LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 469

Search options

  1. Article ; Online: Tendon Cord Rupture of Tricuspid Valve During Chemotherapy for Primary Cardiac Diffuse Large B-Cell Lymphoma.

    Nishikawa, Tomoaki / Miyoshi, Toru / Inoue, Katsuji / Ikeda, Shuntaro / Yamaguchi, Osamu

    Circulation reports

    2023  Volume 5, Issue 5, Page(s) 229–230

    Language English
    Publishing date 2023-04-18
    Publishing country Japan
    Document type Journal Article
    ISSN 2434-0790
    ISSN (online) 2434-0790
    DOI 10.1253/circrep.CR-23-0027
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Transcriptome analysis of human neural cells derived from isogenic embryonic stem cells with 16p11.2 deletion.

    Nomura, Yoshiko / Nomura, Jun / Kamiguchi, Hiroyuki / Nishikawa, Toru / Takumi, Toru

    Neuroscience research

    2021  Volume 171, Page(s) 114–123

    Abstract: 16p11.2 deletion is one of the most influential copy number variations (CNVs) associated with autism spectrum disorder (ASD). Previous studies have investigated the pathophysiology of 16p11.2 deletion both in vitro and in vivo, and have identified ... ...

    Abstract 16p11.2 deletion is one of the most influential copy number variations (CNVs) associated with autism spectrum disorder (ASD). Previous studies have investigated the pathophysiology of 16p11.2 deletion both in vitro and in vivo, and have identified features such as NMDAR dysfunction, excitation-inhibition imbalance, transcriptional dysregulation, and impaired cortical development. However, little is known about the transcriptional profiles of human neural cells. Here, we constructed an isogenic human embryonic stem (hES) cell model with 16p11.2 deletion using a CRISPR/Cas9 system and performed transcriptome analyses of hES-derived 2-dimensional neural cells. We identified several characteristics which may correlate with the neuropathology of 16p11.2 deletion: predisposition to differentiate into neural lineages, enhanced neurogenesis, and dysregulation of G protein-coupled receptor signaling and RAF/MAPK pathway. We also found upregulation of fragile X mental retardation protein (FMRP) target genes including GRM5, which is implicated as a common trait between 16p11.2 deletion and fragile X syndrome. Extending our knowledge into other ASD models would help us to understand the molecular pathology of this disorder.
    MeSH term(s) Autism Spectrum Disorder/genetics ; Chromosome Deletion ; DNA Copy Number Variations ; Embryonic Stem Cells ; Gene Expression Profiling ; Humans
    Language English
    Publishing date 2021-03-27
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 605842-5
    ISSN 1872-8111 ; 0168-0102 ; 0921-8696
    ISSN (online) 1872-8111
    ISSN 0168-0102 ; 0921-8696
    DOI 10.1016/j.neures.2021.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1993: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Parent Artery Occlusion for a Dissecting Posterior Cerebral Artery Aneurysm in the P4 Segment Presenting with Ischemic Stroke and Rapid Growth: A Case Report.

    Ishimoto, Kotaro / Matsuzaki, Jo / Iwata, Ryoichi / Yamamoto, Naoki / Yamagata, Toru / Ikuno, Hiromichi / Nishikawa, Misao / Goto, Takeo

    NMC case report journal

    2024  Volume 11, Page(s) 103–108

    Abstract: A dissecting aneurysm in the P4 segment of the posterior cerebral artery (PCA) is extremely rare, and its treatment is sometimes challenging. Endovascular parent artery occlusion (PAO) was performed for an unruptured P4 segment dissecting PCA aneurysm ... ...

