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Article ; Online: A Post-Lockdown Assessment of Albendazole Treatment Coverage in Mass Drug Administration Campaigns Implemented Before and During COVID-19 Pandemic in Ekiti, Southwest Nigeria.

Mogaji, Hammed O / Okoh, Hilary I / Lawal, Abiodun M / Ojo, Kayode H / Marcus, Ayodele J / Aaron, Nwana O / Adeleye, Damilola R / Olamiju, Francisca O / Ekpo, Uwem F

International journal of public health

2023 Volume 68, Page(s) 1605510

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Child ; Humans ; Albendazole/therapeutic use ; Helminthiasis/drug therapy ; Helminthiasis/epidemiology ; Mass Drug Administration/methods ; Pandemics ; Nigeria/epidemiology ; COVID-19 ; Communicable Disease Control
Chemical Substances	Albendazole (F4216019LN)
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2274130-6
ISSN	1661-8564 ; 1661-8556
ISSN (online)	1661-8564
ISSN	1661-8556
DOI	10.3389/ijph.2023.1605510
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Article ; Online: Evolution of hierarchy in bacterial metabolic networks.

Goodman, Aaron J / Feldman, Marcus W

Bio Systems

2019 Volume 180, Page(s) 71–78

Abstract: Flow hierarchy is a useful way to characterize the movement of information and matter throughout a network. Hierarchical network organizations are shown to arise when there is a cost of maintaining links in the network. A similar constraint exists in ... ...

Abstract	Flow hierarchy is a useful way to characterize the movement of information and matter throughout a network. Hierarchical network organizations are shown to arise when there is a cost of maintaining links in the network. A similar constraint exists in metabolic networks, where costs come from reduced efficiency of nonspecific enzymes or from producing unnecessary enzymes. Previous analyses of bacterial metabolic networks have been used to predict the minimal nutrients that a bacterium needs to grow, its mutualistic relationships with other bacteria, and its major ecological niche. We use metabolic network inference to obtain metabolite flow graphs of 2935 bacterial metabolic networks and find that flow hierarchy evolves independently of modularity and other network properties. By inferring the ancestral metabolic networks and estimating the hierarchical character of the inferred network, we show that hierarchical structure first increased and later decreased over evolutionary history. Furthermore, hierarchical structure in the network is associated with slower growth rates; bacteria with hierarchy scores above the median grow on average 2.25 times faster than those with hierarchy scores below the median.
MeSH term(s)	Algorithms ; Bacteria/classification ; Bacteria/metabolism ; Biological Evolution ; Cluster Analysis ; Computer Simulation ; Metabolic Networks and Pathways ; Models, Biological
Language	English
Publishing date	2019-03-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	186234-0
ISSN	1872-8324 ; 0303-2647
ISSN (online)	1872-8324
ISSN	0303-2647
DOI	10.1016/j.biosystems.2019.02.012
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Article ; Online: The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases

Aaron W Jurrjens / Marcus M Seldin / Corey Giles / Peter J Meikle / Brian G Drew / Anna C Calkin

eLife, Vol

2023 Volume 12

Abstract: Cardiometabolic diseases encompass a range of interrelated conditions that arise from underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle factors. While obesity, dyslipidaemia, smoking, and insulin resistance are ... ...

Abstract	Cardiometabolic diseases encompass a range of interrelated conditions that arise from underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle factors. While obesity, dyslipidaemia, smoking, and insulin resistance are major risk factors for cardiometabolic diseases, individuals still present in the absence of such traditional risk factors, making it difficult to determine those at greatest risk of disease. Thus, it is crucial to elucidate the genetic, environmental, and molecular underpinnings to better understand, diagnose, and treat cardiometabolic diseases. Much of this information can be garnered using systems genetics, which takes population-based approaches to investigate how genetic variance contributes to complex traits. Despite the important advances made by human genome-wide association studies (GWAS) in this space, corroboration of these findings has been hampered by limitations including the inability to control environmental influence, limited access to pertinent metabolic tissues, and often, poor classification of diseases or phenotypes. A complementary approach to human GWAS is the utilisation of model systems such as genetically diverse mouse panels to study natural genetic and phenotypic variation in a controlled environment. Here, we review mouse genetic reference panels and the opportunities they provide for the study of cardiometabolic diseases and related traits. We discuss how the post-GWAS era has prompted a shift in focus from discovery of novel genetic variants to understanding gene function. Finally, we highlight key advantages and challenges of integrating complementary genetic and multi-omics data from human and mouse populations to advance biological discovery.
Keywords	systems genetics ; multi-omics ; genetic reference panels ; genome-wide association studies ; genetic mapping ; Hybrid Mouse Diversity Panel ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New approaches for measurement of platelet reactivity.

