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Article ; Online: Oral-to-rectum microbial transmission in orthopedic patients without a history of intestinal disorders.

Lin, Ge / Kageyama, Shinya / Maeda, Aiko / Sakamoto, Eiji / Ma, Jiale / Asakawa, Mikari / Furuta, Michiko / Yamashita, Yoshihisa / Takeshita, Toru

Frontiers in cellular and infection microbiology

2024 Volume 14, Page(s) 1358684

Abstract: The enrichment of oral taxa in the gut has recently been reported as a notable alteration in the microbial balance in patients with intestinal disorders. However, translocation in populations without such diseases remains controversial. In this study, we ...

Abstract	The enrichment of oral taxa in the gut has recently been reported as a notable alteration in the microbial balance in patients with intestinal disorders. However, translocation in populations without such diseases remains controversial. In this study, we examined 49 pairs of tongue and rectal samples collected from orthopedic patients without a history of intestinal disorders to verify the presence of oral taxa in the rectal microbiota. The bacterial composition of each sample was determined using 16S rRNA gene sequencing and amplicon sequence variant (ASV) analysis. Although the bacterial compositions of the tongue and rectal microbiota were distinctly different, tongue ASVs were detected in 67.3% of the participants and accounted for 0.0%-9.37% of the rectal microbiota. Particularly,
MeSH term(s)	Humans ; Male ; Female ; RNA, Ribosomal, 16S/genetics ; Middle Aged ; Gastrointestinal Microbiome/genetics ; Adult ; Tongue/microbiology ; Aged ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Rectum/microbiology ; Mouth/microbiology ; DNA, Bacterial/genetics ; Young Adult ; Proton Pump Inhibitors ; Sequence Analysis, DNA ; Hypertension/microbiology ; Microbiota
Chemical Substances	RNA, Ribosomal, 16S ; DNA, Bacterial ; Proton Pump Inhibitors
Language	English
Publishing date	2024-04-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2024.1358684
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Article ; Online: Comparison of cold snare polypectomy for sessile serrated lesions ≥10 mm between experienced and trainee endoscopists: A propensity score matching cohort study.

Kimoto, Yoshiaki / Sawada, Rikimaru / Banjoya, Susumu / Iida, Toshihumi / Kimura, Tomoya / Furuta, Koichi / Nagae, Shinya / Ito, Yohei / Yamazaki, Hiroshi / Takeuchi, Nao / Takayanagi, Syunya / Kano, Yuki / Sakuno, Takashi / Ono, Kohei / Negishi, Ryoju / Sakai, Eiji / Minato, Yohei / Chiba, Hideyuki / Ohata, Ken

DEN open

2024 Volume 4, Issue 1, Page(s) e328

Abstract: Objectives: Previous studies of cold snare polypectomy (CSP) for sessile serrated lesions (SSLs) ≥10 mm were performed by experienced endoscopists, and therefore their skills might have significantly influenced results. In this study, we compared the ... ...

Abstract	Objectives: Previous studies of cold snare polypectomy (CSP) for sessile serrated lesions (SSLs) ≥10 mm were performed by experienced endoscopists, and therefore their skills might have significantly influenced results. In this study, we compared the efficacy and safety of CSP for SSLs ≥10 mm between experienced and trainee endoscopists. Methods: In a 1:1 propensity score matched retrospective cohort study, we compared the complete resection rate, en-bloc resection rate, adverse event rate, and procedure time between experienced and trainee groups. Thirteen endoscopists performed CSP, and we defined the experienced group as endoscopists with board certification from the Japan Gastroenterological Endoscopy Society. Results: We examined 616 lesions with SSLs ≥10 mm resected by CSP between February 2018 and May 2022. We excluded 61 lesions from the analysis because they had simultaneously undergone hot snare polypectomy ( Conclusions: We have demonstrated the safety and efficacy of CSP for SSLs ≥10 mm performed by experienced and trainee endoscopists.
Language	English
Publishing date	2024-01-06
Publishing country	Australia
Document type	Journal Article
ISSN	2692-4609
ISSN (online)	2692-4609
DOI	10.1002/deo2.328
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Article: Efficacy and safety of cap-assisted endoscopic mucosal resection for superficial duodenal epithelial neoplasia ≤ 10 mm.

Endoscopy international open

2023 Volume 11, Issue 10, Page(s) E976–E982

Abstract: Background and study ... ...

