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  1. Article ; Online: More Precision in Adjuvant Chemotherapy for Stage II Colon Cancer Using Liquid Biopsy After Surgery.

    Sallinen, Ville

    Gastroenterology

    2022  Volume 163, Issue 5, Page(s) 1471–1472

    MeSH term(s) Humans ; Chemotherapy, Adjuvant ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/surgery ; Colonic Neoplasms/pathology ; Liquid Biopsy ; Neoplasm Staging ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2022.07.083
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  2. Article ; Online: Moderate Fluid Resuscitation Is Preferable in Acute Pancreatitis.

    Sallinen, Ville

    Gastroenterology

    2022  Volume 164, Issue 3, Page(s) 493

    MeSH term(s) Humans ; Pancreatitis ; Acute Disease ; Fluid Therapy ; Resuscitation
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2022.11.015
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  3. Article ; Online: Mechanical and oral antibiotic bowel preparation for all patients undergoing colorectal surgery?

    Koskenvuo, Laura / Sallinen, Ville

    BJS open

    2023  Volume 7, Issue 3

    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Colorectal Surgery ; Antibiotic Prophylaxis ; Digestive System Surgical Procedures
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1093/bjsopen/zrad048
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  4. Article ; Online: Prediction of postoperative pancreatic fistula and pancreatitis after pancreatoduodenectomy or distal pancreatectomy: A review.

    Bonsdorff, Akseli / Sallinen, Ville

    Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society

    2023  Volume 112, Issue 2, Page(s) 126–134

    Abstract: Background and objective: Postoperative pancreatic fistula (POPF) is the leading cause of morbidity and early mortality in patients undergoing pancreatic resection. In addition, recent studies have identified postoperative acute pancreatitis (POAP) as ... ...

    Abstract Background and objective: Postoperative pancreatic fistula (POPF) is the leading cause of morbidity and early mortality in patients undergoing pancreatic resection. In addition, recent studies have identified postoperative acute pancreatitis (POAP) as an independent contributor to morbidity. Most perioperative mitigation strategies experimented for POPF have been shown to be in vain with no consensus on the best perioperative management. Clinical prediction models have been developed with the hope of identifying high POPF risk patients with the leading idea of finding subpopulations possibly benefiting from pre-existing or novel mitigation strategies. The aim of this review was to map out the existing prediction modeling studies to better understand the current stage of POPF prediction modeling, and the methodology behind them.
    Methods: A narrative review of the existing POPF prediction model studies was performed. Studies published before September 2022 were included.
    Results: While the number of POPF prediction models for pancreatoduodenectomy has increased, none of the currently existing models stand out from the crowd. For distal pancreatectomy, two unique POPF prediction models exist, but due to their freshness, no further external validation or adoption in clinics or research has been reported. There seems to be a lack of adherence to correct methodology or reporting guidelines in most of the studies, which has rendered external validity-if assessed-low. Few of the most recent studies have demonstrated preoperative assessment of pancreatic aspects from computed tomography (CT) scans to provide relatively strong predictors of POPF.
    Conclusions: Main goal for the future would be to reach a consensus on the most important POPF predictors and prediction model. At their current state, few models have demonstrated adequate transportability and generalizability to be up to the task. Better understanding of POPF pathophysiology and the possible driving force of acute inflammation and POAP might be required before such a prediction model can be accessed.
    MeSH term(s) Humans ; Pancreatic Fistula/diagnosis ; Pancreatic Fistula/etiology ; Pancreatectomy/adverse effects ; Pancreatectomy/methods ; Pancreaticoduodenectomy/adverse effects ; Pancreatitis/diagnosis ; Pancreatitis/etiology ; Acute Disease ; Risk Factors ; Risk Assessment/methods ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Retrospective Studies
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2077691-3
    ISSN 1799-7267 ; 1457-4969
    ISSN (online) 1799-7267
    ISSN 1457-4969
    DOI 10.1177/14574969231167781
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  5. Article ; Online: Characteristics of Delayed Graft Function and Long-Term Outcomes After Kidney Transplantation From Brain-Dead Donors: A Single-Center and Multicenter Registry-Based Retrospective Study.

