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Article ; Online: Letter to the Editor: Acute Intraocular Pressure Responses to Reading: The Influence of Body Position.

Singla, Ekta / Ichhpujani, Parul

2021 Volume 30, Issue 5, Page(s) e274

MeSH term(s)	Humans ; Intraocular Pressure ; Pattern Recognition, Visual ; Posture ; Reading ; Tonometry, Ocular
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	913494-3
ISSN	1536-481X ; 1057-0829
ISSN (online)	1536-481X
ISSN	1057-0829
DOI	10.1097/IJG.0000000000001821
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Article ; Online: Comment on: Factors affecting the early and mid-term success of needling for early failure of filtering bleb.

Singla, Ekta / Ichhpujani, Parul

Indian journal of ophthalmology

2021 Volume 69, Issue 10, Page(s) 2896–2897

MeSH term(s)	Humans ; Filtering Surgery ; Trabeculectomy
Language	English
Publishing date	2021-10-06
Publishing country	India
Document type	Letter ; Comment
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/ijo.IJO_979_21
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Article ; Online: Homocysteine and nutritional biomarkers in cognitive impairment.

Seema, Bhargava / Prahlad, K Sethi / Anuradha, Batra / Sangeeta, Choudhury / Parul, Takkar / Anjali, Manocha / Mamta, Kankra / Parul, Singla

Molecular and cellular biochemistry

2023 Volume 478, Issue 11, Page(s) 2497–2504

Abstract: Cognitive impairment is a progressive disorder that affects the ageing population. With the increase in the mean age of our population, it is becoming a public health problem. Homocysteinemia has been implicated in cognitive impairment. Whilst it is ... ...

Abstract	Cognitive impairment is a progressive disorder that affects the ageing population. With the increase in the mean age of our population, it is becoming a public health problem. Homocysteinemia has been implicated in cognitive impairment. Whilst it is modulated by vitamins B12 and folate, it acts through MMPs 2 and 9. To assesses the relationship of cognitive impairment with homocysteine, B12, folate and MMPs 2 and 9, so as to detect cases of mild cognitive impairment which are potentially reversible, blood samples were drawn from 73 enrolled subjects, with and without cognitive impairment on basis of Montreal cognitive assessment (MoCA) score < 25 or ≥ 25, respectively. Homocysteine, B12, folate and MMPs2 and 9 were estimated. Correlation between MoCA score and these parameters was elucidated. After adjusting for age and gender, homocysteine was the only significant independent predictor of MoCA score. Cut-off of homocysteine for prediction of MoCA < 25 was derived at 13.5 µmol/L(PPV = 59.6%; NPV = 79.2%). The equation derived for calculation of MoCA score from homocysteine is: MoCA score = 32.893 + [(- 0.223)(homocysteine in μmol/L)]. Homocysteine > 13.5 μmol/L predicts low MoCA (< 25) with 84.8% sensitivity and 50% specificity. Hence, patients with an Hcy > 13.5 μmol/L should be administered B12 and folate to reduce homocysteine, a modifiable risk factor of cognitive decline. Also, a novel equation for calculating MoCA score from homocysteine has been derived. Using this derived equation to calculate MoCA score, it may be possible to identify asymptomatic subjects with early cognitive impairment.
Language	English
Publishing date	2023-03-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-023-04679-2
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Article ; Online: Evolving epidemiology and chemical analysis of urinary stones

Parul Singla / Anjali Manocha / Seema Bhargava / Mamta Kankra / Anisha Sharma

Current Medicine Research and Practice, Vol 13, Iss 2, Pp 50-

A retrospective analysis

2023 Volume 54

Abstract: Background: Renal stones are a painful urological disorder resulting from the combined influence of epidemiological, biochemical and genetic risk factors. A high recurrence risk has been reported for renal stones, and 0.6%–3.2% cases may progress to end ... ...

