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  1. AU=Weder W
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  6. AU="Procopio, Francesco A"
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  1. Artikel ; Online: [Titelangabe fehlt]

    Weder, W

    Pneumologie (Stuttgart, Germany)

    2018  Band 72, Heft 4, Seite(n) 321

    Titelübersetzung Antwort.
    Sprache Deutsch
    Erscheinungsdatum 2018-04-11
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/a-0586-6496
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  2. Artikel: Antwort

    Weder, W.

    Pneumologie

    2018  Band 72, Heft 04, Seite(n) 321–321

    Sprache Deutsch
    Erscheinungsdatum 2018-04-01
    Verlag © Georg Thieme Verlag KG
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/a-0586-6496
    Datenquelle Thieme Verlag

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    Zs.MO 54: Hefte anzeigen

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  3. Artikel ; Online: One-Component Nanocomposites Made from Diblock Copolymer Grafted Cellulose Nanocrystals.

    Rader, Chris / Fritz, Patrick W / Ashirov, Timur / Coskun, Ali / Weder, Christoph

    Biomacromolecules

    2024  Band 25, Heft 3, Seite(n) 1637–1648

    Abstract: Cellulose nanocrystals (CNCs) are bio-based, rod-like, high-aspect-ratio nanoparticles with high stiffness and strength and are widely used as a reinforcing nanofiller in polymer nanocomposites. However, due to hydrogen-bond formation between the large ... ...

    Abstract Cellulose nanocrystals (CNCs) are bio-based, rod-like, high-aspect-ratio nanoparticles with high stiffness and strength and are widely used as a reinforcing nanofiller in polymer nanocomposites. However, due to hydrogen-bond formation between the large number of hydroxyl groups on their surface, CNCs are prone to aggregate, especially in nonpolar polymer matrices. One possibility to overcome this problem is to graft polymers from the CNCs' surfaces and to process the resulting "hairy nanoparticles" (HNPs) into one-component nanocomposites (OCNs) in which the polymer matrix and CNC filler are covalently connected. Here, we report OCNs based on HNPs that were synthesized by grafting gradient diblock copolymers onto CNCs via surface-initiated atom transfer radical polymerization. The inner block (toward the CNCs) is composed of poly(methyl acrylate) (PMA), and the outer block comprises a gradient copolymer rich in poly(methyl methacrylate) (PMMA). The OCNs based on such HNPs microphase separate into a rubbery poly(methyl acrylate) phase that dissipates mechanical energy and imparts toughness, a glassy PMMA phase that provides strength and stiffness, and well-dispersed CNCs that further reinforce the materials. This design afforded OCNs that display a considerably higher stiffness and strength than reference diblock copolymers without the CNCs. At the same time, the extensibility remains high and the toughness is increased up to 5-fold relative to the reference materials.
    Mesh-Begriff(e) Cellulose/chemistry ; Polymethyl Methacrylate ; Polymers/chemistry ; Nanoparticles/chemistry ; Nanocomposites/chemistry ; Acrylates
    Chemische Substanzen Cellulose (9004-34-6) ; methyl acrylate (WC487PR91H) ; Polymethyl Methacrylate (9011-14-7) ; Polymers ; Acrylates
    Sprache Englisch
    Erscheinungsdatum 2024-02-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c01196
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  4. Konferenzbeitrag: CI Elektrodenimpedanz als indirekter Biomarker für Resthörvermögen

    Wimmer, Wilhelm / Schraivogel, Stephan / Weder, Stefan / Caversaccio, Marco

    2024  , Seite(n) 29

    Veranstaltung/Kongress 26. Jahrestagung der Deutschen Gesellschaft für Audiologie; Aalen; Deutsche Gesellschaft für Audiologie e.V.; 2024
    Schlagwörter Medizin, Gesundheit
    Erscheinungsdatum 2024-03-05
    Verlag German Medical Science GMS Publishing House; Düsseldorf
    Dokumenttyp Konferenzbeitrag
    DOI 10.3205/24dga029
    Datenquelle German Medical Science

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  5. Artikel ; Online: Uncovering Vulnerable Phases in Cochlear Implant Electrode Array Insertion: Insights from an In Vitro Model.

    Aebischer, Philipp / Weder, Stefan / Vischer, Mattheus / Mantokoudis, Georgios / Caversaccio, Marco / Wimmer, Wilhelm

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

    2024  Band 45, Heft 4, Seite(n) e271–e280

    Abstract: Objectives: The aim of this study is to improve our understanding of the mechanics involved in the insertion of lateral wall cochlear implant electrode arrays.: Design: A series of 30 insertion experiments were conducted by three experienced surgeons. ...

