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  1. Article: COVID 19: Have we nailed it?

    Gogia, Atul

    Lung India : official organ of Indian Chest Society

    2021  Volume 38, Issue 4, Page(s) 377–378

    Language English
    Publishing date 2021-07-14
    Publishing country India
    Document type Journal Article
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_187_21
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  2. Article: The Hindi Version of International Consensus Criteria: A Cross-cultural Adaptation and Validation Study for Myalgic Encephalomyelitis in Post-COVID Patients.

    Shah, Mansi / Kakar, Atul / Gogia, Atul

    The Journal of the Association of Physicians of India

    2023  Volume 70, Issue 10, Page(s) 11–12

    Abstract: Context: Fatigue is the most prominent feature of long COVID. With the increasing burden of long COVID cases post-acute phase of illness after recurrent waves of the pandemic, understanding its pathophysiology is of paramount importance. Such fatigue ... ...

    Abstract Context: Fatigue is the most prominent feature of long COVID. With the increasing burden of long COVID cases post-acute phase of illness after recurrent waves of the pandemic, understanding its pathophysiology is of paramount importance. Such fatigue and post-viral illness could be associated with features of neuroimmune exhaustion and thus be a part of a larger syndrome such as myalgic encephalomyelitis (ME). Identifying the proportion of patients having ME from those experiencing fatigue would bring us one step closer to understanding the pathophysiology. International consensus criteria (ICC) originally published in English (ICC-E) is a valid and reliable tool for identifying cases of ME. However, a validated Hindi version of ICC-E is not available. : To develop and validate an equivalent version of ICC-E in the native Hindi language (ICC-H) to suit Indian patients and health care workers even at peripheries and to make conducting large scales surveys more feasible.
    Subjects and methods: Once permission from the ethics board was granted, guidelines given by MAPI Research Trust were followed and ICC-H was developed from ICC-E, in the following steps: (a) translation to Hindi, (b) back translation, (c) comparison between the translated and back-translated version performed by experts, and (d) pre-pilot test in the intended population. The ICC-H was applied to 53 bilingual individuals knowing both Hindi and English.
    Statistical analysis used: The distribution of Hindi and English questionnaires was analyzed using the Chi-square test and Spearman's correlation coefficient was used for correlation between answers of each question.
    Results: The score of individual items and its global score was highly correlated with each other (p<0.001). The scores of individual components and global scores of ICC-H at baseline and original ICC-E after 4 weeks did not differ significantly.
    Conclusion: This study shows that the ICC-H is a valid and reliable instrument for the assessment of ME. ICC-H can be used for Hindi speaking population for identifying cases of ME. Key Messages There is a significant overlap in symptoms of long COVID and ME, with fatigue being a major component in both. Understanding the prevalence of ME in the post-acute phase of COVID illness can bring us a step closer to understanding its pathophysiology. In a multilingual country like ours, regionally translated criteria are a must for conducting large-scale surveys.
    MeSH term(s) Humans ; Cross-Cultural Comparison ; Fatigue Syndrome, Chronic ; Consensus ; Post-Acute COVID-19 Syndrome ; COVID-19 ; Language ; Surveys and Questionnaires ; Reproducibility of Results ; Fatigue/etiology
    Language English
    Publishing date 2023-06-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    DOI 10.5005/japi-11001-0090
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  3. Article ; Online: Tubercular aortoiliac aneurysm with challenging management

    Mansi Shah / Atul Kakar / Atul Gogia / Ambarish Satwik

    Current Medicine Research and Practice, Vol 13, Iss 2, Pp 89-

    2023  Volume 92

    Abstract: A 38-year-old male was diagnosed with aortoiliac aneurysm while evaluating for new-onset hypertension. On further workup, the cause was identified as tubercular aortoiliac aneurysm. His aneurysm had stormy course and disseminated further while ongoing ... ...