Abstract	Background: Renal stones are a painful urological disorder resulting from the combined influence of epidemiological, biochemical and genetic risk factors. A high recurrence risk has been reported for renal stones, and 0.6%–3.2% cases may progress to end stage renal disease. Modern lifestyle, sedentary habits and unhealthy dietary practices are primary promoters of the stone boom in this millennium. Aims and Objectives: The aim of the present study is to evaluate the percentage of the stone type according to chemical composition and their association with epidemiological factors like sex and age. A retrospective analysis of the chemical composition of the stone samples received was done. Material and Methods: Stones samples were processed by Stone Analysis Set (BIOLABO S A, France). Qualitative chemical analysis was done for calcium, phosphorus, ammonium ion, oxalate, cystine, magnesium, carbonate and uric acid. Results: Type of renal stone and its incidence with age and sex have been evaluated. The total number of patients reporting to the hospital with renal stones was 123. Of these, 69.11% were male and 30.89% were female, with a male to female ratio of 2.23:1. The maximum occurrence was in the third and fourth decade of life. On analysis, 72.35% of total stones comprised calcium oxalate and 23.57% of nonoxalate (phosphate, magnesium, carbonate, ammonium ion) stones, whereas uric acid was positive in 4.06%. Conclusion: The occurrence of renal stones according to epidemiological factors such as age and sex in our study are similar to those reported in studies from developed countries. The data on urinary stones indicate that 98% were located in the upper urinary tract. Oxalate stones represent the main form of urolithiasis, affecting males more than females. The most important cause studied for renal stone formation is metabolic disturbances, but the genetic factors associated with the occurrence and recurrence of stone and mineral homeostasis of ions in kidney of stone formers should be further evaluated.
Keywords	calcium oxalate ; epidemiology ; urinary stones ; urolithiasis ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
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Article ; Online: Management of multi-surface ocular burns caused by molten iron.

Singla, Ekta / Jha, Ujjwal Prakash / Muralidharan, Shruti / Singh, Rohan Bir / Ichhpujani, Parul

Trauma case reports

2023 Volume 48, Page(s) 100925

Abstract: Ocular thermal burns are medical emergencies that require immediate intervention before the standard management protocol, which involves obtaining a detailed history and performing an ophthalmic examination. In this case report, we report the clinical ... ...

Abstract	Ocular thermal burns are medical emergencies that require immediate intervention before the standard management protocol, which involves obtaining a detailed history and performing an ophthalmic examination. In this case report, we report the clinical manifestations of ocular burns caused by molten iron and the steps taken for good clinical outcomes. The patient presented with an inferior epithelial defect and limbal and lower lid ischemia at four hours post-injury. Over the course of treatment, due to non-resolving epithelial defect and increased superior lid notching, amniotic membrane transplantation (AMT) and lid repair by pentagon wedge excision were performed. Following AMT, the corneal surface completely healed with residual opacity and neovascularization. Additionally, limbal ischemia was significantly reduced with the restoration of normal lid anatomy. Corneal burns initiate a cascade of inflammatory reactions disrupting the balance between pro- and anti-angiogenic factors, leading to corneal neovascularization. The eyelid damage can lead to necrosis of tissues with eschar formation and eventually quantitative tissue loss. Therefore, timely intervention is the key to the successful management of ocular burns.
Language	English
Publishing date	2023-09-02
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2835433-3
ISSN	2352-6440 ; 2352-6440
ISSN (online)	2352-6440
ISSN	2352-6440
DOI	10.1016/j.tcr.2023.100925
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Article: Tobacco use, tuberculosis and Covid-19: A lethal triad.

Mrigpuri, Parul / Gupta, Amitesh / Jha, Ritika / Singla, Pranjal / Singla, Rupak

The Indian journal of tuberculosis

2021 Volume 68S, Page(s) S86–S88

Abstract: Smoking, TB and Covid-19 are high prevalence entities with public health consequences. All three of them have a possible complex interaction at cellular level. Smoking behavior makes it difficult to maintain infection control measures. Smoking is known ... ...

