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Article ; Online: APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry.

Choudhury, Rajarshi / Bonacci, Thomas / Arceci, Anthony / Lahiri, Debojyoti / Mills, Christine A / Kernan, Jennifer L / Branigan, Timothy B / DeCaprio, James A / Burke, Daniel J / Emanuele, Michael J

Cell reports

2017 Volume 16, Issue 12, Page(s) 3359–3372

Abstract: ... a reciprocal feedback circuit between APC/C and a second ubiquitin ligase, the SCF (Skp1-Cul1-F box). We show ... for degradation by APC/C. Furthermore, we establish that Cdh1 is itself a substrate of SCF(cyclin F). Cyclin F ... The anaphase promoting complex/cyclosome (APC/C) is an ubiquitin ligase and core ...

Abstract	The anaphase promoting complex/cyclosome (APC/C) is an ubiquitin ligase and core component of the cell-cycle oscillator. During G1 phase, APC/C binds to its substrate receptor Cdh1 and APC/C(Cdh1) plays an important role in restricting S-phase entry and maintaining genome integrity. We describe a reciprocal feedback circuit between APC/C and a second ubiquitin ligase, the SCF (Skp1-Cul1-F box). We show that cyclin F, a cell-cycle-regulated substrate receptor (F-box protein) for the SCF, is targeted for degradation by APC/C. Furthermore, we establish that Cdh1 is itself a substrate of SCF(cyclin F). Cyclin F loss impairs Cdh1 degradation and delays S-phase entry, and this delay is reversed by simultaneous removal of Cdh1. These data indicate that the coordinated, temporal ordering of cyclin F and Cdh1 degradation, organized in a double-negative feedback loop, represents a fundamental aspect of cell-cycle control. This mutual antagonism could be a feature of other oscillating systems.
MeSH term(s)	Anaphase-Promoting Complex-Cyclosome/metabolism ; Cyclins/metabolism ; Feedback, Physiological/physiology ; HEK293 Cells ; HeLa Cells ; Humans ; S Phase/physiology
Chemical Substances	CCNF protein, human ; Cyclins ; Anaphase-Promoting Complex-Cyclosome (EC 2.3.2.27)
Language	English
Publishing date	2017-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2016.08.058
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: APC/C and SCFcyclin F Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry

Rajarshi Choudhury / Thomas Bonacci / Anthony Arceci / Debojyoti Lahiri / Christine A. Mills / Jennifer L. Kernan / Timothy B. Branigan / James A. DeCaprio / Daniel J. Burke / Michael J. Emanuele

Cell Reports, Vol 16, Iss 12, Pp 3359-

2016 Volume 3372

Abstract: ... feedback circuit between APC/C and a second ubiquitin ligase, the SCF (Skp1-Cul1-F box). We show ... for degradation by APC/C. Furthermore, we establish that Cdh1 is itself a substrate of SCFcyclin F. Cyclin F loss ... The anaphase promoting complex/cyclosome (APC/C) is an ubiquitin ligase and core ...

Abstract	The anaphase promoting complex/cyclosome (APC/C) is an ubiquitin ligase and core component of the cell-cycle oscillator. During G1 phase, APC/C binds to its substrate receptor Cdh1 and APC/CCdh1 plays an important role in restricting S-phase entry and maintaining genome integrity. We describe a reciprocal feedback circuit between APC/C and a second ubiquitin ligase, the SCF (Skp1-Cul1-F box). We show that cyclin F, a cell-cycle-regulated substrate receptor (F-box protein) for the SCF, is targeted for degradation by APC/C. Furthermore, we establish that Cdh1 is itself a substrate of SCFcyclin F. Cyclin F loss impairs Cdh1 degradation and delays S-phase entry, and this delay is reversed by simultaneous removal of Cdh1. These data indicate that the coordinated, temporal ordering of cyclin F and Cdh1 degradation, organized in a double-negative feedback loop, represents a fundamental aspect of cell-cycle control. This mutual antagonism could be a feature of other oscillating systems.
Keywords	Biology (General) ; QH301-705.5
Subject code	572
Language	English
Publishing date	2016-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Highly Fluorinated Ir(III)-2,2':6',2″-Terpyridine-Phenylpyridine-X Complexes via Selective C-F Activation: Robust Photocatalysts for Solar Fuel Generation and Photoredox Catalysis.

