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Article ; Online: Left ventricle patch 'on fire' revealing mycotic endocarditis.

Mangia, Mario / Cecchetto, Antonella / Romano, Silvia / Palermo, Chiara / Mele, Donato

European heart journal. Cardiovascular Imaging

2023 Volume 25, Issue 4, Page(s) e139

MeSH term(s)	Humans ; Heart Ventricles ; Endocarditis ; Endocarditis, Bacterial ; Heart Valve Diseases ; Aneurysm, Infected
Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jead297
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Article ; Online: Alternating Look-Locker for quantitative T

Wu, Lin / Carchi, Chris / Michaeli, Shalom / Mangia, Silvia / Idiyatullin, Djaudat

Magnetic resonance in medicine

2023 Volume 91, Issue 1, Page(s) 149–161

Abstract: Purpose: To develop a new MRI method, entitled alternating Look-Locker (aLL), for quantitative : Methods: A Look-Locker scheme that alternates magnetization from +Z and -Z axes of the laboratory frame is utilized in combination with a 3D Multi-Band ... ...

Abstract	Purpose: To develop a new MRI method, entitled alternating Look-Locker (aLL), for quantitative Methods: A Look-Locker scheme that alternates magnetization from +Z and -Z axes of the laboratory frame is utilized in combination with a 3D Multi-Band Sweep Imaging with Fourier Transformation (MB-SWIFT) readout. The analytical solution describing the spin evolution during aLL, as well as the correction required for segmented acquisition were derived. The simultaneous Results: The accuracy and precision of the analytical solution was tested by Bloch simulations. With the application of MP modules, the aLL method provides simultaneous Conclusion: The proposed method offers a new flexible tool for quantitative mapping of
MeSH term(s)	Animals ; Rats ; Magnetic Resonance Imaging/methods ; Imaging, Three-Dimensional ; Gadolinium DTPA ; Phantoms, Imaging ; Algorithms ; Reproducibility of Results
Chemical Substances	Gadolinium DTPA (K2I13DR72L)
Language	English
Publishing date	2023-08-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.29839
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Article ; Online: Manipulations of sleep-like slow-wave activity by noninvasive brain stimulation.

DiNuzzo, Mauro / Mangia, Silvia / Giove, Federico

Journal of neuroscience research

2022 Volume 100, Issue 5, Page(s) 1218–1225

Abstract: Sleep is a universal and evolutionarily conserved behavior among many animal species, yet we do not have a fundamental understanding of why animals need to sleep. What we do know, however, is that sleep is critical for behavioral performance during the ... ...

Abstract	Sleep is a universal and evolutionarily conserved behavior among many animal species, yet we do not have a fundamental understanding of why animals need to sleep. What we do know, however, is that sleep is critical for behavioral performance during the waking period and for long-term brain health. Here we provide an overview of some putative mechanisms that mediate the restorative effects of sleep, namely metabolic biosynthesis, fluid perfusion, and synaptic homeostasis. We then review recent experimental findings that advance the possibility of inducing sleep-like slow-wave activity (SWA) during wakefulness or enhance SWA during sleep in a top-down manner using noninvasive brain stimulation. SWA induction and SWA enhancement are believed to recapitulate the beneficial effects of sleep independent of the actual state of the subjects. If confirmed, these observations will change the way in which we investigate the neural correlates of sleep, thus paving the way for comprehending and actively controlling its restorative function.
MeSH term(s)	Animals ; Brain/metabolism ; Electroencephalography ; Homeostasis/physiology ; Humans ; Sleep/physiology ; Wakefulness/physiology
Language	English
Publishing date	2022-02-20
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	195324-2
ISSN	1097-4547 ; 0360-4012
ISSN (online)	1097-4547
ISSN	0360-4012
DOI	10.1002/jnr.25029
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Article: Utility of quantitative MRI metrics in brain ageing research.

Filip, Pavel / Kokošová, Viktória / Valenta, Zdeněk / Baláž, Marek / Mangia, Silvia / Michaeli, Shalom / Vojtíšek, Lubomír

Frontiers in aging neuroscience

2023 Volume 15, Page(s) 1099499

Abstract: The advent of new, advanced quantitative MRI metrics allows ... ...

Abstract	The advent of new, advanced quantitative MRI metrics allows for
Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2023.1099499
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Article ; Online: Fermented Milk Produced with Goat Milk Enriched with PUFA Omega-3 by Supplementation of Diet with Extruded Linseed

Mangia, Nicoletta P. / Carta, Silvia / Murgia, Marco A. / Montanari, Luigi / Nudda, Anna

Fermentation. 2023 May 27, v. 9, no. 6

2023

Abstract: This research aimed to evaluate goat milk rich in Omega-3 PUFA from animals fed extruded flaxseed as a raw material to produce fermented milk using beneficial lactobacilli. Experimental fermented milks were produced using Lacticaseibacillus paracasei ... ...

