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Article: Sessile serrated polyp detection rates after fecal immunochemical test or multitarget stool DNA test: Systematic review and meta-analysis.

Garg, Rajat / Burke, Carol A / Aggarwal, Manik / Macaron, Carole / Singh, Amandeep / Kim, Michelle K / Regueiro, Miguel / Amit, Bhatt / Chahal, Prabhleen / Garg, Shashank

Endoscopy international open

2024 Volume 12, Issue 4, Page(s) E474–E487

Abstract: Background and study ... ...

Abstract	Background and study aims
Language	English
Publishing date	2024-04-05
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722
ISSN (online)	2196-9736
ISSN	2364-3722
DOI	10.1055/a-2256-3411
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy and safety of double- versus single-balloon retrograde enteroscopy.

Garg, Rajat / Singh, Amandeep / Mohammed, Abdul / Aggarwal, Manik / Stevens, Tyler / Vargo, John / Jang, Sunguk

European journal of gastroenterology & hepatology

2023 Volume 35, Issue 4, Page(s) 365–370

Abstract: Introduction: Data on the safety and efficacy of double-balloon enteroscopy (DBE) and single-balloon enteroscopy (SBE) are conflicting. We aimed to compare the efficacy and safety of retrograde DBE to SBE.: Methods: We performed a retrospective ... ...

Abstract	Introduction: Data on the safety and efficacy of double-balloon enteroscopy (DBE) and single-balloon enteroscopy (SBE) are conflicting. We aimed to compare the efficacy and safety of retrograde DBE to SBE. Methods: We performed a retrospective analysis of all patients who underwent retrograde DBE or SBE at a large tertiary referral center from 2008 to December 2018. Outcomes assessed included technical success, diagnostic yield, therapeutics, depth of insertion, and procedural duration. Results: A total of 523 (403 DBE, 120 SBE) patients underwent retrograde enteroscopy during the study period. The mean age was 59.4 ± 17.24 and 59.57 ± 16.94 years in DBE and SBE groups, respectively. There was no difference in technical success (91.0% vs. 92.5%, P = 0.85), diagnostic yield (40.9% vs. 40.8%, P = 0.95), and therapeutics (17.1% vs. 19.1%, P = 0.61) between DBE and SBE. Compared to SBE, DBE had significantly shorter mean procedure time (26.5 ± 34.5 min vs. 34.8 ± 29.4 min, P = 0.01) and higher maximal depth of insertion from ileocecal valve (108.1 ± 84.1 cm vs. 73.3 ± 63.4 cm, P = 0.001). Safety events were rare and similar in both groups. Conclusion: Retrograde DBE is associated with a significantly higher depth of insertion and shorter procedural duration, but similar diagnostic yield and technical success compared to SBE.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Aged ; Retrospective Studies ; Intestine, Small ; Single-Balloon Enteroscopy ; Double-Balloon Enteroscopy ; Time Factors ; Intestinal Diseases/diagnosis
Language	English
Publishing date	2023-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000002522
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Article: Natural history of gastrointestinal schwannomas.

Singh, Amandeep / Aggarwal, Manik / Chadalavada, Pravallika / Siddiqui, Mohamed Tausif / Garg, Rajat / Lai, Keith / Chahal, Prabhleen

Endoscopy international open

2022 Volume 10, Issue 6, Page(s) E801–E808

Abstract: Background and study ... ...

Abstract	Background and study aims
Language	English
Publishing date	2022-06-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722
ISSN (online)	2196-9736
ISSN	2364-3722
DOI	10.1055/a-1784-0806
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Article ; Online: Post-pancreatitis diabetes mellitus: insight on optimal management with nutrition and lifestyle approaches.

Singh, Amandeep / Aggarwal, Manik / Garg, Rajat / Stevens, Tyler / Chahal, Prabhleen

Annals of medicine

2022 Volume 54, Issue 1, Page(s) 1776–1786

Abstract: Pancreatitis is the leading gastrointestinal cause of hospitalizations. There are multiple short- and long-term complications associated with pancreatitis. Post-pancreatitis diabetes mellitus (PPDM) is one of the less explored complications of ... ...

