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Article ; Online: The Probable Protective Effect of Photobiomodulation on the Immunologic Factor's mRNA Expression Level in the Lung: An Extended COVID-19 Preclinical and Clinical Meta-analysis.

Arjmand, Babak / Rahim, Fakher

Clinical pathology (Thousand Oaks, Ventura County, Calif.)

2023 Volume 16, Page(s) 2632010X221127683

Abstract: Background: Different expression of cytokine genes in the body determines the type of immune response (Th1 or Th2), which can play an important role in the pathogenesis of the COVID-19 disease.: Aims: This meta-analysis was conducted to evaluate the ... ...

Abstract	Background: Different expression of cytokine genes in the body determines the type of immune response (Th1 or Th2), which can play an important role in the pathogenesis of the COVID-19 disease. Aims: This meta-analysis was conducted to evaluate the probable effect of photobiomodulation (PBMT) therapy on the cytokine's mRNA expression in the lung. Methods: We systematically searched indexing databases, including PubMed/Medline, ISI web of science, Scopus, EMBASE, and Cochrane central, using standard terms without language, study region or type restrictions. Studies on using PBM in lung injury modeling with samples collected from lung tissue to observe IL-1β, TNF-α, IL-10, and IL-6 mRNA expression were included. RevMan 5.3 software was used for data analysis and standardized mean difference as effect size. Results: Of the 438 studies found through initial searches, 17 met the inclusion criteria. The main properties of 13 articles on 384 animals included in this meta-analysis with a wide range of species include rats (n = 10) and rabbits (n = 3). The analysis revealed that PBMT reduced the mRNA expression Conclusion: This meta-analysis revealed that the PBMT utilizes beneficial anti-inflammatory effects and modulation of the immune system on lung damage in animal models and clinical studies. However, animal models and clinical studies appear limited considering the evidence's quality; therefore, large clinical trials are still required.
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2632-010X
ISSN (online)	2632-010X
DOI	10.1177/2632010X221127683
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Article: Gene Ontology Assessment of Indirect Cold Physical Plasma and UV-Radiation Molecular Mechanism at the Cellular Level.

Razzaghi, Zahra / Arjmand, Babak / Hamzeloo-Moghadam, Maryam / Rezaei Tavirani, Mostafa

Journal of lasers in medical sciences

2023 Volume 14, Page(s) e10

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-04-04
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2658681-2
ISSN	2228-6721 ; 2008-9783
ISSN (online)	2228-6721
ISSN	2008-9783
DOI	10.34172/jlms.2023.10
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Article ; Online: Human-Induced Pluripotent Stem Cell‒Derived Keratinocytes, as Therapeutic Option in Vitiligo.

Arjmand, Babak / Bahrami-Vahdat, Elahe / Alavi-Moghadam, Sepideh / Arjmand, Rasta / Rezaei-Tavirani, Mostafa / Namazi, Nazli / Larijani, Bagher

Methods in molecular biology (Clifton, N.J.)

2024

Abstract: Vitiligo is a skin condition affecting 1% of the global population, causing non-scaly, chalky-white macules on the skin and hair. It is caused by the pathologic destruction of melanocytes, which produce melanin. Research has focused on the abnormalities ... ...

Abstract	Vitiligo is a skin condition affecting 1% of the global population, causing non-scaly, chalky-white macules on the skin and hair. It is caused by the pathologic destruction of melanocytes, which produce melanin. Research has focused on the abnormalities of melanocytes and their interaction with neighboring keratinocytes. Current treatments are mainly immunosuppressive drugs and UV radiation, which are scarce and ineffective. To treat vitiligo, regenerative medicine techniques, such as cell-based and cell-free methods, are recommended. Keratinocyte cell transplantation has shown promising results in treating vitiligo. Moreover, studies suggest individualized therapy for diseases can be provided by reprogramming somatic cells into induced pluripotent stem cells. On the other hand, differentiation into particular cell types is a key component of induced pluripotent stem cells-based treatment. In this chapter, the differentiation and validation of human induced pluripotent stem cells into a keratinocyte as a therapeutic option in vitiligo will be discussed.
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/7651_2023_510
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Article ; Online: Isolation and Phenotypic Characterization of Tumor-Infiltrating NK Cells in Skin Carcinoma.

Arjmand, Babak / Hamidpour, Shayesteh Kokabi / Tayanloo-Beik, Akram / Arjmand, Rasta / Rezaei-Tavirani, Mostafa / Aghayan, Hamidreza / Rajaeinejad, Mohsen / Larijani, Bagher

Methods in molecular biology (Clifton, N.J.)