    Abstract A dissecting aneurysm in the P4 segment of the posterior cerebral artery (PCA) is extremely rare, and its treatment is sometimes challenging. Endovascular parent artery occlusion (PAO) was performed for an unruptured P4 segment dissecting PCA aneurysm presenting with ischemic stroke and rapid growth. A 70-year-old man was rushed to our emergency department due to a right-sided headache and a visual field defect. Head magnetic resonance imaging showed a right occipital lobe ischemic stroke, with right PCA occlusion and aneurysm formation in the P4 segment. The diagnosis was PCA dissection in the calcarine artery, and oral aspirin was started. Within a week, the dissecting aneurysm had enlarged progressively to 6.2 mm in diameter. Thus, PAO with coils was performed as a preventive measure against aneurysm rupture, assuming that complication risks were low because the tributary area of the dissecting PCA had already infarcted. A 6-Fr guiding sheath was introduced from the right brachial artery to the right vertebral artery, and a microcatheter/microguidewire was placed into the true lumen of the calcarine artery distal to the aneurysm. PAO with coils was performed, and the blood flow to the aneurysm was completely obliterated. After the treatment, the known infarction in the right occipital lobe was enlarged, but no new neurological symptoms developed. The patient was discharged independently on postoperative day 3. Treatment for a distal PCA dissecting aneurysm is challenging. PAO with coils is one of the reasonable choices, especially when a visual field defect has already developed.
    Language English
    Publishing date 2024-04-05
    Publishing country Japan
    Document type Case Reports
    ISSN 2188-4226
    ISSN 2188-4226
    DOI 10.2176/jns-nmc.2023-0267
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Paroxetine ameliorates whole-body allodynia.

    Shiwaku, Hiroki / Nishikawa, Toru

    European journal of clinical pharmacology

    2018  Volume 74, Issue 7, Page(s) 979–980

    MeSH term(s) Adult ; Female ; Humans ; Hyperalgesia/drug therapy ; Hyperalgesia/physiopathology ; Middle Aged ; Paroxetine/therapeutic use ; Serotonin Uptake Inhibitors/therapeutic use ; Treatment Outcome
    Chemical Substances Serotonin Uptake Inhibitors ; Paroxetine (41VRH5220H)
    Language English
    Publishing date 2018-04-11
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-018-2438-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 672: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Finger necrosis with eosinophilia and symmetrical occlusion of the peripheral artery.

    Nishikawa, Ryo / Hirano, Toru / Kawarada, Osami

    Heart Asia

    2019  Volume 11, Issue 2, Page(s) e011211

    Abstract: Case presentation:: Question: What is the most likely diagnosis?Buerger's diseaseEosinophilic vasculitisDrug abuseCholesterol embolisation syndromeParaneoplastic syndrome. ...

    Abstract Case presentation:
    Question: What is the most likely diagnosis?Buerger's diseaseEosinophilic vasculitisDrug abuseCholesterol embolisation syndromeParaneoplastic syndrome.
    Language English
    Publishing date 2019-06-05
    Publishing country England
    Document type Journal Article
    ISSN 1759-1104
    ISSN 1759-1104
    DOI 10.1136/heartasia-2019-011211
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: A Novel Triple-Bladder Cuff Method for Blood Pressure Estimation Based on Pulse Wave Dynamics in Brachial Artery: Theoretical and Experimental Analyses.

    Uemura, Kazunori / Nishikawa, Takuya / Hasebe, Naotaka / Yokota, Shohei / Kakuuchi, Midori / Saku, Keita / Kawada, Toru / Morodome, Shohei / Furukoshi, Masaki / Sugimachi, Masaru

    IEEE transactions on bio-medical engineering

    2023  Volume 70, Issue 2, Page(s) 703–714

    Abstract: Objective: The objective of this study was to develop a novel triple-bladder cuff method for accurate and automated estimation of systolic (SBP) and diastolic (DBP) blood pressure and validate its reliability in animal experiments.: Methods: The cuff ...

    Abstract Objective: The objective of this study was to develop a novel triple-bladder cuff method for accurate and automated estimation of systolic (SBP) and diastolic (DBP) blood pressure and validate its reliability in animal experiments.
    Methods: The cuff is composed of three bladders each measured one-third the width of a conventional BP cuff, which are designed to measure oscillatory pulsation at the proximal, middle, and distal segments of the upper arm. This structure allows evaluation of the pulse wave propagation in the brachial artery under the cuff. SBP is estimated (SBP
    Results: SBP correlated strongly with SBP
    Conclusion: This method estimates SBP and DBP with acceptable accuracy.
    Significance: Accurate and automated BP estimation by this method may potentially optimize antihypertensive treatment in patients with hypertension.
    MeSH term(s) Animals ; Blood Pressure/physiology ; Brachial Artery/physiology ; Blood Pressure Determination/methods ; Pulse Wave Analysis ; Reproducibility of Results ; Urinary Bladder
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 160429-6
    ISSN 1558-2531 ; 0018-9294
    ISSN (online) 1558-2531
    ISSN 0018-9294
    DOI 10.1109/TBME.2022.3201314
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Anatomical and anastomotic viability indexes for stratifying the risk of anastomotic leakage in esophagectomy with retrosternal reconstruction.

