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  1. Article ; Online: The role of male scent in female attraction in the bank vole, Myodes glareolus.

    Coombes, Holly A / Prescott, Mark C / Stockley, Paula / Beynon, Robert J / Hurst, Jane L

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4812

    Abstract: Chemical signals are frequently utilised by male mammals for intersexual communication and females are often attracted to male scent. However, the mechanism underlying female attraction has only been identified in a small number of mammalian species. ... ...

    Abstract Chemical signals are frequently utilised by male mammals for intersexual communication and females are often attracted to male scent. However, the mechanism underlying female attraction has only been identified in a small number of mammalian species. Mammalian scents contain airborne volatiles, that are detected by receivers at a distance from the scent source, as well as non-volatile molecules, such as proteins, that require physical contact for detection. Lipocalin proteins, produced within the scent secretions of many terrestrial mammals, are thought to be particularly important in chemical signalling. Here, we explore if the male-specific protein, glareosin, expressed by adult male bank voles, Myodes glareolus, stimulates female attraction to male scent. We show that female bank voles are more attracted to male compared to female scent, supporting the results of previous studies. Increased investigation and attraction to male scent occurred to both airborne volatiles and non-volatile proteins when they were presented separately. However, we found no evidence that attraction to male scent was driven by glareosin. Our results differ from those previously described in house mice, where a single protein induces female attraction to male scent, suggesting the mechanism underlying female attraction to male scent differs between species.
    MeSH term(s) Female ; Male ; Animals ; Mice ; Odorants ; Pheromones ; Proteins/metabolism ; Arvicolinae/metabolism ; Mammals/metabolism
    Chemical Substances Pheromones ; Proteins
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55235-x
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  2. Article ; Online: Glycoproteins Involved in Sea Urchin Temporary Adhesion.

    Ventura, Inês / Harman, Victoria / Beynon, Robert J / Santos, Romana

    Marine drugs

    2023  Volume 21, Issue 3

    Abstract: Biomedical adhesives, despite having been used increasingly in recent years, still face a major technological challenge: strong adhesion in wet environments. In this context, biological adhesives secreted by marine invertebrates have appealing ... ...

    Abstract Biomedical adhesives, despite having been used increasingly in recent years, still face a major technological challenge: strong adhesion in wet environments. In this context, biological adhesives secreted by marine invertebrates have appealing characteristics to incorporate into new underwater biomimetic adhesives: water resistance, nontoxicity and biodegradability. Little is still known about temporary adhesion. Recently, a transcriptomic differential analysis of sea urchin
    MeSH term(s) Animals ; Glycoproteins/metabolism ; Adhesives/chemistry ; Adhesives/metabolism ; Paracentrotus/metabolism ; Mass Spectrometry ; Lectins/metabolism
    Chemical Substances Glycoproteins ; Adhesives ; Lectins
    Language English
    Publishing date 2023-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21030145
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  3. Article ; Online: Glycoproteins Involved in Sea Urchin Temporary Adhesion

    Inês Ventura / Victoria Harman / Robert J. Beynon / Romana Santos

    Marine Drugs, Vol 21, Iss 145, p

    2023  Volume 145

    Abstract: Biomedical adhesives, despite having been used increasingly in recent years, still face a major technological challenge: strong adhesion in wet environments. In this context, biological adhesives secreted by marine invertebrates have appealing ... ...

    Abstract Biomedical adhesives, despite having been used increasingly in recent years, still face a major technological challenge: strong adhesion in wet environments. In this context, biological adhesives secreted by marine invertebrates have appealing characteristics to incorporate into new underwater biomimetic adhesives: water resistance, nontoxicity and biodegradability. Little is still known about temporary adhesion. Recently, a transcriptomic differential analysis of sea urchin Paracentrotus lividus tube feet pinpointed 16 adhesive/cohesive protein candidates. In addition, it has been demonstrated that the adhesive secreted by this species is composed of high molecular weight proteins associated with N-Acetylglucosamine in a specific chitobiose arrangement. As a follow-up, we aimed to investigate which of these adhesive/cohesive protein candidates were glycosylated through lectin pulldowns, protein identification by mass spectroscopy and in silico characterization. We demonstrate that at least five of the previously identified protein adhesive/cohesive candidates are glycoproteins. We also report the involvement of a third Nectin variant, the first adhesion-related protein to be identified in P. lividus . By providing a deeper characterization of these adhesive/cohesive glycoproteins, this work advances our understanding of the key features that should be replicated in future sea urchin-inspired bioadhesives.
    Keywords sea urchin ; tube feet ; bioadhesive ; glycoproteins ; biomimetic adhesive ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Unraveling female communication through scent marks in the Norway rat.

