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Article: Xiao-Xu-Ming

Wang, Yue-Hua / Yang, Ying-Lin / Cheng, Xiao / Zhang, Jun / Li, Wan / Du, Guan-Hua

2018 Volume 14, Issue 3, Page(s) 470–479

Abstract: Xiao-Xu-Ming decoction has been widely used to treat stroke and sequelae of stroke. We have ... previously shown that the active fractions of Xiao-Xu-Ming decoction attenuate cerebral ischemic injury ... However, the global protein profile and signaling conduction pathways regulated by Xiao-Xu-Ming decoction are still ...

Abstract	Xiao-Xu-Ming decoction has been widely used to treat stroke and sequelae of stroke. We have previously shown that the active fractions of Xiao-Xu-Ming decoction attenuate cerebral ischemic injury. However, the global protein profile and signaling conduction pathways regulated by Xiao-Xu-Ming decoction are still unclear. This study established a two-vessel occlusion rat model by bilateral common carotid artery occlusion. Rats were intragastrically administered 50 or 150 mg/kg Xiao-Xu-Ming decoction for 4 consecutive weeks. Learning and memory abilities were measured with Morris water maze. Motor ability was detected with prehensile test. Coordination ability was examined using the inclined screen test. Neuronal plasticity was observed by immunofluorescent staining. Differentially expressed proteins of rat hippocampus were analyzed by label-free quantitative proteomics. Real time-polymerase chain reaction and western blot assay were used to identify the changes in proteins. Results showed that Xiao-Xu-Ming decoction dramatically alleviated learning and memory deficits, and motor and coordination dysfunction, and increased the expression of microtubule-associated protein 2. Xiao-Xu-Ming decoction extract remarkably decreased 13 upregulated proteins and increased 39 downregulated proteins. The regulated proteins were mainly involved in oxidation reduction process, intracellular signaling cascade process, and protein catabolic process. The signaling pathways were mainly involved in ubiquitin mediated proteolysis and the phosphatidylinositol signaling system. Furthermore, there was an interaction among Rab2a, Ptpn1, Ppm1e, Cdk18, Gorasp2, Eps15, Capza2, Syngap1 and Mt-nd1. Protein analyses confirmed the changes in expression of MT-ND1. The current findings provide new insights into the molecular mechanisms of Xiao-Xu-Ming decoction extract's effects on chronic cerebral hypoperfusion.
Language	English
Publishing date	2018-12-14
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.245471
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Integrating Metabolomics and Network Pharmacology to Explore the Mechanism of Xiao-Yao-San in the Treatment of Inflammatory Response in CUMS Mice.

Zhang, Yi / Li, Xiao-Jun / Wang, Xin-Rong / Wang, Xiao / Li, Guo-Hui / Xue, Qian-Yin / Zhang, Ming-Jia / Ao, Hai-Qing

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 11

Abstract: ... to the development of other diseases related to inflammation. Xiao-Yao-San (XYS) is a commonly used formula ...

Abstract	Depression can trigger an inflammatory response that affects the immune system, leading to the development of other diseases related to inflammation. Xiao-Yao-San (XYS) is a commonly used formula in clinical practice for treating depression. However, it remains unclear whether XYS has a modulating effect on the inflammatory response associated with depression. The objective of this study was to examine the role and mechanism of XYS in regulating the anti-inflammatory response in depression. A chronic unpredictable mild stress (CUMS) mouse model was established to evaluate the antidepressant inflammatory effects of XYS. Metabolomic assays and network pharmacology were utilized to analyze the pathways and targets associated with XYS in its antidepressant inflammatory effects. In addition, molecular docking, immunohistochemistry, Real-Time Quantitative Polymerase Chain Reaction (RT-qPCR), and Western Blot were performed to verify the expression of relevant core targets. The results showed that XYS significantly improved depressive behavior and attenuated the inflammatory response in CUMS mice. Metabolomic analysis revealed the reversible modulation of 21 differential metabolites by XYS in treating depression-related inflammation. Through the combination of liquid chromatography and network pharmacology, we identified seven active ingredients and seven key genes. Furthermore, integrating the predictions from network pharmacology and the findings from metabolomic analysis, Vascular Endothelial Growth Factor A (VEGFA) and Peroxisome Proliferator-Activated Receptor-γ (PPARG) were identified as the core targets. Molecular docking and related molecular experiments confirmed these results. The present study employed metabolomics and network pharmacology analyses to provide evidence that XYS has the ability to alleviate the inflammatory response in depression through the modulation of multiple metabolic pathways and targets.
Language	English
Publishing date	2023-11-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16111607
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Article ; Online: Effect of oral Xiao-xian decoction combined with acupoint application therapy on pediatric adenoid hypertrophy: A randomized trial.

