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  1. Article ; Online: Meta-analysis of multi-arm trials using empirical logistic transform.

    Chootrakool, Hathaikan / Qing Shi, Jian

    The open medical informatics journal

    2008  Volume 2, Page(s) 112–116

    Abstract: Meta-analysis of multi-arm trials has been used increasingly in recent years. The aim of meta-analysis for multi-arm trials is to combine evidence from all possible similar studies. In this paper we propose normal approximation models by using empirical ... ...

    Abstract Meta-analysis of multi-arm trials has been used increasingly in recent years. The aim of meta-analysis for multi-arm trials is to combine evidence from all possible similar studies. In this paper we propose normal approximation models by using empirical logistic transform to compare different treatments in multi-arm trials, allowing studies of both direct and indirect comparisons. Additionally, a hierarchical structure is introduced in the models to address the problem of heterogeneity among different studies. The proposed models are performed using the data from 31 randomized clinical trials (RCTs) which determine the efficacy of antiplatelet therapy in maintaining vascular patency.
    Language English
    Publishing date 2008-06-06
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2395967-8
    ISSN 1874-4311 ; 1874-4311
    ISSN (online) 1874-4311
    ISSN 1874-4311
    DOI 10.2174/1874431100802010112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Meta-analysis and sensitivity analysis for multi-arm trials with selection bias.

    Chootrakool, Hathaikan / Shi, Jian Qing / Yue, Rongxian

    Statistics in medicine

    2011  Volume 30, Issue 11, Page(s) 1183–1198

    Abstract: Multi-arm trials meta-analysis is a methodology used in combining evidence based on a synthesis of different types of comparisons from all possible similar studies and to draw inferences about the effectiveness of multiple compared-treatments. Studies ... ...

    Abstract Multi-arm trials meta-analysis is a methodology used in combining evidence based on a synthesis of different types of comparisons from all possible similar studies and to draw inferences about the effectiveness of multiple compared-treatments. Studies with statistically significant results are potentially more likely to be submitted and selected than studies with non-significant results; this leads to false-positive results. In meta-analysis, combining only the identified selected studies uncritically may lead to an incorrect, usually over-optimistic conclusion. This problem is known asbiselection bias. In this paper, we first define a random-effect meta-analysis model for multi-arm trials by allowing for heterogeneity among studies. This general model is based on a normal approximation for empirical log-odds ratio. We then address the problem of publication bias by using a sensitivity analysis and by defining a selection model to the available data of a meta-analysis. This method allows for different amounts of selection bias and helps to investigate how sensitive the main interest parameter is when compared with the estimates of the standard model. Throughout the paper, we use binary data from Antiplatelet therapy in maintaining vascular patency of patients to illustrate the methods.
    MeSH term(s) Aspirin/therapeutic use ; Blood Platelet Disorders/drug therapy ; Clinical Trials as Topic/methods ; Dipyridamole/therapeutic use ; Drug Therapy, Combination ; Humans ; Meta-Analysis as Topic ; Models, Statistical ; Selection Bias
    Chemical Substances Dipyridamole (64ALC7F90C) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2011-05-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.4143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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