    Gómez-Baena, Guadalupe / Pounder, Kieran C / Halstead, Josiah O / Roberts, Sarah A / Davidson, Amanda J / Prescott, Mark / Beynon, Robert J / Hurst, Jane L

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 25, Page(s) e2300794120

    Abstract: Chemical communication by females remains poorly understood, with most attention focused on female advertisement of sexual receptivity to males or mother-offspring communication. However, in social species, scents are likely to be important for mediating ...

    Abstract Chemical communication by females remains poorly understood, with most attention focused on female advertisement of sexual receptivity to males or mother-offspring communication. However, in social species, scents are likely to be important for mediating competition and cooperation between females determining individual reproductive success. Here, we explore chemical signaling by female laboratory rats (
    MeSH term(s) Female ; Male ; Animals ; Rats ; Odorants ; Proteomics ; Body Fluids ; Genetic Background ; Hydrolases ; Pheromones
    Chemical Substances Hydrolases (EC 3.-) ; Pheromones
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2300794120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Cryptic kin discrimination during communal lactation in mice favours cooperation between relatives.

    Green, Jonathan P / Franco, Catarina / Davidson, Amanda J / Lee, Vicki / Stockley, Paula / Beynon, Robert J / Hurst, Jane L

    Communications biology

    2023  Volume 6, Issue 1, Page(s) 734

    Abstract: Breeding females can cooperate by rearing their offspring communally, sharing synergistic benefits of offspring care but risking exploitation by partners. In lactating mammals, communal rearing occurs mostly among close relatives. Inclusive fitness ... ...

    Abstract Breeding females can cooperate by rearing their offspring communally, sharing synergistic benefits of offspring care but risking exploitation by partners. In lactating mammals, communal rearing occurs mostly among close relatives. Inclusive fitness theory predicts enhanced cooperation between related partners and greater willingness to compensate for any partner under-investment, while females are less likely to bias investment towards own offspring. We use a dual isotopic tracer approach to track individual milk allocation when familiar pairs of sisters or unrelated house mice reared offspring communally. Closely related pairs show lower energy demand and pups experience better access to non-maternal milk. Lactational investment is more skewed between sister partners but females pay greater energetic costs per own offspring reared with an unrelated partner. The choice of close kin as cooperative partners is strongly favoured by these direct as well as indirect benefits, providing a driver to maintain female kin groups for communal breeding.
    MeSH term(s) Female ; Animals ; Mice ; Lactation ; Milk ; Mammals
    Language English
    Publishing date 2023-07-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-05115-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Rapid identification of mosquito species and age by mass spectrometric analysis.

    Wagner, Iris / Grigoraki, Linda / Enevoldson, Peter / Clarkson, Michael / Jones, Sam / Hurst, Jane L / Beynon, Robert J / Ranson, Hilary

    BMC biology

    2023  Volume 21, Issue 1, Page(s) 10

    Abstract: Background: A rapid, accurate method to identify and to age-grade mosquito populations would be a major advance in predicting the risk of pathogen transmission and evaluating the public health impact of vector control interventions. Whilst other ... ...

    Abstract Background: A rapid, accurate method to identify and to age-grade mosquito populations would be a major advance in predicting the risk of pathogen transmission and evaluating the public health impact of vector control interventions. Whilst other spectrometric or transcriptomic methods show promise, current approaches rely on challenging morphological techniques or simple binary classifications that cannot identify the subset of the population old enough to be infectious. In this study, the ability of rapid evaporative ionisation mass spectrometry (REIMS) to identify the species and age of mosquitoes reared in the laboratory and derived from the wild was investigated.
    Results: The accuracy of REIMS in identifying morphologically identical species of the Anopheles gambiae complex exceeded 97% using principal component/linear discriminant analysis (PC-LDA) and 84% based on random forest analysis. Age separation into 3 different age categories (1 day, 5-6 days, 14-15 days) was achieved with 99% (PC-LDA) and 91% (random forest) accuracy. When tested on wild mosquitoes from the UK, REIMS data could determine the species and age of the specimens with accuracies of 91 and 90% respectively.
    Conclusions: The accuracy of REIMS to resolve the species and age of Anopheles mosquitoes is comparable to that achieved by infrared spectroscopy approaches. The processing time and ease of use represent significant advantages over current, dissection-based methods. Importantly, the accuracy was maintained when using wild mosquitoes reared under differing environmental conditions, and when mosquitoes were stored frozen or desiccated. This high throughput approach thus has potential to conduct rapid, real-time monitoring of vector populations, providing entomological evidence of the impact of alternative interventions.
    MeSH term(s) Animals ; Mosquito Vectors ; Mass Spectrometry/methods ; Anopheles
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2133020-7
    ISSN 1741-7007 ; 1741-7007
    ISSN (online) 1741-7007
    ISSN 1741-7007
    DOI 10.1186/s12915-022-01508-8
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  7. Article ; Online: Dissection of schistosome tissues under LC-MS compatible preservative conditions for quantitative proteomics.

