparring, and less so in boxing-specific simulations. Considerable physiological, endocrine, and biochemical responses are elicited following amateur boxing. Interestingly, neuromuscular and task-specific performance may not deteriorate following boxing-specific activity. The findings of the review may assist in the designing and periodising of boxing-specific training, dependent on the desired physical adaptations, training phase, and recovery status of the amateur boxer.
MeSH term(s)	Humans ; Boxing/physiology ; Athletes ; Physical Examination ; Movement/physiology ; Task Performance and Analysis
Language	English
Publishing date	2022-05-19
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ISSN	1536-7290
ISSN (online)	1536-7290
DOI	10.1080/17461391.2022.2063072
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