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  1. Book ; Thesis: Neonatales Tissue Engineering von kollagenem Bindegewebe für den körpereigenen Ersatz kongenitaler Bauchwanddefekte (Gastroschisis und Omphalozele) durch In-vitro- und In-vivo-Untersuchungen

    Minnerup, Jens

    2007  

    Author's details vorgelegt von: Minnerup, Jens
    Subject code 616.04
    Language German
    Size 129 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Münster (Westfalen), Univ., Diss., 2007
    HBZ-ID HT016827621
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Epileptischer Anfall des Erwachsenen in der Notaufnahme

    Sauer, Raoul Benedikt / Minnerup, Jens / Möddel, Gabriel

    Notaufnahme up2date

    2024  Volume 06, Issue 02, Page(s) 141–156

    Keywords Epilepsie ; Anfälle ; Neurologie ; EEG ; Stufentherapie
    Language German
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2628-7609 ; 2628-7595
    ISSN (online) 2628-7609
    ISSN 2628-7595
    DOI 10.1055/a-2051-9291
    Database Thieme publisher's database

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  3. Article: Editorial: Mechanisms, Measurement, and Management of Vasogenic Edema After Stroke.

    Broocks, Gabriel / Minnerup, Jens / Kamalian, Shervin / Kemmling, Andre

    Frontiers in neurology

    2022  Volume 13, Page(s) 865078

    Language English
    Publishing date 2022-02-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.865078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Neutrophils in Acute Stroke Pathophysiology.

    Schäbitz, Wolf-Rüdiger / Minnerup, Jens

    Stroke

    2019  Volume 50, Issue 3, Page(s) e44–e45

    MeSH term(s) Humans ; Immunity, Cellular ; Neutrophil Infiltration ; Neutrophils/drug effects ; Neutrophils/immunology ; Neutrophils/pathology ; Stroke/immunology ; Stroke/pathology
    Language English
    Publishing date 2019-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.118.024300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Inhibition of leukocyte migration after ischemic stroke by VE-cadherin mutation in a mouse model leads to reduced infarct volumes and improved motor skills.

    Koecke, Mailin Hannah Marie / Strecker, Jan-Kolja / Straeten, Frederike Anne / Beuker, Carolin / Minnerup, Jens / Schmidt-Pogoda, Antje

    Brain and behavior

    2024  Volume 14, Issue 3, Page(s) e3449

    Abstract: Aims: To distinguish between the genuine cellular impact of the ischemic cascade by leukocytes and unspecific effects of edema and humoral components, two knock-in mouse lines were utilized. Mouse lines Y731F and Y685F possess point mutations in VE- ... ...

    Abstract Aims: To distinguish between the genuine cellular impact of the ischemic cascade by leukocytes and unspecific effects of edema and humoral components, two knock-in mouse lines were utilized. Mouse lines Y731F and Y685F possess point mutations in VE-cadherin, which lead to a selective inhibition of transendothelial leukocyte migration or impaired vascular permeability.
    Methods: Ischemic stroke was induced by a model of middle cerebral artery occlusion. Analysis contained structural outcomes (infarct volume and extent of brain edema), functional outcomes (survival analysis, rotarod test, and neuroscore), and the extent and spatial distribution of leukocyte migration (heatmaps and fluorescence-activated cell sorting (FACS) analysis).
    Results: Inhibition of transendothelial leukocyte migration as in Y731F mice leads to smaller infarct volumes (52.33 ± 4719 vs. 70.43 ± 6483 mm
    Conclusion: Selective inhibition of transendothelial leukocyte migration by VE-cadherin mutation after ischemic stroke in a mouse model leads to smaller infarct volumes and improved motor skills.
    MeSH term(s) Mice ; Animals ; Ischemic Stroke ; Motor Skills ; Leukocytes/physiology ; Infarction ; Mutation ; Stroke/genetics ; Antigens, CD ; Cadherins
    Chemical Substances cadherin 5 ; Antigens, CD ; Cadherins
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2623587-0
    ISSN 2162-3279 ; 2162-3279
    ISSN (online) 2162-3279
    ISSN 2162-3279
    DOI 10.1002/brb3.3449
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  6. Article: Long-Term Sonographical Follow-Up of Arterial Stenosis Due to Spontaneous Cervical Artery Dissection.

    Strunk, Daniel / Schwindt, Wolfram / Wiendl, Heinz / Dittrich, Ralf / Minnerup, Jens

    Frontiers in neurology

    2022  Volume 12, Page(s) 792321

    Abstract: Purpose: Little is known about the long-term course of arterial stenosis after spontaneous cervical artery dissection (sCAD). We analyzed changes over time and evaluated factors potentially associated with these changes and recurring sCAD.: Materials ... ...