Porras, Jonathan A / Mills, Isaac N / Transue, Wesley J / Bernhard, Stefan

Journal of the American Chemical Society

2016 Volume 138, Issue 30, Page(s) 9460–9472

Abstract: ... complexes were synthesized by selective C-F activation, whereby perfluorinated phenylpyridines were readily ...

Abstract	A series of fluorinated Ir(III)-terpyridine-phenylpyridine-X (X = anionic monodentate ligand) complexes were synthesized by selective C-F activation, whereby perfluorinated phenylpyridines were readily complexed. The combination of fluorinated phenylpyridine ligands with an electron-rich tri-tert-butyl terpyridine ligand generates a "push-pull" force on the electrons upon excitation, imparting significant enhancements to the stability, electrochemical, and photophysical properties of the complexes. Application of the complexes as photosensitizers for photocatalytic generation of hydrogen from water and as redox photocatalysts for decarboxylative fluorination of several carboxylic acids showcases the performance of the complexes in highly coordinating solvents, in some cases exceeding that of the leading photosensitizers. Changes in the photophysical properties and the nature of the excited states are observed as the compounds increase in fluorination as well as upon exchange of the ancillary chloride ligand to a cyanide. These changes in the excited states have been corroborated using density functional theory modeling.
Language	English
Publishing date	2016-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.6b03246
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Article ; Online: Reactivity of the uranium(IV) carbene complex [U(BIPM(TMS))(Cl)(μ-Cl)₂Li(THF)₂] (BIPM(TMS) = {C(PPh₂NSiMe₃)₂}) towards carbonyl and heteroallene substrates: metallo-Wittig, adduct formation, C-F bond activation, and [2 + 2]-cycloaddition reactions.

Cooper, Oliver J / Mills, David P / Lewis, William / Blake, Alexander J / Liddle, Stephen T

Dalton transactions (Cambridge, England : 2003)

2014 Volume 43, Issue 38, Page(s) 14275–14283

Abstract: ... coordinated to uranium. The reaction of PhCOF with 1 resulted in C-F bond activation and oxidation resulting ... in isolation of [U(O)2(Cl)2(μ-Cl)2{(μ-LiDME)OC(Ph)=C(PPh2NSiMe3)(PPh2NHSiMe3)}2] (5) along with [U(Cl)2(F)2(py ... C(PPh2NSiMe3)2}) towards carbonyl and heteroallene substrates is reported. Reaction of 1 ...

