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Article ; Online: Human Rad51 Protein Requires Higher Concentrations of Calcium Ions for D-Loop Formation than for Oligonucleotide Strand Exchange.

Renodon-Corniere, Axelle / Mikawa, Tsutomu / Kuwabara, Naoyuki / Ito, Kentaro / Levitsky, Dmitri / Iwasaki, Hiroshi / Takahashi, Masayuki

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: Human Rad51 protein (HsRad51)-promoted DNA strand exchange, a crucial step in homologous recombination, is regulated by proteins and calcium ions. Both the activator protein Swi5/Sfr1 and ... ...

Abstract	Human Rad51 protein (HsRad51)-promoted DNA strand exchange, a crucial step in homologous recombination, is regulated by proteins and calcium ions. Both the activator protein Swi5/Sfr1 and Ca
MeSH term(s)	Humans ; Oligonucleotides ; Rad51 Recombinase ; Calcium ; Ions ; DNA
Chemical Substances	Oligonucleotides ; Rad51 Recombinase (EC 2.7.7.-) ; Calcium (SY7Q814VUP) ; Ions ; DNA (9007-49-2)
Language	English
Publishing date	2024-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25073633
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Article: Enhancement of the thermic effect of food by d-fenfluramine.

Levitsky, D A / Stallone, D

Clinical neuropharmacology

1988 Volume 11 Suppl 1, Page(s) S90–2

Abstract: Following approximately a week of daily ingestion of fenfluramine, the body weight of female rats is reduced and remains chronically suppressed for as long as treatment is continued. This chronic suppression of body weight by fenfluramine cannot be ... ...

Abstract	Following approximately a week of daily ingestion of fenfluramine, the body weight of female rats is reduced and remains chronically suppressed for as long as treatment is continued. This chronic suppression of body weight by fenfluramine cannot be explained by the anorectic effects of fenfluramine, since food intake returns to normal after about a week. Part of this chronic suppression of body weight lies in the ability of fenfluramine to enhance the thermic effect of food. Fenfluramine ingested by a fasted rat causes no change in metabolic rate. However, following the ingestion of the meal consisting of mixed nutrients or only carbohydrates, the thermic effect of the food is significantly greater than that of the meal without fenfluramine. A similar observation was observed in humans. These observations when combined with the negligible effects of dieting as a means of controlling body weight, argue for the chronic use of fenfluramine as a therapeutic technique to produce sustained weight loss in humans.
MeSH term(s)	Animals ; Body Temperature Regulation/drug effects ; Body Weight/drug effects ; Eating/drug effects ; Energy Metabolism/drug effects ; Female ; Fenfluramine/pharmacology ; Humans ; Male ; Rats
Chemical Substances	Fenfluramine (2DS058H2CF)
Language	English
Publishing date	1988
Publishing country	United States
Document type	Journal Article
ZDB-ID	199293-4
ISSN	1537-162X ; 0362-5664
ISSN (online)	1537-162X
ISSN	0362-5664
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Article ; Online: Molecular Mechanisms of Pathologies of Skeletal and Cardiac Muscles Caused by Point Mutations in the Tropomyosin Genes.

Matyushenko, A M / Levitsky, D I

Biochemistry. Biokhimiia

2020 Volume 85, Issue Suppl 1, Page(s) S20–S33

Abstract: The review is devoted to tropomyosin (Tpm) - actin-binding protein, which plays a crucial role in the regulation of contraction of skeletal and cardiac muscles. Special attention is paid to myopathies and cardiomyopathies - severe hereditary diseases of ... ...

Abstract	The review is devoted to tropomyosin (Tpm) - actin-binding protein, which plays a crucial role in the regulation of contraction of skeletal and cardiac muscles. Special attention is paid to myopathies and cardiomyopathies - severe hereditary diseases of skeletal and cardiac muscles associated with point mutations in Tpm genes. The current views on the molecular mechanisms of these diseases and the effects of such mutations on the Tpm structure and functions are considered in detail. Besides, some part of the review is devoted to analysis of the properties of Tpm homodimers and heterodimers with myopathic substitutions of amino acid residues in only one of the two chains of the Tpm dimeric molecule.
MeSH term(s)	Actins/metabolism ; Animals ; Cardiomyopathies/genetics ; Dimerization ; Heterozygote ; Humans ; Models, Molecular ; Muscle Contraction/genetics ; Muscle, Skeletal/pathology ; Muscular Diseases/genetics ; Myocardium/pathology ; Point Mutation ; Protein Binding ; Protein Isoforms ; Tropomyosin/chemistry ; Tropomyosin/genetics ; Tropomyosin/metabolism
Chemical Substances	Actins ; Protein Isoforms ; Tropomyosin
Language	English
Publishing date	2020-03-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1109-5
ISSN	1608-3040 ; 0006-2979 ; 0320-9717
ISSN (online)	1608-3040
ISSN	0006-2979 ; 0320-9717
DOI	10.1134/S0006297920140023
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Article: The effects of D-fenfluramine on the development of aflatoxin-B1 induced GGT+ hepatic foci in F344 rats.

