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  1. Article ; Online: Re: Polymorphisms of the serotonin transporter gene and their relation to premature ejaculation in individuals from Iran. M. R. Safarinejad. J Urol 2009; 181: 2656-2661.

    Waldinger, Marcel D / Janssen, Paddy K C / Schweitzer, Dave H

    The Journal of urology

    2009  Volume 182, Issue 6, Page(s) 2983; author reply 2983–4

    MeSH term(s) Ejaculation ; Humans ; Iran ; Male ; Polymorphism, Genetic ; Serotonin Plasma Membrane Transport Proteins/genetics ; Sexual Dysfunction, Physiological/genetics
    Chemical Substances Serotonin Plasma Membrane Transport Proteins
    Language English
    Publishing date 2009-12
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1016/j.juro.2009.08.069
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Three-Dimensional Transmission Electron Microscopic Observations of Mesopores in Dealuminated Zeolite Y Supported by NWO under grant 98037. The research of A.J.K. has been made possible by a fellowship of the Royal Netherlands Academy of Arts and Sciences (KNAW). The authors thank J. E. M. J. Raaymakers for the nitrogen physisorption measurements, A. J. M. Mens for the XPS measurements, J. A. R. van Veen and E. J. Creyghton for physical data and useful discussions, and Shell International Chemicals and Zeolyst for the samples.

    Janssen, Andries H. / Koster, Abraham J. / de Jong, Krijn P.

    Angewandte Chemie (International ed. in English)

    2001  Volume 40, Issue 6, Page(s) 1102–1104

    Language English
    Publishing date 2001-03-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
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  3. Article ; Online: Development of an adverse outcome pathway network for nephrotoxicity.

    Barnes, D A / Firman, J W / Belfield, S J / Cronin, M T D / Vinken, M / Janssen, M J / Masereeuw, R

    Archives of toxicology

    2024  Volume 98, Issue 3, Page(s) 929–942

    Abstract: Adverse outcome pathways (AOPs) were introduced in modern toxicology to provide evidence-based representations of the events and processes involved in the progression of toxicological effects across varying levels of the biological organisation to better ...

    Abstract Adverse outcome pathways (AOPs) were introduced in modern toxicology to provide evidence-based representations of the events and processes involved in the progression of toxicological effects across varying levels of the biological organisation to better facilitate the safety assessment of chemicals. AOPs offer an opportunity to address knowledge gaps and help to identify novel therapeutic targets. They also aid in the selection and development of existing and new in vitro and in silico test methods for hazard identification and risk assessment of chemical compounds. However, many toxicological processes are too intricate to be captured in a single, linear AOP. As a result, AOP networks have been developed to aid in the comprehension and placement of associated events underlying the emergence of related forms of toxicity-where complex exposure scenarios and interactions may influence the ultimate adverse outcome. This study utilised established criteria to develop an AOP network that connects thirteen individual AOPs associated with nephrotoxicity (as sourced from the AOP-Wiki) to identify several key events (KEs) linked to various adverse outcomes, including kidney failure and chronic kidney disease. Analysis of the modelled AOP network and its topological features determined mitochondrial dysfunction, oxidative stress, and tubular necrosis to be the most connected and central KEs. These KEs can provide a logical foundation for guiding the selection and creation of in vitro assays and in silico tools to substitute for animal-based in vivo experiments in the prediction and assessment of chemical-induced nephrotoxicity in human health.
    MeSH term(s) Animals ; Humans ; Adverse Outcome Pathways ; Risk Assessment/methods ; Animal Experimentation ; Drug-Related Side Effects and Adverse Reactions ; Renal Insufficiency
    Language English
    Publishing date 2024-01-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124992-7
    ISSN 1432-0738 ; 0340-5761
    ISSN (online) 1432-0738
    ISSN 0340-5761
    DOI 10.1007/s00204-023-03637-7
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  4. Article ; Online: Exploration of eye movement desensitization and reprocessing in treating posttraumatic stress-disorder in patients with acquired brain injury: a retrospective case series.

    Janssen, E P J / Spauwen, P J J / Rijnen, S J M / Ponds, R W H M

    European journal of psychotraumatology

    2023  Volume 14, Issue 2, Page(s) 2264117

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adult ; Male ; Humans ; Middle Aged ; Female ; Stress Disorders, Post-Traumatic/therapy ; Stress Disorders, Post-Traumatic/psychology ; Eye Movement Desensitization Reprocessing/methods ; Eye Movements ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2586642-4
    ISSN 2000-8066 ; 2000-8066
    ISSN (online) 2000-8066
    ISSN 2000-8066
    DOI 10.1080/20008066.2023.2264117
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  5. Article ; Online: What do Germans really think about health-nudges?