Abstract	The reactivity of the uranium(IV) carbene complex [U(BIPM(TMS))(Cl)(μ-Cl)2Li(THF)2] (1, BIPM(TMS) = {C(PPh2NSiMe3)2}) towards carbonyl and heteroallene substrates is reported. Reaction of 1 with benzophenone proceeds to give the metallo-Wittig terminal alkene product Ph2C=C(PPh2NSiMe3)2 (2); the likely "UOCl2" byproduct could not be isolated. Addition of the bulky ketone PhCOBu(t) to 1 resulted in loss of LiCl, coordination of the ketone, and dimerisation to give [U(BIPM(TMS))(Cl)(μ-Cl){OC(Ph)(Bu(t))}]2 (3). The reaction of 1 with coumarin resulted in ring opening of the cyclic ester and a metallo-Wittig-type reaction to afford [U{BIPM(TMS)[C(O)(CHCHC6H4O-2)]-κ(3)-N,O,O'}(Cl)2(THF)] (4) where the enolate product remains coordinated to uranium. The reaction of PhCOF with 1 resulted in C-F bond activation and oxidation resulting in isolation of [U(O)2(Cl)2(μ-Cl)2{(μ-LiDME)OC(Ph)=C(PPh2NSiMe3)(PPh2NHSiMe3)}2] (5) along with [U(Cl)2(F)2(py)4] (6). The reactions of 1 with tert-butylisocyanate or dicyclohexylcarbodiimide resulted in the isolation of the [2 + 2]-cycloaddition products [U{BIPM(TMS)[C(NBu(t)){OLi(THF)2(μ-Cl)Li(THF)3}]-κ(4)-C,N,N',N''}(Cl)3] (7) and [U{BIPM(TMS)[C(NCy)2]-κ(4)-C,N,N',N''}(Cl)(μ-Cl)2Li(THF)2] (8). Complexes 2-8 have been variously characterised by single crystal X-ray diffraction, multi-nuclear NMR and FTIR spectroscopies, Evans method solution magnetic moments, variable temperature SQUID magnetometry, and elemental analyses.
Language	English
Publishing date	2014-10-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c4dt00909f
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Article: Celebrating the 20th Anniversary of the AEHMS: The Aquatic Ecosystems Puzzle. Celebratory articles. M. Munawar, President and Chief Editor, AEHMS. Africa: M. Van der Knaap, Asia: G. Nagaraj, F. Yusoff, N. Shazili, A. Sharma, D. Wang. Europe: A. Price, M. Kernan, G. Dave. Middle East: W. Hamza, A. Al-Ghadban. North America: J. Hartig, R. Heath, J. Leach, D. Malley, E. Mills, C. Minns, T. Nalepa, H. Regier, J. Sherry

Van der Knaap, M. / Nagaraj, G. / Yusoff, F. / Shazili, N. / Sharma, A. / Wang, D. / Price, A. / Kernan, M. / Dave, G. / Hamza, W. / Al-Ghadban, A. / Hartig, J. / Heath, R. / Leach, J. / Malley, D. / Mills, E. / Minns, C. / Nalepa, T. / Regier, H. /

Sherry, J.

Aquatic ecosystem health & management

2013 Volume 16, Issue 2, Page(s) 125

Language	English
Document type	Article
ZDB-ID	1477121-4
ISSN	1463-4988
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Synthesis and Magnetic Properties of Bis-Halobenzene Decamethyldysprosocenium Cations.

Corner, Sophie C / Gransbury, Gemma K / Vitorica-Yrezabal, Iñigo J / Whitehead, George F S / Chilton, Nicholas F / Mills, David P

Inorganic chemistry

2024

Abstract: The decamethyldysprosocenium cation, [Dy(Cp*) ...

Abstract	The decamethyldysprosocenium cation, [Dy(Cp*)
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c04106
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Article ; Online: Halobenzene Adducts of a Dysprosocenium Single-Molecule Magnet.

Corner, Sophie C / Gransbury, Gemma K / Vitorica-Yrezabal, Iñigo J / Whitehead, George F S / Chilton, Nicholas F / Mills, David P

Inorganic chemistry

2024

Abstract: Dysprosium complexes with strong axial crystal fields are promising candidates for single-molecule magnets (SMMs), which could be used for high-density data storage. Isolated dysprosocenium cations, [Dy( ... ...

Abstract	Dysprosium complexes with strong axial crystal fields are promising candidates for single-molecule magnets (SMMs), which could be used for high-density data storage. Isolated dysprosocenium cations, [Dy(Cp
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c04105
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Article ; Online: Differential relationships between thought dimensions and momentary affect in daily life.

Thiemann, R F / Mills, C / Kam, J W Y

Psychological research

2022 Volume 87, Issue 5, Page(s) 1632–1643

Abstract: Commonly used to characterize mind wandering, task-unrelated thought has long been associated with negative affective outcomes. However, less is known about how other thought dimensions including intentionality and freedom of movement interact with task- ... ...

