Article ; Online: Green synthesis of zinc oxide nanoparticles using ethanolic extract of Gliricidia sepium (Jacq.) kunth. Ex. Walp., stem: Characterizations and their gastroprotective effect on ethanol-induced gastritis in rats.
2024 Volume 145, Page(s) 107225
Abstract: The study presents a significant advancement in drug delivery and therapeutic efficacy through the successful synthesis of Gliricidia sepium(Jacq.) Kunth. ex. Walp., stem zinc oxide nanoparticles(GSS ZnONPs). The phenolic compounds present in Gliricidia ... ...
| Abstract | The study presents a significant advancement in drug delivery and therapeutic efficacy through the successful synthesis of Gliricidia sepium(Jacq.) Kunth. ex. Walp., stem zinc oxide nanoparticles(GSS ZnONPs). The phenolic compounds present in Gliricidia sepium stem (GSS) particularly vanillic acid, apegnin-7-O-glucoside, syringic acid, and p-coumaric acid which were identified by HPLC. These compounds shown antioxidant and anti-inflammatory properties. GSS ZnONPs demonstrate pronounced gastroprotective effects against ethanol-induced gastritis, evidenced by the reduction in gastric lesions and mucosal injury upon its treatment. Histopathological evaluation and immunohistochemical analysis of nuclear factor erythroid 2-related factor 2 (Nrf2) expression further validate these results, revealing the amelioration of ethanol-induced gastritis and improved gastric tissue condition due to their treatment. Noteworthy is the dose-dependent response of GSS ZnONPs, showcasing their efficacy even at lower doses against ethanol-induced gastritis which is confirmed by different biomarkers. These findings have substantial implications for mitigating dosage-related adverse effects while preserving therapeutic benefits, offering a more favorable treatment approach. This study aims to investigate the potential gastroprotective activity of GSS ZnONPs against gastritis. |
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| MeSH term(s) | Rats ; Animals ; Ethanol ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Zinc Oxide ; Gastritis/chemically induced ; Gastritis/drug therapy ; Anti-Inflammatory Agents/therapeutic use ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy ; Stomach Ulcer/pathology |
| Chemical Substances | Ethanol (3K9958V90M) ; Plant Extracts ; Zinc Oxide (SOI2LOH54Z) ; Anti-Inflammatory Agents |
| Language | English |
| Publishing date | 2024-02-23 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 120080-x |
| ISSN | 1090-2120 ; 0045-2068 |
| ISSN (online) | 1090-2120 |
| ISSN | 0045-2068 |
| DOI | 10.1016/j.bioorg.2024.107225 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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