Bell, R C / Levitsky, D A / Campbell, T C

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity

1993 Volume 17, Issue 4, Page(s) 215–221

Abstract: ... with aflatoxin-B1 (AFB) and given the drug D-fenfluramine (FEN). Ingestion of this drug leads to a reduction ...

Abstract	The role of total caloric intake and attained body weight in the carcinogenic process in rodents is controversial. In the present study we examined the development of hepatic pre-neoplastic foci in rats treated with aflatoxin-B1 (AFB) and given the drug D-fenfluramine (FEN). Ingestion of this drug leads to a reduction in body weight by increasing the thermogenic response to a meal and by transiently reducing food intake. Young male rats were dosed with AFB or vehicle alone and were then assigned to receive control diet (NO FEN) or control diet + FEN (FEN; 0.15 g/kg diet) for 12-14 weeks. Body weight gain and food intake were reduced among animals given FEN; brown adipose tissue weight (% body weight) was elevated in these groups. Indices of protein status, and concentrations of T3, T4 and insulin did not differ among the groups. All animals given FEN developed GGT+ hepatic foci. The number and volume fraction of foci were significantly larger in FEN relative to NO FEN animals. The mean diameter of foci was slightly enhanced among FEN animals. These results suggest that FEN promotes the development of AFB-induced hepatocellular foci, despite reduced food intake and lower body weight. Since FEN is widely used as a weight loss aid, these findings deserve further study.
MeSH term(s)	Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Aflatoxin B1 ; Animals ; Blood Chemical Analysis ; Body Weight/drug effects ; Carrier Proteins/drug effects ; Carrier Proteins/metabolism ; Diet ; Eating/drug effects ; Eating/physiology ; Fenfluramine/administration & dosage ; Fenfluramine/pharmacology ; Ion Channels ; Liver Neoplasms/chemically induced ; Liver Neoplasms/metabolism ; Male ; Membrane Proteins/drug effects ; Membrane Proteins/metabolism ; Mitochondrial Proteins ; Organ Size/drug effects ; Rats ; Rats, Inbred F344 ; Uncoupling Protein 1 ; gamma-Glutamyltransferase
Chemical Substances	Carrier Proteins ; Ion Channels ; Membrane Proteins ; Mitochondrial Proteins ; Uncoupling Protein 1 ; Fenfluramine (2DS058H2CF) ; Aflatoxin B1 (9N2N2Y55MH) ; gamma-Glutamyltransferase (EC 2.3.2.2)
Language	English
Publishing date	1993-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1103255-8
ISSN	0307-0565
ISSN	0307-0565
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Article ; Online: The Continued Impact of Acute Rejection in the Last Decade of Liver Transplantation.

Harrington, C R / Bittermann, T / Goldberg, D / Levitsky, J

Gastro hep advances

2022 Volume 1, Issue 5, Page(s) 686–688

Language	English
Publishing date	2022-05-10
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-5723
ISSN (online)	2772-5723
DOI	10.1016/j.gastha.2022.04.021
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Article ; Online: Myopathy-causing mutation R91P in the TPM3 gene drastically impairs structural and functional properties of slow skeletal muscle tropomyosin γβ-heterodimer.

Gonchar, Anastasiia D / Koubassova, Natalia A / Kopylova, Galina V / Kochurova, Anastasia M / Nefedova, Victoria V / Yampolskaya, Daria S / Shchepkin, Daniil V / Bershitsky, Sergey Y / Tsaturyan, Andrey K / Matyushenko, Alexander M / Levitsky, Dmitrii I

Archives of biochemistry and biophysics

2024 Volume 752, Page(s) 109881

Abstract: Tropomyosin (Tpm) is a regulatory actin-binding protein involved in ... ...

Abstract	Tropomyosin (Tpm) is a regulatory actin-binding protein involved in Ca
MeSH term(s)	Humans ; Tropomyosin/chemistry ; Muscle, Skeletal/metabolism ; Muscular Diseases/genetics ; Mutation ; Muscle Weakness/metabolism ; Actins/genetics ; Actins/metabolism
Chemical Substances	Tropomyosin ; Actins ; TPM3 protein, human
Language	English
Publishing date	2024-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	523-x
ISSN	1096-0384 ; 0003-9861
ISSN (online)	1096-0384
ISSN	0003-9861
DOI	10.1016/j.abb.2023.109881
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Article: Vozmozhnosti laparoskopicheskogo metoda v lechenii rasprostranennogo appendikulyarnogo peritonita.