Abstract	Commonly used to characterize mind wandering, task-unrelated thought has long been associated with negative affective outcomes. However, less is known about how other thought dimensions including intentionality and freedom of movement interact with task-unrelated thought to modulate momentary affect in everyday life. To address this, we used ecological momentary assessments to prompt participants to report their thought patterns and affective valence five times a day for seven consecutive days. Each assessment asked participants to report on their affective valence as well as several thought dimensions including their task-relatedness, intentionality and freedom of movement. We examined the latter two thought dimensions alone as well as how they interacted with the commonly examined dimension of task-relatedness with respect to their relationship to momentary affect. We replicated the well-established negative relationship between task-unrelated thought and momentary affect. Furthermore, unintentional task-unrelated thought was associated with more negative affect than intentional thought. This pattern was also observed more broadly in thoughts regardless of their task relevance. In contrast, freely moving thought was positively related to momentary affect in general. A significant interaction between task-relatedness and freedom of movement of thought revealed that the commonly reported negative relationship between task-unrelated thought and more negative affect is mitigated by freely moving thought. In summary, our findings indicate that these various thought dimensions have unique relationships with momentary affect, highlighting the importance of accounting for thought dimensions in establishing its affective and possibly other functional consequences.
MeSH term(s)	Humans ; Movement ; Affect
Language	English
Publishing date	2022-11-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1463034-5
ISSN	1430-2772 ; 0340-0727
ISSN (online)	1430-2772
ISSN	0340-0727
DOI	10.1007/s00426-022-01766-9
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Article: 116 Role of GnRH-II and its receptor in porcine sperm function.

Ross, C E / Ahern, D F / Mills, G A / White, B R

Reproduction, fertility, and development

2022 Volume 34, Issue 2, Page(s) 295

Language	English
Publishing date	2022-03-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1019913-5
ISSN	1448-5990 ; 1031-3613
ISSN (online)	1448-5990
ISSN	1031-3613
DOI	10.1071/RDv34n2Ab116
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Article ; Online: On the relationship between unprompted thought and affective well-being: A systematic review and meta-analysis.

Kam, Julia W Y / Wong, Aaron Y / Thiemann, Raela F / Hasan, Fiza / Andrews-Hanna, Jessica R / Mills, Caitlin

Psychological bulletin

2024

Abstract	There is a growing recognition that thoughts often arise independently of external demands. These thoughts can span from reminiscing your last vacation to contemplating career goals to fantasizing about meeting your favorite musician. Often referred to as mind wandering, such frequently occurring unprompted thoughts have widespread impact on our daily functions, with the dominant narrative converging on a negative relationship between unprompted thought and affective well-being. In this systematic review of 76 studies, we implemented a meta-analysis and qualitative review to elucidate if and when unprompted thought is indeed negatively associated with affective well-being in adults. Using a multilevel mixed-model approach on 386 effect sizes from 23,168 participants across 64 studies, our meta-analyses indicated an overall relationship between unprompted thought and worse affective well-being (r¯ = -.18, 95% CI [-.23, -.14]); however, the magnitude and direction of this relationship changed when considering specific aspects of the phenomenon (including thought content and intentionality) and methodological approaches (including questionnaires vs. experience sampling). The qualitative review further contextualizes this relationship by revealing the nuances of how and when unprompted thought is associated with affective well-being. Taken together, our meta-analysis and qualitative review indicate that the commonly reported relationship between unprompted thought and affective well-being is contingent upon the content and conceptualization of unprompted thought, as well as the methodological and analytic approaches implemented. Based on these findings, we propose emerging directions for future empirical and theoretical work that highlight the importance of accounting for when, how, and for whom unprompted thought is associated with affective well-being. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1321-3
ISSN	1939-1455 ; 0033-2909
ISSN (online)	1939-1455
ISSN	0033-2909
DOI	10.1037/bul0000428
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