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  1. Article ; Online: Chronic neck pain in a child: a case of osteoblastoma of the C5 cervical vertebra.

    Yadav, Sandeep Kumar / Rajnish, Rajesh Kumar / Jacob, Akhil Mathew / Rao, Meenakshi

    BMJ case reports

    2024  Volume 17, Issue 1

    Abstract: Osteoblastoma is a primary bone-forming tumour that usually occurs in the second decade with an affinity to the posterior elements when found in the spine. Its occurrence in the early first decade is uncommon and often causes a diagnostic dilemma. It ... ...

    Abstract Osteoblastoma is a primary bone-forming tumour that usually occurs in the second decade with an affinity to the posterior elements when found in the spine. Its occurrence in the early first decade is uncommon and often causes a diagnostic dilemma. It usually has a late presentation and the symptoms may be non-specific which may lead the clinician to overlook this particular entity. We present a case of osteoblastoma of the posterior elements of the C5 vertebra in a pre-adolescent child who was diagnosed and successfully managed with surgical resection in a timely fashion that led to favourable recovery postoperatively.
    MeSH term(s) Child ; Humans ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Cervical Vertebrae/pathology ; Neck Pain/etiology ; Neck Pain/pathology ; Osteoblastoma/diagnosis ; Osteoblastoma/diagnostic imaging ; Spinal Neoplasms/complications ; Spinal Neoplasms/diagnostic imaging ; Spinal Neoplasms/surgery
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-257171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect of Interpectoral-Pectoserratus Plane (PECS II) Block on Recovery Room Discharge Time in Breast Cancer Surgery.

    Malachauskiené, Laima / Bhavsar, Rajesh Prabhakar / Waldemar, Jacob / Strøm, Thomas

    Medicina (Kaunas, Lithuania)

    2023  Volume 60, Issue 1

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Female ; Adult ; Middle Aged ; Breast Neoplasms/surgery ; Postoperative Nausea and Vomiting/epidemiology ; Analgesics, Opioid/therapeutic use ; Patient Discharge ; Recovery Room ; Retrospective Studies ; Mastectomy ; Anesthesia, General
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2023-12-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60010041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  3. Article ; Online: Ribosomal DNA Sequence-Based Taxonomy and Antimicrobial Activity of

    Mussai, Prakash / Larsen, Jacob / Alrefaei, Abdulwahed Fahad / Jeewon, Rajesh

    Marine drugs

    2023  Volume 21, Issue 4

    Abstract: Microalgae are unicellular organisms and commonly present in the euphotic zone of marine ecosystems. From the western coast of Mauritius, three strains ... ...

    Abstract Microalgae are unicellular organisms and commonly present in the euphotic zone of marine ecosystems. From the western coast of Mauritius, three strains of
    MeSH term(s) Humans ; DNA, Ribosomal/genetics ; Phylogeny ; Ecosystem ; Base Sequence ; Indian Ocean ; Mauritius ; Anti-Infective Agents/pharmacology ; Dinoflagellida
    Chemical Substances DNA, Ribosomal ; Anti-Infective Agents
    Language English
    Publishing date 2023-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21040216
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  4. Article ; Online: Coinfection of SARS-CoV-2 and MTB: how not to miss the wood for the trees.

    Jacob, Jeny / Venkataram, Rajesh / Hosmane, Giridhar Belur

    BMJ case reports

    2021  Volume 14, Issue 7

    Abstract: Scarce data exist about the coinfection of SARS-CoV-2 ... ...

    Abstract Scarce data exist about the coinfection of SARS-CoV-2 and
    MeSH term(s) COVID-19 ; Coinfection ; Female ; Humans ; Mycobacterium tuberculosis ; SARS-CoV-2 ; Sensitivity and Specificity ; Sputum ; Tuberculosis, Pulmonary/complications ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/drug therapy
    Language English
    Publishing date 2021-07-13
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-240581
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  5. Article: Possible Ambiguity in Interpretation Between Immunoglobulin G4-Related Disease (IgG4-RD) and Sarcoidosis in a Post-COVID-19 Pandemic.

    Gurunathan, Rajesh / Dhanasekaran, Pavithra / Devaprasad, Dedeepiya / Jacob, Sheba Sk / Abraham, Babu K

    Cureus

    2023  Volume 15, Issue 4, Page(s) e38124

    Abstract: A 36-year-old lady presented with fever, cough, maculopapular rash, painless sialadenitis, episcleritis, and arthralgia of more than 10 months, occurring in episodes since she tested positive for COVID-19 in 2020. Her symptoms were well controlled with ... ...

    Abstract A 36-year-old lady presented with fever, cough, maculopapular rash, painless sialadenitis, episcleritis, and arthralgia of more than 10 months, occurring in episodes since she tested positive for COVID-19 in 2020. Her symptoms were well controlled with corticosteroid and immunosuppressant therapy. Her clinical presentation and findings on bronchoscopy resembled that of sarcoidosis. However, the bronchial biopsy histopathology ruled out sarcoidosis. An increased serum immunoglobulin G4 level and its possible association with COVID-19 raises the question of whether the possibility of immunoglobulin G4-related disease (IgG4-RD) could be entertained.
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.38124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: NR4A1 deletion promotes pro-angiogenic polarization of macrophages derived from classical monocytes in a mouse model of neovascular age-related macular degeneration.

