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Book: Hepatitis C and B

Poynard, Thierry

management and treatment

2004

Author's details	Thierry Poynard
Keywords	Hepatitis B, Chronic / drug therapy ; Hepatitis C, Chronic / drug therapy ; Hepatitis B, Chronic / complications ; Hepatitis C, Chronic / complications
Language	English
Size	V, 168 S. : Ill., graph. Darst., Kt.
Edition	2. ed.
Publisher	Taylor & Francis
Publishing place	London u.a.
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT013771088
ISBN	1-84184-369-5 ; 978-1-84184-369-8
Database	Catalogue ZB MED Medicine, Health

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Article: Existe-t-il des complications digestives de la corticothérapie?

Poynard, T

Presse medicale (Paris, France : 1983)

1988 Volume 17, Issue 25, Page(s) 1291–1292

Title translation	Do digestive complications of corticotherapy exist?.
MeSH term(s)	Adrenal Cortex Hormones/adverse effects ; Adrenal Cortex Hormones/therapeutic use ; Clinical Trials as Topic ; Diabetes Mellitus/chemically induced ; Double-Blind Method ; Humans ; Hypertension/chemically induced ; Peptic Ulcer/chemically induced ; Skin Diseases/chemically induced
Chemical Substances	Adrenal Cortex Hormones
Language	French
Publishing date	1988-06-25
Publishing country	France
Document type	Clinical Trial ; Journal Article
ZDB-ID	120943-7
ISSN	2213-0276 ; 0755-4982 ; 0032-7867 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0755-4982 ; 0032-7867 ; 0301-1518
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Zs.A 794: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection.

Abel, Michal / Sène, Damien / Pol, Stanislas / Bourlière, Marc / Poynard, Thierry / Charlotte, Frédéric / Cacoub, Patrice / Caillat-Zucman, Sophie

Hepatology (Baltimore, Md.)

2006 Volume 44, Issue 6, Page(s) 1607–1616

Abstract: CD8 T cell killing of hepatitis C virus (HCV)-infected hepatocytes is thought to contribute ... unclear. To visualize the spatial relationship of HCV-specific CD8 T cells with parenchymal target cells ... HCV infection. Intrahepatic tetramer+ (HCV-specific) CD8 T cells protected from hepatic ...

Abstract	CD8 T cell killing of hepatitis C virus (HCV)-infected hepatocytes is thought to contribute to liver damage during chronic HCV infection, whereas the participation of HCV-nonspecific immune cells is unclear. To visualize the spatial relationship of HCV-specific CD8 T cells with parenchymal target cells, and to examine their local functional activity in relation to hepatocellular necrosis and fibrosis, we used HLA tetramers and confocal microscopy in biopsies from 23 HLA-A2 or HLA-B7 patients with chronic HCV infection. Intrahepatic tetramer+ (HCV-specific) CD8 T cells protected from hepatic necroinflammatory disease activity, independently of age, gender, viral load, and viral genotype. Indeed, tetramer+ cells were scattered in the liver within regions of weak fibrosis (low laminin expression) and low hepatocellular apoptosis (TUNEL method), and expressed IL-10 but not IFNgamma. By contrast, tetramer-negative CD8 T cells were associated with active necroinflammatory liver disease, colocalized with strong laminin expression and hepatocellular apoptosis, and expressed more frequently IFNgamma than IL-10. Overall, liver regions harboring HCV-specific CD8 T cells tended to be healthier than areas containing only inflammatory cells of undefined specificity. In conclusion, HCV-specific IL-10-producing CD8 T cells, although not cytotoxic and unable to control viral replication, can attenuate hepatocellular necrosis, liver fibrosis, and inflammation mediated by bystander T cells, and may thus represent antigen-induced regulatory CD8 T cells. Therapeutic modulation of the intrahepatic balance between specific and bystander CD8 T cells might be beneficial in patients with chronic hepatitis C.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; CD8-Positive T-Lymphocytes/immunology ; Female ; HLA-A2 Antigen/immunology ; HLA-B7 Antigen/immunology ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/immunology ; Hepatitis C, Chronic/virology ; Humans ; Interleukin-10/biosynthesis ; Liver/cytology ; Liver/virology ; Liver Cirrhosis/etiology ; Male ; Middle Aged
Chemical Substances	HLA-A2 Antigen ; HLA-B7 Antigen ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2006-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.21438
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Article ; Online: Response to: Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications, by Jerome Boursier et al.

