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Article: Shu Fu Pai

Chen, Gao / Li, Qian / Chen, Junli / Huang, Fei / Qin, Chunjun / He, Xianya

American journal of translational research

2023 Volume 15, Issue 9, Page(s) 5723–5729

Abstract: Objective: To investigate the clinical efficacy of Shu Fu Pai: Methods: A retrospective ... People's Hospital between April 2021 and April 2023. Among them, 148 patients treated with Shu Fu Pai ... regimen was not an influencing factor.: Conclusion: Shu Fu Pai ...

Abstract	Objective: To investigate the clinical efficacy of Shu Fu Pai Methods: A retrospective analysis was conducted on 289 patients with liver cirrhosis and hypoalbuminemia who were admitted to Deyang People's Hospital between April 2021 and April 2023. Among them, 148 patients treated with Shu Fu Pai Results: After treatment, there was a significant improvement in liver function, serum albumin level, Child-Pugh score, inflammatory markers, and coagulation function in both groups (all P=0.001). However, no significant difference was found in the peripheral blood indicators between the two groups (P>0.05). Also, there was no significant difference in complications between the two groups (P=0.194). Logistic regression analysis showed that age, pre-treatment serum albumin level, disease type, and abnormal liver function markers were independent factors affecting the treatment outcome of hypoalbuminemia, and treatment regimen was not an influencing factor. Conclusion: Shu Fu Pai
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Very natural cancer chemoprevention: A research profile of Li-Shu Wang.

Wang, Li-Shu

Food frontiers

2020 Volume 1, Issue 3, Page(s) 350–351

Language	English
Publishing date	2020-08-19
Publishing country	United States
Document type	Journal Article
ISSN	2643-8429
ISSN (online)	2643-8429
DOI	10.1002/fft2.35
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Article ; Online: Obstructive sleep-disordered breathing and orthodontics. An interview with Christian Guilleminault, Michèle Hervy-Auboiron, Yu-Shu Huang and Kasey Li

Guilleminault, Christian / Hervy-Auboiron, Michèle / Huang, Yu-Shu / Li, Kasey / Amat, Philippe

L' Orthodontie francaise

2023 Volume 93, Issue Suppl 1, Page(s) 5–33

Title translation	Obstructive sleep-disordered breathing and orthodontics. An interview with Christian Guilleminault, Michèle Hervy-Auboiron, Yu-Shu Huang and Kasey Li.
MeSH term(s)	Humans ; Orthodontics ; Sleep Apnea, Obstructive/therapy ; Ethnicity ; Dental Care
Language	English
Publishing date	2023-01-26
Publishing country	France
Document type	Interview
ZDB-ID	417383-1
ISSN	1954-3395 ; 0078-6608 ; 1966-5202
ISSN (online)	1954-3395
ISSN	0078-6608 ; 1966-5202
DOI	10.1684/orthodfr.2022.96
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Article ; Online: Non-targeted metabolomics strategy reveals the role of Geng-Nian-Shu in regulating ferroptosis in perimenopausal syndrome.

Lv, Xinyan / Bi, Anqi / Zhang, Zhan / Li, Jinyan / Wei, Yingbo / Wan, Meiqi / Wang, Jinyu / Yan, Tingxu / Jia, Ying

Journal of pharmaceutical and biomedical analysis

2024 Volume 241, Page(s) 115980

Abstract: ... have shown that Geng-Nian-Shu (GNS) plays an important regulatory role in perimenopausal syndrome (PMS ...

