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  1. Article ; Online: Stimulation ovarienne : les complications liées à l’endométriose thoracique.

    Pellerin, M / Fischbach, E / Lemardeley, G / Rongières, C / Garbin, O / Pirrello, O

    Gynecologie, obstetrique, fertilite & senologie

    2020  Volume 48, Issue 4, Page(s) 400–403

    Title translation Ovarian stimulation: Complications caused by thoracic endometriosis.
    MeSH term(s) Adult ; Endometriosis/complications ; Endometriosis/physiopathology ; Female ; Humans ; Infertility, Female/therapy ; Ovarian Hyperstimulation Syndrome/physiopathology ; Ovulation Induction/adverse effects ; Pleural Diseases/etiology ; Pneumothorax/etiology ; Pregnancy ; Pregnancy Outcome ; Reproductive Techniques, Assisted ; Thoracic Diseases/complications ; Thoracic Diseases/physiopathology ; Treatment Outcome
    Language French
    Publishing date 2020-01-30
    Publishing country France
    Document type Case Reports ; Letter
    ZDB-ID 2887456-0
    ISSN 2468-7189
    ISSN (online) 2468-7189
    DOI 10.1016/j.gofs.2020.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1937: Show issues Location:
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  2. Article ; Online: Méningo-encéphalite à tiques chez l’enfant en France : à propos d’un cas.

    Levy, M / Abi-Warde, M-T / Rameau, A-C / Fafi-Kremer, S / Hansmann, Y / Fischbach, M / Higel, L

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

    2016  Volume 23, Issue 10, Page(s) 1055–1058

    Abstract: Tick-borne encephalitis (TBE) is an arbovirus induced by tick-borne encephalitis virus (TBEV) transmitted by tick bite. The disease is rare in France (two to three cases per year) but endemic zones extend from Western Europe to the east coast of Asia (10, ...

    Title translation Tick-borne encephalitis in a child in a nonendemic country: A case report.
    Abstract Tick-borne encephalitis (TBE) is an arbovirus induced by tick-borne encephalitis virus (TBEV) transmitted by tick bite. The disease is rare in France (two to three cases per year) but endemic zones extend from Western Europe to the east coast of Asia (10,000-15,000 cases per year). An 8-year-old boy was admitted to our pediatric ward in Strasbourg (France) for febrile headache with diplopia. Four days after a tick bite, he declared a febrile headache together with maculopapular rash on the elbows, knees, and cheeks. Fourteen days after the outbreak of symptoms, he showed confusion, drowsiness, and binocular diplopia. Brain MRI was normal and the electroencephalogram found diffuse slow activity with no discharge. Lumbar puncture found meningitis with 92 cells (60% neutrophils, 40% lymphocytes). The diagnosis was made with specific IgM and IgG antibody isolation in the serum (Elisa). Lyme serology was negative. The evolution was slowly favorable and the child remained hospitalized for 8 days. The neurological control examination 2 weeks later was normal except for a moderate left deviation during tandem walk and left Romberg manoeuver. Meningitis or meningoencephalitis in a child must raise the diagnosis of TBE in children, even in nonendemic countries, given the recent increased incidence of TBE and the development of tourism. Recent travel in endemic areas, a history of tick bite, and a clinical course in two phases must be sought. The diagnosis is serologic and prevention is based on vaccination.
    MeSH term(s) Animals ; Child ; Encephalitis, Tick-Borne/diagnosis ; France ; Humans ; Male ; Meningoencephalitis/diagnosis
    Language French
    Publishing date 2016-10
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 1181947-9
    ISSN 1769-664X ; 0929-693X
    ISSN (online) 1769-664X
    ISSN 0929-693X
    DOI 10.1016/j.arcped.2016.06.018
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  3. Book: ZUR UNTERSCHIEDLICHEN INKORPORATION VON D- UND L-AMINOSAEUREN IM SERUM-, NIEREN- UND LEBERPROTEINEN DER RATTE

    Fischbach, Wolfgang

    1979  

    Size 32, V S. : ILL.
    Document type Book
    Note WUERZBURG, UNIV., FACHBEREICH MEDIZIN, DISS., 1979
    HBZ-ID HT000118922
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    79 D 3322 order for loan Magazin

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  4. Article ; Online: Randomized, controlled trial of 2 L polyethylene glycol plus ascorbate components versus sodium phosphate for bowel cleansing prior to colonoscopy for cancer screening.

    Ell, C / Fischbach, W / Layer, P / Halphen, M

    Current medical research and opinion

    2014  Volume 30, Issue 12, Page(s) 2493–2503

    Abstract: ... colonoscopy for CRC were randomized to take 2 L PEG+Asc or 90 mL NaP (control) following manufacturer's ...