    Krisam, Mathias / Maier, Mona / Janßen, Rebecca / Krisam, Johannes

    BMC public health

    2021  Volume 21, Issue 1, Page(s) 821

    Abstract: Background: In recent years, policymakers have increasingly used behaviourally informed policies, including 'nudges'. They have been implemented to produce desirable social outcomes such as healthier eating and physical activity. In Germany, a small ... ...

    Abstract Background: In recent years, policymakers have increasingly used behaviourally informed policies, including 'nudges'. They have been implemented to produce desirable social outcomes such as healthier eating and physical activity. In Germany, a small research team at the Federal Chancellery acts as the central unit to promote the introduction of nudges in the design of public life. Despite this, the nudging concept itself as well as the understanding around it has not spread widely among German citizens. When reporting about the concept, German media is often very critical of the concept.
    Methods: Using a for age, sex and educational level nationally representative online survey with 1000 participants, we investigate whether German citizens know about the concept of nudging. We also explore if they approve of the theoretical concept as well as a list of seven specific interventions regarding healthy eating and physical activity. A particular focus is placed on whether the level of approval is dependent on the target group of the intervention, as well as different intervention-initiators.
    Results: We find that nearly 80% of the respondents have never heard of nudging. However when being provided with a definition, we find that a strong majority (90%) supports the concept of nudging as well as all the specific interventions. Acceptance rates are higher if interventions are targeted at the general population compared to only children. All initiators - statutory health insurers, the government, private companies, and independent experts - are accepted as nudge initiators.
    Conclusion: Amongst Germans nudges are an accepted method to promote health behaviours. Policy makers from various fields in Germany should take that into account to improve future health policy.
    MeSH term(s) Child ; Diet, Healthy ; Exercise ; Germany ; Health Policy ; Humans ; Surveys and Questionnaires
    Language English
    Publishing date 2021-04-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2458
    ISSN (online) 1471-2458
    DOI 10.1186/s12889-021-10808-7
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  6. Article ; Online: Health care reform and financial crisis in the Netherlands: consequences for the financial arena of health care organizations.

    van Dijk, T S / van der Scheer, W K / Felder, M / Janssen, R T J M

    Health economics, policy, and law

    2023  Volume 18, Issue 3, Page(s) 305–320

    Abstract: Over the past decade, many health care systems across the Global North have implemented elements of market mechanisms while also dealing with the consequences of the financial crisis. Although effects of these two developments have been researched ... ...

    Abstract Over the past decade, many health care systems across the Global North have implemented elements of market mechanisms while also dealing with the consequences of the financial crisis. Although effects of these two developments have been researched separately, their combined impact on the governance of health care organizations has received less attention. The aim of this study is to understand how health care reforms and the financial crisis together shaped new roles and interactions within health care. The Netherlands - where dynamics between health care organizations and their financial stakeholders (i.e., banks and health insurers) were particularly impacted - provides an illustrative case. Through semi-structured interviews, additional document analysis and insights from institutional change theory, we show how banks intensified relationship management, increased demands on loan applications and shifted financial risks onto health care organizations, while health insurers tightened up their monitoring and accountability practices towards health care organizations. In return, health care organizations were urged to rearrange their operations and become more risk-minded. They became increasingly dependent on banks and health insurers for their existence. Moreover, with this study, we show how institutional arenas come about through both the long-term efforts of institutional agents and unpredictable implications of economic and societal crises.
    MeSH term(s) Humans ; Health Care Reform ; Netherlands ; Delivery of Health Care ; Organizations
    Language English
    Publishing date 2023-05-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2214936-3
    ISSN 1744-134X ; 1744-1331
    ISSN (online) 1744-134X
    ISSN 1744-1331
    DOI 10.1017/S1744133123000075
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  7. Article: Mid-term survival of the Optimys short stem: A prospective case series of 500 patients.

    Hamans, Bryan / de Waard, Sheryl / Kaarsemaker, Sjoerd / Janssen, Esther R C / Sierevelt, Inger N / Kerkhoffs, Gino M M J / Haverkamp, Daniël

    World journal of orthopedics

    2024  Volume 15, Issue 3, Page(s) 257–265

    Abstract: Background: In recent years, there has been an increase in the number of total hip arthroplasty procedures in the younger patient population. This active group has higher expectations of their prosthesis in comparison to the older population, and there ... ...

