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Article ; Online: Editorial: baseline hepatitis B virus haplotype number may help predict a functional cure in patients with chronic hepatitis B treated with nucleotide analogues.

Li, Yu-Jing / Chen, En-Qiang

2023 Volume 57, Issue 5, Page(s) 581–582

MeSH term(s)	Humans ; Hepatitis B virus/genetics ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/genetics ; Nucleotides/therapeutic use ; Haplotypes ; Antiviral Agents/therapeutic use ; Hepatitis B Surface Antigens
Chemical Substances	Nucleotides ; Antiviral Agents ; Hepatitis B Surface Antigens
Language	English
Publishing date	2023-02-14
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17328
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Article ; Online: Editorial: in the era of effective antiviral therapy, long-term dynamic endoscopic monitoring does not seem to be necessary for all CHB patients with compensated cirrhosis.

Li, Lan-Qing / Chen, En-Qiang

Alimentary pharmacology & therapeutics

2023 Volume 57, Issue 12, Page(s) 1467–1468

MeSH term(s)	Humans ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/drug therapy ; Antiviral Agents/therapeutic use
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2023-05-26
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17487
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Article ; Online: Mesenchymal Stem Cell Therapy in Acute Liver Failure.

Wang, Yong-Hong / Chen, En-Qiang

Gut and liver

2023 Volume 17, Issue 5, Page(s) 674–683

Abstract: Acute liver failure (ALF) is a severe liver disease syndrome with rapid deterioration and high mortality. Liver transplantation is the most effective treatment, but the lack of donor livers and the high cost of transplantation limit its broad application. ...

Abstract	Acute liver failure (ALF) is a severe liver disease syndrome with rapid deterioration and high mortality. Liver transplantation is the most effective treatment, but the lack of donor livers and the high cost of transplantation limit its broad application. In recent years, there has been no breakthrough in the treatment of ALF, and the application of stem cells in the treatment of ALF is a crucial research field. Mesenchymal stem cells (MSCs) are widely used in disease treatment research due to their abundant sources, low immunogenicity, and no ethical restrictions. Although MSCs are effective for treating ALF, the application of MSCs to ALF needs to be further studied and optimized. In this review, we discuss the potential mechanisms of MSCs therapy for ALF, summarize some methods to enhance the efficacy of MSCs, and explore optimal approaches for MSC transplantation.
MeSH term(s)	Humans ; Mesenchymal Stem Cell Transplantation/methods ; Liver Failure, Acute/surgery ; Liver ; Mesenchymal Stem Cells ; Treatment Outcome
Language	English
Publishing date	2023-02-27
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2399010-7
ISSN	2005-1212 ; 1976-2283
ISSN (online)	2005-1212
ISSN	1976-2283
DOI	10.5009/gnl220417
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Article ; Online: Mesenchymal Stem Cells Therapy for COVID-19: From Basic Research to Clinical Trial.

Tao, Ya-Chao / Chen, En-Qiang

Current stem cell research & therapy

2023 Volume 19, Issue 1, Page(s) 55–62

Abstract: The novel pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a serious challenge for human health. In severe cases, patients suffer from acute respiratory distress syndrome even organ ... ...

Abstract	The novel pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a serious challenge for human health. In severe cases, patients suffer from acute respiratory distress syndrome even organ failure, usually owing to the dysregulated immune response and widespread inflammation. Considering that there is no known cure for COVID-19 despite the increased morbidity and mortality rate of COVID-19, modalities targeting immunity and inflammation may be promising therapeutics against COVID-19. Mesenchymal stem cells (MSCs) possessing immunomodulatory, anti-inflammatory, anti-apoptotic, and antiviral properties, can be of potential benefit to a subset of severe and critically ill patients with COVID-19. In the present study, we described the underlying mechanisms of MSCs therapy and provided a thorough research study on the recent clinical trials of MSCs for SARS-CoV-2 infection.
MeSH term(s)	Humans ; COVID-19/therapy ; SARS-CoV-2 ; Mesenchymal Stem Cell Transplantation ; Inflammation ; Mesenchymal Stem Cells
Language	English
Publishing date	2023-01-18
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2251937-3
ISSN	2212-3946 ; 1574-888X
ISSN (online)	2212-3946
ISSN	1574-888X
DOI	10.2174/1574888X18666230118122256
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Article ; Online: Free fatty acids-induced neutrophil extracellular traps lead to dendritic cells activation and T cell differentiation in acute lung injury.

Chen, Wei / Chen, Hong / Yang, Zhi-Tao / Mao, En-Qiang / Chen, Ying / Chen, Er-Zhen

Aging

2021 Volume 13, Issue 24, Page(s) 26148–26160

Abstract: This study aimed to investigate whether free fatty acids (FFAs) could induce the release of neutrophil extracellular traps (NETs), as well as the mechanism of FFAs-induced NETs in acute lung injury (ALI). FFAs were used to induce NETs production. The ... ...