Abstract	This research aimed to evaluate goat milk rich in Omega-3 PUFA from animals fed extruded flaxseed as a raw material to produce fermented milk using beneficial lactobacilli. Experimental fermented milks were produced using Lacticaseibacillus paracasei Shirota and two potential probiotic lactobacilli, namely Lacticaseibacillus rhamnosus A2 and Lacticaseibacillus paracasei FS109. The fermented milks were produced using milk from goats fed a basal diet without any supplementation (CON) and milk from goats supplemented with 200 g/d of extruded linseed (LIN). All lactobacilli tested grew well both in CON and LIN milk, reaching high numbers during fermentation. The colony count ranged between 8 and 10 Log CFU/mL, despite slow acidification activity, which occurred especially in milk fermented by L. FS109. By contrast, an undesired post-acidification occurred, more pronounced in CON than in LIN milk, which still highlighted the strong acid-tolerance of L. Shirota and L. rhamnosus A2 in particular. This research showed that goat milk enriched in PUFA had no negative effect on the viability of the tested Lactobacilli. Both values of L. Shirota and L. rhamnosus “live cells” throughout the cold storage of the products were higher than those recommended to guarantee the quality of fermented milk products, making them beneficial to consumers’ health.
Keywords	Lactobacillus ; acid tolerance ; acidification ; cold storage ; diet ; fermentation ; fermented milk ; goat milk ; linseed ; milk ; omega-3 fatty acids ; probiotics ; raw materials ; viability
Language	English
Dates of publication	2023-0527
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2813985-9
ISSN	2311-5637
ISSN	2311-5637
DOI	10.3390/fermentation9060522
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Age-related differences in macromolecular resonances observed in ultra-short-TE STEAM MR spectra at 7T.

Genovese, Guglielmo / Terpstra, Melissa / Filip, Pavel / Mangia, Silvia / McCarten, J Riley / Hemmy, Laura S / Marjańska, Małgorzata

Magnetic resonance in medicine

2024 Volume 92, Issue 1, Page(s) 4–14

Abstract: Purpose: To understand how macromolecular content varies in the human brain with age in a large cohort of healthy subjects.: Methods: In-vivo : Results: While weak age-related effects were observed for macromolecular peaks at ˜0.9 (MM09), ˜1.2 ( ... ...

Abstract	Purpose: To understand how macromolecular content varies in the human brain with age in a large cohort of healthy subjects. Methods: In-vivo Results: While weak age-related effects were observed for macromolecular peaks at ˜0.9 (MM09), ˜1.2 (MM12), and ˜1.4 (MM14) ppm, moderate to strong effects were observed for peaks at ˜1.7 (MM17), and ˜2.0 (MM20) ppm. Significantly higher MM17 and MM20 content started from 30 to 40 y of age, while for MM09, MM12, and MM14, significantly higher content started from 60 to 70 y of age. Conclusions: Our findings provide insights into age-related differences in macromolecular contents and strengthen the necessity of using age-matched measured macromolecules during quantification.
MeSH term(s)	Humans ; Aged ; Middle Aged ; Adult ; Male ; Female ; Aged, 80 and over ; Macromolecular Substances/chemistry ; Young Adult ; Aging ; Brain/diagnostic imaging ; Brain/metabolism ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy/methods ; Gyrus Cinguli/diagnostic imaging ; Gyrus Cinguli/chemistry
Chemical Substances	Macromolecular Substances
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.30061
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Article ; Online: Perception is associated with the brain's metabolic response to sensory stimulation.

DiNuzzo, Mauro / Mangia, Silvia / Moraschi, Marta / Mascali, Daniele / Hagberg, Gisela E / Giove, Federico

eLife

2022 Volume 11

Abstract: Processing of incoming sensory stimulation triggers an increase of cerebral perfusion and blood oxygenation (neurovascular response) as well as an alteration of the metabolic neurochemical profile (neurometabolic response). Here, we show in human primary ...

Abstract	Processing of incoming sensory stimulation triggers an increase of cerebral perfusion and blood oxygenation (neurovascular response) as well as an alteration of the metabolic neurochemical profile (neurometabolic response). Here, we show in human primary visual cortex (V1) that perceived and unperceived isoluminant chromatic flickering stimuli designed to have similar neurovascular responses as measured by blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI) have markedly different neurometabolic responses as measured by proton functional magnetic resonance spectroscopy (1H-fMRS). In particular, a significant regional buildup of lactate, an index of aerobic glycolysis, and glutamate, an index of malate-aspartate shuttle, occurred in V1 only when the flickering was perceived, without any relation with other behavioral or physiological variables. Whereas the BOLD-fMRI signal in V1, a proxy for input to V1, was insensitive to flickering perception by design, the BOLD-fMRI signal in secondary visual areas was larger during perceived than unperceived flickering, indicating increased output from V1. These results demonstrate that the upregulation of energy metabolism induced by visual stimulation depends on the type of information processing taking place in V1, and that 1H-fMRS provides unique information about local input/output balance that is not measured by BOLD-fMRI.
MeSH term(s)	Glutamic Acid/metabolism ; Humans ; Magnetic Resonance Imaging/methods ; Perception ; Photic Stimulation/methods ; Visual Cortex/physiology
Chemical Substances	Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2022-02-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.71016
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Article ; Online: Quantitative characterization of walking on sand inecological conditions: Speed, temporal segmentation, and variability.