    Abstract Objectives: The aim of this study is to improve our understanding of the mechanics involved in the insertion of lateral wall cochlear implant electrode arrays.
    Design: A series of 30 insertion experiments were conducted by three experienced surgeons. The experiments were carried out in a previously validated artificial temporal bone model according to established soft surgery guidelines. The use of an in vitro setup enabled us to comprehensively evaluate relevant parameters, such as insertion force, intracochlear pressure, and exact electrode array position in a controlled and repeatable environment.
    Results: Our findings reveal that strong intracochlear pressure transients are more frequently caused during the second half of the insertion, and that regrasping the electrode array is a significant factor in this phenomenon. For choosing an optimal insertion speed, we show that it is crucial to balance slow movement to limit intracochlear stress with short duration to limit tremor-induced pressure spikes, challenging the common assumption that a slower insertion is inherently better. Furthermore, we found that intracochlear stress is affected by the order of execution of postinsertion steps, namely sealing the round window and posterior tympanotomy with autologous tissue and routing of the excess cable into the mastoid cavity. Finally, surgeons' subjective estimates of physical parameters such as speed, smoothness, and resistance did not correlate with objectively assessed measures, highlighting that a thorough understanding of intracochlear mechanics is essential for an atraumatic implantation.
    Conclusion: The results presented in this article allow us to formulate evidence-based surgical recommendations that may ultimately help to improve surgical outcome and hearing preservation in cochlear implant patients.
    Mesh-Begriff(e) Humans ; Cochlear Implants ; Cochlear Implantation/methods ; Cochlea/surgery ; Round Window, Ear/surgery ; Temporal Bone/surgery ; Electrodes, Implanted
    Sprache Englisch
    Erscheinungsdatum 2024-02-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2036790-9
    ISSN 1537-4505 ; 1531-7129
    ISSN (online) 1537-4505
    ISSN 1531-7129
    DOI 10.1097/MAO.0000000000004130
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  6. Artikel: Cochlear implant electrode impedance subcomponents as biomarker for residual hearing.

    Schraivogel, Stephan / Aebischer, Philipp / Weder, Stefan / Caversaccio, Marco / Wimmer, Wilhelm

    Frontiers in neurology

    2023  Band 14, Seite(n) 1183116

    Abstract: Introduction and objectives: Maintaining the structural integrity of the cochlea and preserving residual hearing is crucial for patients, especially for those for whom electric acoustic stimulation is intended. Impedances could reflect trauma due to ... ...

    Abstract Introduction and objectives: Maintaining the structural integrity of the cochlea and preserving residual hearing is crucial for patients, especially for those for whom electric acoustic stimulation is intended. Impedances could reflect trauma due to electrode array insertion and therefore could serve as a biomarker for residual hearing. The aim of this study is to evaluate the association between residual hearing and estimated impedance subcomponents in a known collective from an exploratory study.
    Methods: A total of 42 patients with lateral wall electrode arrays from the same manufacturer were included in the study. For each patient, we used data from audiological measurements to compute residual hearing, impedance telemetry recordings to estimate near and far-field impedances using an approximation model, and computed tomography scans to extract anatomical information about the cochlea. We assessed the association between residual hearing and impedance subcomponent data using linear mixed-effects models.
    Results: The progression of impedance subcomponents showed that far-field impedance was stable over time compared to near-field impedance. Low-frequency residual hearing demonstrated the progressive nature of hearing loss, with 48% of patients showing full or partial hearing preservation after 6 months of follow-up. Analysis revealed a statistically significant negative effect of near-field impedance on residual hearing (-3.81 dB HL per kΩ;
    Conclusion: Our findings suggest that near-field impedance offers higher specificity for residual hearing monitoring, while far-field impedance was not significantly associated with residual hearing. These results highlight the potential of impedance subcomponents as objective biomarkers for outcome monitoring in cochlear implantation.
    Sprache Englisch
    Erscheinungsdatum 2023-05-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1183116
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Urgent lung volume reduction surgery is effective for secondary pneumothorax in emphysema patients.

    Barbarossa, Annalisa / Van Raemdonck, Dirk / Weder, Walter / Ceulemans, Laurens J

    Interdisciplinary cardiovascular and thoracic surgery

    2023  Band 36, Heft 6

    Abstract: Secondary pneumothorax due to emphysema can be life-threatening and requires surgery in most situations. Here, we extended lung resection to close the fistula using lung volume reduction surgery (LVRS). We present a patient with chronic obstructive ... ...

    Abstract Secondary pneumothorax due to emphysema can be life-threatening and requires surgery in most situations. Here, we extended lung resection to close the fistula using lung volume reduction surgery (LVRS). We present a patient with chronic obstructive pulmonary disease and secondary spontaneous pneumothorax referred after ineffective treatment by chemical pleurodesis. Urgent LVRS followed by elective LVRS was performed obtaining air-leak resolution and significantly improving pulmonary function and quality of life. We discuss the surgical technique and effectiveness of LVRS as a treatment for pneumothorax.
    Sprache Englisch
    Erscheinungsdatum 2023-06-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2753-670X
    ISSN (online) 2753-670X
    DOI 10.1093/icvts/ivad099
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  8. Artikel: Correction: Neural Activity During Audiovisual Speech Processing: Protocol For a Functional Neuroimaging Study.

    Bálint, András / Wimmer, Wilhelm / Caversaccio, Marco / Weder, Stefan

    JMIR research protocols

    2022  Band 11, Heft 6, Seite(n) e40527

    Abstract: This corrects the article DOI: 10.2196/38407.]. ...

