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  1. Article: Complete Genome Sequence Analysis of

    Sánchez-Hidalgo, Marina / García, María Jesús / González, Ignacio / Oves-Costales, Daniel / Genilloud, Olga

    Microorganisms

    2023  Volume 11, Issue 2

    Abstract: Minor genera actinomycetes are considered a promising source of new secondary metabolites. The ... ...

    Abstract Minor genera actinomycetes are considered a promising source of new secondary metabolites. The strain
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11020265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Identification and Heterologous Expression of the Biosynthetic Gene Cluster Encoding the Lasso Peptide Humidimycin, a Caspofungin Activity Potentiator.

    Sánchez-Hidalgo, Marina / Martín, Jesús / Genilloud, Olga

    Antibiotics (Basel, Switzerland)

    2020  Volume 9, Issue 2

    Abstract: Humidimycin (MDN-0010) is a ribosomally synthesized and post-translationally modified peptide (RiPP) belonging to class I lasso peptides, and is structurally related to siamycins, which have been shown to have strong antimicrobial activities against Gram- ...

    Abstract Humidimycin (MDN-0010) is a ribosomally synthesized and post-translationally modified peptide (RiPP) belonging to class I lasso peptides, and is structurally related to siamycins, which have been shown to have strong antimicrobial activities against Gram-positive bacteria and to possess anti-HIV activity. Humidimycin was isolated from the strain
    Language English
    Publishing date 2020-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics9020067
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  3. Article ; Online: Mechanistic Studies on Dehydration in Class V Lanthipeptides.

    Liang, Haoqian / Lopez, Isaiah J / Sánchez-Hidalgo, Marina / Genilloud, Olga / van der Donk, Wilfred A

    ACS chemical biology

    2022  Volume 17, Issue 9, Page(s) 2519–2527

    Abstract: Lanthipeptides are ribosomally synthesized and post-translationally modified peptides characterized by lanthionine (Lan) and/or methyllanthionine (MeLan) residues. Four classes of enzymes have been identified to install these structures in a substrate ... ...

    Abstract Lanthipeptides are ribosomally synthesized and post-translationally modified peptides characterized by lanthionine (Lan) and/or methyllanthionine (MeLan) residues. Four classes of enzymes have been identified to install these structures in a substrate peptide. Recently, a novel class of lanthipeptides was discovered that lack genes for known class I-IV lanthionine synthases in their biosynthetic gene cluster (BGC). In this study, the dehydration of Ser/Thr during the biosynthesis of the class V lanthipeptide cacaoidin was reconstituted
    MeSH term(s) Alanine/analogs & derivatives ; Bacteriocins/metabolism ; Dehydration ; Kanamycin Kinase/metabolism ; Ligases/metabolism ; Lyases/metabolism ; Peptides/chemistry ; Phosphates ; Protein Sorting Signals ; Sulfides
    Chemical Substances Bacteriocins ; Peptides ; Phosphates ; Protein Sorting Signals ; Sulfides ; cacaoidin ; Kanamycin Kinase (EC 2.7.1.95) ; Lyases (EC 4.-) ; Ligases (EC 6.-) ; lanthionine (JO78O46X3K) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.2c00458
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  4. Article ; Online: Pseudoacalasia como presentación de un tumor pediátrico.

    Cortés Hernández, Marta / García Hidalgo, Laura / Escobosa Sánchez, Olga / Acha García, Tomás

    Anales de pediatria

    2021  

    Title translation Pseudoachalasia as first manifestation of adenocarcinoma.
    Language Spanish
    Publishing date 2021-07-29
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpedi.2021.04.011
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  5. Article ; Online: Draft Genome Sequence and Biosynthetic Potential of the Newly Described Strain Longimicrobium terrae CB-286315

    Sánchez-Hidalgo, Marina / Pascual, Javier / González, Ignacio / Genilloud, Olga

    Microbiology resource announcements

    2020  Volume 9, Issue 24

    Abstract: Longimicrobium ... ...

    Abstract Longimicrobium terrae
    Language English
    Publishing date 2020-06-11
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00512-20
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  6. Article: Biosynthesis and Heterologous Expression of Cacaoidin, the First Member of the Lanthidin Family of RiPPs.

    Román-Hurtado, Fernando / Sánchez-Hidalgo, Marina / Martín, Jesús / Ortiz-López, Francisco Javier / Genilloud, Olga

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 4

    Abstract: Cacaoidin is produced by the ... ...

    Abstract Cacaoidin is produced by the strain
    Language English
    Publishing date 2021-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10040403
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  7. Article ; Online: Identification, Cloning and Heterologous Expression of the Gene Cluster Directing RES-701-3, -4 Lasso Peptides Biosynthesis from a Marine

    Oves-Costales, Daniel / Sánchez-Hidalgo, Marina / Martín, Jesús / Genilloud, Olga

    Marine drugs

    2020  Volume 18, Issue 5

    Abstract: RES-701-3 and RES-701-4 are two class II lasso peptides originally identified in the fermentation broth ... ...

