Result 1 - 10 of total 309
EM plus
2024 Volume 2023, Issue Q2, Page(s) 9–13
| Language | English |
|---|---|
| Publishing date | 2024-03-13 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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The American journal of medicine
2004 Volume 10, Issue 4, Page(s) 522–527
| MeSH term(s) | Breast ; Carcinoma ; Humans ; Leukemia ; Leukemia, Lymphoid ; Leukemoid Reaction |
|---|---|
| Language | English |
| Publishing date | 2004-01-21 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 80015-6 |
| ISSN | 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766 |
| ISSN (online) | 1555-7162 ; 1873-2178 |
| ISSN | 0002-9343 ; 1548-2766 |
| DOI | 10.1016/0002-9343(51)90323-3 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ua VI Zs.289: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2024 Volume 11, Issue 1, Page(s) 231270
Abstract: Species with extensive geographical ranges pose special challenges to assessing drivers of wildlife disease, necessitating collaborative and large-scale analyses. The imperilled foothill yellow-legged frog ( ...
| Abstract | Species with extensive geographical ranges pose special challenges to assessing drivers of wildlife disease, necessitating collaborative and large-scale analyses. The imperilled foothill yellow-legged frog ( |
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| Language | English |
| Publishing date | 2024-01-31 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2787755-3 |
| ISSN | 2054-5703 |
| ISSN | 2054-5703 |
| DOI | 10.1098/rsos.231270 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Environmental science & technology
2023 Volume 57, Issue 45, Page(s) 17511–17521
Abstract: ... of bioaccumulation of MeHg in amphibians (R ...
| Abstract | Mercury (Hg) is a toxic contaminant that has been mobilized and distributed worldwide and is a threat to many wildlife species. Amphibians are facing unprecedented global declines due to many threats including contaminants. While the biphasic life history of many amphibians creates a potential nexus for methylmercury (MeHg) exposure in aquatic habitats and subsequent health effects, the broad-scale distribution of MeHg exposure in amphibians remains unknown. We used nonlethal sampling to assess MeHg bioaccumulation in 3,241 juvenile and adult amphibians during 2017-2021. We sampled 26 populations (14 species) across 11 states in the United States, including several imperiled species that could not have been sampled by traditional lethal methods. We examined whether life history traits of species and whether the concentration of total mercury in sediment or dragonflies could be used as indicators of MeHg bioaccumulation in amphibians. Methylmercury contamination was widespread, with a 33-fold difference in concentrations across sites. Variation among years and clustered subsites was less than variation across sites. Life history characteristics such as size, sex, and whether the amphibian was a frog, toad, newt, or other salamander were the factors most strongly associated with bioaccumulation. Total Hg in dragonflies was a reliable indicator of bioaccumulation of MeHg in amphibians (R |
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| MeSH term(s) | Animals ; Methylmercury Compounds ; Odonata ; Water Pollutants, Chemical/analysis ; Mercury/analysis ; Amphibians ; Environmental Monitoring |
| Chemical Substances | Methylmercury Compounds ; Water Pollutants, Chemical ; Mercury (FXS1BY2PGL) |
| Language | English |
| Publishing date | 2023-10-30 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. |
| ISSN | 1520-5851 |
| ISSN (online) | 1520-5851 |
| DOI | 10.1021/acs.est.3c05549 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 178, Page(s) 108061
Abstract: Background: There is increasing evidence for adverse health effects associated with aircraft-emitted particulate matter (PM) exposures, which are largely in the ultrafine (PM: Objective: To assess associations between maternal exposure to aircraft ... ...
| Abstract | Background: There is increasing evidence for adverse health effects associated with aircraft-emitted particulate matter (PM) exposures, which are largely in the ultrafine (PM Objective: To assess associations between maternal exposure to aircraft ultrafine particles (UFP) during pregnancy and offspring autism spectrum disorder (ASD) diagnosis. Methods: This large, representative cohort study included 370,723 singletons born in a single healthcare system. Demographic data, maternal health information, and child's ASD diagnosis by age 5 were extracted from electronic medical records. Aircraft exposure estimates for PM Results: Over the course of follow-up, 4,554 children (1.4 %) were diagnosed with ASD. Increased risk of ASD was associated with maternal exposure to aircraft PM Discussion: The results strengthen the emerging evidence that maternal particulate matter exposure during pregnancy is associated with offspring ASD diagnosis and identify aircraft-derived PM |
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| MeSH term(s) | Pregnancy ; Female ; Humans ; Child ; Child, Preschool ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Maternal Exposure/adverse effects ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Autism Spectrum Disorder/epidemiology ; Autism Spectrum Disorder/etiology ; Cohort Studies ; Air Pollution/analysis ; Aircraft ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis |
| Chemical Substances | Particulate Matter ; Air Pollutants |
| Language | English |
| Publishing date | 2023-07-10 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 554791-x |
| ISSN | 1873-6750 ; 0160-4120 |
| ISSN (online) | 1873-6750 |
| ISSN | 0160-4120 |
| DOI | 10.1016/j.envint.2023.108061 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3131: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2023 Volume 171, Page(s) 107736
Abstract: Background: Traffic-related air pollution exposure is associated with increased risk of autism spectrum disorder (ASD). It is unknown whether carbonaceous material from vehicular tailpipe emissions or redox-active non-tailpipe metals, eg. from tire and ... ...