Abstract	This study aimed to investigate whether free fatty acids (FFAs) could induce the release of neutrophil extracellular traps (NETs), as well as the mechanism of FFAs-induced NETs in acute lung injury (ALI). FFAs were used to induce NETs production. The reactive oxygen species (ROS) production was detected after FFA and NADPH oxidase inhibitor treatments. The association between FFAs-induced NETs and the activation of p38, ERK, and JNK pathways was investigated. The effect of FFAs-induced NETs on the dendritic cells (DCs) activation and T cell differentiation was investigated. FFAs could induce neutrophils to produce NETs. FFAs significantly promoted ROS production and increased the expression of ERK, p38 and JNK, and treatment of the inhibitors of NAPDH oxidase (DPI), p38 (SB202190), ERK1/2 (U0126) and JNK (SP600125) inhibited FAAs-induced NETs production. FFAs induced NETs could promote DCs activation and consequently led to the differentiation of primary CD4+ T cells into Th1 and Th17 cells and the release of IL-1β, IL-12 and TNF-α. FFAs are capable of inducing NETs via NOX, ERK, p38 and JNK pathways. FFA-induced NETs further lead to DCs activation and T cell differentiation, which can well explain the mechanism of ALI caused by FFAs.
MeSH term(s)	Acute Lung Injury/metabolism ; Butadienes ; Cell Differentiation ; Dendritic Cells/metabolism ; Enzyme Inhibitors ; Extracellular Traps/metabolism ; Fatty Acids, Nonesterified/metabolism ; Humans ; MAP Kinase Signaling System/drug effects ; Mitogen-Activated Protein Kinase 3/genetics ; NADPH Oxidases/metabolism ; Neutrophils/metabolism ; Neutrophils/pathology ; Nitriles ; Reactive Oxygen Species/metabolism ; T-Lymphocytes
Chemical Substances	Butadienes ; Enzyme Inhibitors ; Fatty Acids, Nonesterified ; Nitriles ; Reactive Oxygen Species ; U 0126 ; NADPH Oxidases (EC 1.6.3.-) ; MAPK3 protein, human (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24)
Language	English
Publishing date	2021-12-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.203802
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Article ; Online: Development and external validation of a nomogram for the early prediction of acute kidney injury in septic patients: a multicenter retrospective clinical study.

Su, Qin-Yue / Chen, Wen-Jie / Zheng, Yan-Jun / Shi, Wen / Gong, Fang-Chen / Huang, Shun-Wei / Yang, Zhi-Tao / Qu, Hong-Ping / Mao, En-Qiang / Wang, Rui-Lan / Zhu, Du-Ming / Zhao, Gang / Chen, Wei / Wang, Sheng / Wang, Qian / Zhu, Chang-Qing / Yuan, Gao / Chen, Er-Zhen / Chen, Ying

Renal failure

2024 Volume 46, Issue 1, Page(s) 2310081

Abstract: Background and purpose: ...

Abstract	Background and purpose:
MeSH term(s)	Humans ; Nomograms ; Retrospective Studies ; China ; Acute Kidney Injury ; Sepsis
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2024.2310081
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Article ; Online: Magnetically controlled capsule endoscopy in one-time gastro-small intestinal joint examination: a two-centre experience.

Liu, Ya-Wei / Wang, Yuan-Chen / Zhu, Jia-Hui / Jiang, Xi / Zhou, Wei / Zhang, Jie / Liao, Zhuan / Linghu, En-Qiang

BMC gastroenterology

2022 Volume 22, Issue 1, Page(s) 222

Abstract: Background: The lesions of certain diseases are widely distributed in both stomach and small intestine, while the step-by-step strategy of gastroscopy followed by enteroscopy can be burdensome and costly. We aimed to determine if magnetically controlled ...

Abstract	Background: The lesions of certain diseases are widely distributed in both stomach and small intestine, while the step-by-step strategy of gastroscopy followed by enteroscopy can be burdensome and costly. We aimed to determine if magnetically controlled capsule endoscopy (MCE) could be used in one-time gastro-small intestine (GSI) joint examination. Methods: In this study, data of patients in Chinese PLA General Hospital and Changhai Hospital who underwent MCE GSI examination from January 2020 to August 2021 were retrospectively analysed. The primary outcome of this study was the success rate of one-time GSI joint examination, and secondary outcomes included visualization and cleanliness of gastrointestinal tract, gastrointestinal transit times, diagnostic yield and safety of MCE examination. Results: A total of 768 patients were included. The success rate of one-time GSI joint examination was 92.58%. There were 94.92% MCEs observed > 90% gastric mucosa in the 6 anatomic landmarks. The rate of complete small bowel examination was 97.40%. The median gastric examination time, gastric transit time and small intestine transit time were 8.18 min, 63.89 min and 4.89 h, respectively. Magnetic steering of MCE significantly decreased gastric transit time (8.92 min vs. 79.68 min, P = 0.001) and increased duodenal lesion detection rate (13.47% vs. 6.26%, P = 0.001) when compared with non-magnetic steering group. Two capsules were retained and were removed by enteroscopy or spontaneously excreted. Conclusions: MCE is feasible to complete GSI joint examination and the detection of both gastric and small intestinal diseases can be achieved simultaneously. Trial registration Clinical Trial Registration ClinicalTrials.gov, ID: NCT05069233.
MeSH term(s)	Capsule Endoscopy ; Gastroscopy ; Humans ; Intestine, Small/diagnostic imaging ; Retrospective Studies ; Stomach/diagnostic imaging
Language	English
Publishing date	2022-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-022-02302-0
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Article ; Online: A novel immune-related long noncoding RNA (lncRNA) pair model to predict the prognosis of triple-negative breast cancer.