Abstract	Pancreatitis is the leading gastrointestinal cause of hospitalizations. There are multiple short- and long-term complications associated with pancreatitis. Post-pancreatitis diabetes mellitus (PPDM) is one of the less explored complications of pancreatitis. Nonetheless, it has attracted considerable attention during the last decade. PPDM is now the second most common cause of new-onset diabetes mellitus (DM) in adults after type II DM surpassing type 1 DM. However, there exists a knowledge gap amongst practitioners regarding diagnosis, complications, and management of PPDM. In this narrative, we aim to provide a brief review regarding risks, diagnosis and management of PPDM with a special focus on dietary and lifestyle management strategies.KEY MESSAGESPost-pancreatitis diabetes mellitus (PPDM) is now the second most common cause of new-onset diabetes mellitus (DM) in adults after type II DM surpassing type 1 DM.New-onset diabetes in patients with pancreatitis could also be an early marker of occult pancreatic malignancy.Management of PPDM is complex and requires a team-based approach including gastroenterologists, endocrinologists, primary care physicians, nutritionists, and behavioural health specialists.
MeSH term(s)	Adult ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/therapy ; Hospitalization ; Humans ; Life Style ; Pancreatitis/complications ; Pancreatitis/therapy
Language	English
Publishing date	2022-07-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1004226-x
ISSN	1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
ISSN (online)	1365-2060 ; 1651-2219
ISSN	0785-3890 ; 1743-1387
DOI	10.1080/07853890.2022.2090601
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Article ; Online: Post-pancreatitis diabetes mellitus

Amandeep Singh / Manik Aggarwal / Rajat Garg / Tyler Stevens / Prabhleen Chahal

Annals of Medicine, Vol 54, Iss 1, Pp 1776-

insight on optimal management with nutrition and lifestyle approaches

2022 Volume 1786

Abstract	Pancreatitis is the leading gastrointestinal cause of hospitalizations. There are multiple short- and long-term complications associated with pancreatitis. Post-pancreatitis diabetes mellitus (PPDM) is one of the less explored complications of pancreatitis. Nonetheless, it has attracted considerable attention during the last decade. PPDM is now the second most common cause of new-onset diabetes mellitus (DM) in adults after type II DM surpassing type 1 DM. However, there exists a knowledge gap amongst practitioners regarding diagnosis, complications, and management of PPDM. In this narrative, we aim to provide a brief review regarding risks, diagnosis and management of PPDM with a special focus on dietary and lifestyle management strategies.KEY MESSAGESPost-pancreatitis diabetes mellitus (PPDM) is now the second most common cause of new-onset diabetes mellitus (DM) in adults after type II DM surpassing type 1 DM.New-onset diabetes in patients with pancreatitis could also be an early marker of occult pancreatic malignancy.Management of PPDM is complex and requires a team-based approach including gastroenterologists, endocrinologists, primary care physicians, nutritionists, and behavioural health specialists.
Keywords	Post-pancreatitis diabetes ; diet ; nutrition ; management ; Medicine ; R
Subject code	571
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
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Article ; Online: Trends and outcomes of infective endocarditis in cirrhosis: a propensity-matched national study.

Garg, Rajat / Aggarwal, Manik / Ahuja, Keerat R / Singh, Amandeep / Sanaka, Madhusudan R / McCullough, Arthur

European journal of gastroenterology & hepatology

2022 Volume 33, Issue 1S Suppl 1, Page(s) e580–e586

Abstract: Background: Cirrhosis is the most common cause of liver-related death and bacterial infection is a common comorbidity in cirrhosis. We aimed to study the trends and outcomes of infective endocarditis in cirrhosis.: Methods: A propensity-matched ... ...