Poynard, Thierry / Deckmyn, Olivier / Valla, Dominique

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2022 Volume 21, Issue 2, Page(s) 559–560

MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/complications ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/pathology ; Liver/pathology ; Biomarkers ; Biopsy ; Non-alcoholic Fatty Liver Disease/pathology
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-04-08
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2022.03.040
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Book: Acute treatment of duodenal ulcer

Poynard, Thierry

analysis of 293 randomized clinical trials

1989

Author's details	ed. T. Poynard
Keywords	Duodenal Ulcer
Size	149 S. : graph. Darst.
Publisher	Libbey
Publishing place	Montrouge u.a.
Publishing country	France
Document type	Book
HBZ-ID	HT003565449
ISBN	0-86196-211-7 ; 978-0-86196-211-2
Database	Catalogue ZB MED Medicine, Health

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1990 A 4741	order for loan	Magazin

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Article: Decreased frequencies of virus-specific T helper type 1 cells during interferon alpha plus ribavirin treatment in HIV-hepatitis C virus co-infection.

Alatrakchi, Nadia / Di Martino, Vincent / Thibault, Vincent / Benhamou, Yves / Katlama, Christine / Poynard, Thierry / Autran, Brigitte

AIDS (London, England)

2004 Volume 18, Issue 1, Page(s) 121–123

Abstract: ... defined effects on immune responses. Frequencies of T helper (Th) type 1 cells specific for HCV ...

Abstract	Anti-hepatitis C virus (HCV) treatment combining IFN-alpha and ribavirin (IFN+R) has still poorly defined effects on immune responses. Frequencies of T helper (Th) type 1 cells specific for HCV, cytomegalovirus (CMV) and HIV were measured in chronically HCV-infected patients with or without HIV co-infection during IFN+R treatment. Although scarce, peripheral blood HCV-specific Th1 cells did not change significantly, while frequencies of HIV and CMV-specific Th1 cells decreased in co-infected patients independently of CD4 cell count changes. This suggests that IFN+R therapy might compromise virus-specific immune defenses in immunosuppressed patients.
MeSH term(s)	Antiviral Agents/therapeutic use ; CD4 Lymphocyte Count ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/immunology ; Enzyme-Linked Immunosorbent Assay/methods ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/immunology ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/immunology ; Humans ; Immunity, Cellular/immunology ; Interferon-alpha/therapeutic use ; Lymphocyte Activation/immunology ; Ribavirin/therapeutic use ; Th1 Cells/immunology
Chemical Substances	Antiviral Agents ; Interferon-alpha ; Ribavirin (49717AWG6K)
Language	English
Publishing date	2004-01-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/00002030-200401020-00015
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Zs.A 2228: Show issues

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Article ; Online: Liver Assessment in Patients with Ataxia-Telangiectasia: Transient Elastography Detects Early Stages of Steatosis and Fibrosis.

Donath, H / Wölke, S / Knop, V / Heß, U / Duecker, R P / Trischler, J / Poynard, T / Schubert, R / Zielen, S

Canadian journal of gastroenterology & hepatology

2023 Volume 2023, Page(s) 2877350

Abstract: Background: Ataxia-telangiectasia (A-T) is a rare autosomal-recessive multisystem disorder ... biomarkers for liver disease.: Methods: Thirty-one A-T patients aged 2 to 25 years were examined ... A-T patients. TE is an objective measure to detect early stages of steatosis and fibrosis. SteatoTest ...