Abstract	Smoking, TB and Covid-19 are high prevalence entities with public health consequences. All three of them have a possible complex interaction at cellular level. Smoking behavior makes it difficult to maintain infection control measures. Smoking is known to increase TB infection and also adversely affect treatment outcomes in TB. There is also upcoming evidence which suggests that smoking and TB increase the risk of severe Covid-19 symptoms. Simple infection control measures like, social distancing, cough etiquette, isolation, hand hygiene, quarantine, use of masks etc. play a pivotal role in prevention of these diseases. There is need of strengthening of the public health policies and incorporation of the Covid-19 safety awareness measures into the various national programmes.
MeSH term(s)	COVID-19/complications ; COVID-19/prevention & control ; Humans ; Pneumonia, Viral/complications ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; Risk Factors ; SARS-CoV-2 ; Smoking/adverse effects ; Tuberculosis/complications ; Tuberculosis/prevention & control
Language	English
Publishing date	2021-08-12
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	603129-8
ISSN	0019-5707 ; 0019-5705
ISSN	0019-5707 ; 0019-5705
DOI	10.1016/j.ijtb.2021.08.010
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Article ; Online: Navigating Through the Unchartered Waters of the COVID-19 Pandemic with Agility: Comments and Solutions.

Singla, Varun / Bawa, Chashamjot / Gupta, Parul / Singh, Amandeep

Pain physician

2020 Volume 23, Issue 6, Page(s) E742–E743

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Delivery of Health Care ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-11-13
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2146393-1
ISSN	2150-1149 ; 1533-3159
ISSN (online)	2150-1149
ISSN	1533-3159
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Zs.A 5930: Show issues

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Article ; Online: Change in contrast sensitivity and OCT parameters in idiopathic intracranial hypertension.

Rehman, Obaidur / Ichhpujani, Parul / Singla, Ekta / Negi, Reetika / Kumar, Suresh

Therapeutic advances in ophthalmology

2022 Volume 14, Page(s) 25158414221083358

Abstract: Background: Deterioration in peripheral contrast sensitivity (CS) can be an indicator to detect progressive deterioration of visual function in patients with idiopathic intracranial hypertension (IIH).: Objectives: The aim of this study was to ... ...

Abstract	Background: Deterioration in peripheral contrast sensitivity (CS) can be an indicator to detect progressive deterioration of visual function in patients with idiopathic intracranial hypertension (IIH). Objectives: The aim of this study was to evaluate the changes in central and peripheral CS and optical coherence tomography (OCT) parameters and in patients with IIH. Design and methods: In this pilot observational study, data of 20 eyes of 10 'treatment-naïve' IIH patients were analyzed. Detailed ocular examination was performed including CS assessment using both Pelli-Robson (PR) test and Spaeth-Richman Contrast Sensitivity Test (SPARCS) along with the OCT for macular and optic nerve head (ONH) parameters. A comparative analysis was done for CS and OCT parameters from baseline to a follow-up visit > 12 months (range: 18-24 months). Results: The study population had a female preponderance (80%, Conclusion: Peripheral CS showed significant difference in all eyes over time. It showed significant change in eyes with recurrence, even in the presence of intact visual acuity and preserved central CS. Changes in RNFL thickness and nasal MT could differentiate eyes which developed recurrence from normal eyes.
Language	English
Publishing date	2022-03-19
Publishing country	United States
Document type	Journal Article
ISSN	2515-8414
ISSN (online)	2515-8414
DOI	10.1177/25158414221083358
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Article ; Online: Surgical trends in glaucoma management: The current Indian scenario.

Ichhpujani, Parul / Singla, Ekta / Kalra, Gagan / Bhartiya, Shibal / Kumar, Suresh

International ophthalmology

2022 Volume 42, Issue 6, Page(s) 1661–1668

Abstract: Objectives: To assess the current trend in the surgical management of glaucoma in India.: Methods: An anonymous online survey evaluating the preferred choices in the surgical management of glaucoma was circulated among the members of Glaucoma Society ...