    Abstract A 38-year-old male was diagnosed with aortoiliac aneurysm while evaluating for new-onset hypertension. On further workup, the cause was identified as tubercular aortoiliac aneurysm. His aneurysm had stormy course and disseminated further while ongoing antitubercular therapy with multiple episodes of aneurysmal rupture and endovascular interventions. Management of this case was complicated with several other rarer entities, such as haemophagocytosis and thrombotic microangiopathy with disseminated intravascular coagulation resistant to steroids and plasmapheresis, within a span of few weeks. Moreover, first-line antitubercular therapy had to be regularly modified in view of emerging complications. While case reports for each individual entity exists in literature, this is the first case to the best of our knowledge where such varied complications were present in a patient of tubercular mycotic aneurysm.
    Keywords disseminated intravascular coagulation ; disseminated tuberculosis ; extrapulmonary tuberculosis ; haemophagocytosis ; tubercular mycotic aneurysm ; Medicine ; R
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Telemedicine

    Udit Kakar / Shikhar Tripathi / Atul Gogia / Atul Kakar

    Current Medicine Research and Practice, Vol 11, Iss 1, Pp 62-

    An evolving practice in India

    2021  Volume 64

    Keywords Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Anal cytological abnormalities in human immunodeficiency virus-infected men and prevalence of high-risk human papillomavirus co-infection

    Atul Kakar / Pooja Bakshi / Shikhar Tripathi / Atul Gogia

    Current Medicine Research and Practice, Vol 12, Iss 4, Pp 152-

    2022  Volume 156

    Abstract: Background: Human immunodeficiency virus (HIV) infects cells of the immune system, leading to a compromised and depleted immune system. Progressive failure of the immune system predisposes an individual to many life-threatening opportunistic infections ... ...

    Abstract Background: Human immunodeficiency virus (HIV) infects cells of the immune system, leading to a compromised and depleted immune system. Progressive failure of the immune system predisposes an individual to many life-threatening opportunistic infections and malignancies. As compared to the general population, the incidence of anal squamous cell carcinoma (ASCC) is substantially higher in HIV-infected individuals. Majority of ASCC are related to infections caused by high-risk strains of human papillomavirus (HPV). Aims: We conducted an observational study on HIV-positive men who had a history of homosexual contact. The aim of this study was to assess the spectrum of cytological abnormalities on anal smear cytology in individuals with HIV infection, and also estimate the prevalence of anal infection with high-risk HPV strains. Materials and Methods: We enrolled 56 individuals for this pilot study. This study involved the collection of specimens from the anal canal of the patients by using cytobrush in liquid-based cytology (LBC) vial. The sample was simultaneously tested for cytological abnormalities by LBC (Sure Path, BD) and for 13 high-risk strains by Hybrid Capture II technique (Qiagen) based on antibody capture and chemiluminescent signal detection. Anal smear cytology was reported as per guidelines of The Bethesda System of reporting anal cytology, 2014. Results: The prevalence of high-risk HPV infection was seen in 41.07% of individuals and low-grade squamous intraepithelial lesion and atypical squamous cells of undetermined significance were seen in 12.5% and 16.07% individuals, respectively. Cytology was useful in 7% of cases to diagnose opportunistic infections. The latter is a field yet to be tapped. Conclusion: We would recommend LBC in HIV-positive patients, for screening of cytological abnormalities and HPV status. This would also give an opportunity to screen for opportunistic infections, which have otherwise not been diagnosed.
    Keywords anal squamous cell carcinoma ; human immunodeficiency virus/acquired immunodeficiency syndrome ; human papilloma virus ; liquid-based cytology ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A 65-year-old woman with fever and renal failure

    Tanvi Batra / Atul Kakar / Atul Gogia / Sonia Badwal

    Current Medicine Research and Practice, Vol 11, Iss 6, Pp 291-

    2021  Volume 294

    Keywords Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Serum Vitamin B12 in Relation to Anaemia and Neuropathy by MNSI among Type 2 Diabetes

    Tripti Saxena / Uma Iyer / Atul Gogia

    National Board of Examinations Journal of Medical Sciences, Vol Volume 1, Iss 11, Pp 644-

    2023  Volume 657

    Abstract: Background: Hematological and neurological symptoms can be signs of B12 inadequacy. This work was intended to evaluate the severity of B12 deficiency and link it to peripheral neuropathy (PN) and anaemia in type 2 diabetes mellitus (T2DM) adults who were ...

