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  1. Article ; Online: A vicious cycle in atherosclerosis.

    Lusis, Aldons J

    Cell

    2021  Volume 184, Issue 5, Page(s) 1139–1141

    Abstract: Clonal hematopoiesis, defined as the presence of expanded somatic blood cell clones, is associated with about a doubling in the risk of coronary heart disease in humans. Heyde and colleagues now provide evidence that clonal hematopoiesis results largely ... ...

    Abstract Clonal hematopoiesis, defined as the presence of expanded somatic blood cell clones, is associated with about a doubling in the risk of coronary heart disease in humans. Heyde and colleagues now provide evidence that clonal hematopoiesis results largely from increased stem cell proliferation, which is, in turn, stimulated by atherosclerosis.
    MeSH term(s) Atherosclerosis ; Clonal Hematopoiesis ; Hematopoiesis ; Humans ; Mutation
    Language English
    Publishing date 2021-04-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.02.005
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  2. Article ; Online: Genetics unravels protein-metabolite relationships.

    Hilser, James R / Lusis, Aldons J / Allayee, Hooman

    Trends in endocrinology and metabolism: TEM

    2024  Volume 35, Issue 3, Page(s) 183–184

    Abstract: Integrating molecular traits into genetic studies enhances our understanding of how DNA variation influences complex clinical and physiological phenotypes. In a recent article, Benson and colleagues apply this systems genetics approach with proteomics ... ...

    Abstract Integrating molecular traits into genetic studies enhances our understanding of how DNA variation influences complex clinical and physiological phenotypes. In a recent article, Benson and colleagues apply this systems genetics approach with proteomics and metabolomics data in plasma from humans to identify and validate several previously unrecognized causal protein-metabolite associations.
    MeSH term(s) Humans ; Phenotype ; Metabolomics ; Proteomics ; Genome-Wide Association Study
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2024.01.008
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  3. Article ; Online: Coagulation factor with potential for the treatment of heart failure.

    Cao, Yang / Lusis, Aldons J

    Clinical and translational medicine

    2022  Volume 12, Issue 12, Page(s) e1144

    MeSH term(s) Humans ; Blood Coagulation Factors ; Heart Failure/therapy ; Hematologic Agents
    Chemical Substances Blood Coagulation Factors ; Hematologic Agents
    Language English
    Publishing date 2022-11-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1144
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  4. Article ; Online: Y-Chromosome Genetic Variation Associated With Atherosclerosis and Inflammation.

    Lusis, Aldons J

    Arteriosclerosis, thrombosis, and vascular biology

    2019  Volume 39, Issue 11, Page(s) 2201–2202

    MeSH term(s) Atherosclerosis ; Chromosomes, Human, Y ; Genetic Variation ; Humans ; Inflammation
    Language English
    Publishing date 2019-10-23
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.119.313369
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  5. Article ; Online: Atherosclerosis: Recent developments.

    Björkegren, Johan L M / Lusis, Aldons J

    Cell

    2022  Volume 185, Issue 10, Page(s) 1630–1645

    Abstract: Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to ... ...

    Abstract Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome.
    MeSH term(s) Arteries/metabolism ; Atherosclerosis/metabolism ; Clonal Hematopoiesis ; Gastrointestinal Microbiome ; Humans ; Myocytes, Smooth Muscle/metabolism
    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.04.004
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  6. Article ; Online: Gene Regulatory Networks in Coronary Artery Disease.

    Cheng, Jenny / Cheng, Michael / Lusis, Aldons J / Yang, Xia

    Current atherosclerosis reports

    2023  Volume 25, Issue 12, Page(s) 1013–1023

    Abstract: Purpose of review: Coronary artery disease is a complex disorder and the leading cause of mortality worldwide. As technologies for the generation of high-throughput multiomics data have advanced, gene regulatory network modeling has become an ... ...

    Abstract Purpose of review: Coronary artery disease is a complex disorder and the leading cause of mortality worldwide. As technologies for the generation of high-throughput multiomics data have advanced, gene regulatory network modeling has become an increasingly powerful tool in understanding coronary artery disease. This review summarizes recent and novel gene regulatory network tools for bulk tissue and single cell data, existing databases for network construction, and applications of gene regulatory networks in coronary artery disease.
    Recent findings: New gene regulatory network tools can integrate multiomics data to elucidate complex disease mechanisms at unprecedented cellular and spatial resolutions. At the same time, updates to coronary artery disease expression data in existing databases have enabled researchers to build gene regulatory networks to study novel disease mechanisms. Gene regulatory networks have proven extremely useful in understanding CAD heritability beyond what is explained by GWAS loci and in identifying mechanisms and key driver genes underlying disease onset and progression. Gene regulatory networks can holistically and comprehensively address the complex nature of coronary artery disease. In this review, we discuss key algorithmic approaches to construct gene regulatory networks and highlight state-of-the-art methods that model specific modes of gene regulation. We also explore recent applications of these tools in coronary artery disease patient data repositories to understand disease heritability and shared and distinct disease mechanisms and key driver genes across tissues, between sexes, and between species.
    MeSH term(s) Humans ; Gene Regulatory Networks ; Coronary Artery Disease/genetics ; Coronary Artery Disease/metabolism ; Gene Expression Regulation
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057369-8
    ISSN 1534-6242 ; 1523-3804
    ISSN (online) 1534-6242
    ISSN 1523-3804
    DOI 10.1007/s11883-023-01170-7
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  7. Article: Systems genetics approach uncovers associations between host amylase locus, gut microbiome and metabolic traits in hyperlipidemic mice.