Abstract	Background: Ataxia-telangiectasia (A-T) is a rare autosomal-recessive multisystem disorder characterized by pronounced cerebellar ataxia, telangiectasia, cancer predisposition, and altered body composition. Liver diseases with steatosis, fibrosis, and hepatocellular carcinoma are frequent findings in older patients but sensitive noninvasive diagnostic tools are lacking. Objectives: To determine the sensitivity of transient elastography (TE) as a screening tool for early hepatic tissue changes and serum biomarkers for liver disease. Methods: Thirty-one A-T patients aged 2 to 25 years were examined prospectively from 2016-2018 by TE. In addition, we evaluated the diagnostic performance of liver biomarkers for steatosis and necroinflammatory activity (SteatoTest and ActiTest, Biopredictive, Paris) compared to TE. For calculation and comparison, patients were divided into two groups (<12, >12 years of age). Results: TE revealed steatosis in 2/21 (10%) younger patients compared to 9/10 (90%) older patients. Fibrosis was present in 3/10 (30%) older patients as assessed by TE. We found a significant correlation of steatosis with SteatoTest, alpha-fetoprotein (AFP), HbA1c, and triglycerides. Liver stiffness correlated significantly with SteatoTest, ActiTest, HbA1c, and triglycerides. Conclusion: Liver disease is a common finding in older A-T patients. TE is an objective measure to detect early stages of steatosis and fibrosis. SteatoTest and ActiTest are a good diagnostic assessment for steatosis and necroinflammatory activity in patients with A-T and confirmed the TE results.
MeSH term(s)	Child ; Humans ; Ataxia Telangiectasia/complications ; Ataxia Telangiectasia/diagnostic imaging ; Ataxia Telangiectasia/pathology ; Biomarkers ; Biopsy ; Elasticity Imaging Techniques/methods ; Fatty Liver/diagnosis ; Fibrosis ; Glycated Hemoglobin ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/etiology ; Liver Neoplasms/pathology ; Non-alcoholic Fatty Liver Disease/pathology ; Triglycerides
Chemical Substances	Biomarkers ; Glycated Hemoglobin ; Triglycerides
Language	English
Publishing date	2023-03-11
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2762182-0
ISSN	2291-2797 ; 1916-7237 ; 0835-7900
ISSN (online)	2291-2797 ; 1916-7237
ISSN	0835-7900
DOI	10.1155/2023/2877350
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Article: No evidence for abnormal immune activation in peripheral blood T cells in patients with hepatitis C virus (HCV) infection with or without cryoglobulinaemia. Multivirc Group.

Cacoub, P / Musset, L / Hausfater, P / Ghillani, P / Fabiani, F L / Charlotte, F / Angevin, E / Opolon, P / Poynard, T / Piette, J C / Autran, B

Clinical and experimental immunology

1998 Volume 113, Issue 1, Page(s) 48–54

Abstract: The aim of this study was to investigate the peripheral blood lymphocyte (PBL) phenotypes and T ... of B cells (CD19+), natural killer (NK) cells (CD16+CD56+), T cells (CD3+), CD4+ T cell subsets (memory ... CD4+CD45RO+; naive CD4+CD45RO-; Th0/Th2CD4+CD7-; activated CD4+CD25+), and CD8+ T cell subsets ...