    Ahlmark, Amanda / Sallinen, Ville / Eerola, Verner / Lempinen, Marko / Helanterä, Ilkka

    Transplant international : official journal of the European Society for Organ Transplantation

    2024  Volume 37, Page(s) 12309

    Abstract: Delayed graft function (DGF) after kidney transplantation is common and associated with worse graft outcomes. However, little is known about factors affecting graft survival post-DGF. We studied the association of cold ischemia time (CIT) and Kidney ... ...

    Abstract Delayed graft function (DGF) after kidney transplantation is common and associated with worse graft outcomes. However, little is known about factors affecting graft survival post-DGF. We studied the association of cold ischemia time (CIT) and Kidney Donor Profile Index (KDPI) with the long-term outcomes of deceased brain-dead donor kidneys with and without DGF. Data from Finland (
    MeSH term(s) Humans ; Brain ; Delayed Graft Function/etiology ; Graft Survival ; Kidney Transplantation/methods ; Registries ; Retrospective Studies ; Risk Factors ; Tissue Donors ; Multicenter Studies as Topic
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2024.12309
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  6. Article ; Online: Artificial Pancreas and Expanding the Use of Total Pancreatectomy.

    Sallinen, Ville / Puolakkainen, Pauli

    JAMA surgery

    2022  Volume 157, Issue 10, Page(s) 957–958

    MeSH term(s) Blood Glucose ; Humans ; Insulin ; Pancreas/surgery ; Pancreas, Artificial ; Pancreatectomy ; Pancreatic Neoplasms/surgery
    Chemical Substances Blood Glucose ; Insulin
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2022.3731
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  7. Article ; Online: Association of Procurement Time With Pancreas Transplant Outcomes in Brain-Dead Donors.

    Eerola, Verner / Sallinen, Ville / Lempinen, Marko / Helanterä, Ilkka

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 11332

    Abstract: A brain-death-induced cytokine storm damages organs in an organ donor. However, a longer time period between declaration of brain death and organ procurement (procurement interval) is associated with improved outcomes in kidney, liver, heart, and lung ... ...

    Abstract A brain-death-induced cytokine storm damages organs in an organ donor. However, a longer time period between declaration of brain death and organ procurement (procurement interval) is associated with improved outcomes in kidney, liver, heart, and lung transplantation. The aim of this study was to find the optimal procurement interval for pancreas transplantation. Association of procurement interval with pancreas graft outcomes was analyzed using multivariable models adjusted for variables possibly affecting procurement interval and outcomes. Altogether 10,119 pancreas transplantations were included from the Scientific Registry of Transplant Recipients. The median follow-up was 3.2 (IQR 1.01-6.50) years. During the first year, 832 (9.0%) grafts were lost, including 555 (6.0%) within the first 30 days. Longer procurement interval was associated with increased death-censored graft survival in a multivariable model (HR 0.944 95% CI 0.917-0.972, per 10-h increase,
    MeSH term(s) Humans ; Pancreas Transplantation ; Brain Death ; Kidney Transplantation ; Tissue Donors ; Tissue and Organ Procurement ; Graft Survival ; Pancreas ; Brain ; Graft Rejection
    Language English
    Publishing date 2023-06-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.11332
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  8. Article ; Online: Recent and future hydrological trends of aapa mires across the boreal climate gradient

    Sallinen, Antti / Akanegbu, Justice / Marttila, Hannu / Tahvanainen, Teemu

    Journal of Hydrology. 2023 Feb., v. 617 p.129022-

    2023  

    Abstract: Aapa mires are boreal peatland complexes comprised of wet, typically patterned fens in the center and Sphagnum bog vegetation at the margins. Their distribution is controlled by climate and local catchment hydrology. The daily discharge of twelve aapa ... ...