Zhao, Xue / Xu, Jie / Wang, Ming-Yue / Hou, Zi-Wei / Shi, Hui-Shan / Zhang, Xiao-Xia

Medicine

2023 Volume 102, Issue 5, Page(s) e32804

Abstract: Background: This study aimed to observe the clinical effects of Xiao-xian decoction combined ... We randomly divided 93 AH children into 3 groups: AAT alone; Xiao-xian decoction + AAT; control: Montelukast ... tongue image) and secondary symptoms of patients treated with Xiao-xian decoction + AAT significantly ...

Abstract	Background: This study aimed to observe the clinical effects of Xiao-xian decoction combined with acupoint application therapy (AAT) for treating pediatric adenoid hypertrophy (AH). Methods: We randomly divided 93 AH children into 3 groups: AAT alone; Xiao-xian decoction + AAT; control: Montelukast oral therapy. All participants were treated for a month. We used the traditional Chinese medicine syndrome score to evaluate the clinical efficacy and the obstructive sleep apnea-18 scale to evaluate the quality of life. Results: The major symptoms (nasal congestion, open mouth breathing, snoring, and tongue image) and secondary symptoms of patients treated with Xiao-xian decoction + AAT significantly improved compared to before treatment. The pairwise comparison between groups showed that snoring, tongue, secondary symptoms, and total effective rate of the combined treatment group were better than the control and AAT alone. Additionally, the open-mouth breathing, quality of life, and recurrence rate did not differ after treatment. Conclusion: Oral Xiao-xian decoction combined with AAT significantly improved the symptoms and signs of nasal congestion, open-mouth breathing, snoring, tongue, and quality of life of AH children and may be used as a long-term treatment for AH.
MeSH term(s)	Child ; Humans ; Adenoids ; Snoring ; Quality of Life ; Mouth Breathing/complications ; Acupuncture Points ; Hypertrophy ; Nose Diseases/complications
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000032804
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Article ; Online: Exploring the Effect of Xiao-Chai-Hu Decoction on Treating Psoriasis Based on Network Pharmacology and Experiment Validation.

He, Ke / Wang, Ziyang / Liu, Meng / Du, Wenqian / Yin, Tingyi / Bai, Ruimin / Duan, Qiqi / Wang, Yuqian / Lei, Hao / Zheng, Yan

Current pharmaceutical design

2024 Volume 30, Issue 3, Page(s) 215–229

Abstract: Background: Psoriasis is a chronic, inflammatory and recurrent skin disease. Xiao-Chai-Hu ...

Abstract	Background: Psoriasis is a chronic, inflammatory and recurrent skin disease. Xiao-Chai-Hu Decoction (XCHD) has shown good effects against some inflammatory diseases and cancers. However, the pharmacological effect and mechanisms of XCHD on psoriasis are not yet clear. Objective: To uncover the effect and mechanisms of XCHD on psoriasis by integrating network pharmacology, molecular docking, and in vivo experiments. Methods: The active ingredients and corresponding targets of XCHD were screened through Traditional Chinese Medicine Systems Pharmacology Database and Analysis (TCMSP) and Traditional Chinese Medicine Integrated Database (TCMID). Differentially expressed genes (DEGs) of psoriasis were obtained from the gene expression omnibus (GEO) database. The XCHD-psoriasis intersection targets were obtained by intersecting XCHD targets, and DEGs were used to establish the "herb-active ingredient-target" network and Protein-Protein Interaction (PPI) Network. The hub targets were identified based on the PPI network by Cytoscape software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed next. Molecular docking was executed via AutoDockTools-1.5.6. Finally, Results: 58 active components and 219 targets of XCHD were screened. 4 top-active components (quercetin, baicalein, wogonin and kaempferol) and 7 hub targets (IL1B, CXCL8, CCND1, FOS, MMP9, STAT1 and CCL2) were identified. GO and KEGG pathway enrichment analyses indicated that the TNF signaling pathway, IL-17 signaling pathway and several pathways were involved. Molecular docking results indicated that hub genes had a good affinity to the corresponding key compounds. In imiquimod (IMQ)-induced psoriasis mouse models, XCHD could significantly improve psoriasis-like skin lesions, downregulate KRT17 and Ki67, and inhibit inflammation cytokines and VEGF. Conclusion: XCHD showed the therapeutic effect on psoriasis by regulating keratinocyte differentiation, and suppressing inflammation and angiogenesis, which provided a theoretical basis for further experiments and clinical research.
MeSH term(s)	Animals ; Mice ; Network Pharmacology ; Molecular Docking Simulation ; Psoriasis ; Skin ; Inflammation ; Drugs, Chinese Herbal ; Medicine, Chinese Traditional
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2024-03-27
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/0113816128288527240108110844
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Zs.A 4714: Show issues

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Article: [Exploring the application of "Fen Xiao Zou Xie" method based on clearing upward and draining downward in the treatment of benign prostatic hyperplasia].

