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Article ; Online: Prognostic significance of a pathological response in metastatic lymph nodes of patients with gastric cancer who underwent neoadjuvant chemotherapy followed by surgery.

Chen, Fengju / Xian, Jia / Huo, Junjie

2024

Abstract: Purpose: To grade the pathological response of lymph nodes (LNs) to neoadjuvant chemotherapy (NAC) in patients with locally advanced gastric cancer (LAGC) and investigate its prognostic significance.: Methods: This retrospective study included 196 ... ...

Abstract	Purpose: To grade the pathological response of lymph nodes (LNs) to neoadjuvant chemotherapy (NAC) in patients with locally advanced gastric cancer (LAGC) and investigate its prognostic significance. Methods: This retrospective study included 196 patients who underwent NAC, followed by radical gastrectomy for LAGC between January 2010 and October 2019. Pathological responses were evaluated based on the proportion of residual tumor cells within the tumor area in the primary tumor (PT) and LNs and included the following categories: 1a (0%), 1b (< 10%), 2 (10-50%), and 3 (> 50%). Results: Among 166 patients with clinically node-positive disease, 38/27/39/62 were classified as having LN regression grade (LRG) 1a/1b/2/3, respectively. Compared to LN non-responders (LRG 2 or 3), LN responders (LRG 1a or 1b) had significantly higher 5-year overall survival (72.5% vs. 19.0%, P < 0.001) and recurrence-free survival rates (67.8% vs. 22.2%, P < 0.001), irrespective of PT response. Furthermore, a multivariate analysis revealed that the LN response was an independent risk factor for the overall survival (hazard ratio [HR] 0.417, 95% confidence interval [CI] 0.181-0.962, P = 0.040) and recurrence-free survival (HR 0.490, 95% CI 0.242-0.991, P = 0.047), but not the PT response (P > 0.05). Conclusions: The pathological LN response may be a reliable prognostic prediction tool in patients with LAGC who received NAC.
Language	English
Publishing date	2024-04-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1115435-4
ISSN	1436-2813 ; 0941-1291
ISSN (online)	1436-2813
ISSN	0941-1291
DOI	10.1007/s00595-024-02829-7
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Article ; Online: The biomechanical proteins different between low myopic corneas and moderate to high myopic corneas in human.

Wu, Wenjing / Wang, Yan / Chen, Jingyi / Zhang, Fengju

Contact lens & anterior eye : the journal of the British Contact Lens Association

2024 , Page(s) 102134

Abstract: Purpose: To explore the biomechanical proteins different between low myopic corneas and moderate to high myopic corneas.: Methods: A total of 27 myopic corneas were used for the Tandem Mass Tag (TMT) proteomics analysis. Differentially expressed ... ...

Abstract	Purpose: To explore the biomechanical proteins different between low myopic corneas and moderate to high myopic corneas. Methods: A total of 27 myopic corneas were used for the Tandem Mass Tag (TMT) proteomics analysis. Differentially expressed proteins (DEPs) were clustered with fold changes > 1.20 or < 0.83 and p < 0.05. Proteins and Proteins Interactions (PPIs) were conducted to find hub proteins; Uniprot database was to screen proteins with biomechanical functions, and Parallel Reaction Monitoring (PRM) was performed to verify the TMT results. Pearson analysis was used to reveal the correlations between myopic degrees and biomechanical proteins. The Immunofluorescence (IF) staining was used to observe the protein distributions. Results: In total, 34 DEPs were observed between moderate myopic corneas and low myopic corneas; 103 DEPs were observed between high myopic corneas and low myopic corneas, 20 proteins overlapped. The PPIs analysis showed keratin 2, keratins 10 and PRSS1 were hub proteins. The Uniprot function analysis suggested keratin 2 and keratin 10 exhibited biomechanical functions. The PRM demonstrated keratin 2 and keratin 10 levels were significantly lower in moderate and high myopic corneas, which was consistent with the TMT proteomics results. IF staining also demonstrated keratin 2 and keratin 10 were less distributed in moderate and high myopic corneas than in low myopic corneas. Conclusions: The levels of biomechanical proteins keratin 2 and keratin 10 are significantly lower in moderate and high myopic corneas than in low myopic corneas.
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2004847-6
ISSN	1476-5411 ; 1367-0484
ISSN (online)	1476-5411
ISSN	1367-0484
DOI	10.1016/j.clae.2024.102134
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Article ; Online: Association between lipoprotein(a) and peripheral arterial disease in coronary artery bypass grafting patients.