Pacini Panebianco, Giulia / Bisi, Maria Cristina / Mangia, Anna Lisa / Fantozzi, Silvia / Stagni, Rita

Gait & posture

2021 Volume 86, Page(s) 211–216

Abstract: Background: Walking on compliant surfaces, on sand in particular, is now recommended for training in both elderlies and injured subjects/individuals, allowing to perform high intensity exercises (i.e. augmented energy expenditure) in safe conditions (i ... ...

Abstract	Background: Walking on compliant surfaces, on sand in particular, is now recommended for training in both elderlies and injured subjects/individuals, allowing to perform high intensity exercises (i.e. augmented energy expenditure) in safe conditions (i.e. minimizing the impact on the joints and the risk of fall). Nevertheless, despite the assessment of energetics of walking on sand, the quantitative biomechanical characterization of walking on sand in ecological conditions is largely lacking. Research question: Which is the effect of sand surface on gait speed, gait temporal segmentation and their variability as related to surface compliance in ecological condition? Methods: Eighteen healthy adults were assessed while walking on solid ground, dry-, and wet sand in ecological conditions by means of wearable inertial sensors (Miniwave, Cometa s.r.l., Italy). The best performing algorithm for the segmentation of walking on sand was selected among 17 algorithms designed for solid ground. Gait timing (i.e. speed, temporal segmentation, variability) was analysed, for the first time, with respect to sand compliance, and compared to walking on solid ground. Results: Self-selected speed on a 60 m distance increased when walking on sand with respect to solid ground (Median 1.02 m/s), with the highest speed on wet sand (Median 1.15 m/s). A stabilizing strategy on the uneven surface provided by sand was highlighted by i) increased stance and double support durations with respect to speed on wet sand, and ii) increased short-term variability of stride, corresponding to continual adjustments of the lower limbs due to shifting surface provided by sand. Significance: This study represents the first step in the objective characterization of walking on compliant surfaces as sand, necessary for the definition of training and rehabilitative programs.
MeSH term(s)	Adult ; Algorithms ; Biomechanical Phenomena ; Female ; Gait/physiology ; Humans ; Male ; Sand ; Walking/physiology ; Walking Speed/physiology
Chemical Substances	Sand
Language	English
Publishing date	2021-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1162323-8
ISSN	1879-2219 ; 0966-6362
ISSN (online)	1879-2219
ISSN	0966-6362
DOI	10.1016/j.gaitpost.2021.03.019
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Article ; Online: Perception is associated with the brain’s metabolic response to sensory stimulation

Mauro DiNuzzo / Silvia Mangia / Marta Moraschi / Daniele Mascali / Gisela E Hagberg / Federico Giove

eLife, Vol

2022 Volume 11

Abstract	Processing of incoming sensory stimulation triggers an increase of cerebral perfusion and blood oxygenation (neurovascular response) as well as an alteration of the metabolic neurochemical profile (neurometabolic response). Here, we show in human primary visual cortex (V1) that perceived and unperceived isoluminant chromatic flickering stimuli designed to have similar neurovascular responses as measured by blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI) have markedly different neurometabolic responses as measured by proton functional magnetic resonance spectroscopy (1H-fMRS). In particular, a significant regional buildup of lactate, an index of aerobic glycolysis, and glutamate, an index of malate–aspartate shuttle, occurred in V1 only when the flickering was perceived, without any relation with other behavioral or physiological variables. Whereas the BOLD-fMRI signal in V1, a proxy for input to V1, was insensitive to flickering perception by design, the BOLD-fMRI signal in secondary visual areas was larger during perceived than unperceived flickering, indicating increased output from V1. These results demonstrate that the upregulation of energy metabolism induced by visual stimulation depends on the type of information processing taking place in V1, and that 1H-fMRS provides unique information about local input/output balance that is not measured by BOLD-fMRI.
Keywords	central visual system ; visual perception ; human brain metabolism ; lactate ; BOLD-fMRI ; single-voxel 1H-fMRS ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	610 ; 150
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO

DiNuzzo, Mauro / Dienel, Gerald A / Behar, Kevin L / Petroff, Ognen A / Benveniste, Helene / Hyder, Fahmeed / Giove, Federico / Michaeli, Shalom / Mangia, Silvia / Herculano-Houzel, Suzana / Rothman, Douglas L

Journal of neurochemistry

2023

Abstract: During transient brain activation cerebral blood flow (CBF) increases substantially more than cerebral metabolic rate of oxygen consumption ( ... ...

Abstract	During transient brain activation cerebral blood flow (CBF) increases substantially more than cerebral metabolic rate of oxygen consumption (CMRO
Language	English
Publishing date	2023-05-07
Publishing country	England
Document type	Journal Article
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1111/jnc.15839
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