    Abstract [This corrects the article DOI: 10.2196/38407.].
    Sprache Englisch
    Erscheinungsdatum 2022-06-28
    Erscheinungsland Canada
    Dokumenttyp Published Erratum
    ZDB-ID 2719222-2
    ISSN 1929-0748
    ISSN 1929-0748
    DOI 10.2196/40527
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  9. Artikel: Neural Activity During Audiovisual Speech Processing: Protocol For a Functional Neuroimaging Study.

    Bálint, András / Wimmer, Wilhelm / Caversaccio, Marco / Weder, Stefan

    JMIR research protocols

    2022  Band 11, Heft 6, Seite(n) e38407

    Abstract: Background: Functional near-infrared spectroscopy (fNIRS) studies have demonstrated associations between hearing outcomes after cochlear implantation and plastic brain changes. However, inconsistent results make it difficult to draw conclusions. A major ...

    Abstract Background: Functional near-infrared spectroscopy (fNIRS) studies have demonstrated associations between hearing outcomes after cochlear implantation and plastic brain changes. However, inconsistent results make it difficult to draw conclusions. A major problem is that many variables need to be controlled. To gain further understanding, a careful preparation and planning of such a functional neuroimaging task is key.
    Objective: Using fNIRS, our main objective is to develop a well-controlled audiovisual speech comprehension task to study brain activation in individuals with normal hearing and hearing impairment (including cochlear implant users). The task should be deductible from clinically established tests, induce maximal cortical activation, use optimal coverage of relevant brain regions, and be reproducible by other research groups.
    Methods: The protocol will consist of a 5-minute resting state and 2 stimulation periods that are 12 minutes each. During the stimulation periods, 13-second video recordings of the clinically established Oldenburg Sentence Test (OLSA) will be presented. Stimuli will be presented in 4 different modalities: (1) speech in quiet, (2) speech in noise, (3) visual only (ie, lipreading), and (4) audiovisual speech. Each stimulus type will be repeated 10 times in a counterbalanced block design. Interactive question windows will monitor speech comprehension during the task. After the measurement, we will perform a 3D scan to digitize optode positions and verify the covered anatomical locations.
    Results: This paper reports the study protocol. Enrollment for the study started in August 2021. We expect to publish our first results by the end of 2022.
    Conclusions: The proposed audiovisual speech comprehension task will help elucidate neural correlates to speech understanding. The comprehensive study will have the potential to provide additional information beyond the conventional clinical standards about the underlying plastic brain changes of a hearing-impaired person. It will facilitate more precise indication criteria for cochlear implantation and better planning of rehabilitation.
    International registered report identifier (irrid): DERR1-10.2196/38407.
    Sprache Englisch
    Erscheinungsdatum 2022-06-21
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 2719222-2
    ISSN 1929-0748
    ISSN 1929-0748
    DOI 10.2196/38407
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Cochlear Implant Electrode Impedance as Potential Biomarker for Residual Hearing.

    Wimmer, Wilhelm / Sclabas, Luca / Caversaccio, Marco / Weder, Stefan

    Frontiers in neurology

    2022  Band 13, Seite(n) 886171

    Abstract: Introduction and objectives: Among cochlear implant candidates, an increasing number of patients are presenting with residual acoustic hearing. To monitor the postoperative course of structural and functional preservation of the cochlea, a reliable ... ...

    Abstract Introduction and objectives: Among cochlear implant candidates, an increasing number of patients are presenting with residual acoustic hearing. To monitor the postoperative course of structural and functional preservation of the cochlea, a reliable objective biomarker would be desirable. Recently, impedance telemetry has gained increasing attention in this field. The aim of this study was to investigate the postoperative course of the residual acoustic hearing and clinical impedance in patients with long electrode arrays and to explore the applicability of impedance telemetry for monitoring residual hearing.
    Methods: We retrospectively analyzed records of 42 cochlear implant recipients with residual hearing covering a median postoperative follow-up of 25 months with repeated simultaneous pure tone audiometry and impedance telemetry. We used a linear mixed-effects model to estimate the relation between clinical electrode impedance and residual hearing. Besides the clinical impedance, the follow-up time, side of implantation, gender, and age at implantation were included as fixed effects. An interaction term between impedance and follow-up time, as well as subject-level random intercepts and slopes, were included.
    Results: Loss of residual hearing occurred either during surgery or within the first 6 post-operative months. Electrode contacts inserted further apically (i.e., deeper) had higher impedances, independent of residual hearing. The highest impedances were measured 1 month postoperatively and gradually decreased over time. Basal electrodes were more likely to maintain higher impedance. Follow-up time was significantly associated with residual hearing. Regardless of the time, we found that a 1 kΩ increase in clinical impedance was associated with a 4.4 dB deterioration of residual hearing (
    Conclusion: Pure tone audiometry is the current gold standard for monitoring postoperative residual hearing. However, the association of clinical impedances with residual hearing thresholds found in our study could potentially be exploited for objective monitoring using impedance telemetry. Further analysis including near-field related impedance components could be performed for improved specificity to local immune responses.
    Sprache Englisch
    Erscheinungsdatum 2022-06-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.886171
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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