Yi, Cheng / Junyi, Gao / Fengju, Liu / Qing, Zhao / Jie, Chen

Clinical cardiology

2023 Volume 46, Issue 5, Page(s) 512–520

Abstract: Objective: Peripheral arterial disease (PAD) affects a large population and is associated with various adverse clinical outcomes. Lipoprotein(a) has proatherogenic properties and is associated with PAD incidence and severity. The aim of this study is to ...

Abstract	Objective: Peripheral arterial disease (PAD) affects a large population and is associated with various adverse clinical outcomes. Lipoprotein(a) has proatherogenic properties and is associated with PAD incidence and severity. The aim of this study is to explore the association between LP(a) and PAD in coronary artery bypass grafting (CABG) patients. Methods: A total of 1001 patients were included and divided into two groups: low Lp(a) group [LP(a) < 30 mg/dL] and high Lp(a) group [LP(a) ≥ 30 mg/dL]. A comparison of PAD incidence diagnosed by ultrasound was made between the groups. Multivariate logistic regression was conducted to explore the risk factors for PAD. During the analysis, the influence of diabetes mellitus (DM) and gender on LP(a) serum level was taken into consideration. Results: DM history (odds ratio [OR], 2.330, p = .000 for males; OR, 2.499, p = .002 for females) and age (OR, 1.101, p = .000 for males; OR, 1.071, p = .001 for females) were risk factors for PAD. LP(a) ≥ 30 mg/dL was a risk factor for PAD only in female patients (OR, 2.589, p = .003), while smoking history was a risk factor only in male patients (OR, 1.928, p = .000). LP(a) level was not associated with PAD severity in DM patients of both gender. As for female patients without DM, PAD was more severe in the high LP(a) group. Conclusions: In CABG patients, DM history and age were risk factors for PAD. But a high level of LP(a) was a significant risk factor only in female patients. In addition, we are the first to propose a gender deviation in the correlation between LP(a) serum level and severity of PAD diagnosed by ultrasound.
MeSH term(s)	Humans ; Male ; Female ; Lipoprotein(a) ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/epidemiology ; Coronary Artery Bypass/adverse effects ; Risk Factors ; Logistic Models ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/surgery
Chemical Substances	Lipoprotein(a)
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	391935-3
ISSN	1932-8737 ; 0160-9289
ISSN (online)	1932-8737
ISSN	0160-9289
DOI	10.1002/clc.24003
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Article ; Online: Determination of Acetylcholinesterase Activity Based on Ratiometric Fluorescence Signal Sensing.

Zhao, Fengju / Guo, Hui / Yang, Wei / Guo, Lili / Li, Jiaxin / Chen, Hanqi

Journal of fluorescence

2024

Abstract: Acetylcholinesterase (AChE) plays an important role in the treatment of human diseases, environmental security and global food supply. In this study, the simple fluorescent indicators and ... ...

Abstract	Acetylcholinesterase (AChE) plays an important role in the treatment of human diseases, environmental security and global food supply. In this study, the simple fluorescent indicators and MnO
Language	English
Publishing date	2024-04-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2016892-5
ISSN	1573-4994 ; 1053-0509
ISSN (online)	1573-4994
ISSN	1053-0509
DOI	10.1007/s10895-024-03703-y
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Article ; Online: Germline structural variation globally impacts the cancer transcriptome including disease-relevant genes.

Chen, Fengju / Zhang, Yiqun / Sedlazeck, Fritz J / Creighton, Chad J

Cell reports. Medicine

2024 Volume 5, Issue 3, Page(s) 101446

Abstract: Germline variation and somatic alterations contribute to the molecular profile of cancers. We combine RNA with whole genome sequencing across 1,218 cancer patients to determine the extent germline structural variants (SVs) impact expression of nearby ... ...

