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Article ; Online: Investigating the Role and Importance of Persian Crown Jewels in Economic and Political Developments in Shah Abbas I Era (1587-1629)

Sayed Masud Sayed Bonakdar / Hussein Mir Jafari / Loghman Dehghan Niri

Asian Culture and History, Vol 4, Iss

2012 Volume 2

Abstract: ... to this. In the reign of Shah Abbas as the greatest Safavid king, the importance of possessing a treasury full of jewels ... developments in the reign of Shah Abbas I. Library research method and comparison and analysis of existing ...

Abstract	From their early history, Persians have always been charmed by jewelry and whenever a powerful dynasty came to power, economy of the country would become more dynamic and a collection of the most precious gems and jewels would be accumulated. The glorious age of the Safavids was not an exception to this. In the reign of Shah Abbas as the greatest Safavid king, the importance of possessing a treasury full of jewels, gold and silver for king’s own person made him expand his treasury and jewelry collection more than ever and use it in achieving other political ends during his reign. Using existing resources, this study aims to investigate the role and importance of crown jewels in the economic and political developments in the reign of Shah Abbas I. Library research method and comparison and analysis of existing resources, especially the original resources are used in this article. After necessary data are collected, they are organized and then analyzed and finally conclusions are drawn.
Keywords	History of Asia ; DS1-937 ; History (General) and history of Europe ; D ; Philosophy (General) ; B1-5802 ; Philosophy. Psychology. Religion ; B
Subject code	940
Language	English
Publishing date	2012-06-01T00:00:00Z
Publisher	Canadian Center of Science and Education
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of interleukin 6 signaling pathway in the anti-inflammatory effects of statins on coronary artery disease: Evidence from Mendelian randomization analysis.

Yazdanpanah, Mojgan / Yazdanpanah, Nahid / Chardoli, Mojtaba / Dehghan, Abbas

International journal of cardiology

2024 , Page(s) 131964

Abstract: Background: Statins are currently widely used in the prevention of coronary artery disease (CAD) primarily for lipid-lowering with a potential anti-inflammatory effect. However, it is not clear if their potential anti-inflammatory effects are mediated ... ...

Abstract	Background: Statins are currently widely used in the prevention of coronary artery disease (CAD) primarily for lipid-lowering with a potential anti-inflammatory effect. However, it is not clear if their potential anti-inflammatory effects are mediated through the interleukin 6 (IL-6) signaling pathway. Methods: Using the Mendelian randomization (MR) approach followed by multivariable MR analyses, we examined the extent to which the effects of statins on CAD might be mediated through the IL-6 signaling pathway. Results: Our observations showed that HMG-CoA reductase, using LDL levels as a proxy, had a significant effect on upstream IL-6 (βMR = 0.47, P-IVW = 0.01) and nominally significant effects on IL-6RA (βMR = 0.22, P-IVW = 0.047) and APOB (βMR = 0.82, P-IVW = 1.8 × 10-33). While the IL-6 signaling cascade (IL-6RA βMR = -0.06, P-IVW = 3.45 × 10-20 and IL-6 βMR = -0.03, P-IVW = 0.09) and the anti-inflammatory effect of HMG-CoA reductase (βMR = -0.31, P-IVW = 0.01) was found to influence the risk of CAD, the multivariable MR (MVMR) model indicated that the anti-inflammatory effect of HMG-CoA reductase is not likely to be mediated through the IL-6 signaling cascade, including APOB and IL-6RA (MVMRβ = 0.23, P = 0.688). Conclusions: Our findings suggest that statins may use inflammatory mechanisms independent of the IL-6 signaling pathway to prevent CAD. This result could potentially affect the definition of the target population for statin use.
Language	English
Publishing date	2024-03-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2024.131964
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Article ; Online: Genome-Wide Association Studies.

Dehghan, Abbas

Methods in molecular biology (Clifton, N.J.)

2018 Volume 1793, Page(s) 37–49

Abstract: Genetic association studies have made a major contribution to our understanding of the genetics of complex disorders over the last 10 years through genome-wide association studies (GWAS). In this chapter, we review the key concepts that underlie the GWAS ...