| Abstract | Background: Traffic-related air pollution exposure is associated with increased risk of autism spectrum disorder (ASD). It is unknown whether carbonaceous material from vehicular tailpipe emissions or redox-active non-tailpipe metals, eg. from tire and brake wear, are responsible. We assessed ASD associations with fine particulate matter (PM Methods: This retrospective cohort study included 318,750 children born in Kaiser Permanente Southern California (KPSC) hospitals during 2001-2014, followed until age 5. ASD cases were identified by ICD codes. Monthly estimates of PM Results: There were 4559 children diagnosed with ASD. In single-pollutant models, increased ASD risk was associated with gestational exposures to tracers of both tailpipe and non-tailpipe emissions. The ASD hazard ratios (HRs) per inter-quartile increment of exposure) for EC, OC, Cu, Fe, and Mn were 1.11 (95% CI: 1.06-1.16), 1.09 (95% CI: 1.04-1.15), 1.09 (95% CI: 1.04-1.13), 1.14 (95% CI: 1.09-1.20), and 1.17 (95% CI: 1.12-1.22), respectively. Estimated effects of Cu, Fe, and Mn (reflecting non-tailpipe sources) were largely unchanged in two-pollutant models adjusting for PM Conclusion: Results suggest that non-tailpipe emissions may contribute to ASD. Implications are that reducing tailpipe emissions, especially from vehicles with internal combustion engines, may not eliminate ASD associations with traffic-related air pollution. |
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| MeSH term(s) | Child, Preschool ; Female ; Humans ; Pregnancy ; Air Pollutants/analysis ; Air Pollution/analysis ; Autism Spectrum Disorder/etiology ; Autism Spectrum Disorder/chemically induced ; Carbon ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Environmental Pollutants ; Manganese ; Nitrogen Dioxide/analysis ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Prenatal Exposure Delayed Effects/epidemiology ; Prenatal Exposure Delayed Effects/chemically induced ; Retrospective Studies ; Vehicle Emissions/analysis ; Infant, Newborn ; Infant |
| Chemical Substances | Air Pollutants ; Carbon (7440-44-0) ; Environmental Pollutants ; Manganese (42Z2K6ZL8P) ; Nitrogen Dioxide (S7G510RUBH) ; Particulate Matter ; Vehicle Emissions |
| Language | English |
| Publishing date | 2023-01-05 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. |
| ZDB-ID | 554791-x |
| ISSN | 1873-6750 ; 0160-4120 |
| ISSN (online) | 1873-6750 |
| ISSN | 0160-4120 |
| DOI | 10.1016/j.envint.2023.107736 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3131: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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iScience
2022 Volume 25, Issue 10, Page(s) 105040
Abstract: ... for Cystatin C (CyC) production in patients with COVID-19. We analyzed the predictive value of longitudinal ...
| Abstract | COVID-19 has highly variable clinical courses. The search for prognostic host factors for COVID-19 outcome is a priority. We performed logistic regression for ICU admission against a polygenic score (PGS) for Cystatin C (CyC) production in patients with COVID-19. We analyzed the predictive value of longitudinal plasma CyC levels in an independent cohort of patients hospitalized with COVID-19. In four cohorts spanning European and African ancestry populations, we identified a significant association between CyC-production PGS and odds of critical illness (n cases=2,319), with the strongest association captured in the UKB cohort (OR 2.13, 95% CI 1.58-2.87, p=7.12e-7). Plasma proteomics from an independent cohort of hospitalized COVID-19 patients (n cases = 131) demonstrated that CyC production was associated with COVID-specific mortality (p=0.0007). Our findings suggest that CyC may be useful for stratification of patients and it has functional role in the host response to COVID-19. |
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| Language | English |
| Publishing date | 2022-08-31 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2589-0042 |
| ISSN (online) | 2589-0042 |
| DOI | 10.1016/j.isci.2022.105040 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2020
Abstract: Event cameras are paradigm-shifting novel sensors that report asynchronous, per-pixel brightness changes called 'events' with unparalleled low latency. This makes them ideal for high speed, high dynamic range scenes where conventional cameras would fail. ...