Abstract	Objectives: To assess the current trend in the surgical management of glaucoma in India. Methods: An anonymous online survey evaluating the preferred choices in the surgical management of glaucoma was circulated among the members of Glaucoma Society of India (GSI). Survey responses were compared to prior survey among GSI members in 2013 and members of American Glaucoma Society (AGS), 2016. Results: A total of 175 of 879(20%) GSI members participated in the survey of which 75.3% of the survey participants were practicing in the private sector. Trabeculectomy with or without augmentation with Mitomycin C(MMC) was the first-choice glaucoma incisional surgery for 96.6% of the survey participants. Of the participants doing tube surgery, use of valved GDD was the preferred choice (83.4%). Re-trabeculectomy was the preferred approach (60.7%) in case of trabeculectomy failure. For paediatric glaucomas, combined trabeculotomy with trabeculectomy was the preferred surgical approach for both hazy cornea (84.5%) as well as clear cornea (66%). For a POAG patient without prior incisional surgery and presenting with visually significant cataract, phacoemulsification with trabeculectomy was the preferred management approach by 58.7% of the participants. Conclusion: Trabeculectomy continues to be the clear winner for the Indian glaucoma surgeon because of its cost effectiveness, lack of expensive instrumentation, and a more robust surgical training for trabeculectomy during residency programs. A higher proportion of angle closure disease precludes the use of minimally invasive glaucoma surgery and very often tube shunts also. Economics, ease of access and follow-up made a combined cataract and glaucoma surgery a preferred choice among Indian surgeons.
MeSH term(s)	Cataract/complications ; Child ; Glaucoma/etiology ; Glaucoma/surgery ; Glaucoma Drainage Implants/adverse effects ; Humans ; Intraocular Pressure ; Mitomycin/therapeutic use ; Trabeculectomy/adverse effects ; Treatment Outcome
Chemical Substances	Mitomycin (50SG953SK6)
Language	English
Publishing date	2022-01-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-021-02160-x
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Article ; Online: Impact of moderate and severe primary open-angle glaucoma on quality of life due to activity limitation.

Nayyar, Shifali / Kumar, Suresh / Rehman, Obaidur / Ichhpujani, Parul / Singla, Ekta

Indian journal of ophthalmology

2022 Volume 70, Issue 2, Page(s) 552–557

Abstract: Purpose: To study the impact of moderate and severe primary open-angle glaucoma (POAG) on the quality of life (QoL) due to activity limitation using glaucoma-specific questionnaires.: Methods: This cross-sectional study enrolled 122 participants, 50% ...

Abstract	Purpose: To study the impact of moderate and severe primary open-angle glaucoma (POAG) on the quality of life (QoL) due to activity limitation using glaucoma-specific questionnaires. Methods: This cross-sectional study enrolled 122 participants, 50% (n = 61) being controls and 50% were diagnosed cases of moderate/severe POAG. Three orally administered glaucoma-specific QoL instruments were used: Glaucoma Activity Limitation (GAL-9), Glaucoma Quality of Life (GQL-15), and Viswanathan questionnaires. The questions related to activity limitation were identified and analyzed for each questionnaire separately. Results: The mean age of the participants was 61.04 ± 9.88 years and a majority were males (64.8%, n = 79). The mean scores in controls, moderate glaucoma, and severe POAG patients for GAL-9 questionnaire were 9.77 ± 1.36 (P = 0.44), 13.75 ± 4.76 (P < 0.001), and 23.45 ± 5.62 (P < 0.001), for GQL-15, these were 16.39 ± 2.18 (P = 0.5), 22.75 ± 7.89 (P < 0.001), and 39.34 ± 9.42 (P < 0.001), respectively, while for the Viswanathan questionnaire, they were 9.49 ± 0.94 (P = 0.38), 7.91 ± 1.59 (P < 0.001), and 4.41 ± 2.20 (P < 0.001), respectively. The GQL-15 and GAL-9 questionnaires concluded that activity limitation pertaining to dark adaptation-related tasks affected the QoL the most in moderate as well as severe POAG (P < 0.001). Using the Viswanathan questionnaire, it was observed that the peripheral vision-related activity limitation was most significant for the decrease in QoL in moderate POAG while near vision-related activity limitation affected the QoL the most in severe POAG (P < 0.001). Conclusion: All three questionnaires concluded that the activity limitation due to moderate and severe glaucoma has a negative impact on the QoL. The limitation of the tasks involving dark adaptation/glare and peripheral vision has the most significant impact on the QoL in moderate glaucoma. As the disease progresses to a severe category, the limitation of activities requiring central and near vision causes the most significant worsening in QoL.
MeSH term(s)	Aged ; Cross-Sectional Studies ; Glaucoma, Open-Angle/diagnosis ; Humans ; Male ; Middle Aged ; Quality of Life ; Surveys and Questionnaires ; Visual Acuity
Language	English
Publishing date	2022-01-27
Publishing country	India
Document type	Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/ijo.IJO_1687_21
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