    Abstract Purpose: Little is known about the long-term course of arterial stenosis after spontaneous cervical artery dissection (sCAD). We analyzed changes over time and evaluated factors potentially associated with these changes and recurring sCAD.
    Materials and methods: Adult patients with sCAD, admitted to our neurological department between 2004 and 2018, were included. All patients underwent initial and follow-up repetitive neurovascular ultrasound for a mean duration of 15.3 ± 21 months. Clinical and imaging data were registered for each patient.
    Results: A total of 259 sCADs were diagnosed in 224 patients. Either internal carotid arteries (
    Conclusion: The sonographical course of sCAD is highly dynamic within the first year after disease onset and should be monitored carefully. Decreasing degrees of stenosis and recanalization of occluded arteries occurred in half of all patients. Recurrent sCAD was a rare event in our cohort.
    Language English
    Publishing date 2022-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.792321
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  7. Article: Thrombektomie bei Schlaganfall - diese Patienten profitieren besonders. Zusammenfassung aktueller Studien

    Minnerup, Jens

    Der Neurologe & Psychiater

    2016  Volume 17, Issue 6, Page(s) 26

    Language German
    Document type Article
    ZDB-ID 2036795-8
    ISSN 1616-2455
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5588: Show issues Location:
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  8. Article ; Online: Seltene Schlaganfallursachen – im Alltag gar nicht so selten.

    Schmidt-Pogoda, Antje / Minnerup, Jens

    Der Nervenarzt

    2019  Volume 90, Issue 10, Page(s) 1013–1020

    Abstract: As a whole, rare stroke causes represent a frequent stroke etiology. Since rare stroke causes affect primarily young patients, early diagnosis and treatment are of high socioeconomic relevance. In our everyday clinical practice, cervical artery ... ...

    Title translation Rare causes of stroke-a frequent stroke etiology.
    Abstract As a whole, rare stroke causes represent a frequent stroke etiology. Since rare stroke causes affect primarily young patients, early diagnosis and treatment are of high socioeconomic relevance. In our everyday clinical practice, cervical artery dissection, which is the most common stroke etiology among patients < 45 years, and vasculitis are particularly important. In the case of vasculitis, devastating disease courses and potentially harmful treatment options complicate clinical decision-making. Non-vasculitic vasculopathies, infections, hematological disorders, coagulation disorders, metabolic disorders and malignancies are further rare causes of stroke with variable clinical manifestations, thus impeding an early diagnosis. If eligible, patients with rare stroke causes should be considered for thrombectomy. Except for infective endocarditis, most rare stroke causes are not per se a contraindication to thrombolysis, so that eligible patients should also be considered for thrombolysis. Evidence based recommendations for the secondary prevention of most rare stroke causes are still missing. In many cases, treatment regimens are adapted to the patients' individual risk of stroke recurrence and bleeding complications.
    MeSH term(s) Age Factors ; Contraindications ; Humans ; Stroke/etiology ; Stroke/therapy ; Thrombectomy
    Language German
    Publishing date 2019-08-30
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 123291-5
    ISSN 1433-0407 ; 0028-2804
    ISSN (online) 1433-0407
    ISSN 0028-2804
    DOI 10.1007/s00115-019-00789-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Common Data Elements for Meaningful Stroke Documentation in Routine Care and Clinical Research: Retrospective Data Analysis.

    Berenspöhler, Sarah / Minnerup, Jens / Dugas, Martin / Varghese, Julian

    JMIR medical informatics

    2021  Volume 9, Issue 10, Page(s) e27396

    Abstract: Background: Medical information management for stroke patients is currently a very time-consuming endeavor. There are clear guidelines and procedures to treat patients having acute stroke, but it is not known how well these established practices are ... ...

    Abstract Background: Medical information management for stroke patients is currently a very time-consuming endeavor. There are clear guidelines and procedures to treat patients having acute stroke, but it is not known how well these established practices are reflected in patient documentation.
    Objective: This study compares a variety of documentation processes regarding stroke. The main objective of this work is to provide an overview of the most commonly occurring medical concepts in stroke documentation and identify overlaps between different documentation contexts to allow for the definition of a core data set that could be used in potential data interfaces.
    Methods: Medical source documentation forms from different documentation contexts, including hospitals, clinical trials, registries, and international standards, regarding stroke treatment followed by rehabilitation were digitized in the operational data model. Each source data element was semantically annotated using the Unified Medical Language System. The concept codes were analyzed for semantic overlaps. A concept was considered common if it appeared in at least two documentation contexts. The resulting common concepts were extended with implementation details, including data types and permissible values based on frequent patterns of source data elements, using an established expert-based and semiautomatic approach.
    Results: In total, 3287 data elements were identified, and 1051 of these emerged as unique medical concepts. The 100 most frequent medical concepts cover 9.51% (100/1051) of all concept occurrences in stroke documentation, and the 50 most frequent concepts cover 4.75% (50/1051). A list of common data elements was implemented in different standardized machine-readable formats on a public metadata repository for interoperable reuse.
    Conclusions: Standardization of medical documentation is a prerequisite for data exchange as well as the transferability and reuse of data. In the long run, standardization would save time and money and extend the capabilities for which such data could be used. In the context of this work, a lack of standardization was observed regarding current information management. Free-form text fields and intricate questions complicate automated data access and transfer between institutions. This work also revealed the potential of a unified documentation process as a core data set of the 50 most frequent common data elements, accounting for 34% of the documentation in medical information management. Such a data set offers a starting point for standardized and interoperable data collection in routine care, quality management, and clinical research.
    Language English
    Publishing date 2021-10-12
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2798261-0
    ISSN 2291-9694
    ISSN 2291-9694
    DOI 10.2196/27396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reply.

    Kemmling, André / Minnerup, Jens

    Annals of neurology

    2017  Volume 81, Issue 4, Page(s) 609–610

    MeSH term(s) Humans ; Stroke ; Tomography, X-Ray Computed ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2017-04-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.24912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 478: Show issues

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