Abstract	Germline variation and somatic alterations contribute to the molecular profile of cancers. We combine RNA with whole genome sequencing across 1,218 cancer patients to determine the extent germline structural variants (SVs) impact expression of nearby genes. For hundreds of genes, recurrent and common germline SV breakpoints within 100 kb associate with increased or decreased expression in tumors spanning various tissues of origin. A significant fraction of germline SV expression associations involves duplication of intergenic enhancers or 3' UTR disruption. Genes altered by both somatic and germline SVs include ATRX and CEBPA. Genes essential in cancer cell lines include BARD1 and IRS2. Genes with both expression and germline SV breakpoint patterns associated with patient survival include GCLM. Our results capture a class of phenotypic variation at work in the disease setting, including genes with cancer roles. Specific germline SVs represent potential cancer risk variants for genetic testing, including those involving genes with targeting implications.
MeSH term(s)	Humans ; Transcriptome/genetics ; Neoplasms/genetics ; RNA ; Germ Cells
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2024.101446
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Article ; Online: Pan-cancer molecular subtypes of metastasis reveal distinct and evolving transcriptional programs.

Zhang, Yiqun / Chen, Fengju / Creighton, Chad J

Cell reports. Medicine

2023 Volume 4, Issue 2, Page(s) 100932

Abstract: Molecular mechanisms underlying cancer metastasis span diverse tissues of origin. Here, we synthesize and collate the transcriptomes of patient-derived xenografts and patient tumor metastases, and these data collectively represent 38 studies and over 3, ... ...

Abstract	Molecular mechanisms underlying cancer metastasis span diverse tissues of origin. Here, we synthesize and collate the transcriptomes of patient-derived xenografts and patient tumor metastases, and these data collectively represent 38 studies and over 3,000 patients and 4,000 tumors. We identify four expression-based subtypes of metastasis transcending tumor lineage. The first subtype has extensive copy alterations, higher expression of MYC transcriptional targets and DNA repair genes, and bromodomain inhibitor response association. The second subtype has higher expression of genes involving metabolism and prostaglandin synthesis and regulation. The third subtype has evidence of neuronal differentiation, higher expression of DNA and histone methylation genes and EZH2 transcriptional targets, and BCL2 inhibitor response association. The fourth subtype has higher expression of immune checkpoint and Notch pathway genes. The metastasis subtypes reflect expression differences from paired primaries, with subtype switching being common. These subtypes facilitate understanding of the molecular underpinnings of metastases beyond tissue-oriented domains, with therapeutic implications.
MeSH term(s)	Humans ; Neoplasms/drug therapy ; Antineoplastic Agents/therapeutic use ; Transcriptome
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2023.100932
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Article ; Online: The Regulation and Double-Edged Roles of the Deubiquitinase OTUD5.

Fu, Lin / Lu, Kun / Jiao, Qian / Chen, Xi / Jia, Fengju

Cells

2023 Volume 12, Issue 8

Abstract: OTUD5 (OTU Deubiquitinase 5) is a functional cysteine protease with deubiquitinase activity and is a member of the ovarian tumor protease (OTU) family. OTUD5 is involved in the deubiquitination of many key proteins in various cellular signaling pathways ... ...

Abstract	OTUD5 (OTU Deubiquitinase 5) is a functional cysteine protease with deubiquitinase activity and is a member of the ovarian tumor protease (OTU) family. OTUD5 is involved in the deubiquitination of many key proteins in various cellular signaling pathways and plays an important role in maintaining normal human development and physiological functions. Its dysfunction can affect physiological processes, such as immunity and DNA damage repair, and it can even lead to tumors, inflammatory diseases and genetic disorders. Therefore, the regulation of OTUD5 activity and expression has become a hot topic of research. A comprehensive understanding of the regulatory mechanisms of OTUD5 and its use as a therapeutic target for diseases is of great value. Herein, we review the physiological processes and molecular mechanisms of OTUD5 regulation, outline the specific regulatory processes of OTUD5 activity and expression, and link OTUD5 to diseases from the perspective of studies on signaling pathways, molecular interactions, DNA damage repair and immune regulation, thus providing a theoretical basis for future studies.
MeSH term(s)	Female ; Humans ; Ubiquitination ; DNA Repair ; Signal Transduction ; Ovarian Neoplasms/genetics ; Deubiquitinating Enzymes/metabolism
Chemical Substances	Deubiquitinating Enzymes (EC 3.4.19.12)
Language	English
Publishing date	2023-04-14
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12081161
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Article ; Online: Effects of riboflavin/ultraviolet-A(UVA) scleral crosslinking on the mechanical behavior of the scleral fibroblasts of lens-induced myopia Guinea pigs.