    Droho, Steven / Voigt, Andrew P / Sterling, Jacob K / Rajesh, Amrita / Chan, Kyle S / Cuda, Carla M / Perlman, Harris / Lavine, Jeremy A

    Journal of neuroinflammation

    2023  Volume 20, Issue 1, Page(s) 238

    Abstract: Background: Neovascular age-related macular degeneration causes vision loss from destructive angiogenesis, termed choroidal neovascularization (CNV). Cx3cr1: Main body: We subjected Nr4a1: Conclusions: These results suggest that non-classical ... ...

    Abstract Background: Neovascular age-related macular degeneration causes vision loss from destructive angiogenesis, termed choroidal neovascularization (CNV). Cx3cr1
    Main body: We subjected Nr4a1
    Conclusions: These results suggest that non-classical monocytes are dispensable during CNV, and NR4A1 deficiency results in increased recruitment of pro-angiogenic macrophages.
    MeSH term(s) Animals ; Mice ; Choroidal Neovascularization/genetics ; Disease Models, Animal ; Macrophages/physiology ; Macular Degeneration/genetics ; Mice, Inbred C57BL ; Microglia ; Monocytes
    Chemical Substances Nr4a1 protein, mouse
    Language English
    Publishing date 2023-10-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2156455-3
    ISSN 1742-2094 ; 1742-2094
    ISSN (online) 1742-2094
    ISSN 1742-2094
    DOI 10.1186/s12974-023-02928-1
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  7. Article ; Online: Increasing obesity is associated with lower postoperative bleeding in coronary bypass patients.

    Bhavsar, Rajesh / Tang, Mariann / Greisen, Jacob / Jakobsen, Carl-Johan

    Journal of cardiothoracic and vascular anesthesia

    2023  Volume 37, Issue 7, Page(s) 1129–1137

    Abstract: Objective: Despite inherent comorbidities, obese cardiac surgical patients paradoxically had shown lower morbidity and mortality, although the nature of this association is still unclear. Thus, the authors intended in this large registry-based study to ... ...

    Abstract Objective: Despite inherent comorbidities, obese cardiac surgical patients paradoxically had shown lower morbidity and mortality, although the nature of this association is still unclear. Thus, the authors intended in this large registry-based study to investigate the impact of obesity on short- and long-term postoperative outcomes, focusing on bleeding and transfusion requirements.
    Design: Retrospective registry study.
    Setting: Three university hospitals.
    Participants: A cohort of 12,330 prospectively compiled data from coronary bypass grafting patients undergoing surgery between 2007 to 2020 were retrieved from the Western Denmark Heart Registry.
    Interventions: The parameters were analyzed to assess the association between body mass index (BMI) and the selected outcome parameters.
    Measurements and main results: The crude data showed a clear statistically significant association in postoperative drainage from 637 (418-1108) mL in underweight patients with BMI <18.5 kg/m
    Conclusion: Patients with high BMI may carry protection against postoperative bleeding after cardiac surgery, probably secondary to an inherent hypercoagulable state, whereas underweight patients carry a higher risk of bleeding and worse outcomes.
    MeSH term(s) Humans ; Retrospective Studies ; Thinness/complications ; Thinness/surgery ; Treatment Outcome ; Coronary Artery Bypass/adverse effects ; Obesity/complications ; Postoperative Hemorrhage/diagnosis ; Postoperative Hemorrhage/epidemiology ; Postoperative Hemorrhage/etiology ; Body Mass Index ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Risk Factors
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2023.03.012
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2203: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 31: Show issues

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  8. Article ; Online: Small vessel disease: Connections between the kidney and the heart.

    Meariman, Jacob K / Zulli, Hannah / Perez, Annalisa / Bajracharya, S D / Mohandas, Rajesh

    American heart journal plus : cardiology research and practice

    2023  Volume 26, Page(s) 100257

    Abstract: Small vessel disease is characterized by global dysfunction of the microvascular system leading to reduced perfusion of various organ systems. The kidney is significantly vulnerable for microvascular dysfunction given its intricate capillary network and ... ...

    Abstract Small vessel disease is characterized by global dysfunction of the microvascular system leading to reduced perfusion of various organ systems. The kidney is significantly vulnerable for microvascular dysfunction given its intricate capillary network and extensive endocrine influence. Studies have demonstrated a relationship between impaired renal function and small vessel disease in other organ systems, particularly the heart. Here we discuss the relationship between the kidney and the heart in the setting of microvascular dysfunction and identify areas of future study to better understand this relationship and potentially identify novel therapeutic strategies.
    Language English
    Publishing date 2023-01-21
    Publishing country United States
    Document type Journal Article
    ISSN 2666-6022
    ISSN (online) 2666-6022
    DOI 10.1016/j.ahjo.2023.100257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Altered microRNA Transcriptome in Cultured Human Airway Cells upon Infection with SARS-CoV-2.