Marcus, Aaron J

Blood

2012 Volume 119, Issue 15, Page(s) 3378–3379

Abstract: In a highly interesting, intricate, and novel paper in this issue of Blood, Fung and colleagues have extended their previous pioneering studies and now reveal that molecules such as ATP can promote platelet activation through the P2X1 receptor. ...

Abstract	In a highly interesting, intricate, and novel paper in this issue of Blood, Fung and colleagues have extended their previous pioneering studies and now reveal that molecules such as ATP can promote platelet activation through the P2X1 receptor.
MeSH term(s)	Animals ; Blood Platelets/metabolism ; Calcium/metabolism ; Humans ; Platelet Membrane Glycoproteins/metabolism ; Receptors, Purinergic P2X1/metabolism ; Toll-Like Receptors/metabolism
Chemical Substances	Platelet Membrane Glycoproteins ; Receptors, Purinergic P2X1 ; Toll-Like Receptors ; platelet membrane glycoprotein VI ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2012-04-12
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2012-01-403717
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Article ; Online: The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases.

Jurrjens, Aaron W / Seldin, Marcus M / Giles, Corey / Meikle, Peter J / Drew, Brian G / Calkin, Anna C

eLife

2023 Volume 12

Abstract	Cardiometabolic diseases encompass a range of interrelated conditions that arise from underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle factors. While obesity, dyslipidaemia, smoking, and insulin resistance are major risk factors for cardiometabolic diseases, individuals still present in the absence of such traditional risk factors, making it difficult to determine those at greatest risk of disease. Thus, it is crucial to elucidate the genetic, environmental, and molecular underpinnings to better understand, diagnose, and treat cardiometabolic diseases. Much of this information can be garnered using systems genetics, which takes population-based approaches to investigate how genetic variance contributes to complex traits. Despite the important advances made by human genome-wide association studies (GWAS) in this space, corroboration of these findings has been hampered by limitations including the inability to control environmental influence, limited access to pertinent metabolic tissues, and often, poor classification of diseases or phenotypes. A complementary approach to human GWAS is the utilisation of model systems such as genetically diverse mouse panels to study natural genetic and phenotypic variation in a controlled environment. Here, we review mouse genetic reference panels and the opportunities they provide for the study of cardiometabolic diseases and related traits. We discuss how the post-GWAS era has prompted a shift in focus from discovery of novel genetic variants to understanding gene function. Finally, we highlight key advantages and challenges of integrating complementary genetic and multi-omics data from human and mouse populations to advance biological discovery.
MeSH term(s)	Animals ; Humans ; Mice ; Cardiovascular Diseases/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Obesity/genetics ; Phenotype ; Risk Factors
Language	English
Publishing date	2023-03-31
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.86139
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Article ; Online: Urinary microbiome differences between lichen sclerosus induced and non-lichen sclerosus induced urethral stricture disease.

Jamil, Marcus L / Perecman, Aaron / Sherman, Amanda / Sullivan, Travis / Christ, Kimberly / Hansma, Alexandra / Burks, Eric / Vanni, Alex J

World journal of urology

2023 Volume 41, Issue 9, Page(s) 2495–2501

Abstract: Objective: To describe differences in the urinary microbiome of patients with pathologically confirmed lichen sclerosus (LS) urethral stricture disease (USD) vs non-lichen sclerosus (non-LS) USD pre- and post-operatively.: Methods: Patients were pre- ... ...

