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  1. Article ; Online: Biomarker Assessment of Lymphatic System Remodeling in Acute Heart Failure.

    Salah, Husam M / Alvarez, Paulino

    Journal of cardiac failure

    2023  Volume 29, Issue 12, Page(s) 1639–1641

    MeSH term(s) Humans ; Heart Failure/diagnosis ; Biomarkers ; Lymphatic System ; Ventricular Remodeling
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2023.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4340: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Best time for administration of antihypertensive medications: morning or evening?

    Salah, Husam M / Mehta, Jawahar L

    Lancet (London, England)

    2022  Volume 400, Issue 10361, Page(s) 1383–1385

    MeSH term(s) Humans ; Antihypertensive Agents/therapeutic use ; Hypertension/drug therapy ; Blood Pressure Monitoring, Ambulatory ; Circadian Rhythm ; Blood Pressure
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2022-10-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)01900-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.5: Show issues Location:
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  3. Article ; Online: Tolerability and safety barriers to sodium-glucose cotransporter 2 inhibitor initiation in heart failure with reduced ejection fraction.

    Salah, Husam M / Fudim, Marat

    European journal of heart failure

    2022  Volume 24, Issue 9, Page(s) 1633–1635

    MeSH term(s) Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Glucose ; Heart Failure/drug therapy ; Humans ; Sodium ; Stroke Volume ; Ventricular Dysfunction, Left
    Chemical Substances Sodium (9NEZ333N27) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-08-02
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2633
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    Zs.A 5299: Show issues Location:
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  4. Article: Sodium-glucose Cotransporter 2 Inhibitors and Nonalcoholic Fatty Liver Disease.

    Salah, Husam M / Fudim, Marat

    Heart failure clinics

    2022  Volume 18, Issue 4, Page(s) 625–634

    Abstract: Nonalcoholic fatty liver disease (NAFLD) is a systemic disorder with cardiovascular manifestations; due to its complex and multifactorial pathophysiological mechanisms, no effective pharmacologic treatment has been identified to date. Sodium-glucose ... ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) is a systemic disorder with cardiovascular manifestations; due to its complex and multifactorial pathophysiological mechanisms, no effective pharmacologic treatment has been identified to date. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have demonstrated potentially favorable effects on NAFLD incidence and progression in preclinical and clinical studies. This review summarizes the evidence from preclinical and human studies supporting the use of SGLT2 inhibitors in NAFLD and proposes several mechanisms that may drive these favorable effects (ie, increasing insulin sensitivity, decreasing intrahepatic fat accumulation and lipotoxicity, decreasing oxidative stress and endoplasmic reticulum (ER) stress, improving autophagy, and inhibiting apoptosis).
    MeSH term(s) Humans ; Liver ; Non-alcoholic Fatty Liver Disease/drug therapy ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2212019-1
    ISSN 1551-7136
    ISSN 1551-7136
    DOI 10.1016/j.hfc.2022.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6554: Show issues Location:
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  5. Article ; Online: COVID-19 Vaccine and Myocarditis.

    Salah, Husam M / Mehta, Jawahar L

    The American journal of cardiology

    2021  Volume 157, Page(s) 146–148

    MeSH term(s) COVID-19 Vaccines/adverse effects ; Humans ; Myocarditis/etiology ; Stroke Volume ; Troponin/blood
    Chemical Substances COVID-19 Vaccines ; Troponin
    Language English
    Publishing date 2021-07-12
    Publishing country United States
    Document type Letter ; Meta-Analysis ; Review
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2021.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.73: Show issues Location:
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  6. Article ; Online: Role of the Renal Lymphatic System in Heart Failure.

    Salah, Husam M / Biegus, Jan / Fudim, Marat

    Current heart failure reports

    2023  Volume 20, Issue 2, Page(s) 113–120

    Abstract: Purpose of review: The lymphatic system plays a major but overlooked role in maintaining fluid homeostasis. Given the unique fluid homeostasis functions of the kidneys, dysregulation of the renal lymphatic system underlies the development of self- ... ...

