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  1. Article ; Online: A

    Jain, Dhruv / Sachdeva, Honey

    International journal of surgical pathology

    2019  Volume 28, Issue 4, Page(s) 420

    MeSH term(s) Breast Neoplasms/pathology ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Female ; Humans
    Language English
    Publishing date 2019-09-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/1066896919877957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4500: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Training in interventional pulmonology: a leap into the future.

    Lamb, Carla / Sachdeva, Ash

    Current opinion in pulmonary medicine

    2024  Volume 30, Issue 2, Page(s) 195–199

    Abstract: Purpose of review: This review holds significant relevance and is timely; as of June 2022, the United States Accreditation Council of Graduate Medical Education (ACGME) formally recognized interventional pulmonary medicine as a novel subspecialty with a ...

    Abstract Purpose of review: This review holds significant relevance and is timely; as of June 2022, the United States Accreditation Council of Graduate Medical Education (ACGME) formally recognized interventional pulmonary medicine as a novel subspecialty with a unique fellowship training program pathway beyond Pulmonary and Critical Care Medicine. This recognition stands as a culmination of extensive efforts spanning decades, aimed at establishing a specialized training program for interventional pulmonary medicine beyond traditional Pulmonary and Critical Care Fellowship in the United States. Globally, there are apprenticeship models in non-US programs with ongoing efforts to further standardize training in interventional pulmonary medicine. It underscores the progressive evolution and innovative nature inherent to this subspecialty, signifying a distinctive leap forward in medical education and practice, which calls for further inventive development of training tools and standardized educational delivery.
    Recent findings: Newly discovered insights from the recent literature review will highlight methodologies of procedural education and innovative training approaches. These findings will underscore the significance of standardized curriculum development within the field as well as ongoing challenges.
    Summary: Identifying and addressing future challenges in integrating new technologies into clinical education and broadening the educational scope of trainees in this newly recognized subspecialty is crucial for enhancing competency. The implications of moving toward a more standardized process, creating new clinical pathways with research, and adopting emerging minimally invasive technologies aim to impact patient outcomes in both nonmalignant and malignant thoracic diseases. This progressive shift is redefining the specialty, moving beyond specific procedures, and pivoting towards a more distinct educational pathway. Such a transformation will lead to more diverse, comprehensive, and evidence-based driven patient care delivery.
    MeSH term(s) Humans ; United States ; Pulmonary Medicine/education ; Clinical Competence ; Accreditation ; Education, Medical, Graduate ; Fellowships and Scholarships
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000001049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4900: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: A linear cross-coupled gate-driven quasi-floating bulk low-power wide input range transconductor.

    Sharma, Kulbhushan / Sachdeva, Ashish

    The Review of scientific instruments

    2024  Volume 95, Issue 3

    Abstract: High linearity for a wider input voltage range and low-power operation of the operational transconductance amplifier (OTA) are indispensable parameters for health care applications, which require high quality and accurate signal conditioning. However, ... ...

    Abstract High linearity for a wider input voltage range and low-power operation of the operational transconductance amplifier (OTA) are indispensable parameters for health care applications, which require high quality and accurate signal conditioning. However, achieving low-power operation along with high linearity at low supply voltages is challenging for OTA using conventional low-power and linearization techniques. This paper proposes an OTA based on a cross-coupled gate-driven quasi-floating bulk (CGDQFB) MOSFET and source-degenerated linearization techniques, which works at a supply of ±0.5 V. The post-layout simulations of the proposed OTA are performed in the 180 nm standard CMOS process, which shows a transconductance of 0.321 μS, an output impedance of 331 MΩ, an input impedance of 897 GΩ, a DC gain of 40.54 dB, a gain-bandwidth of 0.145 MHz, a total harmonic distortion (THD) of 51.09 dB for an input voltage range of 626.7 mV at a frequency of 100.39 Hz, and a power consumption of 0.45 μW. The proposed OTA shows an input common mode range of -0.34 to 0.4 V, an output voltage swing of -0.34 to 0.34 V, a common mode rejection ratio of 91.08 dB, and a consumption area of 23 965.92 µm2. Furthermore, with 200 Monte Carlo iterations, the proposed OTA shows variability for gain and THD of 0.003 and 0.036, respectively. The proposed CGDQFB OTA is a suitable contender for conditioning bio-signals used in health care applications.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/5.0193906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 46/112: Show issues

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  4. Article ; Online: Engineering Homogeneous Photoactive Antibody Fragments.

    Bridge, Thomas / Sachdeva, Amit

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2676, Page(s) 21–40

    Abstract: Genetically encoded site-specifically incorporated noncanonical amino acids (ncAAs) have been used to modulate properties of several proteins. Here, we describe a procedure for engineering photoactive antibody fragments that bind to their target antigen ... ...