    Takahashi, Keita / Nishikawa, Katsunori / Tanishima, Yuichiro / Ishikawa, Yoshitaka / Kurogochi, Takanori / Yuda, Masami / Matsumoto, Akira / Yano, Fumiaki / Ikegami, Toru / Eto, Ken

    Annals of gastroenterological surgery

    2023  Volume 7, Issue 6, Page(s) 896–903

    Abstract: Background: Risk prediction of anastomotic leakage using anatomical and vascular factors has not been well established. This study aimed to assess the anatomical and vascular factors affecting the hemodynamics of the gastric conduit and develop a novel ... ...

    Abstract Background: Risk prediction of anastomotic leakage using anatomical and vascular factors has not been well established. This study aimed to assess the anatomical and vascular factors affecting the hemodynamics of the gastric conduit and develop a novel risk stratification system in patients undergoing esophagectomy with retrosternal reconstruction.
    Methods: This retrospective cohort study analyzed 202 patients with esophageal cancer who underwent subtotal esophagectomy with gastric tube retrosternal reconstruction between January 2008 and December 2020. Risk factors for anastomotic leakage (AL), including the anatomical index (AI) and anastomotic viability index (AVI), were evaluated using a logistic regression model.
    Results: According to the logistic regression model, the independent risk factors for AL were preoperative body mass index ≥23.6 kg/m
    Conclusion: The combination of AI and AVI strongly predicted AL. Additionally, the use of AI and AVI enabled the stratification of the risk of AL in patients who underwent esophagectomy with retrosternal reconstruction.
    Language English
    Publishing date 2023-05-16
    Publishing country Japan
    Document type Journal Article
    ISSN 2475-0328
    ISSN (online) 2475-0328
    DOI 10.1002/ags3.12693
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Comprehensive analysis of effective reflection distance and its association with wave reflection strength under diverse hemodynamic conditions in anesthetized dogs.

    Uemura, Kazunori / Nishikawa, Takuya / Kawada, Toru / Sugimachi, Masaru

    Journal of biomechanics

    2020  Volume 104, Page(s) 109753

    Abstract: Pressure wave reflection is associated with cardiovascular risk. The conceptual distance to a theoretical major reflection site, termed effective reflection distance (ERD), has been associated with aging and augmentation index (AIx) clinically. However, ... ...

    Abstract Pressure wave reflection is associated with cardiovascular risk. The conceptual distance to a theoretical major reflection site, termed effective reflection distance (ERD), has been associated with aging and augmentation index (AIx) clinically. However, it remains unclear whether and how ERD varies and associates with AIx when the hemodynamic condition is acutely perturbed in a patient. The objective of this study was to address this issue in rigorously controlled animal experiments. In 13 anesthetized dogs, we measured arterial pressure, aortic flow and femoral arterial flow, while altering the hemodynamic condition over wide ranges by administering zatebradine (bradycardic agent), nitroprusside (vasodilator), noradrenaline (vasoconstrictor), dobutamine (inotrope), and dextran (volume-expander). Using the measured data, we determined ERD based on an arterial model comprising a tube with a complex frequency-dependent load (ERD
    MeSH term(s) Aging ; Animals ; Aorta ; Arterial Pressure ; Blood Pressure ; Dogs ; Hemodynamics ; Humans ; Pulse Wave Analysis ; Vascular Stiffness
    Language English
    Publishing date 2020-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218076-5
    ISSN 1873-2380 ; 0021-9290
    ISSN (online) 1873-2380
    ISSN 0021-9290
    DOI 10.1016/j.jbiomech.2020.109753
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 700: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Body Roundness Index Is Better Correlated with Insulin Sensitivity than Body Shape Index in Young and Middle-Aged Japanese Persons.

