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  1. AU=Shibley I A Jr
  2. AU="Shin Ohta"
  3. AU="Herrera, José M."
  4. AU="Bolanle, Ogunyemi Folasade"
  5. AU="Spezialetti, Matteo"
  6. AU=Rosas Lucia E
  7. AU="Spadotto, Valeria"
  8. AU="Jimenez-Macias, Jorge L"

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  1. Artikel ; Online: Signaling Pathways Regulating Ornithine Decarboxylase Activity in the Embryonic Chicken

    Shibley, Jr., Ivan A. / Pennington, Sam N.

    Neonatology - Fetal and Neonatal Research

    1995  Band 67, Heft 6, Seite(n) 441–449

    Abstract: The pathways regulating ornithine decarboxylase (ODC) activity in the chick embryo were studied to determine which kinase-signaling pathways regulate ODC activity levels during development. Insulin-dependent tyrosine kinase, protein kinase C and cAMP- ... ...

    Abstract The pathways regulating ornithine decarboxylase (ODC) activity in the chick embryo were studied to determine which kinase-signaling pathways regulate ODC activity levels during development. Insulin-dependent tyrosine kinase, protein kinase C and cAMP-dependent protein kinase were activated by the addition of insulin, tetradecanoylphorbol-12,13-acetate, and forskolin, respectively. All three drugs increased ODC activity and forskolin combined with insulin increased ODC activity above the increase caused by either drug alone. These results suggest that all three signaling pathways regulate ODC activity during development and that common intermediates exist among the pathways downstream of the kinases.
    Schlagwörter Ornithine decarboxylase ; Chick embryo ; Insulin ; Tyrosine kinase, insulin-dependent ; Protein kinase A ; Protein kinase C
    Sprache Englisch
    Verlag S. Karger AG
    Erscheinungsort Basel
    Erscheinungsland Switzerland
    Dokumenttyp Artikel ; Online
    ZDB-ID 2266911-5
    ISSN 1661-7819 ; 1661-7800 ; 1661-7800
    ISSN (online) 1661-7819
    ISSN 1661-7800
    DOI 10.1159/000244197
    Datenquelle Karger Verlag

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  2. Artikel: The effect of maternal malnutrition during pregnancy in the rat on the offsprings' weight, glucose uptake, glucose transporter protein levels and behaviors

    Pennington, S.N / Pennington, J.S / Ellington, L.D / Carver, F.M / Shibley, I.A. Jr / Jeansonne, N / Lynch, S.A / Roberson, L.A / Miles, D.S / Wormington, E.P / Means, L.W

    Nutrition research (New York, N.Y.) Nutrition research. May 2001. v. 21 (5)

    2001  

    Abstract: Intrauterine growth retardation (IUGR) is associated with multiple molecular and physiological changes in the offspring. In the current study, offspring of dams acutely fasted on days 17-19 were compared to the offspring of non-food deprived dams with ... ...

    Abstract Intrauterine growth retardation (IUGR) is associated with multiple molecular and physiological changes in the offspring. In the current study, offspring of dams acutely fasted on days 17-19 were compared to the offspring of non-food deprived dams with respect to postnatal growth, glucose uptake, brain glucose transporter Glut 1 protein levels and age-specific behaviors. Further, in a chronic study, control mothers were given ad lib. access to a nutritionally balanced liquid diet from day 0 until day 18 or day 20 of pregnancy. These offspring were compared to the offspring of mothers who consumed 90% of the ad lib mothers' calories. Overall, the malnourished offspring had: 1) IUGR, 2) small changes in brain glucose uptake and in Glut 1 transport protein content and, 3) minor alterations in their behavior. In both models, pups whose dams were malnourished weighed less than control offspring at birth and the growth retardation was sustained through six months of age. In the acute model, behavioral comparisons revealed that rats from acutely malnourished litters were impaired only on incline descent, requiring more time to descend than did the non-malnourished control pups. Brain glucose uptake showed only modest differences. Western blotting of glucose transporter proteins indicated that there was little correlation between brain glucose uptake and Glut 1 protein levels in pups from either malnourished or control litters. At 60 days, malnourished offspring were glucose intolerant relative to offspring from control litters.
    Schlagwörter maternal nutrition ; pregnancy ; glucose ; intestinal absorption ; nutrient uptake ; animal proteins ; behavior ; progeny ; starvation ; restricted feeding ; growth retardation ; psychomotor development ; cognitive development ; brain ; weight ; rats ; animal models ; body weight ; glucose tolerance
    Sprache Englisch
    Erscheinungsverlauf 2001-05
    Umfang p. 755-769.
    Dokumenttyp Artikel
    ZDB-ID 582432-1
    ISSN 1879-0739 ; 0271-5317
    ISSN (online) 1879-0739
    ISSN 0271-5317
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel: Quantitative immunoelectrophoretic assay for murine oncornavirus p30: noncovalent facilitation by sodium dodecyl sulfate

    Robinson, O.R. Jr / Shibley, G.P / Sevoian, M

    Infection and immunity. Oct 1977, 18 (1)

    1977  

    Schlagwörter animal health ; animal diseases
    Sprache Englisch
    Umfang p. 60-67.
    Dokumenttyp Artikel
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    Datenquelle NAL Katalog (AGRICOLA)

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