Abstract	Genetic association studies have made a major contribution to our understanding of the genetics of complex disorders over the last 10 years through genome-wide association studies (GWAS). In this chapter, we review the key concepts that underlie the GWAS approach. We will describe the "common disease, common variant" theory, and will review how we finally afforded to capture the common variance in genome to make GWAS possible. Finally, we will go over technical aspects of GWAS such as genotype imputation, epidemiologic designs, analysis methods, and considerations such as genomic inflation, multiple testing, and replication.
MeSH term(s)	Epidemiologic Research Design ; Genetic Predisposition to Disease ; Genome-Wide Association Study/methods ; Humans ; Models, Genetic ; Models, Statistical
Language	English
Publishing date	2018-06-06
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-7868-7_4
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Article ; Online: Mass spectrometry in epidemiological studies: What are the key considerations?

Dehghan, Abbas

European journal of epidemiology

2016 Volume 31, Issue 8, Page(s) 715–716

Language	English
Publishing date	2016-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632614-6
ISSN	1573-7284 ; 0393-2990
ISSN (online)	1573-7284
ISSN	0393-2990
DOI	10.1007/s10654-016-0195-x
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Zs.A 2090: Show issues

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Article ; Online: Harmony in hardship: Unveiling parental coping strategies with the challenges of child's hematopoietic stem cell transplantation.

Maleki, Maryam / Dehghan Nayeri, Nahid / Hamidieh, Amir Ali / Pouraboli, Batool / Mardani, Abbas

Journal of pediatric nursing

2024

Abstract: Purpose: Pediatric Hematopoietic Stem Cell Transplant (HSCT) profoundly affects various dimensions of parents' lives. Effective coping strategies are essential for improving psychological well-being and overall quality of life. Therefore, this study ... ...

Abstract	Purpose: Pediatric Hematopoietic Stem Cell Transplant (HSCT) profoundly affects various dimensions of parents' lives. Effective coping strategies are essential for improving psychological well-being and overall quality of life. Therefore, this study aimed to explore parental coping strategies with their child's HSCT challenges. Design and methods: This qualitative study was conducted in Iran from February to November 2023, utilizing conventional content analysis with purposive sampling. For data collection, unstructured interviews were conducted, followed by in-depth semi-structured interviews with open-ended questions. Saturation was reached after analyzing qualitative data from 20 participants. Results: Data analysis unveiled a main theme labeled "harmony in hardship". This overarching concept encapsulates the participants' endeavors to cope with the various hurdles and complexities stemming from their child's HSCT. This theme consisted of five categories: "emotional release", "positive coping", "avoidance coping", "spiritual coping", and "seeking support". Conclusion: Parents utilized multifaceted coping strategies to manage the complexities of their child's HSCT journey. Understanding these mechanisms is crucial as they can positively influence parents' psychological well-being and improve their overall quality of life. Implications for clinical practice: Healthcare professionals should recognize the diverse coping strategies employed by parents of children undergoing HSCT and provide tailored interventions and support. Furthermore, implementing structured support programs and training initiatives for healthcare professionals can enhance their capacity to meet the diverse needs of parents during this challenging journey.
Language	English
Publishing date	2024-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	632731-x
ISSN	1532-8449 ; 0882-5963
ISSN (online)	1532-8449
ISSN	0882-5963
DOI	10.1016/j.pedn.2024.04.030
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Zs.B 2871: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 375: Show issues

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Article ; Online: Metabolomics of Ramadan fasting and associated risk of chronic diseases.

Al-Jafar, Rami / Pinto, Rui Climaco / Elliott, Paul / Tsilidis, Konstantinos K / Dehghan, Abbas

The American journal of clinical nutrition

2024 Volume 119, Issue 4, Page(s) 1007–1014

Abstract: Background: The dramatic change in lifestyle associated with Ramadan fasting raises questions about its effect on metabolism and health. Metabolites, as the end product of metabolism, are excellent candidates to be studied in this regard.: Objective: ...