Li, Jing-Ying / Hu, Chen-Ji / Peng, Hui / Chen, En-Qiang

Translational cancer research

2024 Volume 13, Issue 3, Page(s) 1252–1267

Abstract: Background: Breast cancer (BC) is the most prevalent cancer type and is the principal cause of cancer-related death in women. Anti-programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) immunotherapy has shown promising effects in ... ...

Abstract	Background: Breast cancer (BC) is the most prevalent cancer type and is the principal cause of cancer-related death in women. Anti-programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) immunotherapy has shown promising effects in metastatic triple-negative breast cancer (TNBC), but the potential factors affecting its efficacy have not been elucidated. Immune-related long noncoding RNAs (irlncRNAs) have been reported to be involved in immune escape to influence the carcinogenic process through the PD-1/PD-L1 signaling pathway. Therefore, exploring the potential regulatory mechanism of irlncRNAs in PD-1/PD-L1 immunotherapy in TNBC is of great importance. Methods: We retrieved transcriptome profiling data from The Cancer Genome Atlas (TCGA) and identified differentially expressed irlncRNA (DEirlncRNA) pairs. Least absolute shrinkage and selection operator (LASSO) regression analysis was performed to construct a risk assessment model. Results: Receiver operating characteristic (ROC) curve analysis indicated that the risk model may serve as a potential prediction tool in TNBC patients. Clinical stage and risk score were proved to be independent prognostic predictors by univariate and multivariate Cox regression analyses. Subsequently, we investigated the correlation between the risk model and tumor-infiltrating immune cells and immune checkpoints. Finally, we identified USP30-AS1 through the StarBase and Multi Experiment Matrix (MEM) databases, predicted the potential target genes of USP30-AS1, and then discovered that these target genes were closely associated with immune responses. Conclusions: Our study constructed a risk assessment model by irlncRNA pairs regardless of expression levels, which contributed to predicting the efficacy of immunotherapy in TNBC. Furthermore, the lncRNA USP30-AS1 in the model was positively correlated with the expression of PD-L1 and provided a potential therapeutic target for TNBC.
Language	English
Publishing date	2024-03-11
Publishing country	China
Document type	Journal Article
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr-23-1975
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Article ; Online: Editorial: switching to tenofovir alafenamide monotherapy is effective and safe for other nucleos(t)ide analogues-treated patients with chronic hepatitis B.

Wang, Meng-Lan / Chen, En-Qiang

Alimentary pharmacology & therapeutics

2022 Volume 56, Issue 6, Page(s) 1090–1091

MeSH term(s)	Adenine/adverse effects ; Alanine ; Hepatitis B e Antigens ; Hepatitis B, Chronic/drug therapy ; Humans ; Tenofovir/analogs & derivatives
Chemical Substances	Hepatitis B e Antigens ; Tenofovir (99YXE507IL) ; tenofovir alafenamide (EL9943AG5J) ; Adenine (JAC85A2161) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2022-08-25
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17122
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Article ; Online: Clinical treatment of cryptococcal meningitis: an evidence-based review on the emerging clinical data.

Liu, Mao-Zhu / Dai, Xin-Hua / Zeng, Ming-Tang / Chen, En-Qiang

Journal of neurology

2024

Abstract: Cryptococcal meningitis (CM) is a fatal fungal central nervous system (CNS) infection caused by Cryptococcus infecting the meninges and/or brain parenchyma, with fever, headache, neck stiffness, and visual disturbances as the primary clinical ... ...

Abstract	Cryptococcal meningitis (CM) is a fatal fungal central nervous system (CNS) infection caused by Cryptococcus infecting the meninges and/or brain parenchyma, with fever, headache, neck stiffness, and visual disturbances as the primary clinical manifestations. Immunocompromised individuals with human immunodeficiency virus (HIV) infection or who have undergone organ transplantation, as well as immunocompetent people can both be susceptible to CM. Without treatment, patients with CM may have a mortality rate of up to 100% after hospital admission. Even after receiving therapy, CM patients may still suffer from problems such as difficulty to cure, poor prognosis, and high mortality. Therefore, timely and effective treatment is essential to improve the mortality and prognosis of CM patients. Currently, the clinical outcomes of CM are frequently unsatisfactory due to limited drug choices, severe adverse reactions, drug resistance, etc. Here, we review the research progress of CM treatment strategies and discuss the suitable options for managing CM, hoping to provide a reference for physicians to select the most appropriate treatment regimens for CM patients.
Language	English
Publishing date	2024-01-30
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-024-12193-8
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