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Article ; Online: The M w 7.5 Tadine (Maré, Loyalty Islands) earthquake and related tsunami of 5 December 2018

J. Roger / B. Pelletier / M. Duphil / J. Lefèvre / J. Aucan / P. Lebellegard / B. Thomas / C. Bachelier / D. Varillon

Natural Hazards and Earth System Sciences, Vol 21, Pp 3489-

seismotectonic context and numerical modeling

2021 Volume 3508

Abstract: On 5 December 2018, a magnitude M w 7.5 earthquake occurred southeast of Maré, an island ...

Abstract	On 5 December 2018, a magnitude M w 7.5 earthquake occurred southeast of Maré, an island of the Loyalty Islands archipelago, New Caledonia. This earthquake is located at the junction between the plunging Loyalty Ridge and the southern part of the Vanuatu Arc, in a tectonically complex and very active area regularly subjected to strong seismic crises and earthquakes higher than magnitude 7 and up to 8. Widely felt in New Caledonia, it was immediately followed by a tsunami warning, confirmed shortly after by a first wave arrival at the Loyalty Islands tide gauges (Maré and Lifou), and then along the east coast of Grande Terre of New Caledonia and in several islands of the Vanuatu Archipelago. Two solutions of the seafloor initial deformation are considered for tsunami generation modeling, one using a non-uniform finite-source model from USGS and the other being a uniform slip model built from the Global Centroid Moment Tensor (GCMT) solution, with the geological knowledge of the region and empirical laws establishing relationships between the moment magnitude and the fault plane geometry. Both tsunami generation and propagation are simulated using the Semi-implicit Cross-scale Hydroscience Integrated System Model (SCHISM), an open-source modeling code solving the shallow-water equations on an unstructured grid allowing refinement in many critical areas. The results of numerical simulations are compared to tide gauge records, field observations and testimonials from 2018. Careful inspection of wave amplitude and wave energy maps for the two simulated scenarios shows clearly that the heterogeneous deformation model is inappropriate, while it raises the importance of the fault plane geometry and azimuth for tsunami amplitude and directivity. The arrival times, wave amplitude and polarities obtained with the uniform slip model are globally coherent, especially in far-field locations (Hienghène, Poindimié and Port Vila). Due to interactions between the tsunami waves and the numerous bathymetric structures like the ...
Keywords	Environmental technology. Sanitary engineering ; TD1-1066 ; Geography. Anthropology. Recreation ; G ; Environmental sciences ; GE1-350 ; Geology ; QE1-996.5
Subject code	551
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Thermoelectric properties of the chalcopyrite Cu1−xMxFeS2−y series (M = Mn, Co, Ni)

Lefèvre, Robin / Berthebaud, David / Mychinko, M. Yu / Lebedev, Oleg I / Mori, Takao / Gascoin, Franck / Maignan, Antoine

RSC advances. 2016 June 08, v. 6, no. 60

2016

Abstract: ... deficient CuFeS2 chalcopyrite based series Cu1−xMxFeS2−y (M = Mn, Co, Ni, x ≤ 0.05 and y ≤ 0.02 ...

Abstract	The natural chalcopyrite mineral CuFeS2 is a semiconductor material with potential for thermoelectric applications. This study presents the thermoelectric properties – electrical resistivity ρ, Seebeck coefficient S and thermal conductivity κ – of the substituted on the Cu site and/or sulfur deficient CuFeS2 chalcopyrite based series Cu1−xMxFeS2−y (M = Mn, Co, Ni, x ≤ 0.05 and y ≤ 0.02). All samples have been densified by spark plasma sintering, allowing proper measurements of S, ρ and κ at high temperature. All compounds show n-type semiconducting properties with large absolute values of S, from −220 to −340 μV K−1. Maximum ZT values up to 0.20 at 623 K were obtained for Cu0.97Mn0.03FeS2 and Cu0.98Co0.02FeS1.98. The veracity of Mn for Cu substitution into the structure has been confirmed by EDS analyses, coupled to electron diffraction within a transmission electron microscope. The latter study demonstrates the existence of twinned domains. The thermal conductivity reaches values as low as κ ∼ 1.2 W m−1 K−1 at 623 K. The magnetic properties of a Mn substituted sample did not show any significant modification in the magnetic behavior compared to the pristine CuFeS2 compound. The small negative magnetoresistance observed in CuFeS2 of about −2% at 5 K in 9 T is degraded in the Mn substituted sample.
Keywords	cobalt ; copper ; electrical resistance ; energy-dispersive X-ray analysis ; magnetic properties ; magnetism ; manganese ; nickel ; semiconductors ; sulfides ; sulfur ; temperature ; thermal conductivity ; transmission electron microscopes
Language	English
Dates of publication	2016-0608
Size	p. 55117-55124.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c6ra10046e
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of body mass index <20 kg/m(2) on events in patients who underwent transcatheter aortic valve replacement.