    Neves, Leandro Xavier / Wilson, R Alan / Brownridge, Philip / Holman, Stephen W / Harman, Victoria M / Eyers, Claire E / Beynon, Robert J / Castro-Borges, William

    Rapid communications in mass spectrometry : RCM

    2023  Volume 38 Suppl 1, Page(s) e9523

    Abstract: Schistosomes are blood flukes with specialised tissues and organs, each one playing a pivotal role in perpetuating the parasite life cycle. Herein, we describe a detailed methodology for preserving the proteome of adult Schistosoma mansoni worms during ... ...

    Abstract Schistosomes are blood flukes with specialised tissues and organs, each one playing a pivotal role in perpetuating the parasite life cycle. Herein, we describe a detailed methodology for preserving the proteome of adult Schistosoma mansoni worms during manual dissection for enrichment of tissues associated with the parasite's alimentary tract. We provide step-by-step directions for specimen storage and dissection while in preservative solution, tissue homogenisation, protein extraction and digestion using a methodology fully compatible with downstream quantitative liquid chromatography-mass spectrometry analysis. Our methodology uses label-free and QconCAT-based absolute quantification for detection of S. mansoni oesophageal gland products proposed as vaccine candidates. Through stabilisation of the proteome and minimising sample degradation during dissection our approach has allowed us to access the hidden proteome of target tissues not readily available from total lysates because of their small volume. This protocol can be replicated or adapted to other Schistosoma species lacking quantitative proteomics characterisation of specialised tissues for discovery of proteins with potential diagnostic and therapeutic utility.
    MeSH term(s) Animals ; Proteomics/methods ; Liquid Chromatography-Mass Spectrometry ; Chromatography, Liquid ; Proteome/metabolism ; Tandem Mass Spectrometry ; Schistosoma mansoni/chemistry ; Schistosoma mansoni/metabolism
    Chemical Substances Proteome
    Language English
    Publishing date 2023-06-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 58731-x
    ISSN 1097-0231 ; 0951-4198
    ISSN (online) 1097-0231
    ISSN 0951-4198
    DOI 10.1002/rcm.9523
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3461: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book: Buffer solutions

    Beynon, Robert J. / Easterby, J. S.

    the basics

    (The basics)

    1996  

    Author's details R. J. Beynon and J. S. Easterby
    Series title The basics
    Keywords Buffers ; Pufferlösung
    Subject Puffer
    Language English
    Size VIII, 84 S. : graph. Darst.
    Publisher IRL Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007351323
    ISBN 0-19-963442-4 ; 978-0-19-963442-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 975 order for loan Magazin

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  9. Article: The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles.

    Tse, Karen / Beamer, Edward / Simpson, Deborah / Beynon, Robert J / Sills, Graeme J / Thippeswamy, Thimmasettappa

    Frontiers in neurology

    2021  Volume 12, Page(s) 625017

    Abstract: Intracranial electroencephalography (EEG) is commonly used to study epileptogenesis and epilepsy in experimental models. Chronic gliosis and neurodegeneration at the injury site are known to be associated with surgically implanted electrodes in both ... ...

    Abstract Intracranial electroencephalography (EEG) is commonly used to study epileptogenesis and epilepsy in experimental models. Chronic gliosis and neurodegeneration at the injury site are known to be associated with surgically implanted electrodes in both humans and experimental models. Currently, however, there are no reports on the impact of intracerebral electrodes on proteins in the hippocampus and proinflammatory cytokines in the cerebral cortex and plasma in experimental models. We used an unbiased, label-free proteomics approach to identify the altered proteins in the hippocampus, and multiplex assay for cytokines in the cerebral cortex and plasma of C57BL/6J mice following bilateral surgical implantation of electrodes into the cerebral hemispheres. Seven days following surgery, a repeated low dose kainate (KA) regimen was followed to induce
    Language English
    Publishing date 2021-07-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.625017
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  10. Book: Proteolytic enzymes

    Beynon, Robert J.

    a practical approach

    (Practical approach series ; [51])

    1989  

    Author's details ed. by R. J. Beynon
    Series title Practical approach series ; [51]
    The practical approach series
    Collection The practical approach series
    Keywords Peptide Hydrolases ; Proteasen
    Subject EC 3.4 ; Proteinasen ; Peptidasen ; Proteolytisches Enzym ; Peptid-Hydrolasen
    Language English
    Size XVIII, 259 S. : Ill., graph. Darst.
    Publisher IRL Pr. at Oxford Univ. Pr
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT003522384
    ISBN 0-19-963058-5 ; 0-19-963059-3 ; 978-0-19-963058-5 ; 978-0-19-963059-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 3362 order for loan Magazin

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