Abstract	The aim of this study was to investigate the peripheral blood lymphocyte (PBL) phenotypes and T cell repertoire in patients with HCV infection, with or without mixed cryoglobulinaemia (MC). The patients were: Group 1, 23 patients with HCV infection and MC; Group 2, 14 patients with HCV infection but without MC; Group 3, 10 patients with symptomatic essential MC. Twenty healthy blood donors were used as controls. Blood lymphocyte counts were determined, and flow cytometry was used to measure proportions of B cells (CD19+), natural killer (NK) cells (CD16+CD56+), T cells (CD3+), CD4+ T cell subsets (memory CD4+CD45RO+; naive CD4+CD45RO-; Th0/Th2CD4+CD7-; activated CD4+CD25+), and CD8+ T cell subsets (immunoregulatory CD8+CD57+; cytotoxic CD8+S6F1+, activated CD8+CD25+). Bias in the usage of T cell receptor (TCR) Vbeta chains was studied in a subgroup of 10 representative patients of Group 1 using a polymerase chain reaction (PCR) analysis of the Vbeta segments with a series of 20 oligonucleotides specific for the Vbeta families. The three groups were comparable for blood lymphocyte counts, and we observed no abnormal repartition of the following PBL subsets: T cells (CD3+), CD4+ and CD8+ subpopulations, B cells (CD19+), and the NK cells (CD16+56+). In none of the groups could we observe lymphocyte ex vivo activation as assessed by the normal expression of the activation cell markers: CD25 on CD4+ or CD8+ T cells, or CD5 on B cells. The repartition of naive and memory (CD45RO-/RO+) CD4+ T cells was normal and we did not observe any amplification of the CD4+CD7- T cell subset differentiated in vivo in Th0/Th2 cells. There was no significant amplification of cytotoxic (SF6+) and immunoregulatory (CD57+) CD8+ T cells in HCV patients with or without MC. Finally, the usage of Vbeta families in the TCR repertoire was normal in the patients tested. In patients with chronic HCV infection, with or without MC, we did not find any significant expansion or abnormal activation of T, B and NK cell subsets, dysbalance of the naive/memory subsets, or expansion of the Th0/Th2 subpopulation. These findings differ from the profound immune alterations that are observed in other chronic infections such as HIV or Epstein-Barr virus. Although this study was restricted to the peripheral blood, it suggests that in chronic HCV infection, MC is not the consequence of a chronic activation or dysregulation of the peripheral blood immune cells.
MeSH term(s)	Adult ; Aged ; Antigens, CD34/immunology ; CD4-Positive T-Lymphocytes/immunology ; Cryoglobulinemia/complications ; Cryoglobulinemia/immunology ; Cryoglobulinemia/pathology ; Female ; Hepatitis C/complications ; Hepatitis C/immunology ; Hepatitis C/pathology ; Humans ; Liver/pathology ; Male ; Middle Aged ; Phenotype ; Receptors, Antigen, T-Cell, alpha-beta/analysis ; T-Lymphocyte Subsets/immunology
Chemical Substances	Antigens, CD34 ; Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	1998-07
Publishing country	England
Document type	Journal Article
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1046/j.1365-2249.1998.00635.x
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Article ; Online: First-line assessment of patients with chronic liver disease with non-invasive techniques and without recourse to liver biopsy.

Poynard, Thierry

Journal of hepatology

2011 Volume 54, Issue 3, Page(s) 586–587

MeSH term(s)	Biomarkers/analysis ; Biopsy ; Chronic Disease ; Evidence-Based Medicine ; Fatty Liver/diagnosis ; France ; Humans ; Liver Cirrhosis/diagnosis ; Liver Diseases/diagnosis ; Liver Diseases/metabolism ; Practice Guidelines as Topic
Chemical Substances	Biomarkers
Language	English
Publishing date	2011-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2010.09.012
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Article: Faut-il encore faire des biopsies du foie?

Poynard, T

La Revue de medecine interne

2007 Volume 28, Issue 2, Page(s) 67–70

Title translation	Is liver biopsy still useful?.
MeSH term(s)	Biopsy/adverse effects ; Humans ; Liver/pathology ; Liver Diseases/diagnosis ; Liver Diseases/pathology ; Predictive Value of Tests ; Sensitivity and Specificity
Language	French
Publishing date	2007-02
Publishing country	France
Document type	Editorial ; Review
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2006.09.003
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