    Abstract Purpose of review: The lymphatic system plays a major but overlooked role in maintaining fluid homeostasis. Given the unique fluid homeostasis functions of the kidneys, dysregulation of the renal lymphatic system underlies the development of self-propagating congestive pathomechanisms. In this review, we outline the roles of the renal lymphatic system in heart failure (HF).
    Recent findings: Studies have uncovered several pathomechanisms involving the renal lymphatic system in congestive states, such as impaired interstitial draining by the renal lymphatic system, impaired structure and valves of renal lymphatics, lymphatic-induced increase in renal reabsorption of water and sodium, and development of albuminuria with proteinuria-induced renal lymphangiogenesis. These self-propagating mechanisms result in "renal tamponade" with manifestations of cardiorenal syndrome and inappropriate renal response to diuretics. Dysregulation of the renal lymphatic system is integral to the development and progression of congestion in HF. Targeting renal lymphatics may provide a novel pathway to treat intractable congestion.
    MeSH term(s) Humans ; Heart Failure ; Kidney ; Cardio-Renal Syndrome ; Lymphatic System ; Diuretics
    Chemical Substances Diuretics
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2151202-4
    ISSN 1546-9549 ; 1546-9530
    ISSN (online) 1546-9549
    ISSN 1546-9530
    DOI 10.1007/s11897-023-00595-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5936: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Device Interventions for Heart Failure.

    Salah, Husam M / Fudim, Marat / Burkhoff, Daniel

    JACC. Heart failure

    2023  Volume 11, Issue 8 Pt 2, Page(s) 1039–1054

    Abstract: Despite remarkable advances in drug therapy for heart failure (HF), the residual HF-related morbidity, mortality, and hospitalizations remain substantial across all HF phenotypes, and significant proportions of patients with HF remain symptomatic despite ...

    Abstract Despite remarkable advances in drug therapy for heart failure (HF), the residual HF-related morbidity, mortality, and hospitalizations remain substantial across all HF phenotypes, and significant proportions of patients with HF remain symptomatic despite optimal drug therapy. Driven by these unmet clinical needs, the exponential growth of transcatheter interventions, and a recent shift in the regulatory landscape of device-based therapies, novel device-based interventions have emerged as a potential therapy for various phenotypes of HF. Device-based interventions can overcome some of the limitations of drug therapy (eg, intolerance, nonadherence, inconsistent delivery, and recurrent and long-term cost) and can target some HF-related pathophysiologic pathways more effectively than drug therapy. This paper reviews the current evolving landscape of device-based interventions in HF and highlights critical points related to implementation of these therapies in the current workflow of HF management.
    MeSH term(s) Humans ; Heart Failure/therapy ; Hospitalization ; Phenotype
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2023.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Meta-analysis of the Effect of Colchicine on Mortality and Mechanical Ventilation in COVID-19.

    Salah, Husam M / Mehta, Jawahar L

    The American journal of cardiology

    2021  Volume 145, Page(s) 170–172

    MeSH term(s) COVID-19/mortality ; COVID-19/therapy ; Colchicine/therapeutic use ; Global Health ; Gout Suppressants/therapeutic use ; Humans ; Pandemics ; Respiration, Artificial/methods ; SARS-CoV-2 ; Survival Rate/trends
    Chemical Substances Gout Suppressants ; Colchicine (SML2Y3J35T)
    Language English
    Publishing date 2021-02-19
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2021.02.005
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    Ui IV Zs.73: Show issues Location:
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  9. Article ; Online: Meta-Analysis of the Effect of Aspirin on Mortality in COVID-19.

    Salah, Husam M / Mehta, Jawahar L

    The American journal of cardiology

    2021  Volume 142, Page(s) 158–159

    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Aspirin/therapeutic use ; COVID-19/drug therapy ; COVID-19/mortality ; Global Health ; Humans ; Pandemics ; Prognosis ; SARS-CoV-2 ; Survival Rate/trends
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Letter ; Meta-Analysis
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2020.12.073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Heparan sulfate consumption as a potential mechanism of intra-cardiac thrombosis in SARS-CoV-2 infection.

    Salah, Husam M / Mehta, Jawahar L

    Heart & lung : the journal of critical care

    2020  Volume 50, Issue 2, Page(s) 242–243

    Language English
    Publishing date 2020-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193129-5
    ISSN 1527-3288 ; 0147-9563
    ISSN (online) 1527-3288
    ISSN 0147-9563
    DOI 10.1016/j.hrtlng.2020.12.008
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