| Abstract | Event cameras are paradigm-shifting novel sensors that report asynchronous, per-pixel brightness changes called 'events' with unparalleled low latency. This makes them ideal for high speed, high dynamic range scenes where conventional cameras would fail. Recent work has demonstrated impressive results using Convolutional Neural Networks (CNNs) for video reconstruction and optic flow with events. We present strategies for improving training data for event based CNNs that result in 20-40% boost in performance of existing state-of-the-art (SOTA) video reconstruction networks retrained with our method, and up to 15% for optic flow networks. A challenge in evaluating event based video reconstruction is lack of quality ground truth images in existing datasets. To address this, we present a new High Quality Frames (HQF) dataset, containing events and ground truth frames from a DAVIS240C that are well-exposed and minimally motion-blurred. We evaluate our method on HQF + several existing major event camera datasets. Comment: Had incorrect font for ECCV camera ready submission -fixed this and rearranged paper to fit. Added results from other literature to MVSEC AEE table. Fixed FWL in contrast threshold experiment table |
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| Keywords | Computer Science - Computer Vision and Pattern Recognition |
| Subject code | 004 |
| Publishing date | 2020-03-19 |
| Publishing country | us |
| Document type | Book ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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2023 Volume 7, Issue 16, Page(s) 4539–4549
Abstract: Liposomal daunorubicin and cytarabine (CPX-351) improved overall survival (OS) compared with 7+3 chemotherapy in older patients with secondary acute myeloid leukemia (AML); to date, there have been no randomized studies in younger patients. The high-risk ...
| Abstract | Liposomal daunorubicin and cytarabine (CPX-351) improved overall survival (OS) compared with 7+3 chemotherapy in older patients with secondary acute myeloid leukemia (AML); to date, there have been no randomized studies in younger patients. The high-risk cohort of the UK NCRI AML19 trial (ISRCTN78449203) compared CPX-351 with FLAG-Ida in younger adults with newly diagnosed adverse cytogenetic AML or high-risk myelodysplastic syndromes (MDS). A total of 189 patients were randomized (median age, 56 years). Per clinical criteria, 49% of patients had de novo AML, 20% had secondary AML, and 30% had high-risk MDS. MDS-related cytogenetics were present in 73% of the patients, with a complex karyotype in 49%. TP53 was the most common mutated gene, in 43%. Myelodysplasia-related gene mutations were present in 75 (44%) patients. The overall response rate (CR + CRi) after course 2 was 64% and 76% for CPX-351 and FLAG-Ida, respectively. There was no difference in OS (13.3 months vs 11.4 months) or event-free survival in multivariable analysis. However, relapse-free survival was significantly longer with CPX-351 (median 22.1 vs 8.35 months). There was no difference between the treatment arms in patients with clinically defined secondary AML or those with MDS-related cytogenetic abnormalities; however, an exploratory subgroup of patients with MDS-related gene mutations had significantly longer OS with CPX-351 (median 38.4 vs 16.3 months). In conclusion, the OS of younger patients with adverse risk AML/MDS was not significantly different between CPX-351 and FLAG-Ida. |
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| MeSH term(s) | Adult ; Humans ; Aged ; Middle Aged ; Daunorubicin/therapeutic use ; Cytarabine/therapeutic use ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Myelodysplastic Syndromes/drug therapy ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/complications ; Karyotype ; United Kingdom |
| Chemical Substances | CPX-351 ; Daunorubicin (ZS7284E0ZP) ; Cytarabine (04079A1RDZ) |
| Language | English |
| Publishing date | 2023-05-12 |
| Publishing country | United States |
| Document type | Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2915908-8 |
| ISSN | 2473-9537 ; 2473-9529 |
| ISSN (online) | 2473-9537 |
| ISSN | 2473-9529 |
| DOI | 10.1182/bloodadvances.2023010276 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 7153: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Cell genomics
2023 Volume 3, Issue 8, Page(s) 100347
Abstract: Cystatin C (CyC), a secreted cysteine protease inhibitor, has unclear biological functions ...
| Abstract | Cystatin C (CyC), a secreted cysteine protease inhibitor, has unclear biological functions. Many patients exhibit elevated plasma CyC levels, particularly during glucocorticoid (GC) treatment. This study links GCs with CyC's systemic regulation by utilizing genome-wide association and structural equation modeling to determine CyC production genetics in the UK Biobank. Both CyC production and a polygenic score (PGS) capturing predisposition to CyC production were associated with increased all-cause and cancer-specific mortality. We found that the GC receptor directly targets CyC, leading to GC-responsive CyC secretion in macrophages and cancer cells. CyC-knockout tumors displayed significantly reduced growth and diminished recruitment of TREM2+ macrophages, which have been connected to cancer immunotherapy failure. Furthermore, the CyC-production PGS predicted checkpoint immunotherapy failure in 685 patients with metastatic cancer from combined clinical trial cohorts. In conclusion, CyC may act as a GC effector pathway via TREM2+ macrophage recruitment and may be a potential target for combination cancer immunotherapy. |
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| Language | English |
| Publishing date | 2023-06-23 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2666-979X |
| ISSN (online) | 2666-979X |
| DOI | 10.1016/j.xgen.2023.100347 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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