2024

Abstract: In oncological research, the function of tumor-infiltrating natural killer (NK) cells in skin carcinoma presents a viable avenue for novel therapeutic methods. NK cells are essential to the body's defense against malignancies, including skin cancer, and ... ...

Abstract	In oncological research, the function of tumor-infiltrating natural killer (NK) cells in skin carcinoma presents a viable avenue for novel therapeutic methods. NK cells are essential to the body's defense against malignancies, including skin cancer, and are especially important in more sophisticated cancer immunotherapies such as vaccinations containing dendritic cells. The deadliest type of skin cancer, malignant melanoma, still has a poor prognosis even with advancements in early-stage therapies, which emphasizes the need for novel therapeutic strategies. NK cells from human melanoma metastases were subjected to single-cell RNA-seq analysis, which demonstrated notable variations in the transcriptional programs of tumor-infiltrating and circulating NK cells. Different transcriptional states are displayed by NK cells that have invaded tumors, indicating that they are functionally specialized in areas like chemokine production and cytotoxicity. These results emphasize the functions of NK cells in recruiting other significant immune cell types, such as cross-presenting dendritic cells, and in direct cytotoxicity against malignant cells. Investigating NK cells that infiltrate tumors in skin carcinomas presents a viable approach to comprehending and may be modifying the immune environment surrounding these cancers. It is essential to comprehend the distinct characteristics and roles of NK cells inside the tumor microenvironment in order to create more potent immunotherapeutic approaches to treat skin cancer. In order to perhaps open the door for new directions in cancer immunotherapy, the project intends to establish a thorough technique for the isolation and thorough phenotypic characterization of tumor-infiltrating NK cells in skin carcinoma.
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/7651_2023_512
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Article ; Online: Management of Fluoropyrimidine-Induced Cardiac Adverse Outcomes Following Cancer Treatment.

Rajaeinejad, Mohsen / Parhizkar-Roudsari, Peyvand / Khoshfetrat, Mehran / Kazemi-Galougahi, Mohammad Hassan / Mosaed, Reza / Arjmand, Rasta / Mohsenizadeh, Seyed Abolfazl / Arjmand, Babak

Cardiovascular toxicology

2024 Volume 24, Issue 2, Page(s) 184–198

Abstract: Advancements in cancer treatments have improved survival rates but have also led to increased cardiotoxicities, which can cause adverse cardiovascular events or worsen pre-existing conditions. Herein, cardiotoxicity is a severe adverse effect of 5- ... ...

Abstract	Advancements in cancer treatments have improved survival rates but have also led to increased cardiotoxicities, which can cause adverse cardiovascular events or worsen pre-existing conditions. Herein, cardiotoxicity is a severe adverse effect of 5-fluorouracil (5-FU) therapy in cancer patients, with reported incidence rates ranging from 1 to 20%. Some studies have also suggested subclinical effects and there are reports which have documented instances of cardiac arrest or sudden death during 5-FU treatment, highlighting the importance of timely management of cardiovascular symptoms. However, despite being treated with conventional medical approaches for this cardiotoxicity, a subset of patients has demonstrated suboptimal or insufficient responses. The frequent use of 5-FU in chemotherapy and its association with significant morbidity and mortality indicates the need for a greater understanding of 5-FU-associated cardiotoxicity. It is essential to reduce the adverse effects of anti-tumor medications while preserving their efficacy, which can be achieved through drugs that mitigate toxicity associated with these drugs. Underpinning cardiotoxicity associated with 5-FU therapy also has the potential to offer valuable guidance in pinpointing pharmacological approaches that can be employed to prevent or ameliorate these effects. The present study provides an overview of management strategies for cardiac events induced by fluoropyrimidine-based cancer treatments. The review encompasses the underlying molecular and cellular mechanisms of cardiotoxicity, associated risk factors, and diagnostic methods. Additionally, we provide information on several available treatments and drug choices for angina resulting from 5-FU exposure, including nicorandil, ranolazine, trimetazidine, ivabradine, and sacubitril-valsartan, which have demonstrated potential in mitigating or protecting against chemotherapy-induced adverse cardiac effects.
MeSH term(s)	Humans ; Cardiotoxicity ; Fluorouracil/adverse effects ; Heart ; Heart Diseases/pathology ; Neoplasms/drug therapy
Chemical Substances	Fluorouracil (U3P01618RT)
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2036765-X
ISSN	1559-0259 ; 1530-7905
ISSN (online)	1559-0259
ISSN	1530-7905
DOI	10.1007/s12012-024-09834-9
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Article: Efficacy Evaluation of Human Skin Treatment with Photodynamic Therapy in Actinic Keratoses Patients.