Ma, Dong-Yue / Wang, Hao / Guo, Jun / Wang, Fu

Zhonghua nan ke xue = National journal of andrology

2024 Volume 29, Issue 7, Page(s) 649–653

Abstract: ... in resolving the condition. "Fen Xiao Zou Xie" is an important treatment method used by Ye Tianshi to address ... Fen Xiao" refers to the removal of pathogenic factors through different pathways, while "Zou Xie ... of "Fen Xiao Zou Xie" in the treatment of benign prostatic hyperplasia provides new insights ...

Abstract	Benign Prostatic Hyperplasia, as a common disease in the male urinary system, has traditionally been considered to have the basic pathogenesis of kidney deficiency and blood stasis. However, this disease involves many pathological factors such as "damp-heat", leading to confusion and difficulty in resolving the condition. "Fen Xiao Zou Xie" is an important treatment method used by Ye Tianshi to address damp-heat patterns and is now widely applied in the diagnosis and treatment of urinary system diseases. "Fen Xiao" refers to the removal of pathogenic factors through different pathways, while "Zou Xie" means using medications that promote excretion and do not stay, allowing the elimination of pathogenic factors from the body. The concept of "Clearing Up and Draining Down" is derived from the theory of "clearing and turbidity" in the Huang Di Nei Jing, suggesting that Qi, blood, water, and damp toxins blockages in the body are difficult to clear, leading to disorder in the ascending and descending of Triple Energizer Qi, causing obstruction or poor flow in the channels, and consequently resulting in abnormal urination. Exploring the application of the "Clearing Upward and Draining Downward" perspective in the use of "Fen Xiao Zou Xie" in the treatment of benign prostatic hyperplasia provides new insights for the clinical diagnosis and treatment of BPH.
MeSH term(s)	Male ; Humans ; Animals ; Prostatic Hyperplasia/drug therapy ; Body Fluids ; Estrus ; Hot Temperature ; Kidney
Language	Chinese
Publishing date	2024-04-15
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Zs.A 6577: Show issues

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Article: Xiao Cheng Qi Decoction, an Ancient Chinese Herbal Mixture, Relieves Loperamide-Induced Slow-Transit Constipation in Mice: An Action Mediated by Gut Microbiota.

Tuohongerbieke, Amanguli / Wang, Huaiyou / Wu, Jiahui / Wang, Zhengqi / Dong, Tingxia / Huang, Yamiao / Zhu, Dequan / Sun, Dongmei / Tsim, Karl Wah Keung

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 2

Abstract: Xiao Cheng Qi (XCQ) decoction, an ancient Chinese herbal mixture, has been used in treating slow ...

Abstract	Xiao Cheng Qi (XCQ) decoction, an ancient Chinese herbal mixture, has been used in treating slow-transit constipation (STC) for years. The underlying action mechanism in relieving the clinical symptoms is unclear. Several lines of evidence point to a strong link between constipation and gut microbiota. Short-chain fatty acids (SCFAs) and microbial metabolites have been shown to affect 5-HT synthesis by activating the GPR43 receptor localized on intestinal enterochromaffin cells, since 5-HT receptors are known to influence colonic peristalsis. The objective of this study was to evaluate the efficacy of XCQ in alleviating clinical symptoms in a mouse model of STC induced by loperamide. The application of loperamide leads to a decrease in intestinal transport and fecal water, which is used to establish the animal model of STC. In addition, the relationship between constipation and gut microbiota was determined. The herbal materials, composed of Rhei Radix et Rhizoma (Rhizomes of
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17020153
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Article ; Online: Inhibiting virus replication and excessive inflammatory response: Mechanism of combined prescription of Ma-Xing-Shi-Gan decoction and Xiao-Chai-Hu decoction against influenza virus.

Cheng, Miao / Zhang, Yanan / Yan, Jun / Huang, Yuanming / Wang, Mingzhe / Zhai, Zhiguang / Liu, Guoxing / Liu, Chang / Li, Jintong / Zhang, Yue / Xiao, Yuchun / Wang, Chengxiang / Ban, Chengjun / Ren, Zhihong / Song, Liqiong

Journal of ethnopharmacology

2023 Volume 313, Page(s) 116481

Abstract: ... Gan decoction with Xiao-Chai-Hu decoction), named as San-Yang-He-Zhi (SYHZ) decoction, has been widely ...