    Abstract Genetically encoded site-specifically incorporated noncanonical amino acids (ncAAs) have been used to modulate properties of several proteins. Here, we describe a procedure for engineering photoactive antibody fragments that bind to their target antigen only after irradiation with 365 nm light. The procedure starts with identification of tyrosine residues in antibody fragments that are important for antibody-antigen binding and thus targets for replacement with photocaged tyrosine (pcY). This is followed by cloning of plasmids and expression of pcY-containing antibody fragments in E. coli. Finally, we describe a cost-effective and biologically-relevant method for measuring the binding affinity of photoactive antibody fragments to antigens expressed on the surface of live cancer cells.
    MeSH term(s) Immunoglobulin Fragments/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Amino Acids/chemistry ; Tyrosine/metabolism ; Proteins/chemistry ; Antigens/metabolism
    Chemical Substances Immunoglobulin Fragments ; Amino Acids ; Tyrosine (42HK56048U) ; Proteins ; Antigens
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3251-2_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Interventional pulmonology: reflection on the past, perfecting the present and innovating for the future.

    Lee, Pyng / Sachdeva, Ashutosh

    Current opinion in pulmonary medicine

    2023  Volume 30, Issue 1, Page(s) 1–2

    MeSH term(s) Humans ; Pulmonary Medicine ; Bronchoscopy
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000001037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4900: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Motivation and Learning: Leveraging Artificial Intelligence to Improve Bronchoscopy Performance.

    Sachdeva, Ashutosh / Sethi, Sonali

    Chest

    2023  Volume 165, Issue 2, Page(s) 243–245

    MeSH term(s) Humans ; Artificial Intelligence ; Motivation ; Bronchoscopy ; Learning
    Language English
    Publishing date 2023-12-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.09.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  7. Article ; Online: Protein kinase D2-Aurora kinase A-ERK1/2 signalling axis drives neuroendocrine differentiation of epithelial ovarian cancer.

    Sachdeva, Abha / Roy, Adhiraj / Mandal, Supratim

    Molecular and cellular biochemistry

    2024  

    Abstract: Epithelial ovarian cancer (EOC) is deadliest gynecological malignancy with poor prognosis and patient survival. Despite development of several therapeutic interventions such as poly-ADP ribose polymerase (PARP) inhibitors, EOC remains unmanageable and ... ...

    Abstract Epithelial ovarian cancer (EOC) is deadliest gynecological malignancy with poor prognosis and patient survival. Despite development of several therapeutic interventions such as poly-ADP ribose polymerase (PARP) inhibitors, EOC remains unmanageable and discovery of novel early detection biomarkers and treatment targets are highly warranted. Although neuroendocrine differentiation (NED) is implicated in different human cancers including prostate adenocarcinoma and lung cancer, mechanistic studies concerning NED of epithelial ovarian cancer are lacking. We report that Aurora kinase A drives NED of epithelial ovarian cancer in an ERK1/2-dependent manner and pharmacological and genetic inhibition of Aurora kinase A suppress NED of ovarian cancer. Moreover, we demonstrate that protein kinase D2 positively regulated Aurora kinase A to drive NED. Overexpression of catalytically active PKD2 drives NED and collectively, PKD2 cross talks with Aurora kinase A/ERK1/2 signalling axis to positively regulate NED of EOC. PKD2/Aurora kinase A/ERK1/2 signalling axis is a novel therapeutic target against neuroendocrine differentiated EOC.
    Language English
    Publishing date 2024-04-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-024-04986-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 892: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Familial non-Hodgkin lymphoma with inborn error of immunity due to ORAI1 defect.

    Selvaraj, Harish / Sachdeva, Anupam / Kalra, Manas

    Pediatric blood & cancer

    2024  Volume 71, Issue 4, Page(s) e30897

    MeSH term(s) Humans ; Lymphoma, Non-Hodgkin ; Hodgkin Disease ; ORAI1 Protein
    Chemical Substances ORAI1 protein, human ; ORAI1 Protein
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Letter
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.30897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Book ; Online: The Manga Whisperer

    Sachdeva, Ragav / Zisserman, Andrew

    Automatically Generating Transcriptions for Comics

    2024  

    Abstract: In the past few decades, Japanese comics, commonly referred to as Manga, have transcended both cultural and linguistic boundaries to become a true worldwide sensation. Yet, the inherent reliance on visual cues and illustration within manga renders it ... ...

    Abstract In the past few decades, Japanese comics, commonly referred to as Manga, have transcended both cultural and linguistic boundaries to become a true worldwide sensation. Yet, the inherent reliance on visual cues and illustration within manga renders it largely inaccessible to individuals with visual impairments. In this work, we seek to address this substantial barrier, with the aim of ensuring that manga can be appreciated and actively engaged by everyone. Specifically, we tackle the problem of diarisation i.e. generating a transcription of who said what and when, in a fully automatic way. To this end, we make the following contributions: (1) we present a unified model, Magi, that is able to (a) detect panels, text boxes and character boxes, (b) cluster characters by identity (without knowing the number of clusters apriori), and (c) associate dialogues to their speakers; (2) we propose a novel approach that is able to sort the detected text boxes in their reading order and generate a dialogue transcript; (3) we annotate an evaluation benchmark for this task using publicly available [English] manga pages. The code, evaluation datasets and the pre-trained model can be found at: https://github.com/ragavsachdeva/magi.
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Publishing date 2024-01-18
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Health Promotion: Looking Back... Moving Forward.

    Sachdeva, Anupam

    Indian pediatrics

    2018  Volume 54, Issue 12, Page(s) 999

    MeSH term(s) Health Promotion ; Humans ; India ; Organizational Objectives ; Public Health
    Language English
    Publishing date 2018-01-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
    DOI 10.1007/s13312-017-1199-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 859: Show issues Location:
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