Abstract	Ovariectomy (OVX) is usually accompanied by the occurrence of metabolic syndrome. Previous studies have shown that Geng-Nian-Shu (GNS) plays an important regulatory role in perimenopausal syndrome (PMS) rats. GNS is a traditional Chinese medicine (TCM) prescription which composed of Suanzaoren Decoction and Ganmai Dazao Decoction in "Jingui Yaolue" and Siwu Decoction in "Heji Jufang". Recently, metabolomics analysis has been used to identify slight changes in the metabolic profile and to help understand disease progression and therapeutic interventions in PMS. However, the mechanism of GNS in the treatment of PMS is still unknown. We purposed to study the metabolic characteristics of PMS by serum and fecal metabolomics, and revealed the internal mechanism of GNS regulating ferroptosis against PMS. The PMS model was established by surgical removal of 4/5 ovaries of rats. HPLC-Q-TOF/MS was used to analyze the metabolomics of rat plasma and feces to explore the potential mechanism of GNS in PMS. The expression of ferroptosis-related proteins in rat ovaries was detected by tissue Prussian blue staining, Elisa kit and Western blotting. Cluster analysis of differential metabolites in plasma and feces between the control group and the model group showed that organic acids and their derivatives, lipids and lipid molecules were mainly disturbed during PMS in rats. After GNS administration, 17 differential metabolites were adjusted, involving several major pathways, such as the tricarboxylic acid (TCA) cycle, biosynthesis of amino acids and biosynthesis of unsaturated fatty acids. Further, we found that GNS affected ferroptosis in ovarian cells by regulating endogenous substances in OVX rats. Our study provides new insights into the mechanism of OVX-induced metabolic syndrome based on non-targeted metabolomics. It provides new ideas for the development and application of GNS and the diagnosis and treatment of PMS.
MeSH term(s)	Female ; Rats ; Animals ; Metabolic Syndrome ; Ferroptosis ; Perimenopause ; Metabolomics ; Metabolome ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2024.115980
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Article ; Online: Efficacy of Shu-yi-ning-chang decoction on IBS-D: Modulating Nr4a3 pathway to reduce visceral hypersensitivity.

Guo, Yajing / Lu, Qiongqiong / Yang, Xiao-Jun / He, Yuxi / Wu, Yue / Qin, Baijun / Li, Ting / Duan, Min / Liu, Nvping / Wu, Xin / He, Yuanjun

PloS one

2024 Volume 19, Issue 4, Page(s) e0299376

Abstract: Aim of the study: To evaluate the therapeutic effect of SYNC in diarrhea irritable bowel syndrome (IBS-D) and explore its underlying mechanism through transcriptomic sequencing (RNA-Seq).: Materials and methods: A rat model of IBS-D was constructed ... ...

Abstract	Aim of the study: To evaluate the therapeutic effect of SYNC in diarrhea irritable bowel syndrome (IBS-D) and explore its underlying mechanism through transcriptomic sequencing (RNA-Seq). Materials and methods: A rat model of IBS-D was constructed to elucidate the effects of SYNC. Abdominal withdrawal reflex (AWR), fecal water content (FWC), and recording body weight were calculated to assess visceral sensitivity in rats. Histopathological changes in the colon and alterations in mast cell (MC) count were determined. Immunohistochemistry was employed to assess mast cell tryptase (MCT) expression in rat colons. Serum levels of corticotropin-releasing Hormone (CRH), interleukin-6 (IL-6), calcitonin gene-related peptide (CGRP), and 5-hydroxytryptamine (5-HT) were quantified using ELISA. RNA-Seq of colon tissue was performed, followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Western blot analysis was conducted to quantify the expression levels of key proteins in the Nr4a3 pathway in the colon and hypothalamus tissues of rats. Results: SYNC alleviated visceral hypersensitivity and mood disorders in rats with IBS-D. Moreover, it was positively correlated with its dosage and the observed effects, such as the enhancement of the colon's mucosal lining condition and reduction in the number and activation of MCs within the model group. SYNC reduced the expression levels of factors related to the brain-gut axis and inflammatory markers in the bloodstream. RNA-Seq analysis indicated that SYNC down-regulated the expression of Nr4a3 and PI3K. These SYNC-targeted genes primarily played roles in immune regulation and inflammatory responses, correlating with the modulation of Nr4a3 and the PI3K/AKT pathway. Western blot analysis further confirmed SYNC's influence on inflammation-related MC activation by downregulating key proteins in the Nr4a3/PI3K pathway. Conclusions: SYNC inhibited mast cell activation and attenuated visceral hypersensitivity in the colon tissues of IBS-D rats. These effects were mediated by the Nr4a3/PI3K signaling pathway.
MeSH term(s)	Rats ; Animals ; Irritable Bowel Syndrome/pathology ; Rats, Sprague-Dawley ; Phosphatidylinositol 3-Kinases ; Diarrhea ; Corticotropin-Releasing Hormone/metabolism ; DNA-Binding Proteins ; Nerve Tissue Proteins
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Corticotropin-Releasing Hormone (9015-71-8) ; Nr4a3 protein, rat ; DNA-Binding Proteins ; Nerve Tissue Proteins
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299376
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Article ; Online: Erratum for Shu et al., "Transcriptomic-Guided Phosphonate Utilization Analysis Unveils Evidence of Clathrin-Mediated Endocytosis and Phospholipid Synthesis in the Model Diatom, Phaeodactylum tricornutum".