Yamamoto, Masanori / Hayashida, Kentaro / Watanabe, Yusuke / Mouillet, Gauthier / Hovasse, Thomas / Chevalier, Bernard / Oguri, Atsushi / Dubois-Randé, Jean-Luc / Morice, Marie-Claude / Lefèvre, Thierry / Teiger, Emmanuel

The American journal of cardiology

2015 Volume 115, Issue 2, Page(s) 227–233

Abstract: The Valve Academic Research Consortium-2 has defined body mass index (BMI) <20 as indicative of frailty, which may be one of the co-morbidities not captured by traditional risk factors after transcatheter aortic valve replacement (TAVR). This study aimed ...

Abstract	The Valve Academic Research Consortium-2 has defined body mass index (BMI) <20 as indicative of frailty, which may be one of the co-morbidities not captured by traditional risk factors after transcatheter aortic valve replacement (TAVR). This study aimed to assess the impact of low BMI on clinical outcomes after TAVR. A total of 777 consecutive patients scheduled for TAVR were classified into 3 groups as BMI <20 (n = 56), 20 to 24.9 (n = 322), and ≥25 (n = 399). Procedural complications and clinical outcomes were compared among the 3 groups. They were also analyzed according to propensity-matching model A (BMI <20 [n = 50] vs ≥20 [n = 50]), model B (BMI <20 [n = 50] vs 20 to 24.9 [n = 50]), and model C (BMI <20 [n = 47] vs ≥25 [n = 47]). The differences in baseline characteristics among the 3 groups were adequately adjusted in 3 matched models. Valve Academic Research Consortium-2-defined end points and other complications were similar among the 3 groups in each model. Kaplan-Meier curves indicated no significant differences in cumulative 30-day survival (BMI <20 [91.0%] vs 20 to 24.9 [86.3%], p = 0.33; BMI <20 [91.0%] vs ≥25 [91.4%], p = 0.91, respectively) and 1-year survival (BMI <20 [74.3%] vs 20 to 24.9 [71.8%], p = 0.71; BMI <20 [74.3%] vs ≥25 [77.0%], p = 0.71; respectively). These survival rates were also similar in each of the 3 matched models. In conclusion, BMI <20 was not associated with increased early or midterm mortality. BMI <20 alone may not constitute an additional co-morbidity factor in patients who underwent TAVR.
MeSH term(s)	Aged, 80 and over ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/mortality ; Aortic Valve Stenosis/surgery ; Body Mass Index ; Cause of Death ; Female ; Follow-Up Studies ; France/epidemiology ; Hospital Mortality/trends ; Humans ; Kaplan-Meier Estimate ; Male ; Prognosis ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Survival Rate/trends ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
Language	English
Publishing date	2015-01-15
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2014.10.026
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Article ; Online: IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008.

Cloeckaert, Axel / Praud, Karine / Lefevre, Martine / Doublet, Benoît / Pardos de la Gandara, Maria / Granier, Sophie A / Brisabois, Anne / Weill, François-Xavier

Antimicrobial agents and chemotherapy

2010 Volume 54, Issue 10, Page(s) 4484–4486

Abstract: We report the dissemination of a conjugative IncI1 plasmid carrying bla(CTX-M-1), conferring ...

Abstract	We report the dissemination of a conjugative IncI1 plasmid carrying bla(CTX-M-1), conferring resistance to extended-spectrum cephalosporins, in Salmonella enterica isolates from poultry and humans in France from 2003 to 2008. By IncI1 plasmid subtyping, this plasmid was shown to be genetically related to that found in Escherichia coli isolates from healthy poultry in France.
MeSH term(s)	Animals ; Electrophoresis, Gel, Pulsed-Field ; Escherichia coli/genetics ; France ; Humans ; Plasmids/genetics ; Poultry/microbiology ; Salmonella enterica/genetics ; beta-Lactamases/genetics
Chemical Substances	beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2010-07-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.00460-10
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Article: Monitoring translocations by M-FISH and three-color FISH painting techniques: a study of two radiotherapy patients.