Abstract	Ethnopharmacological relevance: The combined prescription of two classical decoctions (Ma-Xing-Shi-Gan decoction with Xiao-Chai-Hu decoction), named as San-Yang-He-Zhi (SYHZ) decoction, has been widely used for the treatment of influenza virus (IFV) infections for decades. Aim of the study: This study aimed to evaluate the anti-influenza effect of SYHZ decoction and explore the underlying mechanism. Materials and methods: The ingredients of SYHZ decoction were analyzed by mass spectrometry. An animal model of IFV infection was established by challenging C57BL/6J mice with PR8 virus. Three groups of mice were infected with lethal or non-lethal doses of IFV, then followed by oral administration of phosphate-buffered saline (PBS), or SYHZ, or oseltamir; blank control mice (without IFV infection) were treated with PBS. Survival rate, Lung index, colon length, body weight loss and IFV viral load were measured 7 days post infection; histology and electron-microscopy examinations of lung tissue were performed; cytokine and chemokine levels in lung and serum were measured; and the intestinal metagenome, the cecum metabolome, and the lung transcriptome were analyzed. Results: SYHZ treatment significantly improved survival rate compared with PBS (40% vs 0%); improved lung index, colon length, and body weight loss; and alleviated lung histological damage and viral load. SYHZ-treated mice had significantly lower levels of IL-1β, TNF-α, IL-6, CCL2, CXCL10 in lung and serum, and increased levels of multiple bioactive components in cecum. Pro-inflammatory cytokines, Toll- and NOD-like receptors, pro-apoptosis molecules, and lung-injury-related proteins were downregulated in SYHZ mice, whereas surfactant protein and mucin were upregulated. The NOD-like receptor pathway, Toll-like receptor pathway, and NF-κB pathway were downregulated by SYHZ treatment. Conclusions: SYHZ decoction alleviated IFV infection in a mouse model. Multiple bioactive ingredients of SYHZ may inhibit replication of IFV and suppress excessive immune response.
MeSH term(s)	Mice ; Animals ; Mice, Inbred C57BL ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Lung ; Orthomyxoviridae Infections ; Cytokines/metabolism ; Orthomyxoviridae/metabolism ; Virus Replication ; Weight Loss
Chemical Substances	Drugs, Chinese Herbal ; Cytokines
Language	English
Publishing date	2023-04-16
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116481
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Zs.A 1494: Show issues

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Article ; Online: Towards high-density storage of text and images into DNA by the "Xiao-Pang" codec system.

Lu, Mingwei / Wang, Yang / Qiang, Wei / Cui, Junting / Wang, Yu / Huang, Xiaoluo / Dai, Junbiao

Science China. Life sciences

2023 Volume 66, Issue 6, Page(s) 1447–1450

MeSH term(s)	Proteins ; DNA
Chemical Substances	Proteins ; DNA (9007-49-2)
Language	English
Publishing date	2023-01-16
Publishing country	China
Document type	Letter
ZDB-ID	2546732-3
ISSN	1869-1889 ; 1674-7305
ISSN (online)	1869-1889
ISSN	1674-7305
DOI	10.1007/s11427-022-2252-0
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Article: Chemical characterization and metabolic profiling of Xiao-Er-An-Shen Decoction by UPLC-QTOF/MS.

Yang, Ruipei / Wei, Lifang / Wang, Jie / Huang, Shiying / Mo, Pingli / Chen, Qiugu / Zheng, Ping / Chen, Jihang / Zhang, Shangbin / Chen, Jianping

Frontiers in pharmacology

2023 Volume 14, Page(s) 1219866

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-11-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1219866
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Article: Corrigendum: Detecting key functional components group and speculating the potential mechanism of Xiao-Xu-Ming decoction in treating stroke.

Chen, Yu-Peng / Wang, Ke-Xin / Cai, Jie-Qi / Li, Yi / Yu, Hai-Lang / Wu, Qi / Meng, Wei / Wang, Han-Duo / Yin, Chuan-Hui / Wu, Jie / Huang, Mian-Bo / Li, Rong / Guan, Dao-Gang

Frontiers in cell and developmental biology

2023 Volume 10, Page(s) 1107236

Abstract: This corrects the article DOI: 10.3389/fcell.2022.753425.]. ...

Abstract	[This corrects the article DOI: 10.3389/fcell.2022.753425.].
Language	English
Publishing date	2023-01-20
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.1107236
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