Shu, Huilin / You, Yanchun / Wang, Hongwei / Wang, Jingtian / Li, Ling / Ma, Jian / Lin, Xin

mSystems

2023 Volume 8, Issue 1, Page(s) e0129422

Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Journal Article ; Published Erratum
ISSN	2379-5077
ISSN (online)	2379-5077
DOI	10.1128/msystems.01294-22
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Article ; Online: Troubles respiratoires obstructifs du sommeil et orthodontie. Un entretien avec Christian Guilleminault, Michèle Hervy-Auboiron, Yu-Shu Huang et Kasey Li.

Guilleminault, Christian / Hervy-Auboiron, Michèle / Huang, Yu-Shu / Li, Kasey / Amat, Philippe

L' Orthodontie francaise

2021 Volume 90, Issue 3-4, Page(s) 215–245

Title translation	Obstructive sleep-disordered breathing and orthodontics. An interview with Christian Guilleminault, Michèle Hervy-Auboiron, Yu-Shu Huang and Kasey Li.
Language	French
Publishing date	2021-10-13
Publishing country	France
Document type	Journal Article
ZDB-ID	417383-1
ISSN	1954-3395 ; 0078-6608 ; 1966-5202
ISSN (online)	1954-3395
ISSN	0078-6608 ; 1966-5202
DOI	10.1051/orthodfr/2019038
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Article: Acupuncture at Back-Shu point improves insomnia by reducing inflammation and inhibiting the ERK/NF-κB signaling pathway.

Zhang, Ming-Ming / Zhao, Jing-Wei / Li, Zhi-Qiang / Shao, Jing / Gao, Xi-Yan

World journal of psychiatry

2023 Volume 13, Issue 6, Page(s) 340–350

Abstract: ... mechanism of acupuncture at Back-Shu point for the treatment of insomnia.: Methods: We first prepared ... These findings suggest that acupuncture at Back-Shu point can inhibit the ERK/NF-κB signaling pathway and treat ...

Abstract	Background: Insomnia is a disease where individuals cannot maintain a steady and stable sleep state or fail to fall asleep. Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia, and long-term use is prone to drug resistance and other adverse reactions. Acupuncture has a good curative effect and unique advantages in the treatment of insomnia. Aim: To explore the molecular mechanism of acupuncture at Back-Shu point for the treatment of insomnia. Methods: We first prepared a rat model of insomnia, and then carried out acupuncture for 7 consecutive days. After treatment, the sleep time and general behavior of the rats were determined. The Morris water maze test was used to assess the learning ability and spatial memory ability of the rats. The expression levels of inflammatory cytokines in serum and the hippocampus were detected by ELISA. qRT-PCR was used to detect the mRNA expression changes in the ERK/NF-κB signaling pathway. Western blot and immunohistochemistry were carried out to evaluate the protein expression levels of RAF-1, MEK-2, ERK1/2 and NF-κB. Results: Acupuncture can prolong sleep duration, and improve mental state, activity, diet volume, learning ability and spatial memory. In addition, acupuncture increased the release of 1L-1β, 1L-6 and TNF-α in serum and the hippocampus and inhibited the mRNA and protein expression of the ERK/NF-κB signaling pathway. Conclusion: These findings suggest that acupuncture at Back-Shu point can inhibit the ERK/NF-κB signaling pathway and treat insomnia by increasing the release of inflammatory cytokines in the hippo-campus.
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Journal Article
ISSN	2220-3206
ISSN	2220-3206
DOI	10.5498/wjp.v13.i6.340
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Article ; Online: A Lifetime Achievement in Bioengineering: Professor Shu Chien.