    Abstract Background: Colonoscopy requires effective bowel preparation for adequate mucosal visualization. Safety and acceptability of bowel preparation are key components in colorectal cancer screening (CRC) populations.
    Objective: To compare the efficacy, safety and acceptability of bowel preparation with polyethylene glycol (PEG), ascorbic acid, sodium ascorbate (ascorbate components), sodium sulfate and electrolytes (PEG+Asc) or sodium phosphate (NaP).
    Methods: Consenting adults undergoing elective out-patient colonoscopy for CRC were randomized to take 2 L PEG+Asc or 90 mL NaP (control) following manufacturer's instructions. PEG+Asc was taken the evening before and morning of the colonoscopy; NaP was taken the morning and evening before colonoscopy. Participants followed a restricted diet specific to each preparation. Primary endpoint was bowel cleansing success (100% colon mucosa visible) rated by an independent expert panel (all experienced endoscopists) unaware of treatment allocations. Subject reported outcomes about the preparations were elicited. Adverse events were recorded.
    Clinical trial registration: Clinicaltrials.gov: NCT00427089.
    Results: Successful bowel cleansing rate was significantly higher in the PEG+Asc (N = 242) than the NaP (N = 114) group (PEG+Asc 93.4% [95% CI 89.5-96.2] versus NaP 22.8% [15.5-31.6%], p < 0.0001). Subject reported outcomes on acceptability of the two different preparations were not significantly different (p = 0.238). However, taste ratings for PEG+Asc were significantly better versus NaP (mean VAS: 31.2 and 38.1 respectively, p = 0.0111). The proportion of patients prepared to receive the same preparation again was significantly higher in the PEG+Asc group (88.4% vs. 78.1%, p < 0.0001).
    Conclusions: PEG+Asc provided superior bowel cleansing to NaP and was well tolerated. Findings for PEG+Asc are aligned with previous similar studies; however, differences observed in NaP cleansing results, especially for the proximal colon segments, may be due to factors including: differences in demographics and population types and the use of the validated Harefield Cleansing Scale as an assessment tool combined with expert reviews, which may have resulted in conservative cleansing assessments.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Ambulatory Care ; Cathartics/administration & dosage ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Female ; Humans ; Male ; Middle Aged ; Patient Satisfaction ; Phosphates/administration & dosage ; Polyethylene Glycols/administration & dosage ; Preoperative Care ; Young Adult
    Chemical Substances Cathartics ; MoviPrep ; Phosphates ; Polyethylene Glycols (30IQX730WE) ; sodium phosphate (SE337SVY37)
    Language English
    Publishing date 2014-12
    Publishing country England
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80296-7
    ISSN 1473-4877 ; 0300-7995
    ISSN (online) 1473-4877
    ISSN 0300-7995
    DOI 10.1185/03007995.2014.960513
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  5. Article ; Online: A Special Issue of

    Strang, John F / Fischbach, Abigail L

    Autism in adulthood : challenges and management

    2023  Volume 5, Issue 2, Page(s) 109–111

    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Editorial
    ISSN 2573-959X
    ISSN (online) 2573-959X
    DOI 10.1089/aut.2023.0056.editorial
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Limited Effect of Chronic Renal Insufficiency on the Colon Microbiome.

    Guthrie, Leah / Sonnenburg, Justin L / Fischbach, Michael A / Meyer, Timothy W

    Journal of the American Society of Nephrology : JASN

    2023  Volume 34, Issue 4, Page(s) 527–529

    MeSH term(s) Humans ; Renal Insufficiency, Chronic/complications ; Microbiota ; Colon
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000064
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  7. Article ; Online: Creating and Implementing a Community-Focused, Culturally Tailored Health Marketing Campaign to Address Menthol Cigarette Use in Los Angeles County.

    Humphrey, Rachel / Truong, Amy / Fraser, Renee / Gallow, Tonya Gorham / Fischbach, Lori / Kuo, Tony

    Preventing chronic disease

    2024  Volume 21, Page(s) E25

    Abstract: Introduction: Menthol tobacco products have been marketed disproportionately to communities of color for decades.: Methods: In Los Angeles County, California, a health marketing campaign, which used glossy visuals and attractive people in appealing ... ...