    Zhang, Qijun / Hutchison, Evan R / Pan, Calvin / Warren, Matthew F / Keller, Mark P / Attie, Alan D / Lusis, Aldons J / Rey, Federico E

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The molecular basis for how host genetic variation impacts gut microbial community and bacterial metabolic niches remain largely unknown. We leveraged 90 inbred hyperlipidemic mouse strains from the Hybrid Mouse Diversity Panel (HMDP), previously studied ...

    Abstract The molecular basis for how host genetic variation impacts gut microbial community and bacterial metabolic niches remain largely unknown. We leveraged 90 inbred hyperlipidemic mouse strains from the Hybrid Mouse Diversity Panel (HMDP), previously studied for a variety of cardio-metabolic traits. Metagenomic analysis of cecal DNA followed by genome-wide association analysis identified genomic loci that were associated with microbial enterotypes in the gut. Among these we detected a genetic locus surrounding multiple amylase genes that was associated with abundances of Firmicutes (
    Language English
    Publishing date 2024-03-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.28.582610
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  8. Article ; Online: TRIM13 reduces cholesterol efflux and increases oxidized LDL uptake leading to foam cell formation and atherosclerosis.

    Govatati, Suresh / Kumar, Raj / Boro, Monoranjan / Traylor, James G / Orr, A Wayne / Lusis, Aldons J / Rao, Gadiparthi N

    The Journal of biological chemistry

    2024  Volume 300, Issue 5, Page(s) 107224

    Abstract: Impaired cholesterol efflux and/or uptake can influence arterial lipid accumulation leading to atherosclerosis. Here, we report that tripartite motif-containing protein 13 (TRIM13), a RING-type E3 ubiquitin ligase, plays a role in arterial lipid ... ...

    Abstract Impaired cholesterol efflux and/or uptake can influence arterial lipid accumulation leading to atherosclerosis. Here, we report that tripartite motif-containing protein 13 (TRIM13), a RING-type E3 ubiquitin ligase, plays a role in arterial lipid accumulation leading to atherosclerosis. Using molecular approaches and KO mouse model, we found that TRIM13 expression was induced both in the aorta and peritoneal macrophages (pMφ) of ApoE
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2024.107224
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  9. Article ; Online: Effects of dietary iron deficiency or overload on bone: Dietary details matter.

    Baschant, Ulrike / Fuqua, Brie K / Ledesma-Colunga, Maria / Vulpe, Christopher D / McLachlan, Stela / Hofbauer, Lorenz C / Lusis, Aldons J / Rauner, Martina

    Bone

    2024  Volume 184, Page(s) 117092

    Abstract: ... of different high and low iron diets on bone in six inbred mouse strains (C57BL/6J, A/J, BALB/cJ, AKR/J, C3H ... change bone microarchitecture or turnover in C57BL/6J, A/J, and DBA/2J mice, but increased trabecular ... bone mass in BALB/cJ, C3H/HeJ and AKR/J mice. In contrast to the UCLA study, male C57BL/6J mice ...

    Abstract Purpose: Bone is susceptible to fluctuations in iron homeostasis, as both iron deficiency and overload are linked to poor bone strength in humans. In mice, however, inconsistent results have been reported, likely due to different diet setups or genetic backgrounds. Here, we assessed the effect of different high and low iron diets on bone in six inbred mouse strains (C57BL/6J, A/J, BALB/cJ, AKR/J, C3H/HeJ, and DBA/2J).
    Methods: Mice received a high (20,000 ppm) or low-iron diet (∼10 ppm) after weaning for 6-8 weeks. For C57BL/6J males, we used two dietary setups with similar amounts of iron, yet different nutritional compositions that were either richer ("TUD study") or poorer ("UCLA study") in minerals and vitamins. After sacrifice, liver, blood and bone parameters as well as bone turnover markers in the serum were analyzed.
    Results: Almost all mice on the UCLA study high iron diet had a significant decrease of cortical and trabecular bone mass accompanied by high bone resorption. Iron deficiency did not change bone microarchitecture or turnover in C57BL/6J, A/J, and DBA/2J mice, but increased trabecular bone mass in BALB/cJ, C3H/HeJ and AKR/J mice. In contrast to the UCLA study, male C57BL/6J mice in the TUD study did not display any changes in trabecular bone mass or turnover on high or low iron diet. However, cortical bone parameters were also decreased in TUD mice on the high iron diet.
    Conclusion: Thus, these data show that cortical bone is more susceptible to iron overload than trabecular bone and highlight the importance of a nutrient-rich diet to potentially mitigate the negative effects of iron overload on bone.
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2024.117092
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  10. Article: Atherosclerosis: Recent developments

    Björkegren, Johan L.M. / Lusis, Aldons J.

    Cell. 2022 May 12, v. 185, no. 10

    2022  

    Abstract: Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to ... ...

    Abstract Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome.
    Keywords atherosclerosis ; hematopoiesis ; intestinal microorganisms ; smooth muscle
    Language English
    Dates of publication 2022-0512
    Size p. 1630-1645.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.04.004
    Database NAL-Catalogue (AGRICOLA)

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