    Diallo, Idrissa / Jacob, Rajesh Abraham / Vion, Elodie / Kozak, Robert A / Mossman, Karen / Provost, Patrick

    Viruses

    2023  Volume 15, Issue 2

    Abstract: Numerous proteomic and transcriptomic studies have been carried out to better understand the current multi-variant SARS-CoV-2 virus mechanisms of action and effects. However, they are mostly centered on mRNAs and proteins. The effect of the virus on ... ...

    Abstract Numerous proteomic and transcriptomic studies have been carried out to better understand the current multi-variant SARS-CoV-2 virus mechanisms of action and effects. However, they are mostly centered on mRNAs and proteins. The effect of the virus on human post-transcriptional regulatory agents such as microRNAs (miRNAs), which are involved in the regulation of 60% of human gene activity, remains poorly explored. Similar to research we have previously undertaken with other viruses such as Ebola and HIV, in this study we investigated the miRNA profile of lung epithelial cells following infection with SARS-CoV-2. At the 24 and 72 h post-infection time points, SARS-CoV-2 did not drastically alter the miRNome. About 90% of the miRNAs remained non-differentially expressed. The results revealed that miR-1246, miR-1290 and miR-4728-5p were the most upregulated over time. miR-196b-5p and miR-196a-5p were the most downregulated at 24 h, whereas at 72 h, miR-3924, miR-30e-5p and miR-145-3p showed the highest level of downregulation. In the top significantly enriched KEGG pathways of genes targeted by differentially expressed miRNAs we found, among others, MAPK, RAS, P13K-Akt and renin secretion signaling pathways. Using RT-qPCR, we also showed that SARS-CoV-2 may regulate several predicted host mRNA targets involved in the entry of the virus into host cells (ACE2, TMPRSS2, ADAM17, FURIN), renin-angiotensin system (RAS) (Renin, Angiotensinogen, ACE), innate immune response (IL-6, IFN1β, CXCL10, SOCS4) and fundamental cellular processes (AKT, NOTCH, WNT). Finally, we demonstrated by dual-luciferase assay a direct interaction between miR-1246 and ACE-2 mRNA. This study highlights the modulatory role of miRNAs in the pathogenesis of SARS-CoV-2.
    MeSH term(s) Humans ; MicroRNAs/genetics ; SARS-CoV-2 ; Transcriptome ; Renin ; Proteomics ; Proto-Oncogene Proteins c-akt ; COVID-19/genetics
    Chemical Substances MicroRNAs ; Renin (EC 3.4.23.15) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; MIRN145 microRNA, human
    Language English
    Publishing date 2023-02-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Ribosomal DNA Sequence-Based Taxonomy and Antimicrobial Activity of Prorocentrum spp. (Dinophyceae) from Mauritius Coastal Waters, South-West Indian Ocean

    Mussai, Prakash / Larsen, Jacob / Alrefaei, Abdulwahed Fahad / Jeewon, Rajesh

    Mar Drugs. 2023 Mar. 28, v. 21, no. 4

    2023  

    Abstract: Microalgae are unicellular organisms and commonly present in the euphotic zone of marine ecosystems. From the western coast of Mauritius, three strains of Prorocentrum species were isolated from macrophytes and cultured under standard laboratory ... ...

    Abstract Microalgae are unicellular organisms and commonly present in the euphotic zone of marine ecosystems. From the western coast of Mauritius, three strains of Prorocentrum species were isolated from macrophytes and cultured under standard laboratory conditions. Morphologies were examined by light, fluorescence, and scanning electron microscopy, and phylogenetic analyses were based on partial large subunit LSU rDNA (D1-D2) and ITS1-5.8S-ITS2 (ITS) regions. Three Prorocentrum species, including the P. fukuyoi complex, P. rhathymum, and P. lima complex, were identified. The antimicrobial activities were assayed against potential human pathogenic bacterial strains. The highest zone of inhibition was recorded for intracellular and extracellular protein extracts of Prorocentrum rhathymum against Vibrio parahaemolyticus. The polysaccharide extracts of the Prorocentrum fukuyoi complex had a higher zone of inhibition (24 ± 0.4 mm) against MRSA at a minimum concentration of 0.625 μg/mL. The extracts from the three Prorocentrum species had different levels of activity against the pathogens used, and this can be of scientific interest in the search for antibiotics from natural marine sources.
    Keywords Prorocentrum ; Vibrio parahaemolyticus ; antimicrobial properties ; coastal water ; coasts ; electron microscopy ; euphotic zone ; fluorescence ; macrophytes ; methicillin-resistant Staphylococcus aureus ; microalgae ; pathogens ; phylogeny ; polysaccharides ; ribosomal DNA ; taxonomy ; Indian Ocean ; Mauritius
    Language English
    Dates of publication 2023-0328
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21040216
    Database NAL-Catalogue (AGRICOLA)

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