Abstract	Background: Cirrhosis is the most common cause of liver-related death and bacterial infection is a common comorbidity in cirrhosis. We aimed to study the trends and outcomes of infective endocarditis in cirrhosis. Methods: A propensity-matched analysis of the National Inpatient Sample database was performed to assess outcomes of infective endocarditis in adult patients (>18 years) from 2004-2013 with and without cirrhosis. Various outcomes were assessed for outcomes of infective endocarditis in cirrhosis. Multivariate regression analysis was performed for predictors of mortality in infective endocarditis. Results: There has been no significant change in incidence (3.3-3.6%, P = 0.27) and overall mortality (6.3-8.6%, P = 0.42) of infective endocarditis in cirrhosis. After propensity matching, patients with cirrhosis had significantly higher in-hospital mortality (15 vs. 10.6%, P < 0.001) and acute kidney injury (AKI) (31.8 vs. 28.5%, P < 0.001) as compared to no cirrhosis. Microbiological analysis revealed significantly higher rates of streptococci (35.3 vs. 31.9%, P < 0.001) and fungal infective endocarditis (0.03 vs. 0%, P < 0.001) and lower incidence of Gram-negative infective endocarditis (3.9 vs. 6.3%, P < 0.001) in cirrhosis. Cirrhosis patients had significantly less surgical intervention (10.2 vs. 30.3%, P < 0.001) along with overall total cost and length of stay as compared to no cirrhosis. On multivariate analysis, advanced age, AKI, shock and mechanical ventilation were positive predictors of mortality in infective endocarditis patients with cirrhosis patients. Conclusions: Cirrhosis is an independent predictor of mortality in infective endocarditis with worse outcomes and less surgical intervention. Gram-negative infective endocarditis is lower in cirrhosis, whereas streptococci and fungal infective endocarditis are higher than noncirrhotic patients.
MeSH term(s)	Acute Kidney Injury ; Adult ; Endocarditis/diagnosis ; Endocarditis/epidemiology ; Endocarditis/therapy ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/epidemiology ; Endocarditis, Bacterial/therapy ; Hospital Mortality ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/epidemiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2022-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000002177
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Article ; Online: Development of machine learning model to detect fibrotic non-alcoholic steatohepatitis in patients with non-alcoholic fatty liver disease.

Aggarwal, Manik / Rozenbaum, Daniel / Bansal, Agam / Garg, Rajat / Bansal, Parikshit / McCullough, Arthur

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2021 Volume 53, Issue 12, Page(s) 1669–1672

MeSH term(s)	Adult ; Cross-Sectional Studies ; Female ; Fibrosis ; Humans ; Machine Learning ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/pathology
Language	English
Publishing date	2021-08-13
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2021.07.016
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Article ; Online: Efficacy and Safety of Azilsartan Medoxomil and Telmisartan in Hypertensive Patients: A Randomized, Assessor-Blinded Study.

Garg, Megha / Manik, Geetesh / Singhal, Alok / Singh, V K / Varshney, Rohit K / Sethi, Aseem

Saudi journal of medicine & medical sciences

2020 Volume 8, Issue 2, Page(s) 87–94

Abstract: Background: Few studies have compared the safety and efficacy of azilsartan medoxomil (AZL-M) and telmisartan in hypertensive patients, especially using ambulatory blood pressure monitoring (ABPM).: Objective: The objective of this study was to ... ...