Pouzoulet, F / Roch-Lefèvre, S / Giraudet, A L / Vaurijoux, A / Voisin, Pa / Buard, V / Delbos, M / Bourhis, J / Voisin, Ph / Roy, Laurence

Journal of radiation research

2007 Volume 48, Issue 5, Page(s) 425–434

Abstract: Purpose: To compare translocation rate using either M-FISH or FISH-3 in two patients treated ... and follow-up points, the translocation yields were higher with FISH-3 than with M-FISH ... Conclusions: More translocations were detected with M-FISH than with FISH-3, and so M-FISH is expected ...

Abstract	Purpose: To compare translocation rate using either M-FISH or FISH-3 in two patients treated for head and neck cancer, with a view to retrospective dosimetry. Materials and methods: Translocation analysis was performed on peripheral blood lymphocyte cultures from blood samples taken at different times during the radiotherapy (0 Gy, 12 Gy and 50 Gy) and a few months after the end of the treatment (follow-up). Results: Estimated translocation yield varied according to the FISH technique used. At 50 Gy and follow-up points, the translocation yields were higher with FISH-3 than with M-FISH. This difference can be attributed to three events. First, an increase in complex aberrations was observed for 50 Gy and follow-up points compared with 0 Gy and 12 Gy points. Second, at the end of treatment for patient A, involvement of chromosomes 2, 4, 12 in translocations was less than expected according to the Lucas formula. Third, a clone bearing a translocation involving a FISH-3 painted chromosome was detected. Conclusions: More translocations were detected with M-FISH than with FISH-3, and so M-FISH is expected to improve the accuracy of chromosome aberration analyses in some situations.
MeSH term(s)	Aged ; Chromosome Painting/methods ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/radiotherapy ; Humans ; In Situ Hybridization, Fluorescence/methods ; Male ; Microscopy, Fluorescence, Multiphoton/methods ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity ; Translocation, Genetic/genetics ; Translocation, Genetic/radiation effects
Language	English
Publishing date	2007-08-31
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	603983-2
ISSN	0449-3060
ISSN	0449-3060
DOI	10.1269/jrr.07013
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Article ; Online: Arrivée du mépolizumab dans les syndromes hyperéosinophiliques : la position et les propositions du Centre de référence maladies rares des syndromes hyperéosinophiliques.

Kahn, J E / Lefèvre, G / Groh, M

La Revue de medecine interne

2023 Volume 44, Issue 4, Page(s) 155–157

Title translation	Use of mepolizumab in hypereosinophilic syndromes: The position and proposals of the national reference center for hypereosinophilic syndromes.
MeSH term(s)	Humans ; Antibodies, Monoclonal, Humanized/therapeutic use ; Hypereosinophilic Syndrome/drug therapy ; Eosinophils
Chemical Substances	mepolizumab (90Z2UF0E52) ; Antibodies, Monoclonal, Humanized
Language	French
Publishing date	2023-03-30
Publishing country	France
Document type	Editorial
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2023.03.006
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Article: On the Risk of Ruin in a SIS Type Epidemic.

Lefèvre, Claude / Simon, Matthieu

Methodology and computing in applied probability

2022 Volume 24, Issue 2, Page(s) 939–961

Abstract: The paper deals with the problem of possible ruin when providing insurance coverage for an epidemic. The model studied is an SIS type epidemic which generalizes the well-known logistic model. Contractually, the premiums are paid by susceptible people ... ...

Abstract	The paper deals with the problem of possible ruin when providing insurance coverage for an epidemic. The model studied is an SIS type epidemic which generalizes the well-known logistic model. Contractually, the premiums are paid by susceptible people while the care costs are reimbursed to infected people via an annuity or a lump-sum benefit. Our goal is to determine the distribution of the main statistics of the ruin when it occurs during the epidemic. The case where the reserve alternates between normal and epidemic episodes is also discussed using a Brownian modeling of the reserve. Finally, some of the results are illustrated for two particular SIS epidemic models.
Language	English
Publishing date	2022-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2003336-9
ISSN	1573-7713 ; 1387-5841
ISSN (online)	1573-7713
ISSN	1387-5841
DOI	10.1007/s11009-021-09924-z
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Article ; Online: The crucial and multifaceted roles of main-group cations and their salts in iron-mediated cross-couplings.

Wowk, Vincent / Lefèvre, Guillaume

Dalton transactions (Cambridge, England : 2003)

2022 Volume 51, Issue 28, Page(s) 10674–10680

Abstract: ... organometallics R-[M] as nucleophiles, the role of the [M] ...