Razzaghi, Zahra / Arjmand, Babak / Hamzeloo-Moghadam, Maryam / Rezaei Tavirani, Mostafa / Zamanian Azodi, Mona

Journal of lasers in medical sciences

2023 Volume 14, Page(s) e60

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-11-29
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2658681-2
ISSN	2228-6721 ; 2008-9783
ISSN (online)	2228-6721
ISSN	2008-9783
DOI	10.34172/jlms.2023.60
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Article ; Online: Cold atmospheric plasma treatment enhances recombinant model protein production in yeast Pichia pastoris.

Kabarkouhi, Zeinab / Arjmand, Sareh / Ranaei Siadat, Seyed Omid / Shokri, Babak

Scientific reports

2023 Volume 13, Issue 1, Page(s) 6797

Abstract: Cold atmospheric pressure plasma (CAP) has been described as a novel technology with expanding applications in biomedicine and biotechnology. In the present study, we provide a mildly stressful condition using non-lethal doses of CAP (120, 180, and 240 s) ...

Abstract	Cold atmospheric pressure plasma (CAP) has been described as a novel technology with expanding applications in biomedicine and biotechnology. In the present study, we provide a mildly stressful condition using non-lethal doses of CAP (120, 180, and 240 s) and evaluate its potential benefits on the recombinant production of a model protein (enhanced green fluorescent protein (eGFP)) in yeast Pichia pastoris. The measured eGFP fluorescence augmented proportional to CAP exposure time. After 240 s treatment with CAP, the measured fluorescent intensity of culture supernatant (after 72 h) and results of real-time PCR (after 24 h) indicated an 84% and 76% increase in activity and related RNA concentration, respectively. Real-time analysis of a list of genes involved in oxidative stress response revealed a significant and durable improvement in their expression at five h and 24 h following CAP exposure. The improvement of the recombinant model protein production may be partly explained by the impact of the RONS on cellular constituents and altering the expression of specific stress genes. In conclusion, using CAP strategy may be considered a valuable strategy to improve recombinant protein production, and deciphering the molecular background mechanism could be inspiring in the reverse metabolic engineering of host cells.
MeSH term(s)	Saccharomyces cerevisiae/metabolism ; Pichia/genetics ; Pichia/metabolism ; Recombinant Proteins/metabolism ; Biotechnology
Chemical Substances	Recombinant Proteins
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-34078-y
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Article: Introducing Albumin and Interleukin 6 as Common Critical Dysregulated Proteins Between Migraine and Gliosarcoma.

Arjmand, Babak / Mansouri, Vahid / Hamzeloo Moghadam, Maryam / Tavirani, Sina Rezaei

Basic and clinical neuroscience

2023 Volume 14, Issue 2, Page(s) 185–191

Abstract: Introduction: It is reported that migraine may be a risk factor for brain cancers. Since one of the best ways to assess this possible relationship is to study the molecular mechanism, here the common central dysregulated proteins between these diseases ... ...

Abstract	Introduction: It is reported that migraine may be a risk factor for brain cancers. Since one of the best ways to assess this possible relationship is to study the molecular mechanism, here the common central dysregulated proteins between these diseases are investigated via network analysis. Methods: The dysregulated proteins of migraine and gliosarcoma are extracted from the STRING database and interacted via Cytoscape software, version 3.7.2. to form two separate networks. Central nodes of the networks are compared to find the common central district proteins. First neighbors of the common central proteins are studied. Results: The number of 11 hub bottlenecks was identified for each of the migraine and gliosarcoma cancer networks. Albumin (ALB) and interleukin 6 (IL6) were introduced as common differentially expressed central proteins. Kininogen 1 (KNG1), vascular endothelial growth factor A (VEGFA), and neurofibromatosis type I (NF1) the first neighbors of ALB-IL6 were connected to the central nodes of networks of the two studied diseases. Conclusion: ALB and IL6 can be considered molecular links between migraine and brain cancers. Highlights: Differentially expression of albumin (ALB) and interleukin 6 (IL6) is highlighted as the common key events in migraine and gliosarcoma.Kininogen 1 (KNG1), vascular endothelial growth factor A (VEGFA), and neurofibromatosis type I (NF1) are introduced as possible critical players in migraine and gliosarcoma.Based on four centrality parameters, ALB is characterized with stronger centrality properties relative to IL6. Plain language summary: Migraine is considered as a possible risk factor for brain cancers. Therefor exploring of relationship between brain cancers and migraine is attracted attention of researchers. Understanding of diseases molecular mechanism is an important tool to better diagnosis and therapy of the studied disorders. In the present study, the common features of molecular events in migraine and gliosarcoma are studied based on protein expression changes. Analysis indicates that a few numbers of proteins play critical roles in migraine and gliosarcoma. ALB, IL6, KNG1, VEGFA, and NF1 are highlighted as the key proteins which are dysregulated in the two studied diseases. Prominent role of ALB in development of cancers is pointed out by several researchers. Important role of IL6 in promotion of migraine is disused in the previous documents. Since some diseases are risk factors for the other disorders, understanding the common features of two diseases can provide suitable therapeutic protocol to prevent development of diseases. Our finding can be used to provide suitable procedure to prevent conversion of migraine to brain cancer.
Language	English
Publishing date	2023-03-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2652444-2
ISSN	2228-7442 ; 2008-126X
ISSN (online)	2228-7442
ISSN	2008-126X
DOI	10.32598/bcn.2021.1483.2
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Article ; Online: The Pro-tumor and Anti-tumor Effects of NLRP3 Inflammasome as a New Therapeutic Option for Colon Cancer: a Meta-analysis of Pre-clinical Studies.