    Abstract Background: Hematological and neurological symptoms can be signs of B12 inadequacy. This work was intended to evaluate the severity of B12 deficiency and link it to peripheral neuropathy (PN) and anaemia in type 2 diabetes mellitus (T2DM) adults who were using metformin. Methods: To assess PN, the Michigan Neuropathy Screening Instrument (MNSI) directed a hospital-based cross-sectional investigation of 245 adults with T2DM who were taking metformin. 155 subjects who fulfilled the insertion and rejection criteria provided fasting blood samples for measurement of vitamin B12, haemoglobin, HbA1c, and cell morphology using chemiluminescent enzyme immunoassay (C.L.I.A), high performance liquid chromatography (HPLC), and C.B.C respectively. Results: Among adults with T2DM taking metformin, B12 deficiency (B12< 200pg/ml) was prevalent in 52% cases. O.R of vegetarian diet and B12 insufficiency was 2.33 (C.I. 1.22-4.47) (p < 0.05). Despite the fact that there were no cases of macrocytic anaemia, 40% of people had anaemia, which was not related to a B12 deficiency. According to ROC analysis, serum B12 has emerged as a fair test to predict PN scores of 2.25 (p < 0.001). 38% of people had PN (PN score ≥ 2.5) Conclusions: The usage of metformin was linked to biochemical B12 insufficiency. B12 deficiency was likely to result in PN scores ≥ 2.5 on the MNSI. In T2DM individuals using metformin, serum B12 screening and the use of MNSI for PN are suggested.
    Keywords metformin ; b12 deficiency ; neuropathy ; mnsi ; anemia ; type 2 diabetes mellitus ; Medicine ; R
    Subject code 571
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher National Board of Examinations
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Acute pancreatic injury induced by COVID-19.

    Patnaik, R Nikhil Kumar / Gogia, Atul / Kakar, Atul

    IDCases

    2020  Volume 22, Page(s) e00959

    Abstract: We report a patient with COVID-19 infection presenting with acute pancreatitis. The diagnosis of pancreatitis was based on laboratory as well as radiological evidence, and all the usual etiologies were ruled out. The temporal association with COVID-19 is ...

    Abstract We report a patient with COVID-19 infection presenting with acute pancreatitis. The diagnosis of pancreatitis was based on laboratory as well as radiological evidence, and all the usual etiologies were ruled out. The temporal association with COVID-19 is strongly suggestive of novel coronavirus induced pancreatic injury.
    Keywords covid19
    Language English
    Publishing date 2020-09-10
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2020.e00959
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  9. Article ; Online: Essential role of aerobic glycolysis in epithelial-to-mesenchymal transition during carcinogenesis.

    Prasad, Chandra Prakash / Gogia, Ajay / Batra, Atul

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2022  Volume 24, Issue 10, Page(s) 1844–1855

    Abstract: Epithelial-to-mesenchymal transition (EMT) confers the most lethal characteristics to cancer cells i.e., metastasis and resistance to chemo-and-radio-therapy, and therefore exhibit an appealing target in the field of oncology. Research in the past decade ...

    Abstract Epithelial-to-mesenchymal transition (EMT) confers the most lethal characteristics to cancer cells i.e., metastasis and resistance to chemo-and-radio-therapy, and therefore exhibit an appealing target in the field of oncology. Research in the past decade has demonstrated the crucial role of aerobic glycolysis in EMT, which is generally credited as the glucose metabolism for the creation of biomass such as fatty acids, amino acids, and nucleotides thereby providing building blocks for limitless proliferation. In the present review, apart from discussing EMT's evident role in the metastatic process and cancer stemness, we also talked about the vital role of glycolytic enzymes viz. GLUTs, HKs, PGI, PFK-1, aldolase, enolase, PK, LDHA, etc. in the induction of the EMT process in cancerous cells.
    MeSH term(s) Carcinogenesis ; Epithelial-Mesenchymal Transition ; Glycolysis ; Humans ; Neoplasms ; Neoplastic Stem Cells
    Language English
    Publishing date 2022-06-25
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-022-02851-6
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  10. Article: COVID-19 in pregnancy: A review.

    Tripathi, Shikhar / Gogia, Atul / Kakar, Atul

    Journal of family medicine and primary care

    2020  Volume 9, Issue 9, Page(s) 4536–4540

    Abstract: COVID-19 has led on to a global healthcare crisis, similar to none in the recent past. Special emphasis must be laid on the status of pregnant women amid this outbreak, considering the vulnerability seen in pregnant women toward previous coronavirus ... ...

    Abstract COVID-19 has led on to a global healthcare crisis, similar to none in the recent past. Special emphasis must be laid on the status of pregnant women amid this outbreak, considering the vulnerability seen in pregnant women toward previous coronavirus diseases. In this review, we will try to elicit the correlation between the complications of previous coronavirus diseases (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome) and COVID-19, the possibility of materno-fetal vertical transmission and the obstetric management protocol.
    Keywords covid19
    Language English
    Publishing date 2020-09-30
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_714_20
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