Abstract	Background: The dramatic change in lifestyle associated with Ramadan fasting raises questions about its effect on metabolism and health. Metabolites, as the end product of metabolism, are excellent candidates to be studied in this regard. Objective: This study aims to investigate the effect of Ramadan fasting on the metabolic profile and risk of chronic diseases. Methods: The London Ramadan study (LORANS) is an observational study in which 2 blood samples were collected from 72 participants a few days before and after the fasting month of Ramadan. We conducted metabolomic profiling using nuclear magnetic resonance spectroscopy to assess the change in individual metabolites from before to after Ramadan. Also, we generated metabolic scores (scaled from 0 to 100) for 7 chronic diseases in the UK Biobank and assessed the association of Ramadan fasting with these scores in LORANS. Results: Of the 72 participants, 35 were male (48.6%); the mean (± standard deviation) age was 45.7 (±16) y. Ramadan fasting was associated with changes in 14 metabolites (1 inflammation marker, 1 amino acid, 2 glycolysis-related metabolites, 2 ketone bodies, 2 triglyceride, and 6 lipoprotein subclasses), independent of changes in body composition. Using data from 117,981 participants in the UK Biobank, we generated metabolic scores for diabetes, hypertension, coronary artery disease, renal failure, colorectal cancer, breast cancer, and lung cancer. The metabolic scores for lung cancer, colorectal cancer, and breast cancer were lower after Ramadan in LORANS (-4.74, 9.6%, 95% confidence interval -6.56, -2.91, P < 0.001), (-1.09, -2.4%, -1.69, -0. 50, P < 0.001), and (-0.48, -1.1%, -0. 81, -0.15, P = 0.006), respectively. Conclusions: Ramadan fasting is associated with short-term favorable changes in the metabolic profile concerning risk of some chronic diseases. These findings should be further investigated in future, larger studies of longer follow-up with clinical outcomes.
MeSH term(s)	Humans ; Male ; Female ; Islam ; Fasting ; Diabetes Mellitus ; Chronic Disease ; Breast Neoplasms
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
DOI	10.1016/j.ajcnut.2024.01.019
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Article ; Online: Phenome-wide association study on miRNA-related sequence variants: the UK Biobank.

Mustafa, Rima / Ghanbari, Mohsen / Karhunen, Ville / Evangelou, Marina / Dehghan, Abbas

Human genomics

2023 Volume 17, Issue 1, Page(s) 104

Abstract: Background: Genetic variants in the coding region could directly affect the structure and expression levels of genes and proteins. However, the importance of variants in the non-coding region, such as microRNAs (miRNAs), remain to be elucidated. Genetic ...

Abstract	Background: Genetic variants in the coding region could directly affect the structure and expression levels of genes and proteins. However, the importance of variants in the non-coding region, such as microRNAs (miRNAs), remain to be elucidated. Genetic variants in miRNA-related sequences could affect their biogenesis or functionality and ultimately affect disease risk. Yet, their implications and pleiotropic effects on many clinical conditions remain unknown. Methods: Here, we utilised genotyping and hospital records data in the UK Biobank (N = 423,419) to investigate associations between 346 genetic variants in miRNA-related sequences and a wide range of clinical diagnoses through phenome-wide association studies. Further, we tested whether changes in blood miRNA expression levels could affect disease risk through colocalisation and Mendelian randomisation analysis. Results: We identified 122 associations for six variants in the seed region of miRNAs, nine variants in the mature region of miRNAs, and 27 variants in the precursor miRNAs. These included associations with hypertension, dyslipidaemia, immune-related disorders, and others. Nineteen miRNAs were associated with multiple diagnoses, with six of them associated with multiple disease categories. The strongest association was reported between rs4285314 in the precursor of miR-3135b and celiac disease risk (odds ratio (OR) per effect allele increase = 0.37, P = 1.8 × 10 Conclusions: Our study demonstrates the pleiotropic effect of miRNAs and offers insights to their possible clinical importance.
MeSH term(s)	Humans ; MicroRNAs/genetics ; Biological Specimen Banks ; Dyslipidemias ; United Kingdom ; Genome-Wide Association Study
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2147618-4
ISSN	1479-7364 ; 1479-7364
ISSN (online)	1479-7364
ISSN	1479-7364
DOI	10.1186/s40246-023-00553-w
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Article ; Online: Association between systolic blood pressure and low-density lipoprotein cholesterol with coronary heart disease according to age.