Arutyunyan, A S / Blagovestnov, D A / Yartsev, P A / Levitsky, V D / Gulyaev, A A / Kislukhina, E V

Khirurgiia

2022 , Issue 7, Page(s) 24–32

Abstract: Objective: To analyze treatment outcomes in patients with acute appendicitis complicated by widespread peritonitis.: Material and methods: The study included 165 patients acute appendicitis complicated by widespread peritonitis. Inclusion criteria: ... ...

Title translation	Safety and efficacy of laparoscopic approach for widespread appendicular peritonitis.
Abstract	Objective: To analyze treatment outcomes in patients with acute appendicitis complicated by widespread peritonitis. Material and methods: The study included 165 patients acute appendicitis complicated by widespread peritonitis. Inclusion criteria: acute appendicitis complicated by widespread peritonitis MIP grade 1-2 in reactive or toxic phase (grading system by Simonyan K.S.), abdominal cavity index ≤16. Exclusion criteria: MIP grade 3, terminal phase, abdominal cavity index ≥17. Results: Analysis of postoperative data revealed no correlation between surgical approach and incidence of postoperative intra-abdominal abscesses and infiltrates. In the main group, intra-abdominal abscesses occurred in 4.9% of patients ( Conclusion: The developed differentiated surgical strategy for patients with appendicular peritonitis is effective and reduces the incidence of wound infection, extra-abdominal complications, and hospital-stay, as well as contributes to early rehabilitation of patients.
MeSH term(s)	Abdominal Abscess/diagnosis ; Abdominal Abscess/etiology ; Abdominal Abscess/surgery ; Appendicitis/complications ; Appendicitis/diagnosis ; Appendicitis/surgery ; Appendix ; Humans ; Laparoscopy/adverse effects ; Peritonitis/diagnosis ; Peritonitis/etiology ; Peritonitis/surgery
Language	Russian
Publishing date	2022-07-01
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	419230-8
ISSN	2309-5628 ; 0023-1207
ISSN (online)	2309-5628
ISSN	0023-1207
DOI	10.17116/hirurgia202207124
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Article: Evaluation of the topical hemostatic efficacy and safety of TISSEEL VH S/D fibrin sealant compared with currently licensed TISSEEL VH in patients undergoing cardiac surgery: a phase 3, randomized, double-blind clinical study.

Lowe, J / Luber, J / Levitsky, S / Hantak, E / Montgomery, J / Schiestl, N / Schofield, N / Marra, S

The Journal of cardiovascular surgery

2007 Volume 48, Issue 3, Page(s) 323–331

Abstract: ... to conventional methods of hemostasis during cardiac surgery. A next generation fibrin sealant (TISSEEL VH S/D ... detergent [S/D] treatment) to provide added safety and convenience to the currently licensed product ... prospective, randomized, double-blind, multicenter study to compare TISSEEL VH S/D to TISSEEL VH during ...

Abstract	Aim: TISSEEL VH is the only commercially available fibrin sealant indicated as an adjunct to conventional methods of hemostasis during cardiac surgery. A next generation fibrin sealant (TISSEEL VH S/D) has been developed in frozen, ready-to-use form with an added virus inactivation step (solvent/detergent [S/D] treatment) to provide added safety and convenience to the currently licensed product. This study was performed to compare efficacy and safety of the two products. Methods: Phase 3, prospective, randomized, double-blind, multicenter study to compare TISSEEL VH S/D to TISSEEL VH during cardiac surgery. The primary efficacy endpoint was the proportion of patients who achieved hemostasis at the primary treatment site within 5 min, and maintained hemostasis until surgical closure. Results: The proportion of patients who achieved hemostasis at the primary treatment site within 5 min, and maintained hemostasis until surgical closure was 88.2% for TISSEEL VH S/D and 89.6% for TISSEEL VH in the intent-to-treat population. The difference in proportions, TISSEEL VH S/D minus TISSEEL VH, was 1.4% with a standard error of 3.70%. The lower 97.5% confidence bound of this difference was 8.6%, which is above the predefined noninferiority margin of 15%. Therefore, TISSEEL VH S/D is at least as efficacious as TISSEEL VH. The safety profile of TISSEEL VH S/D was very similar to that of currently licensed TISSEEL VH as assessed by the safety endpoints. Conclusion: TISSEEL VH S/D is safe and effective for use as an adjunct to hemostasis in patients undergoing cardiac surgery.
MeSH term(s)	Administration, Topical ; Adult ; Aged ; Aged, 80 and over ; Blood Loss, Surgical/prevention & control ; Cardiac Surgical Procedures ; Cardiopulmonary Bypass ; Double-Blind Method ; Female ; Fibrin Tissue Adhesive/administration & dosage ; Fibrin Tissue Adhesive/adverse effects ; Fibrin Tissue Adhesive/therapeutic use ; Hemostasis, Surgical/methods ; Hemostatics/administration & dosage ; Hemostatics/adverse effects ; Hemostatics/therapeutic use ; Humans ; Male ; Middle Aged ; Postoperative Hemorrhage/prevention & control ; Prospective Studies ; Sternum/surgery ; Time Factors ; Tissue Adhesives/administration & dosage ; Tissue Adhesives/adverse effects ; Tissue Adhesives/therapeutic use ; Treatment Outcome ; United States
Chemical Substances	Fibrin Tissue Adhesive ; Hemostatics ; Tissue Adhesives
Language	English
Publishing date	2007-06
Publishing country	Italy
Document type	Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	80143-4
ISSN	1827-191X ; 0021-9509
ISSN (online)	1827-191X
ISSN	0021-9509
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Article ; Online: Essential Light Chains of Myosin and Their Role in Functioning of the Myosin Motor.