    Murai, Norimitsu / Saito, Naoko / Oka, Rie / Nii, Sayuri / Nishikawa, Hiroto / Suzuki, Asami / Kodama, Eriko / Iida, Tatsuya / Mikura, Kentaro / Imai, Hideyuki / Hashizume, Mai / Tadokoro, Rie / Sugisawa, Chiho / Iizaka, Toru / Otsuka, Fumiko / Ishibashi, Shun / Nagasaka, Shoichiro

    Metabolic syndrome and related disorders

    2024  Volume 22, Issue 2, Page(s) 151–159

    Abstract: Aims: ...

    Abstract Aims:
    MeSH term(s) Male ; Middle Aged ; Humans ; Adult ; Body Mass Index ; Insulin Resistance ; Obesity/diagnosis ; Risk Factors ; Glucose Intolerance/diagnosis ; Japan ; Anthropometry ; Waist Circumference
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2151220-6
    ISSN 1557-8518 ; 1540-4196
    ISSN (online) 1557-8518
    ISSN 1540-4196
    DOI 10.1089/met.2023.0175
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5950: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Effects of Quinolinate-Induced Lesion of the Medial Prefrontal Cortex on Prefrontal and Striatal Concentrations of D-Serine in the Rat.

    Umino, Asami / Iwama, Hisayuki / Umino, Masakazu / Shimazu, Dai / Kiuchi, Yuji / Nishikawa, Toru

    Neurochemical research

    2022  Volume 47, Issue 9, Page(s) 2728–2740

    Abstract: D-Serine has been shown to play an important role in the expression and control of a variety of brain functions by acting as the endogenous coagonist for the N-methyl-D-aspartate type glutamate receptor (NMDAR), at least, in the forebrain. To obtain ... ...

    Abstract D-Serine has been shown to play an important role in the expression and control of a variety of brain functions by acting as the endogenous coagonist for the N-methyl-D-aspartate type glutamate receptor (NMDAR), at least, in the forebrain. To obtain further insight into the still debatable cellular localization of the D-amino acid, we have examined the effects of the selective destruction of the neuronal cell bodies by quinolinate on the tissue or extracellular D-serine concentrations in the medial prefrontal cortex of the rat. A local quinolinate infusion into the bilateral medial prefrontal cortex produced a cortical lesion with a marked (- 65%) and non-significant alteration (- 5%) in the cortical and striatal tissue D-serine concentrations, respectively, 7 days post-infusion. In vivo microdialysis experiments in the right prefrontal lesion site 9 days after the quinolinate application revealed that the basal extracellular D-serine levels were also dramatically reduced (- 64%). A prominent reduction in the tissue levels of GABA in the interneurons of the prefrontal cortex (- 78%) without significant changes in those in the striatum (+ 12%) verified that a major lesion part was confined to the cortical portion. The lack of a significant influence of the prefrontal quinolinate lesion on its dopamine concentrations in the mesocortical dopamine projections suggests that the nerve terminals and axons in the lesion site may be spared. These findings are consistent with the perikarya-selective nature of the present quinolinate-induced lesion and further support the view that neuronal cell bodies of intrinsic neurons in the prefrontal cortical region contain substantial amounts of D-serine, which may sustain the basal extracellular concentrations of D-serine.
    MeSH term(s) Animals ; Corpus Striatum/metabolism ; Dopamine/metabolism ; Prefrontal Cortex/metabolism ; Quinolinic Acid/metabolism ; Rats ; Receptors, N-Methyl-D-Aspartate/metabolism ; Serine/metabolism
    Chemical Substances Receptors, N-Methyl-D-Aspartate ; Serine (452VLY9402) ; Quinolinic Acid (F6F0HK1URN) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 199335-5
    ISSN 1573-6903 ; 0364-3190
    ISSN (online) 1573-6903
    ISSN 0364-3190
    DOI 10.1007/s11064-022-03627-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top