Wang, Nelson / Mustafa, Rima / Zuber, Verena / Rodgers, Anthony / Dehghan, Abbas

PloS one

2023 Volume 18, Issue 12, Page(s) e0295004

Abstract: Background: The impact of elevated systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDL-C) on the risk of coronary heart disease (CHD) at different stages of life is unclear. We aimed to investigate whether genetically mediated SBP/ ...

Abstract	Background: The impact of elevated systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDL-C) on the risk of coronary heart disease (CHD) at different stages of life is unclear. We aimed to investigate whether genetically mediated SBP/LDL-C is associated with the risk of CHD throughout life. Methods and findings: We conducted a three-sample Mendelian randomization analysis using data from the UK Biobank including 136,648 participants for LDL-C, 135,431 participants for SBP, and 24,052 cases for CHD to assess the effect of duration of exposure to the risk factors on risk of CHD. Analyses were stratified by age at enrolment. In univariable analyses, there was a consistent association between exposure to higher LDL-C and SBP with increased odds of incident CHD in individuals aged ≤55 years, ≤60 years, and ≤65 years (p-value for heterogeneity = 1.00 for LDL-C and 0.67 for SBP, respectively). In multivariable Mendelian randomization analyses, exposure to elevated LDL-C/SBP early in life (age ≤55 years) was associated with a higher risk of CHD independent of later life levels (age >55 years) (odds ratio 1.68, 95% CI 1.20-2.34 per 1 mmol/L LDL-C, and odds ratio 1.33, 95% CI 1.18-1.51 per 10 mmHg SBP). Conclusions: Genetically predicted SBP and LDL-C increase the risk of CHD independent of age. Elevated SBP and LDL-C in early to middle life is associated with increased CHD risk independent of later-life SBP and LDL-C levels. These findings support the importance of lifelong risk factor control in young individuals, whose risk of CHD accumulates throughout life.
MeSH term(s)	Humans ; Autonomic Nervous System Diseases ; Blood Pressure ; Cholesterol, LDL ; Coronary Disease/epidemiology ; Coronary Disease/genetics ; Mendelian Randomization Analysis ; Risk Factors ; Middle Aged ; Aged
Chemical Substances	Cholesterol, LDL
Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0295004
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Article ; Online: Forecasts of cardiac and respiratory mortality in Tehran, Iran, using ARIMAX and CNN-LSTM models.

Mahmudimanesh, Marzieh / Mirzaee, Moghaddameh / Dehghan, Azizallah / Bahrampour, Abbas

Environmental science and pollution research international

2022 Volume 29, Issue 19, Page(s) 28469–28479

Abstract: Cardiovascular diseases belong to the leading causes of disability and premature death worldwide, including in Iran. It is predicted that the burden of the disease in Iran in 2025 will be more than doubled compared to 2005. Therefore, many forecasting ... ...

Abstract	Cardiovascular diseases belong to the leading causes of disability and premature death worldwide, including in Iran. It is predicted that the burden of the disease in Iran in 2025 will be more than doubled compared to 2005. Therefore, many forecasting models have been used to predict disease progression, estimate mortality rates, and assess risk factors. Our study focused on two time series prediction on models: autoregressive integrated moving average with exogenous variable (ARIMAX) and Convolutional neural network-long short-term memory network (CNN-LSTM). ARIMAX (6,1,6) had the best MSE of 0.655 among time series regression models. The prediction of this model shows a significant association in lag 4 and lag 6. Nitrogen dioxide (NO
MeSH term(s)	Forecasting ; Humans ; Iran ; Neural Networks, Computer ; Respiratory Tract Diseases ; Time Factors
Language	English
Publishing date	2022-01-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-18205-8
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Article: New challenge for the health care system in Iran: The need to prepare for the monkeypox virus.

Zakeri, Mohammad Ali / Zakeri Bazmandeh, Abbas / Kahnooji, Mahmood / Dehghan, Mahlagha

Frontiers in medicine

2022 Volume 9, Page(s) 974169

Language	English
Publishing date	2022-09-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.974169
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