Logvinova, D S / Levitsky, D I

Biochemistry. Biokhimiia

2018 Volume 83, Issue 8, Page(s) 944–960

Abstract: This review summarizes current data on the structure and functions of myosin essential light chains (ELCs) and on their role in functioning of the myosin head as a molecular motor. The data on structural and functional features of the N-terminal ... ...

Abstract	This review summarizes current data on the structure and functions of myosin essential light chains (ELCs) and on their role in functioning of the myosin head as a molecular motor. The data on structural and functional features of the N-terminal extension of myosin ELC from skeletal and cardiac muscles are analyzed; the role of this extension in the ATP-dependent interaction of myosin heads with actin in the molecular mechanism of muscle contraction is discussed. The data on possible interactions of the ELC N-terminal extension with the myosin head motor domain in the myosin ATPase cycle are presented, including the results of the authors' studies that are in favor of such interactions.
MeSH term(s)	Amino Acid Sequence ; Animals ; Humans ; Myosin Light Chains/chemistry ; Myosin Light Chains/metabolism ; Protein Isoforms/chemistry ; Protein Isoforms/metabolism ; Structure-Activity Relationship
Chemical Substances	Myosin Light Chains ; Protein Isoforms
Language	English
Publishing date	2018-09-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1109-5
ISSN	1608-3040 ; 0006-2979 ; 0320-9717
ISSN (online)	1608-3040
ISSN	0006-2979 ; 0320-9717
DOI	10.1134/S0006297918080060
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Article: The effects of D-fenfluramine on the development of aflatoxin-B1 induced GGT+ hepatic foci in F344 rats

Bell, R.C / Levitsky, D.A / Campbell, T.C

International journal of obesity. Apr 1993. v. 17 (4)

1993

Abstract: ... with aflatoxin-B1 (AFB) and given the drug D-fenfluramine (FEN). Ingestion of this drug leads to a reduction ...

Abstract	The role of total caloric intake and attained body weight in the carcinogenic process in rodents is controversial. In the present study we examined the development of hepatic pre-neoplastic foci in rats treated with aflatoxin-B1 (AFB) and given the drug D-fenfluramine (FEN). Ingestion of this drug leads to a reduction in body weight by increasing the thermogenic response to a meal and by transiently reducing food intake. Young male rats were dosed with AFB or vehicle alone and were then assigned to receive control diet (NO FEN) or control diet + FEN (FEN; 0.15 g/kg diet) for 12-14 weeks. Body weight gain and food intake were reduced among animals given FEN; brown adipose tissue weight (% body weight) was elevated in these groups. Indices of protein status, and concentrations of T3, T4 and insulin did not differ among the groups. All animals given FEN developed GGT+ hepatic foci. The number and volume fraction of foci were significantly larger in FEN relative to NO FEN animals. The mean diameter of foci was slightly enhanced among FEN animals. These results suggest that FEN promotes the development of AFB-induced hepatocellular foci, despite reduced food intake and lower body weight. Since FEN is widely used as a weight loss aid, these findings deserve further study.
Keywords	aflatoxins ; fenfluramine ; energy intake ; body weight ; carcinogenesis ; rats
Language	English
Dates of publication	1993-04
Size	p. 215-221.
Document type	Article
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
Database	NAL-Catalogue (AGRICOLA)

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