Abstract	Background and study aims
Language	English
Publishing date	2023-10-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722
ISSN (online)	2196-9736
ISSN	2364-3722
DOI	10.1055/a-2161-2212
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Article ; Online: Efficacy and Safety of Nepcell S

Goya, Reimi / Takemoto, Masao / Nyuta, Eiji / Antoku, Yoshibumi / Yamaguchi, Arisa / Furuta, Noriko / Eto, Ayako / Mito, Takahiro / Kurachi, Michiko / Koga, Tokushi / Tsuchihashi, Takuya

Circulation reports

2021 Volume 3, Issue 12, Page(s) 691–698

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-09-09
Publishing country	Japan
Document type	Journal Article
ISSN	2434-0790
ISSN (online)	2434-0790
DOI	10.1253/circrep.CR-21-0105
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Article: Favorite Music Mediates Pain-related Responses in the Anterior Cingulate Cortex and Skin Pain Thresholds.

Antioch, Iulia / Furuta, Tsumugu / Uchikawa, Ryutaro / Okumura, Masayo / Otogoto, Junichi / Kondo, Eiji / Sogawa, Norio / Ciobica, Alin / Tomida, Mihoko

Journal of pain research

2020 Volume 13, Page(s) 2729–2737

Abstract: Purpose: Music therapy is widely used to enhance well-being, reduce pain, and distract patients from unpleasant symptoms in the clinical setting. However, the degree to which music modulates pain perception is unknown. The medial pain pathway including ... ...

Abstract	Purpose: Music therapy is widely used to enhance well-being, reduce pain, and distract patients from unpleasant symptoms in the clinical setting. However, the degree to which music modulates pain perception is unknown. The medial pain pathway including the limbic system is associated with emotion, but how music alters pathway activity is unclear. The aim of the study was to investigate pain thresholds and pain-related responses in the anterior cingulate cortex (ACC) and whether they were modulated when subjects listened to their favorite music genre. Subjects and methods: First, 30 subjects were examined for left forearm pain threshold using electrical stimulation with Pain Vision PS-2011N. The pain thresholds with and without music were compared. Second, when an 80-μA current from Pain Vision was applied to the left ankle of eight women, the pain-related responses of the ACC with and without music were observed with functional magnetic resonance device (fMRI). The changes in the pain-related activity in both parameters were discussed. Results: The median pain threshold with favorite music was 38.9 μA, compared to 29.0 μA without, which was significantly different ( Conclusion: The present findings suggest that pain perception might be strongly affected by listening to favorite music, possibly through modulation of pain-related responses in the ACC.
Language	English
Publishing date	2020-10-29
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S276274
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Article: Efficacy and safety of cap-assisted endoscopic mucosal resection for superficial duodenal epithelial neoplasia ≤ 10 mm

Endoscopy International Open

2023 Volume 11, Issue 10, Page(s) E976–E982

Abstract: Background and study aims: Endoscopic treatment strategies for small superficial duodenal epithelial neoplasia (SDET) have not been established, and the R0 resection rates of all previously reported endoscopic techniques are somewhat low. Furthermore, ... ...

Abstract	Background and study aims: Endoscopic treatment strategies for small superficial duodenal epithelial neoplasia (SDET) have not been established, and the R0 resection rates of all previously reported endoscopic techniques are somewhat low. Furthermore, no reports of cap-assisted endoscopic mucosal resection (EMRC), which is reportedly associated with a relatively high R0 resection rate, have been evaluated in sufficient numbers of patients. Therefore, we assessed the efficacy and safety of EMRC for SDETs ≤ 10 mm in a retrospective cohort study. Patients and methods: We examined a prospectively maintained database and identified 248 consecutive patients (248 lesions) who had undergone endoscopic resection for SDETs ≤ 10 mm between January 2017 and June 2022. Our treatment strategy was consistent, with EMRC indicated for all SDETs ≤ 10 mm without non-lifting signs. The primary endpoint was the R0 resection rate. Results: Overall, 20 lesions had non-lifting signs and were selected for endoscopic submucosal dissection, while the remaining 228 lesions were treated with EMRC. As a result of EMRC, the median tumor size was 5 mm, and the mean procedure time was 5 minutes. Most of the lesions (89.2%) were located in the descending part. The R0 resection rate was 97.4% (222/228 cases), and the en bloc resection rate was 99.6%. Only seven patients(3.1%) experienced adverse events (6 patients, delayed bleeding; 1 patient, acute pancreatitis), which were successfully managed without surgical intervention. Furthermore, no recurrences were observed. Conclusions: We have demonstrated that EMRC is an effective and safe treatment for SDETs ≤ 10 mm that do not have non-lifting signs.
Keywords	Endoscopy Upper GI Tract ; Diagnosis and imaging (inc chromoendoscopy, NBI, iSCAN, FICE, CLE) ; Endoscopic resection (ESD, EMRc, ...) ; Endoscopy Small Bowel ; Neoplasia
Language	English
Publishing date	2023-08-28
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722 ; 2196-9736
ISSN (online)	2196-9736
ISSN	2364-3722 ; 2196-9736
DOI	10.1055/a-2161-2212
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Article ; Online: Glycoform of a newly identified pollen allergen, Cha o 3, from Chamaecyparis obtusa (Japanese cypress, Hinoki).