    Abstract RES-701-3 and RES-701-4 are two class II lasso peptides originally identified in the fermentation broth of
    MeSH term(s) Amino Acid Sequence ; Animals ; Cloning, Molecular ; Gene Expression Regulation ; Molecular Sequence Data ; Peptides, Cyclic/biosynthesis ; Peptides, Cyclic/genetics ; Streptomyces/metabolism
    Chemical Substances Peptides, Cyclic ; RES 701-3 ; RES 701-4
    Language English
    Publishing date 2020-05-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md18050238
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  8. Article ; Online: Total Synthesis and Biosynthesis of Cyclodepsipeptide Cochinmicin I.

    Schnegotzki, Romina / Wiebach, Vincent / Sánchez-Hidalgo, Marina / Tietzmann, Marcel / Zur Bonsen, Andreas B / Genilloud, Olga / Süssmuth, Roderich D

    Organic letters

    2022  Volume 24, Issue 12, Page(s) 2344–2348

    Abstract: Phenylglycines are building blocks of many non-ribosomally synthesized peptides. The dihydroxyphenylglycine-containing cyclodepsipeptide cochinmicin I exhibits endothelin receptor antagonist activity. Therefore, it represents an interesting and ... ...

    Abstract Phenylglycines are building blocks of many non-ribosomally synthesized peptides. The dihydroxyphenylglycine-containing cyclodepsipeptide cochinmicin I exhibits endothelin receptor antagonist activity. Therefore, it represents an interesting and synthetically challenging molecule because of the racemization-prone nature of dihydroxyphenylglycine. We present the total synthesis of cochinmicin I and the non-natural derivative cochinmicin VI and describe the identification and assignment of the cochinmicin (
    MeSH term(s) Depsipeptides ; Multigene Family ; Peptides, Cyclic
    Chemical Substances Depsipeptides ; Peptides, Cyclic ; cochinmicin I (143728-97-6)
    Language English
    Publishing date 2022-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c00525
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  9. Article ; Online: Metaanalysis of the epidemiology and clinical manifestations of odontomas.

    Hidalgo-Sánchez, Olga / Leco-Berrocal, Ma Isabel / Martínez-González, José Ma

    Medicina oral, patologia oral y cirugia bucal

    2008  Volume 13, Issue 11, Page(s) E730–4

    Abstract: Objective: To evaluate the epidemiological and clinical aspects of the different types of odontomas.: Study design: A metaanalysis was made of 3065 odontomas obtained from a literature review of 30 articles published in recent years.: Results: ... ...

    Abstract Objective: To evaluate the epidemiological and clinical aspects of the different types of odontomas.
    Study design: A metaanalysis was made of 3065 odontomas obtained from a literature review of 30 articles published in recent years.
    Results: Odontomas show no gender predilection, and are most often diagnosed in the second decade of life. They are preferentially located in the upper maxilla, particularly in the anterior sector. Compound odontomas are more prevalent than complex odontoma, and show no predilection in terms of patient gender, age or location. Most such lesions are asymptomatic and constitute casual findings in X-ray studies indicated for other reasons. The most common clinical manifestations are the retention of permanent teeth and the presence of a tumor. Treatment consists of surgical removal of the lesion. The prognosis is very good, with a scant tendency towards relapse.
    Conclusions: Odontomas are the most common odontogenic tumors. Their most significant characteristics comprise alterations in tooth eruption, and the diagnosis is casually established in the course of routine X-ray studies.
    MeSH term(s) Adolescent ; Female ; Humans ; Jaw Neoplasms/diagnosis ; Jaw Neoplasms/epidemiology ; Male ; Odontoma/diagnosis ; Odontoma/epidemiology
    Language English
    Publishing date 2008-11-01
    Publishing country Spain
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 2171573-7
    ISSN 1698-6946 ; 1698-4447
    ISSN (online) 1698-6946
    ISSN 1698-4447
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  10. Article: One Pathway, Two Cyclic Non-Ribosomal Pentapeptides: Heterologous Expression of BE-18257 Antibiotics and Pentaminomycins from

    Román-Hurtado, Fernando / Sánchez-Hidalgo, Marina / Martín, Jesús / Ortiz-López, Francisco Javier / Carretero-Molina, Daniel / Reyes, Fernando / Genilloud, Olga

    Microorganisms

    2021  Volume 9, Issue 1

    Abstract: ... The ... ...

    Abstract The strain
    Language English
    Publishing date 2021-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9010135
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