    Abstract Background: In recent years, there has been an increase in the number of total hip arthroplasty procedures in the younger patient population. This active group has higher expectations of their prosthesis in comparison to the older population, and there is a greater physical demand for the prosthesis. Short femoral stems were introduced to retain proximal bone stock and joint biomechanics and became more common to implant in this specific population. Currently, the long-term survival and functional outcomes of various short stems are still being investigated in different clinics.
    Aim: To determine the 5-year survival of the Optimys hip stem.
    Methods: This was a prospective multicenter cohort study of 500 patients conducted in two hospitals in the Netherlands. All patients received the Optimys short stem (Mathys Ltd, Bettlach, Switzerland). The primary outcome measure was survival of the hip stem, with revision as the endpoint. The secondary outcome measurements included patient-reported outcome measures (PROMs). Kaplan-Meier analysis was used to calculate the 5-year survival rate. Log-minus-log transformation was performed to calculate the 95% confidence interval (95%CI). Mixed model analyses were performed to assess the course of the PROMs during the 1
    Results: The mean age of the total 500 patients was 62.3 years (standard deviation: 10.6) and 202 were male (40%). At a median follow-up of 5.5 years (interquartile range: 4.5-6.7), 7 patients were deceased and 6 revisions were registered, for infection (
    Conclusion: The Optimys stem has a 5-year survival of 98.8%. Patient-reported outcome measures increased significantly in the 1
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649712-8
    ISSN 2218-5836
    ISSN 2218-5836
    DOI 10.5312/wjo.v15.i3.257
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  8. Article ; Online: Reply to: Hypoxia treatment of Parkinson's disease may disrupt the circadian system.

    Janssen Daalen, Jules M / Meinders, Marjan J / Straatsma, Isabel R / Ainslie, Philip N / Thijssen, Dick H J / Bloem, Bastiaan R

    BMC neurology

    2023  Volume 23, Issue 1, Page(s) 235

    MeSH term(s) Humans ; Parkinson Disease ; Circadian Rhythm ; Hypoxia
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-023-03281-9
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  9. Article ; Online: Isolating mononuclear cells from fetal bone and liver for metabolic, functional, and immunophenotypic analyses in nonhuman primates.

    Nash, Michael J / Dobrinskikh, Evgenia / Wang, Dong / Pietras, Eric M / Janssen, Rachel C / Friedman, Jacob E / Wesolowski, Stephanie R

    STAR protocols

    2024  Volume 5, Issue 1, Page(s) 102849

    Abstract: Studying fetal hematopoiesis is challenging as hematopoiesis transitions from the liver to bone marrow. Obtaining human samples is not possible, and small animal models may not provide sufficient biological material. Here, we present a protocol for ... ...

    Abstract Studying fetal hematopoiesis is challenging as hematopoiesis transitions from the liver to bone marrow. Obtaining human samples is not possible, and small animal models may not provide sufficient biological material. Here, we present a protocol for isolating hematopoietic cells from the nonhuman primate fetal liver and bone. We describe steps for using cells from the same fetus for fluorescence lifetime imaging microscopy to measure metabolism, assessing cellular function, and flow cytometry for immunophenotyping at the single-cell level. For complete details on the use and execution of this protocol, please refer to Nash et al. (2023).
    MeSH term(s) Animals ; Humans ; Immunophenotyping ; Liver ; Leukocytes ; Fetus ; Primates
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2024.102849
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  10. Article ; Online: Baseline dependent minimally important differences for clinical outcomes of pulmonary rehabilitation in people with COPD.

    Jenkins, A R / Groenen, M T J / Vaes, A W / Janssen, D J A / Wouters, E F M / Franssen, F M E / Spruit, M A

    Pulmonology

    2023  Volume 30, Issue 1, Page(s) 24–33

    Abstract: ... Activity=7.1 points, Impact=8.1 points) and FFMI were produced (0.36kg/m: Discussion: Findings suggest ...

    Abstract Introduction: Minimally important differences (MIDs) for common outcomes of pulmonary rehabilitation are well documented for people with chronic obstructive pulmonary disease (COPD). It is not known whether MIDs differ based on COPD disease characteristics. This study aimed to estimate MIDs for clinical outcomes of pulmonary rehabilitation dependent upon baseline characteristics.
    Methods: A database containing 2791 people with COPD was split into derivation (n=2245; age 66±9 years; 50% males; FEV
    Results: MID estimates were comparable to previously reported values. MIDs for SGRQ domains (Symptom=8.7 points, Activity=7.1 points, Impact=8.1 points) and FFMI were produced (0.36kg/m
    Discussion: Findings suggest that baseline presentation should be considered for people with COPD when assessing the efficacy of pulmonary rehabilitation. However, clinical significance of the variation underpinning MIDs is yet to be determined.
    MeSH term(s) Male ; Humans ; Middle Aged ; Aged ; Female ; Pulmonary Disease, Chronic Obstructive ; Surveys and Questionnaires ; Respiratory Function Tests ; Walk Test
    Language English
    Publishing date 2023-07-16
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2023.06.004
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