Osada, Toshihiro / Maeda, Megumi / Tanabe, Chinatsu / Furuta, Kaori / Vavricka, Christopher J / Sasaki, Eiji / Okano, Mitsuhiro / Kimura, Yoshinobu

Carbohydrate research

2017 Volume 448, Page(s) 18–23

Abstract: Cha o 3 is a newly found glycosylated allergen from Chamaecyparis obtusa (Japanese cypress) pollen. The deduced amino acid sequence of Cha o 3 indicates that this glycoallergen contains a cellulase domain and a number of putative N-glycosylation sites. ... ...

Abstract	Cha o 3 is a newly found glycosylated allergen from Chamaecyparis obtusa (Japanese cypress) pollen. The deduced amino acid sequence of Cha o 3 indicates that this glycoallergen contains a cellulase domain and a number of putative N-glycosylation sites. However, the structures of N -glycans linked to Cha o 3 remain to be determined. In this study, therefore, we analyzed the glycoform of Cha o 3 and found that this glycoallergen carries exclusively plant complex-type N-glycans; major structures were GlcNAc
Language	English
Publishing date	2017-08-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1435-7
ISSN	1873-426X ; 0008-6215
ISSN (online)	1873-426X
ISSN	0008-6215
DOI	10.1016/j.carres.2017.05.005
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Article ; Online: Nonstructural protein 5A/P32 deletion after failure of ledipasvir/sofosbuvir in hepatitis C virus genotype 1b infection.

Doi, Akira / Hikita, Hayato / Sakamori, Ryotaro / Tahata, Yuki / Kai, Yugo / Yamada, Ryoko / Yakushijin, Takayuki / Mita, Eiji / Ohkawa, Kazuyoshi / Imai, Yasuharu / Furuta, Kunimaro / Kodama, Takahiro / Tatsumi, Tomohide / Takehara, Tetsuo

Hepatology (Baltimore, Md.)

2018 Volume 68, Issue 1, Page(s) 380–383

MeSH term(s)	Aged ; Antiviral Agents/therapeutic use ; Benzimidazoles/therapeutic use ; Fluorenes/therapeutic use ; Genotype ; Hepacivirus/genetics ; Hepatitis C/drug therapy ; Hepatitis C/virology ; Humans ; Male ; Sequence Deletion ; Sofosbuvir/therapeutic use ; Treatment Failure ; Viral Nonstructural Proteins/genetics
Chemical Substances	Antiviral Agents ; Benzimidazoles ; Fluorenes ; Viral Nonstructural Proteins ; ledipasvir (013TE6E4WV) ; NS-5 protein, hepatitis C virus (EC 2.7.7.48) ; Sofosbuvir (WJ6CA3ZU8B)
Language	English
Publishing date	2018-05-14
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.29836
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Article: Metabolic genes in cancer: their roles in tumor progression and clinical implications.

Furuta, Eiji / Okuda, Hiroshi / Kobayashi, Aya / Watabe, Kounosuke

Biochimica et biophysica acta

2010 Volume 1805, Issue 2, Page(s) 141–152

Abstract: Re-programming of metabolic pathways is a hallmark of physiological changes in cancer cells. The expression of certain genes that directly control the rate of key metabolic pathways including glycolysis, lipogenesis and nucleotide synthesis are ... ...

