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  1. Article ; Online: Is it necrotising enterocolitis? Is it focal intestinal perforation? Or is it something else? And does it matter?

    Hall, Nigel J

    Archives of disease in childhood. Fetal and neonatal edition

    2022  Volume 107, Issue 3, Page(s) 234–235

    MeSH term(s) Enterocolitis, Necrotizing/diagnosis ; Female ; Fetal Diseases ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases ; Infant, Premature ; Intestinal Perforation/diagnosis ; Intestinal Perforation/etiology ; Intestinal Perforation/surgery
    Language English
    Publishing date 2022-02-21
    Publishing country England
    Document type Editorial
    ZDB-ID 2007331-8
    ISSN 1468-2052 ; 1359-2998
    ISSN (online) 1468-2052
    ISSN 1359-2998
    DOI 10.1136/archdischild-2021-323220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Letter to the Editor in Response to: Early Laparoscopic-Assisted Surgery is Associated with Decreased Post-Operative Inflammation and Intestinal Strictures in Infants with Necrotizing Enterocolitis.

    Bethell, George S / Hall, Nigel J

    Journal of pediatric surgery

    2023  Volume 58, Issue 7, Page(s) 1403

    MeSH term(s) Infant, Newborn ; Infant ; Humans ; Enterocolitis, Necrotizing/complications ; Enterocolitis, Necrotizing/surgery ; Constriction, Pathologic/surgery ; Intestinal Obstruction/surgery ; Intestinal Obstruction/complications ; Infant, Newborn, Diseases/surgery ; Inflammation ; Laparoscopy
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2023.02.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 607: Show issues Location:
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  3. Article: Recent advances in our understanding of NEC diagnosis, prognosis and surgical approach.

    Bethell, George S / Hall, Nigel J

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1229850

    Abstract: Necrotising enterocolitis (NEC) remains a devasting condition that has seen limited improvement in outcomes in recent years. The incidence of the disease is increasing as more extremely premature infants survive. NEC is responsible for 1 in 10 neonatal ... ...

    Abstract Necrotising enterocolitis (NEC) remains a devasting condition that has seen limited improvement in outcomes in recent years. The incidence of the disease is increasing as more extremely premature infants survive. NEC is responsible for 1 in 10 neonatal deaths and up to 61% of survivors have significant neurodevelopmental delay. The aim of this review is to highlight recent advances in diagnosis, prognosis and surgical approach in this condition. Many recent studies have reported novel methods of diagnosis of NEC with the aim of earlier and more accurate identification. These include imaging and machine learning techniques. Prognostication of NEC is particularly important to allow earlier escalation of therapy. Around 25% of infants with NEC will require surgery and recent data has shown that time from disease onset to surgery is greater in infants whose indication for surgery is failed medical management, rather than pneumoperitoneum. This indication was also associated with worse outcomes compared to pneumoperitoneum. Ongoing research has highlighted several new methods of disease prognostication which includes differentiating surgical from medical NEC. Finally, recent randomised controlled trials in surgical technique are discussed along with the implications of these for practice. Further, high quality research utilising multi-centre collaborations and high fidelity data from electronic patient records is needed to address the issues discussed and ultimately improve outcomes in NEC.
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1229850
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  4. Article ; Online: Nonoperative Management of Appendicitis in Children: An Update.

    Jobson, Matthew / Hall, Nigel J / Stanton, Michael

    The Pediatric infectious disease journal

    2023  Volume 43, Issue 1, Page(s) e11–e13

    MeSH term(s) Child ; Humans ; Appendicitis/diagnosis ; Appendicitis/surgery ; Anti-Bacterial Agents/therapeutic use ; Treatment Outcome ; Appendectomy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000004141
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1852: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Factors associated with outcomes in congenital duodenal obstruction: population-based study.

    Bethell, George S / Long, Anna-May / Knight, Marian / Hall, Nigel J

    The British journal of surgery

    2023  Volume 110, Issue 9, Page(s) 1053–1056

    MeSH term(s) Humans ; Duodenal Obstruction/surgery ; Duodenal Obstruction/congenital ; Intestines ; Retrospective Studies ; Research
    Language English
    Publishing date 2023-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znad040
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  6. Article ; Online: Clinical law: what do paediatricians want to know?

    Wheeler, Robert / Stedman, Francesca / Hall, Nigel J

    Archives of disease in childhood

    2022  Volume 108, Issue 6, Page(s) 423–426

    MeSH term(s) Humans ; Pediatricians ; Attitude of Health Personnel
    Language English
    Publishing date 2022-12-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2022-325081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Um IV Zs.106: Show issues Location:
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  7. Article: Parental Knowledge of Appendicitis and Preference for Operative or Non-Operative Treatment at a United Kingdom Children's Hospital.

    Monks, Kitty / Hall, Nigel J

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 8

    Abstract: Appendicitis is a common cause of abdominal pain in children, and is the most common reason for children to undergo emergency abdominal surgery. To guide our research program in this field, we aimed to determine parental understanding with regard to ... ...