Abstract	While a broad variety of iron-catalyzed cross-couplings involve the use of main-group organometallics R-[M] as nucleophiles, the role of the [M]
MeSH term(s)	Cations/chemistry ; Iron/chemistry ; Oxidation-Reduction ; Salts/chemistry
Chemical Substances	Cations ; Salts ; Iron (E1UOL152H7)
Language	English
Publishing date	2022-07-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d2dt00871h
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Article ; Online: Managing uncertainty in forecasting health workforce demand using the Robust Workforce Planning Framework: the example of midwives in Belgium.

Benahmed, Nadia / Lefèvre, Mélanie / Stordeur, Sabine

Human resources for health

2023 Volume 21, Issue 1, Page(s) 75

Abstract: Background: In Belgium, the Planning Commission for Medical Supply is responsible for monitoring human resources for health (HRH) and ultimately proposing workforce quotas. It is supported by the Planning Unit for the Supply of the Health Professions. ... ...

Abstract	Background: In Belgium, the Planning Commission for Medical Supply is responsible for monitoring human resources for health (HRH) and ultimately proposing workforce quotas. It is supported by the Planning Unit for the Supply of the Health Professions. This Unit quantifies and forecasts the workforce in the healthcare professions on the basis of a stock and flow model, based on trends observed in the past. In 2019, the Planning Unit asked the KCE (Belgian Health Care Knowledge Centre) to develop additional forecasting scenarios for the midwifery workforce, to complement the standard historical trend approach. The aim of this paper is to present the development of such forecasting scenarios. Methods: The Robust Workforce Planning Framework, developed by the Centre for Workforce Intelligence in the UK was used to develop alternative midwifery workforce scenarios. The framework consists of four steps (Horizon scanning, Scenario generation, Workforce modelling, and Policy analysis), the first two of which were undertaken by KCE, using two online surveys and five workshops with stakeholders. Results: Three alternative scenarios are proposed. The first scenario (close to the current situation) envisages pregnancy and maternity care centred on gynaecologists working either in a hospital or in private practice. The second scenario describes an organisation of midwife-led care in hospitals. In the third scenario, care is primarily organised by primary care practitioners (midwives and general practitioners) in outpatient settings. Conclusions: The Robust Workforce Planning Framework provides an opportunity to adjust the modelling of the health workforce and inform decision-makers about the impact of their future decisions on the health workforce.
MeSH term(s)	Pregnancy ; Female ; Humans ; Health Workforce ; Midwifery ; Belgium ; Uncertainty ; Maternal Health Services ; Workforce ; General Practitioners
Language	English
Publishing date	2023-09-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2126923-3
ISSN	1478-4491 ; 1478-4491
ISSN (online)	1478-4491
ISSN	1478-4491
DOI	10.1186/s12960-023-00861-1
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Article ; Online: Nouveautés dans la prise en charge de l’hyperkaliémie.

Lefevre, F / Mousseaux, C / Bobot, M

La Revue de medecine interne

2024

Abstract: Hyperkalemia is common in everyday clinical practice, and is a major risk factor for mortality. It mainly affects patients with chronic renal failure (CKD), diabetes or receiving treatment with inhibitors of the renin-angiotensin-aldosterone system ( ... ...

Title translation	What's new in hyperkalemia management?
Abstract	Hyperkalemia is common in everyday clinical practice, and is a major risk factor for mortality. It mainly affects patients with chronic renal failure (CKD), diabetes or receiving treatment with inhibitors of the renin-angiotensin-aldosterone system (iRAAS). Therapeutic management aims not only to avoid the complications of hyperkalemia, but also to avoid discontinuation of cardio- and nephroprotective treatments such as iRAAS. The use of polystyrene sulfonate, widely prescribed, is often limited by patient acceptability. Recent data have cast doubt on its safety, particularly in terms of digestive tolerance. Two new potassium exchange molecules have appeared on the market: patiromer and zirconium sulfonate. Their value in clinical practice, and their acceptability in the event of prolonged prescription, remain to be demonstrated. The combination of a thiazide diuretic or an inhibitor of the sodium-glucose cotransporter type 2 (iSGLT2) with iRAAS therapy in CKD, may also improve control of kalemia. At present, there are no recommendations for the positioning of the various hypokalemic treatments. The choice of these treatments must be adapted to the patient's pathologies and consider the other expected effects of these molecules.
Language	French
Publishing date	2024-01-13
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2024.01.004
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