    Abstract Aapa mires are boreal peatland complexes comprised of wet, typically patterned fens in the center and Sphagnum bog vegetation at the margins. Their distribution is controlled by climate and local catchment hydrology. The daily discharge of twelve aapa mires across the boreal zone was explored for 1961-2099, with the CPIsnow model using observational weather data and projections based on climate models (CMIP5) and emission scenarios (RCP4.5 and RCP8.5). Mire hydrology was assessed for climate-zonal differences, seasonal patterns, and longer-term trends. The results indicated past and future changes in hydrology, particularly related to the duration and magnitude of snow cover and the timing of snowmelt. Increasing winter discharge and decreasing spring discharge were detected in recent past in the southern sites, and these trends were indicated to continue in the future throughout the study area. By the end of the 21st century, the typical seasonality of discharge is indicated to weaken throughout the study area and to largely disappear in the south boreal catchments. In the northernmost sites, a mismatch between past trends and future projections of spring discharge was discovered, indicating complexity and uncertainty of snow process modeling. The hydrological changes indicated in this study, together with direct impacts of increasing temperatures, threaten aapa mires, affecting biodiversity and greenhouse gas balance. In changing climate, special attention should be paid to winter conditions and snow, essential for the hydrological cycle in the north but under-explored in mire hydrology studies.
    Keywords Sphagnum ; biodiversity ; fens ; greenhouse gases ; hydrologic cycle ; meteorological data ; models ; peatlands ; snow ; snowmelt ; snowpack ; springs (water) ; subarctic climates ; uncertainty ; vegetation ; watershed hydrology ; Catchment ; Climate change ; Hydrological modeling ; Patterned fen ; Peatland ; Snow hydrology
    Language English
    Dates of publication 2023-02
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 1473173-3
    ISSN 1879-2707 ; 0022-1694
    ISSN (online) 1879-2707
    ISSN 0022-1694
    DOI 10.1016/j.jhydrol.2022.129022
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  9. Article ; Online: Recent Advances in Pancreatic Surgery.

    Sallinen, Ville

    Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society

    2016  Volume 105, Issue 4, Page(s) 213–214

    Language English
    Publishing date 2016-10-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077691-3
    ISSN 1799-7267 ; 1457-4969
    ISSN (online) 1799-7267
    ISSN 1457-4969
    DOI 10.1177/1457496916673801
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  10. Article ; Online: Surgical and oncological outcomes of D1 versus D2 gastrectomy among elderly patients treated for gastric cancer.

    Back, Johan / Sallinen, Ville / Kokkola, Arto / Puolakkainen, Pauli

    Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society

    2022  Volume 111, Issue 2, Page(s) 14574969221096193

    Abstract: Introduction: Gastrectomy with D2 lymphadenectomy is considered standard treatment in gastric cancer (GC). Among Western patients, morbidity and mortality seem to increase in D2 relative to D1 lymphadenectomy. As elderly patients with co-morbidities are ...

    Abstract Introduction: Gastrectomy with D2 lymphadenectomy is considered standard treatment in gastric cancer (GC). Among Western patients, morbidity and mortality seem to increase in D2 relative to D1 lymphadenectomy. As elderly patients with co-morbidities are more prone to possible complications, it is unclear whether they benefit from D2 lymphadenectomy. This study aims to compare the short- and long-term results of D1 and D2 lymphadenectomy in elderly patients undergoing gastrectomy for GC.
    Methods: All elderly (⩾75 years) patients undergoing gastrectomy with curative intent for GC during 2000-2015 were included and grouped according to the level of lymph node dissection into the D1 or D2 group. Short-term surgical outcome included the Comprehensive Complication Index (CCI) and 30-day mortality. Long-term outcomes comprised overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS). Cox regression was used in multivariable analyses.
    Results: In total, 99 elderly patients were included in the study (51 in D1 group, 48 in D2 group). The median follow-up was 32.5 months. Patients in the D1 group were older and had a higher American Society of Anesthesiologist (ASA) score. Both groups had similar burden of postoperative complications (CCI 20.9 versus 22.6, p = 0.26, respectively) and 90-day mortality (2% for both groups). The OS, DSS, and DFS were similar between groups. Multivariable analysis adjusted for potential confounders detected no difference in the survival between the D1 and D2 groups.
    Conclusions: Gastrectomy with D2 lymphadenectomy can be performed with low postoperative morbidity and mortality suggesting its use also in the elderly. Long-term outcomes seem similar but need further studies.
    MeSH term(s) Aged ; Disease-Free Survival ; Gastrectomy/adverse effects ; Humans ; Lymph Node Excision/adverse effects ; Postoperative Complications/etiology ; Retrospective Studies ; Stomach Neoplasms/pathology ; Survival Rate
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077691-3
    ISSN 1799-7267 ; 1457-4969
    ISSN (online) 1799-7267
    ISSN 1457-4969
    DOI 10.1177/14574969221096193
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