Weinbaum, Sheldon / Li, Yi-Shuan Julie / Schmid-Schönbein, Geert W

Annals of biomedical engineering

2019 Volume 47, Issue 11, Page(s) 2147–2150

MeSH term(s)	Bioengineering/history ; Hemodynamics ; History, 20th Century ; History, 21st Century ; Mechanotransduction, Cellular ; Rheology
Language	English
Publishing date	2019-10-24
Publishing country	United States
Document type	Biography ; Editorial ; Historical Article ; Portrait
ZDB-ID	185984-5
ISSN	1573-9686 ; 0191-5649 ; 0090-6964
ISSN (online)	1573-9686
ISSN	0191-5649 ; 0090-6964
DOI	10.1007/s10439-019-02390-2
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Article ; Online: The Herbal Combination Shu Gan Jie Yu Regulates the SNCG/ER-a/AKT-ERK Pathway in DMBA-Induced Breast Cancer and Breast Cancer Cell Lines Based on RNA-Seq and IPA Analysis.

Zhao, Yi / Zhao, Linan / Wang, Tao / Liu, Zhenghao / Tang, Suyuan / Huang, Hongxia / Wu, Li / Sun, Youzhi

Integrative cancer therapies

2024 Volume 23, Page(s) 15347354241233258

Abstract: Background: Soothing the liver (called : The aim of the study: To investigate the inhibiting effect of SGJY on breast cancer in vivo and vitro, and to explore the potential mechanisms.: Materials and methods: SGJY herbal combination was extracted ... ...

Abstract	Background: Soothing the liver (called The aim of the study: To investigate the inhibiting effect of SGJY on breast cancer in vivo and vitro, and to explore the potential mechanisms. Materials and methods: SGJY herbal combination was extracted using water. A breast cancer rat model was developed by chemical DMBA by gavage, then treated with SGJY for 11 weeks. The tumor tissue was preserved for RNA sequencing and analyzed by IPA software. The inhibition effects of SGJY on MCF-7 and T47D breast cancer cells were investigated by SRB assay and cell apoptosis analysis, and the protein expression levels of SNCG, ER-α, Results: SGJY significantly reduced the tumor weight and volume, and the level of estradiol in serum. The results of IPA analysis reveal SGJY upregulated 7 canonical pathways and downregulated 16 canonical pathways. Estrogen receptor signaling was the key canonical pathway with 9 genes downregulated. The results of upstream regulator analysis reveal beta-estradiol was the central target; the upstream regulator network scheme showed that 86 genes could affect the expression of the beta-estradiol, including SNCG, CCL21 and MB. Additionally, SGJY was verified to significantly alter the expression of SNCG mRNA, CCL21 mRNA and MB mRNA which was consistent with the data of RNA-Seq. The inhibition effects of SGJY exhibited a dose-dependent response. The apoptosis rates of MCF7 and T47D cells were upregulated. The protein expression of SNCG, ER-α, Conclusion: The results demonstrate that SGJY may inhibit the growth of breast cancer. The mechanism might involve downregulating the level of serum estradiol, and suppressing the protein expression in the SNCG/ER-α/AKT-ERK pathway.
MeSH term(s)	Animals ; Female ; Humans ; Rats ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Estradiol ; gamma-Synuclein/genetics ; gamma-Synuclein/metabolism ; MAP Kinase Signaling System ; MCF-7 Cells ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Estrogen/metabolism ; RNA, Messenger/metabolism ; RNA-Seq
Chemical Substances	Estradiol (4TI98Z838E) ; gamma-Synuclein ; Neoplasm Proteins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Receptors, Estrogen ; RNA, Messenger ; SNCG protein, human
Language	English
Publishing date	2024-02-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2182320-0
ISSN	1552-695X ; 1534-7354
ISSN (online)	1552-695X
ISSN	1534-7354
DOI	10.1177/15347354241233258
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