Chen, Zhe / Lv, Xiaotong / Lai, Lingbo / Xu, Yushan / Zhang, Fengju

Experimental eye research

2023 Volume 235, Page(s) 109618

Abstract: Myopia is becoming increasingly severe, and studies have shown that the cellular mechanics of scleral fibroblasts are altered following myopia. Scleral UVA-Riboflavin Collagen Crosslinking（sCXL） is a promising treatment for myopia prevention and control ... ...

Abstract	Myopia is becoming increasingly severe, and studies have shown that the cellular mechanics of scleral fibroblasts are altered following myopia. Scleral UVA-Riboflavin Collagen Crosslinking（sCXL） is a promising treatment for myopia prevention and control of axial growth. Understanding the mechanical properties of scleral fibroblasts is crucial, as it influences the cellular response and limits the extent of molecular deformation triggered. Thus, our study aimed to investigate the effect of mechanical properties of scleral fibroblasts in a lens-induced myopic guinea pig model following sCXL. For this purpose, we performed the 0.1% riboflavin/UVA scleral crosslinking (365 nm,3 mW/cm
MeSH term(s)	Guinea Pigs ; Animals ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Ultraviolet Rays ; Disease Models, Animal ; Cross-Linking Reagents/pharmacology ; Riboflavin/pharmacology ; Myopia/prevention & control ; Sclera ; Fibroblasts ; Collagen/pharmacology
Chemical Substances	Photosensitizing Agents ; Cross-Linking Reagents ; Riboflavin (TLM2976OFR) ; Collagen (9007-34-5)
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2023.109618
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Article ; Online: Author Correction: Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways.

Zhang, Yiqun / Chen, Fengju / Chandrashekar, Darshan S / Varambally, Sooryanarayana / Creighton, Chad J

Nature communications

2022 Volume 13, Issue 1, Page(s) 4688

Language	English
Publishing date	2022-08-10
Publishing country	England
Document type	Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-32539-y
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Article ; Online: Design and preparation of fluorescent covalent organic frameworks for biological sensing.

Yang, Yajie / Zhang, Cheng / Cao, Doudou / Song, Yingbo / Chen, Shusen / Song, Yan / Wang, Fengju / Wang, Guangtong / Yuan, Ye

Chemical communications (Cambridge, England)

2024 Volume 60, Issue 19, Page(s) 2605–2612

Abstract: Covalent organic frameworks (COFs) are a new class of functional solids featuring several fantastic structural characteristics, including a great diversity of building units and cross-linking patterns, precise integration of building blocks, and ... ...

Abstract	Covalent organic frameworks (COFs) are a new class of functional solids featuring several fantastic structural characteristics, including a great diversity of building units and cross-linking patterns, precise integration of building blocks, and adjustable topology of porous architecture. In addition to the above features, some COF samples are constructed with high-density conjugated fragments, which have unique potential advantages in fluorescence imaging, and thus may have great potential applications in bioimaging. Herein, this article summarizes the recent progress in the design and preparation of fluorescent covalent organic frameworks. We investigate the systemic correlation between the structural qualities of COF networks and biological sensors. Finally, the significant advantages, major challenges, and future opportunities of fluorescent covalent organic frameworks are discussed for the development of next-generation porous materials for sensing applications.
MeSH term(s)	Metal-Organic Frameworks ; Coloring Agents ; Data Accuracy ; Optical Imaging ; Porosity
Chemical Substances	Metal-Organic Frameworks ; Coloring Agents
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d4cc00167b
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