    Abstract Appendicitis is a common cause of abdominal pain in children, and is the most common reason for children to undergo emergency abdominal surgery. To guide our research program in this field, we aimed to determine parental understanding with regard to appendicitis and its treatment. We also wished to assess parental preference for non-operative or surgical treatment of children with uncomplicated appendicitis. We asked parents attending a children's outpatient clinic to complete a brief questionnaire that was interspersed with educational content to rectify any knowledge gaps. A total of 396 parents (of 414 approached) agreed to participate. There were gaps in parental knowledge, including not knowing where the appendix is located (one-third of respondents), not knowing what appendicitis is (40% of respondents), and underestimating the incidence of appendicitis. Parents typically overestimated the risks of complications and dying from both uncomplicated and complicated appendicitis. There was no influence of gender, age, or previous experience of appendicitis on these findings. When presented with the scenario of equal effectiveness of non-operative treatment and surgery for uncomplicated appendicitis, 59% of respondents expressed a preference for non-operative treatment over surgery, while 21% expressed a preference for surgery (20% expressed no preference). These findings are important for clinicians and researchers when discussing appendicitis and treatment options with families, and justify ongoing research into the comparative effectiveness of non-operative treatment and surgery.
    Language English
    Publishing date 2022-08-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9081191
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  8. Article ; Online: Tunnelled external versus implanted port central venous catheters in paediatric oncology: a systematic review and meta-analysis.

    Neville, Jonathan J / Aye, Hinn Moe / Hall, Nigel J

    Archives of disease in childhood

    2023  Volume 108, Issue 12, Page(s) 975–981

    Abstract: Objective: To evaluate and compare the complications associated with tunnelled external and implanted port (PORT) central venous catheters (CVCs) in children with cancer.: Design: A systematic review in accordance with PRISMA (Preferred Reporting ... ...

    Abstract Objective: To evaluate and compare the complications associated with tunnelled external and implanted port (PORT) central venous catheters (CVCs) in children with cancer.
    Design: A systematic review in accordance with PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) guidelines was performed (pre-registered on PROSPERO: CRD42022300869). MEDLINE, Web of Science and the Cochrane Library databases were searched.
    Patients: Patients ≤18 years of age with haematological or solid malignancies.
    Interventions: Studies comparing tunnelled external and PORT CVCs.
    Main outcomes measures: Infection, mechanical failure, thrombosis, bleeding, acceptability, quality of life (QoL), cost, premature removal, and days from insertion to removal for any reason.
    Results: Twenty-three observational studies met the inclusion criteria, representing 6644 devices and 6032 patients. Tunnelled external CVCs were associated with an increased risk for systemic infection (OR 2.10, 95% CI 1.59 to 2.77, p<0.001, 16 studies, 3425 devices). There was no significant difference in the risk of localised infection (OR 1.15, 95% CI 0.66 to 2.01, p=0.62, 5 studies, 979 devices). Tunnelled external CVCs were also associated with a significantly increased risk of mechanical complications (OR 2.47, 95% CI 1.21 to 5.05, p=0.01, 11 studies, 2187 devices) and premature device removal (OR 3.24, 95% CI 1.28 to 8.22, p=0.01, 6 studies, 1514 devices).
    Conclusion: This study shows that PORTs associate with a reduced risk of infectious and mechanical complications, and a lower overall risk of removal, compared with tunnelled external CVCs in children with cancer. Further work is required to confirm these findings in a prospective randomised trial and to compare cost implications and acceptability to patients and caregivers.
    MeSH term(s) Child ; Humans ; Catheterization, Central Venous/adverse effects ; Central Venous Catheters/adverse effects ; Neoplasms/etiology ; Prospective Studies ; Quality of Life
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2023-325789
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  9. Article ; Online: Necrotising enterocolitis: better data, still many questions.

    Hall, Nigel J

    The lancet. Gastroenterology & hepatology

    2017  Volume 2, Issue 1, Page(s) 6–7

    Language English
    Publishing date 2017-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(16)30158-3
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  10. Article ; Online: Development Methodology, Availability, and Implementation of Core Outcome Sets in Pediatric Surgery.

    Allin, Benjamin S R / Bethell, George S / Hall, Nigel J

    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie

    2023  Volume 34, Issue 2, Page(s) 128–136

    Abstract: Core outcome sets (COSs) provide a mechanism to guide researchers and clinicians when deciding which outcomes to report in research related to a specific clinical condition or intervention. The intention behind creating a COS for a specific condition is ... ...

    Abstract Core outcome sets (COSs) provide a mechanism to guide researchers and clinicians when deciding which outcomes to report in research related to a specific clinical condition or intervention. The intention behind creating a COS for a specific condition is to improve the reporting of important and meaningful outcomes, thus enhancing the relevance of research. Additionally, a COS helps facilitate comparison of outcomes between different clinical studies and reduces research waste. In this paper, we discuss the availability of COSs in the field of pediatric general surgery. We provide an overview of the methodologies used to develop a COS, including common pitfalls, and finally, we discuss COS uptake and implementation. An understanding of all these aspects is important for researchers considering developing a new COS and for those reading research where a COS has been developed or used within a study. Failure to adequately appreciate the nuances of COS development, in particular, risks fundamental flaws that may jeopardize COS validity and subsequently hinder COS uptake and implementation.
    MeSH term(s) Child ; Humans ; Research Design ; Delphi Technique ; Consensus ; Specialties, Surgical ; Outcome Assessment, Health Care ; Treatment Outcome
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1065043-x
    ISSN 1439-359X ; 0939-7248 ; 0939-6764 ; 0930-7249
    ISSN (online) 1439-359X
    ISSN 0939-7248 ; 0939-6764 ; 0930-7249
    DOI 10.1055/a-2196-1887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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