    Abstract Introduction: Menthol tobacco products have been marketed disproportionately to communities of color for decades.
    Methods: In Los Angeles County, California, a health marketing campaign, which used glossy visuals and attractive people in appealing poses, reminiscent of tobacco marketing tactics, was created and implemented to educate smokers on the health risks of using menthol cigarettes. The campaign encouraged smokers to make a quit attempt by offering access to free or low-cost resources through the Kick It California quitline and the LAQuits website (laquits.com). A survey tailored for public health professionals and community members from the approximately 382,000 people in the county who smoked menthol cigarettes and were exposed to their smoke (our primary audience) was administered to generate insights about this problem. Survey data were used to finesse the campaign creative materials prior to launch. Advertisement exposures, website visits, and quitline call volume were monitored and tabulated to assess the performance of the campaign.
    Results: At the conclusion of its initial run (February-April 2021), the "Done with Menthol" campaign had garnered more than 66 million impressions, received approximately 56,000 clicks on its various digital media platforms, and had click-through rates that surpassed industry benchmarks. The quitline call volume for African American and Latino subgroups were 1.9 and 1.8 times higher than the average inbound call volume for corresponding months during 2018 and 2019, respectively. In its second run (May-June 2023), the campaign garnered approximately 11 million additional impressions.
    Conclusions: Despite having a lower budget and fewer resources than the tobacco industry, the "Done with Menthol" campaign attained excellent reach and offered free, low-cost, and accessible resources to county residents interested in tobacco use cessation.
    MeSH term(s) Humans ; Smoking ; Menthol ; Internet ; Los Angeles ; Tobacco Products ; Marketing ; Nicotiana
    Chemical Substances Menthol (1490-04-6)
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2135684-1
    ISSN 1545-1151 ; 1545-1151
    ISSN (online) 1545-1151
    ISSN 1545-1151
    DOI 10.5888/pcd21.230282
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  8. Article ; Online: Artificial Hsp104-mediated systems for re-localizing protein aggregates.

    Fischbach, Arthur / Johns, Angela / Schneider, Kara L / Hao, Xinxin / Tessarz, Peter / Nyström, Thomas

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 2663

    Abstract: Spatial Protein Quality Control (sPQC) sequesters misfolded proteins into specific, organelle-associated inclusions within the cell to control their toxicity. To approach the role of sPQC in cellular fitness, neurodegenerative diseases and aging, we ... ...

    Abstract Spatial Protein Quality Control (sPQC) sequesters misfolded proteins into specific, organelle-associated inclusions within the cell to control their toxicity. To approach the role of sPQC in cellular fitness, neurodegenerative diseases and aging, we report on the construction of Hsp100-based systems in budding yeast cells, which can artificially target protein aggregates to non-canonical locations. We demonstrate that aggregates of mutant huntingtin (mHtt), the disease-causing agent of Huntington's disease can be artificially targeted to daughter cells as well as to eisosomes and endosomes with this approach. We find that the artificial removal of mHtt inclusions from mother cells protects them from cell death suggesting that even large mHtt inclusions may be cytotoxic, a trait that has been widely debated. In contrast, removing inclusions of endogenous age-associated misfolded proteins does not significantly affect the lifespan of mother cells. We demonstrate also that this approach is able to manipulate mHtt inclusion formation in human cells and has the potential to be useful as an alternative, complementary approach to study the role of sPQC, for example in aging and neurodegenerative disease.
    MeSH term(s) Humans ; Protein Aggregates ; Neurodegenerative Diseases/genetics ; Aging ; Longevity ; Cell Death
    Chemical Substances Protein Aggregates
    Language English
    Publishing date 2023-05-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-37706-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Managing Water Quality in the Face of Uncertainty

    Fischbach, Jordan R / Lempert, Robert J / Molina-Perez, Edmundo / Tariq, Abdul Ahad / Finucane, Melissa L

    A Robust Decision Making Demonstration for EPA's National Water Program

    2015  

    Keywords History of the Americas ; Complex analysis, complex variables ; Environmental policy & protocols ; Meteorology & climatology ; Political Science ; History ; Mathematics ; Physics
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030612295
    ISBN 9780833090669 ; 0833090666
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article ; Online: The yeast guanine nucleotide exchange factor Sec7 is a bottleneck in spatial protein quality control and detoxifies neurological disease proteins.

    Babazadeh, Roja / Schneider, Kara L / Fischbach, Arthur / Hao, Xinxin / Liu, Beidong / Nystrom, Thomas

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 14068

    Abstract: ER-to-Golgi trafficking partakes in the sorting of misfolded cytoplasmic proteins to reduce their cytological toxicity. We show here that yeast Sec7, a protein involved in proliferation of the Golgi, is part of this pathway and participates in an Hsp70- ... ...

    Abstract ER-to-Golgi trafficking partakes in the sorting of misfolded cytoplasmic proteins to reduce their cytological toxicity. We show here that yeast Sec7, a protein involved in proliferation of the Golgi, is part of this pathway and participates in an Hsp70-dependent formation of insoluble protein deposits (IPOD). Sec7 associates with the disaggregase Hsp104 during a mild heat shock and increases the rate of Hsp104 diffusion in an Hsp70-dependent manner when overproduced. Sec7 overproduction increased formation of IPODs from smaller aggregates and mitigated the toxicity of Huntingtin exon-1 upon heat stress while Sec7 depletion increased sensitivity to aẞ42 of the Alzheimer's disease and α-synuclein of the Parkinson's disease, suggesting a role of Sec7 in mitigating proteotoxicity.
    MeSH term(s) Humans ; Saccharomyces cerevisiae/genetics ; Yeast, Dried ; Nervous System Diseases ; Parkinson Disease ; Alzheimer Disease ; HSP70 Heat-Shock Proteins/genetics
    Chemical Substances HSP70 Heat-Shock Proteins
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-41188-0
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