Ghanawat, Majid / Arjmand, Babak / Rahim, Fakher

Journal of gastrointestinal cancer

2022 Volume 54, Issue 1, Page(s) 227–236

Abstract: In this review, we aimed to elaborate on these findings and explore how NLRP3 inflammasome affects CRC and which mechanism could be a potential therapeutic target. For this purpose, major indexing databases consist of Cochrane central, ISI web of science ...

Abstract	In this review, we aimed to elaborate on these findings and explore how NLRP3 inflammasome affects CRC and which mechanism could be a potential therapeutic target. For this purpose, major indexing databases consist of Cochrane central, ISI web of science (WOS), PubMed/Medline, Scopus, and EMBASE were systematically searched using standard terms without any language, study region, or type restrictions. After applying the exclusion criteria, the main properties of 12 articles on 326 animals included in this meta-analysis. Of 12, eight were about an anti-tumoral effect, and four were on a pro-tumoral effect of the inflammasome. NLRP3 inhibition reduced IL-1β (SMD: -4.14, 95% CI: -5.49, -2.79, P < 0.00001, I
MeSH term(s)	Animals ; Humans ; Colonic Neoplasms/drug therapy ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Reactive Oxygen Species/metabolism
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Reactive Oxygen Species
Language	English
Publishing date	2022-01-24
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2452514-5
ISSN	1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
ISSN (online)	1941-6636 ; 1559-0739
ISSN	1941-6628 ; 1537-3649
DOI	10.1007/s12029-022-00805-3
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Article ; Online: Preparation and Validation of Zebrafish Psoriasis Model to Investigate the Therapeutic Effects of Stem Cells.

Arjmand, Babak / Alavi-Moghadam, Sepideh / Kokabi-Hamidpour, Shayesteh / Arjmand, Rasta / Rezaei-Tavirani, Mostafa / Larijani, Bagher

Methods in molecular biology (Clifton, N.J.)

2023

Abstract: Psoriasis is a chronic, inflammatory, autoimmune disease with systemic symptoms including seborrheic psoriasis, pustular lesions, plaque lesions, intestinal eruptions, and sometimes arthritis. Moreover, most of the psoriatic subjects report life ... ...

Abstract	Psoriasis is a chronic, inflammatory, autoimmune disease with systemic symptoms including seborrheic psoriasis, pustular lesions, plaque lesions, intestinal eruptions, and sometimes arthritis. Moreover, most of the psoriatic subjects report life challenges due to the condition, impacting social activities and daily tasks. Generally, psoriasis treatment options depend on the severity, coexisting conditions, and medical availability. Although psoriasis therapies reduce symptoms and appearance, still it is not curable. Hereupon, searching for optimal therapeutic options continues. Accordingly, stem cell therapy is considered an advanced psoriasis treatment. Subsequently, stem cell therapies' efficacy is uncertain yet. Therefore, further studies are needed. In this context, preclinical studies such as animal experiments are essential for evaluation of treatment modalities. Herein, zebrafish offer advantages in testing treatments and biomedical research applications compared to other vertebrate models. Further, zebrafish skin shares similarities with human skin, making it suitable for studying inflammatory disorders. Hence, the authors discuss the zebrafish psoriasis development method for evaluating the stem cell therapeutic influence.
Language	English
Publishing date	2023-10-07
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/7651_2023_505
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