Abstract	Background: Few studies have compared the safety and efficacy of azilsartan medoxomil (AZL-M) and telmisartan in hypertensive patients, especially using ambulatory blood pressure monitoring (ABPM). Objective: The objective of this study was to compare the efficacy and safety profile of AZL-M and telmisartan in hypertensive patients using ABPM and clinic blood pressure (BP) monitoring. Materials and methods: This prospective, randomized, open-label, blinded endpoint, parallel-arm study included 700 patients, aged 18-70 years, with clinic and 24-h mean ambulatory systolic BP (SBP) of 150-180 mmHg and 130-170 mmHg, respectively. They were randomized equally into two groups: Group A received AZL-M 40 mg and Group T received telmisartan 40 mg; the dose was force titrated to 80 mg after 2 weeks if the response rate was not achieved. BP (clinical and ambulatory) was measured after 12 weeks and compared with baseline measurements. Results: AZL-M significantly reduced the 24-h mean ambulatory SBP (Group A: 112.74 ± 7.58 mmHg; Group T: 113.96 ± 8.52 mmHg; Conclusion: This study found that AZL-M has greater antihypertensive efficacy than telmisartan, with comparable side effects. In addition, ABPM was shown to be a feasible method for such studies.
Language	English
Publishing date	2020-04-17
Publishing country	India
Document type	Journal Article
ZDB-ID	2734896-9
ISSN	2321-4856 ; 2321-4856
ISSN (online)	2321-4856
ISSN	2321-4856
DOI	10.4103/sjmms.sjmms_19_19
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Article ; Online: Meta-analysis of COVID-19 single-cell studies confirms eight key immune responses

Manik Garg / Xu Li / Pablo Moreno / Irene Papatheodorou / Yuelong Shu / Alvis Brazma / Zhichao Miao

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 10

Abstract: Abstract Several single-cell RNA sequencing (scRNA-seq) studies analyzing immune response to COVID-19 infection have been recently published. Most of these studies have small sample sizes, which limits the conclusions that can be made with high ... ...

Abstract	Abstract Several single-cell RNA sequencing (scRNA-seq) studies analyzing immune response to COVID-19 infection have been recently published. Most of these studies have small sample sizes, which limits the conclusions that can be made with high confidence. By re-analyzing these data in a standardized manner, we validated 8 of the 20 published results across multiple datasets. In particular, we found a consistent decrease in T-cells with increasing COVID-19 infection severity, upregulation of type I Interferon signal pathways, presence of expanded B-cell clones in COVID-19 patients but no consistent trend in T-cell clonal expansion. Overall, our results show that the conclusions drawn from scRNA-seq data analysis of small cohorts of COVID-19 patients need to be treated with some caution.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Real-world effectiveness and safety of ustekinumab and vedolizumab in elderly patients with Crohn's disease.

Garg, Rajat / Aggarwal, Manik / Mohammed, Abdul / Achkar, Jean Paul / Lashner, Bret / Philpott, Jessica / Cohen, Benjamin / Qazi, Taha / Rieder, Florian / Regueiro, Miguel / Click, Benjamin

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

2023 Volume 42, Issue 5, Page(s) 718–723

Abstract: Studies report favorable efficacy and safety profiles of ustekinumab (UST) and vedolizumab (VDZ) in Crohn's disease (CD), but effectiveness and safety data in elderly patients with CD is lacking. We retrospectively analyzed 78 elderly patients (39 each ... ...

Abstract	Studies report favorable efficacy and safety profiles of ustekinumab (UST) and vedolizumab (VDZ) in Crohn's disease (CD), but effectiveness and safety data in elderly patients with CD is lacking. We retrospectively analyzed 78 elderly patients (39 each UST and VDZ) and found that patients on UST and VDZ experienced similar rates of clinical response, remission and mucosal healing despite high proportion of prior biologic exposure. Both UST and VDZ appear to be effective and safe in this at-risk CD population. Further large studies are needed to validate our findings.
MeSH term(s)	Humans ; Aged ; Crohn Disease/drug therapy ; Ustekinumab/adverse effects ; Retrospective Studies ; Antibodies, Monoclonal, Humanized/adverse effects ; Treatment Outcome ; Remission Induction
Chemical Substances	Ustekinumab (FU77B4U5Z0) ; vedolizumab (9RV78Q2002) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-07-31
Publishing country	India
Document type	Journal Article
ZDB-ID	632595-6
ISSN	0975-0711 ; 0254-8860
ISSN (online)	0975-0711
ISSN	0254-8860
DOI	10.1007/s12664-023-01391-3
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