Abstract	Objective: To describe differences in the urinary microbiome of patients with pathologically confirmed lichen sclerosus (LS) urethral stricture disease (USD) vs non-lichen sclerosus (non-LS) USD pre- and post-operatively. Methods: Patients were pre-operatively identified and prospectively followed, all underwent surgical repair and had tissue samples obtained to make a pathological diagnosis of LS. Pre- and post-operative urine samples were collected. Bacterial genomic DNA was extracted. Alpha and beta diversity measurements were calculated and compared. A zero-inflated negative binomial model was utilized to compare taxa abundances between disease status and surgery status. Results: Urine samples were obtained from both cohorts, 69 samples in total: 36 samples were obtained pre-operatively and 33 samples were obtained post-operatively. Ten patients provided both a pre-operative and post-operative urine sample. Twenty-six patients had pathological evidence of LS and 33 patients did not. There was a statistically significant difference in alpha diversity between the pre-operative urine samples of patients with non-LS USD and LS USD, (p = 0.01). There was no significant difference in alpha diversity within post-operative urine samples between patients with non-LS USD and LS USD, (p = 0.1). A significant difference was observed in Weighed UniFrac distances with respect to disease and operative status, (p = 0.001 and 0.002). Conclusions: LS USD have significant alterations in diversity and differential abundance of urine microbiota compared to non-LS USD controls. These findings could be used to guide further investigations into the role of the urinary microbiome in LS USD pathogenesis, severity of presentation, and stricture recurrence.
MeSH term(s)	Humans ; Urethral Stricture/etiology ; Constriction, Pathologic ; Lichen Sclerosus et Atrophicus/complications ; Lichen Sclerosus et Atrophicus/pathology
Language	English
Publishing date	2023-07-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-023-04490-0
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Article ; Online: Predicting variable gene content in

Nguyen, Marcus / Elmore, Zachary / Ihle, Clay / Moen, Francesco S / Slater, Adam D / Turner, Benjamin N / Parrello, Bruce / Best, Aaron A / Davis, James J

mSystems

2023 Volume 8, Issue 4, Page(s) e0005823

Abstract: Having the ability to predict the protein-encoding gene content of an incomplete genome or metagenome-assembled genome is important for a variety of bioinformatic tasks. In this study, as a proof of concept, we built machine learning classifiers for ... ...

Abstract	Having the ability to predict the protein-encoding gene content of an incomplete genome or metagenome-assembled genome is important for a variety of bioinformatic tasks. In this study, as a proof of concept, we built machine learning classifiers for predicting variable gene content in
MeSH term(s)	Escherichia coli/genetics ; Genome, Bacterial/genetics ; Plasmids ; Escherichia coli Proteins/genetics ; Anti-Infective Agents
Chemical Substances	Escherichia coli Proteins ; Anti-Infective Agents
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2379-5077
ISSN (online)	2379-5077
DOI	10.1128/msystems.00058-23
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Article ; Online: Changes in adipose tissue distribution and relation to cardiometabolic risk factors after Roux-en-Y gastric bypass in adolescents.

Beamish, Andrew J / Dengel, Olivia H / Palzer, Elise F / Gronowitz, Eva / Kelly, Aaron S / Dengel, Donald R / Rudser, Kyle D / Brissman, Markus / Olbers, Torsten / Dahlgren, Jovanna / Flodmark, Carl-Erik / Marcus, Claude / Ryder, Justin R

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

2023 Volume 19, Issue 10, Page(s) 1154–1161

Abstract: Background: Roux-en-Y gastric bypass (RYGB) among adolescents with obesity results in significant weight loss; however, depot-specific changes have been understudied.: Objective: We hypothesized that visceral adipose tissue (VAT) reduction in ... ...

Abstract	Background: Roux-en-Y gastric bypass (RYGB) among adolescents with obesity results in significant weight loss; however, depot-specific changes have been understudied. Objective: We hypothesized that visceral adipose tissue (VAT) reduction in adolescents undergoing RYGB would be greater than other depots and associated with improvement in cardiometabolic risk factors. Setting: Three specialized treatment centers in Sweden. Methods: Fifty-nine adolescents underwent dual x-ray absorptiometry before surgery and at 1, 2, and 5 years after RYGB. Changes in body composition in multiple depots (total fat, lean body, gynoid fat, android fat, subcutaneous adipose tissue, and VAT) and cardiometabolic risk factors were assessed using multiple linear regression analysis and generalized estimating equations adjusting for age, sex, and baseline risk factor levels. Data are presented as percent change (95% CI) with regression models showing slopes and estimated P values. Results: At 1 year post-RYGB, a significant reduction was observed across all body composition measures (P < .001) with the greatest reduction observed in VAT (-65.1% [-68.7, -61.8]). From year 1 to 5 years post-RYGB, a regain was observed in all depots except lean body mass (1.2% [.3, 2.7], P = .105). A sex-specific difference in overall trajectories was only observed in lean body mass with males consistently having higher mean levels. Change in VAT at 1 year correlated with change in triglycerides (slope: .21 mg/dL/kg, P = .034) and fasting plasma insulin (slope: 44 pmol/L/kg, P = .027). Conclusions: Adiposity measures all decreased after RYGB but poorly predicted change in cardiometabolic risk. Despite significant reductions at 1 year, a steady regain was observed out to 5 years, with values still well below baseline. Further research should consider control group comparison and extended follow-up.
MeSH term(s)	Male ; Female ; Humans ; Adolescent ; Gastric Bypass/methods ; Cardiometabolic Risk Factors ; Tissue Distribution ; Obesity/surgery ; Body Fat Distribution
Language	English
Publishing date	2023-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2274243-8
ISSN	1878-7533 ; 1550-7289
ISSN (online)	1878-7533
ISSN	1550-7289
DOI	10.1016/j.soard.2023.04.326
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Article ; Online: Long-Term Outcomes in Patients With Localized Ewing Sarcoma Treated With Interval-Compressed Chemotherapy on Children's Oncology Group Study AEWS0031.