Abstract	Re-programming of metabolic pathways is a hallmark of physiological changes in cancer cells. The expression of certain genes that directly control the rate of key metabolic pathways including glycolysis, lipogenesis and nucleotide synthesis are drastically altered at different stages of tumor progression. These alterations are generally considered as an adaptation of tumor cells; however, they also contribute to the progression of tumor cells to become more aggressive phenotypes. This review summarizes the recent information about the mechanistic link of these genes to oncogenesis and their potential utility as diagnostic markers as well as for therapeutic targets. We particularly focus on three groups of genes; GLUT1, G6PD, TKTL1 and PGI/AMF in glycolytic pathway, ACLY, ACC1 and FAS in lipogenesis and RRM2, p53R2 and TYMS for nucleotide synthesis. All these genes are highly up-regulated in a variety of tumor cells in cancer patients, and they play active roles in tumor progression rather than expressing merely as a consequence of phenotypic change of the cancer cells. Molecular dissection of their orchestrated networks and understanding the exact mechanism of their expression will provide a window of opportunity to target these genes for specific cancer therapy. We also reviewed existing database of gene microarray to validate the utility of these genes for cancer diagnosis.
MeSH term(s)	Disease Progression ; Genes, Neoplasm/physiology ; Humans ; Metabolic Networks and Pathways/genetics ; Neoplasms/genetics ; Neoplasms/physiopathology
Language	English
Publishing date	2010-02-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbcan.2010.01.005
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Article ; Online: Clopidogrel response predicts thromboembolic events associated with coil embolization of unruptured intracranial aneurysms: A prospective cohort study.

Higashi, Eiji / Matsumoto, Shoji / Nakahara, Ichiro / Hatano, Taketo / Ishii, Akira / Sadamasa, Nobutake / Ohta, Tsuyoshi / Ishihara, Takuma / Tokunaga, Keisuke / Ando, Mitsushige / Chihara, Hideo / Furuta, Konosuke / Hashimoto, Tetsuya / Tanaka, Koji / Sonoda, Kazutaka / Koge, Junpei / Takita, Wataru / Hashikawa, Takuro / Funakoshi, Yusuke /

Kondo, Daisuke / Kamata, Takahiko / Tsujimoto, Atsushi / Matsushita, Takuya / Murai, Hiroyuki / Matsuo, Keitaro / Kitazono, Takanari / Kira, Junichi

PloS one

2021 Volume 16, Issue 4, Page(s) e0249766

Abstract: Objective: Periprocedural thromboembolic events are a serious complication associated with coil embolization of unruptured intracranial aneurysms. However, no established clinical rule for predicting thromboembolic events exists. This study aimed to ... ...

Abstract	Objective: Periprocedural thromboembolic events are a serious complication associated with coil embolization of unruptured intracranial aneurysms. However, no established clinical rule for predicting thromboembolic events exists. This study aimed to clarify the significance of adding preoperative clopidogrel response value to clinical factors when predicting the occurrence of thromboembolic events during/after coil embolization and to develop a nomogram for thromboembolic event prediction. Methods: In this prospective, single-center, cohort study, we included 345 patients undergoing elective coil embolization for unruptured intracranial aneurysm. Thromboembolic event was defined as the occurrence of intra-procedural thrombus formation and postprocedural symptomatic cerebral infarction within 7 days. We evaluated preoperative clopidogrel response and patients' clinical information. We developed a patient-clinical-information model for thromboembolic event using multivariate analysis and compared its efficiency with that of patient-clinical-information plus preoperative clopidogrel response model. The predictive performances of the two models were assessed using area under the receiver-operating characteristic curve (AUC-ROC) with bootstrap method and compared using net reclassification improvement (NRI) and integrated discrimination improvement (IDI). Results: Twenty-eight patients experienced thromboembolic events. The clinical model included age, aneurysm location, aneurysm dome and neck size, and treatment technique. AUC-ROC for the clinical model improved from 0.707 to 0.779 after adding the clopidogrel response value. Significant intergroup differences were noted in NRI (0.617, 95% CI: 0.247-0.987, p < .001) and IDI (0.068, 95% CI: 0.021-0.116, p = .005). Conclusions: Evaluation of preoperative clopidogrel response in addition to clinical variables improves the prediction accuracy of thromboembolic event occurrence during/after coil embolization of unruptured intracranial aneurysm.
MeSH term(s)	Aged ; Blood Vessel Prosthesis/adverse effects ; Clopidogrel/therapeutic use ; Embolization, Therapeutic/adverse effects ; Female ; Humans ; Intracranial Aneurysm/therapy ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/therapeutic use ; Prospective Studies ; Thromboembolism/prevention & control
Chemical Substances	Platelet Aggregation Inhibitors ; Clopidogrel (A74586SNO7)
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0249766
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