Cash, Thomas / Krailo, Mark D / Buxton, Allen B / Pawel, Bruce R / Healey, John H / Binitie, Odion / Marcus, Karen J / Grier, Holcombe E / Grohar, Patrick J / Reed, Damon R / Weiss, Aaron R / Gorlick, Richard / Janeway, Katherine A / DuBois, Steven G / Womer, Richard B

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2023 Volume 41, Issue 30, Page(s) 4724–4728

Abstract: Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned coprimary or secondary analyses are not yet available. Clinical trial ... ...

Abstract	Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned coprimary or secondary analyses are not yet available. Clinical trial updates provide an opportunity to disseminate additional results from studies, published in
MeSH term(s)	Humans ; Child ; Sarcoma, Ewing/pathology ; Bone Neoplasms/therapy ; Etoposide ; Ifosfamide ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Doxorubicin ; Vincristine
Chemical Substances	Etoposide (6PLQ3CP4P3) ; Ifosfamide (UM20QQM95Y) ; Doxorubicin (80168379AG) ; Vincristine (5J49Q6B70F)
Language	English
Publishing date	2023-08-31
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.23.00053
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Article ; Online: A Post-Lockdown Assessment of Albendazole Treatment Coverage in Mass Drug Administration Campaigns Implemented Before and During COVID-19 Pandemic in Ekiti, Southwest Nigeria

Hammed O. Mogaji / Hilary I. Okoh / Abiodun M. Lawal / Kayode H. Ojo / Ayodele J. Marcus / Nwana O. Aaron / Damilola R. Adeleye / Francisca O. Olamiju / Uwem F. Ekpo

International Journal of Public Health, Vol

2023 Volume 68

Abstract: Objective: This study assessed the coverage of albendazole (ALB) in mass drug administration (MDA) programs implemented before (2019) and during the (2020 and 2021) COVID-19 pandemic in Ekiti State, Nigeria.Methods: Standardized questionnaires were ... ...

Abstract	Objective: This study assessed the coverage of albendazole (ALB) in mass drug administration (MDA) programs implemented before (2019) and during the (2020 and 2021) COVID-19 pandemic in Ekiti State, Nigeria.Methods: Standardized questionnaires were administered to 1,127 children across three peri-urban communities to ascertain if they received and swallowed ALB across the years. Reasons, why ALB was not received, were documented and analyzed in SPSS. 20.0.Results: In 2019, the medicine reach was between 42.2%–57.8%, however, during the pandemic, the reach significantly reduced to 12.3%–18.6%, and increased to 28.5%–35.2% in 2021 (p < 0.000). About 19.6%–27.2% of the participants have missed 1 MDA, while 26.9%–37.8% and 22.4%–32.8% have missed 2 and 3 MDAs, respectively. The majority who did not receive ALB (60.8%–75%) claimed drug distributors never came, while about 14.9%–20.3% mentioned they did not hear about MDA. However, individual compliance towards swallowing was above 94% across the study years (p < 0.00).Conclusion: These results highlight the need to explore the perceptions of those who have consistently missed MDAs, and also understand the health-system-related issues including those imposed by the pandemic affecting MDA.
Keywords	COVID-19 ; Nigeria ; soil-transmitted helminthiasis ; albendazole ; mass drug administration ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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