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  1. Book ; Online: Kita-Entwicklung - Organisationsentwicklung als Chance für die frühe Bildung

    Bergs-Winkels, Dagmar / Cloos, Peter / Iller, Carola / Prigge, Jessica / Simon, Stephanie / Ulber, Daniela

    (Wissenschaftliche Untersuchungen zur Arbeit der Stiftung "Haus der kleinen Forscher")

    2023  

    Series title Wissenschaftliche Untersuchungen zur Arbeit der Stiftung "Haus der kleinen Forscher"
    Keywords Pre-school & kindergarten ; Kindertagestätte;organizational development;elementary and primary education;Kita;early childhood education and care (ECEC);Organisationsentwicklung;Elementar- und Primarbereich;organizational culture;frühe Bildung;participation;human resources;Professionalisierung;Organisationskultur;personnel development;change management;Partizipation;Kita-Leitung;Personalentwicklung
    Language German
    Size 1 electronic resource (210 pages)
    Publisher Verlag Barbara Budrich
    Publishing place Leverkusen
    Document type Book ; Online
    Note German
    HBZ-ID HT030613101
    ISBN 9783847427001 ; 3847427008
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Construction of Small-Insert and Large-Insert Metagenomic Libraries.

    Simon, Carola / Daniel, Rolf

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2555, Page(s) 1–12

    Abstract: The vast majority of the Earth's biological diversity are hidden in uncultured and yet uncharacterized microbial genomes. The construction of metagenomic libraries is one cultivation-independent molecular approach to assess this unexplored genetic ... ...

    Abstract The vast majority of the Earth's biological diversity are hidden in uncultured and yet uncharacterized microbial genomes. The construction of metagenomic libraries is one cultivation-independent molecular approach to assess this unexplored genetic reservoir. High numbers of novel biocatalysts have been identified by function-based or sequence-based screening of metagenomic libraries derived from various environments. Here, we describe detailed protocols for the construction of metagenomic small-insert and large-insert libraries in plasmids and fosmids, respectively, from environmental DNA.
    MeSH term(s) Gene Library ; Metagenomics/methods ; Metagenome ; Biodiversity ; Plasmids/genetics
    Language English
    Publishing date 2022-10-28
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2795-2_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; Thesis: Modelling future global change impacts on African ecosystems and their carbon dynamics and associated uncertainties and challenges

    Martens, Carola [Verfasser] / Hickler, Thomas Gutachter] / [Scheiter, Simon [Gutachter]

    2023  

    Author's details Carola Martens ; Gutachter: Thomas Hickler, Simon Scheiter
    Keywords Geowissenschaften ; Earth Sciences
    Subject code sg550
    Language English
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article ; Online: Transforming growth factor-beta superfamily regulates mesenchymal stem cell osteogenic differentiation: A microRNA linking.

    Santibanez, Juan F / Echeverria, Cesar / Millan, Carola / Simon, Felipe

    Acta histochemica

    2023  Volume 125, Issue 8, Page(s) 152096

    Abstract: The ability to differentiate into cells of different lineages, such as bone cells, is the principal value of adult mesenchymal stem cells (MSCs), which can be used with the final aim of regenerating damaged tissue. Due to its potential use and importance ...

    Abstract The ability to differentiate into cells of different lineages, such as bone cells, is the principal value of adult mesenchymal stem cells (MSCs), which can be used with the final aim of regenerating damaged tissue. Due to its potential use and importance in regenerative medicine and tissue engineering, several questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, the transforming growth factor-beta (TGF-β) superfamily directs MSCs' commitment to selecting differentiation pathways. This review aims to give an overview of the current knowledge on the mechanisms of the TGF-β superfamily in MSCs bone differentiation, with additional insight into the mutual regulation of microRNAs and TGF-β in osteogenesis.
    MeSH term(s) Osteogenesis/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Cell Differentiation/genetics ; Transforming Growth Factor beta/metabolism ; Mesenchymal Stem Cells ; Transforming Growth Factors/metabolism
    Chemical Substances MicroRNAs ; Transforming Growth Factor beta ; Transforming Growth Factors (76057-06-2)
    Language English
    Publishing date 2023-10-07
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 77-2
    ISSN 1618-0372 ; 0065-1281
    ISSN (online) 1618-0372
    ISSN 0065-1281
    DOI 10.1016/j.acthis.2023.152096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.185: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Thesis: Klinische Langzeitergebnisse nach operativer Therapie einer chronischen Pankreatitis mittels Duodenum-erhaltender Pankreaskopfresektion

    Angelova, Yoana / Schimmack, Simon

    2022  

    Institution Universität Heidelberg
    Author's details vorgelegt von Yoana Angelova ; Doktorvater: Prof. Dr. med. Simon Schimmack
    Language German
    Size XXXVI, 51 Seiten, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2023
    HBZ-ID HT030621184
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 1504 order for loan Magazin

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  6. Article ; Online: Combined impacts of future climate-driven vegetation changes and socioeconomic pressures on protected areas in Africa.

    Martens, Carola / Scheiter, Simon / Midgley, Guy F / Hickler, Thomas

    Conservation biology : the journal of the Society for Conservation Biology

    2022  Volume 36, Issue 6, Page(s) e13968

    Abstract: Africa's protected areas (PAs) are the last stronghold of the continent's unique biodiversity, but they appear increasingly threatened by climate change, substantial human population growth, and land-use change. Conservation planning is challenged by ... ...

    Abstract Africa's protected areas (PAs) are the last stronghold of the continent's unique biodiversity, but they appear increasingly threatened by climate change, substantial human population growth, and land-use change. Conservation planning is challenged by uncertainty about how strongly and where these drivers will interact over the next few decades. We investigated the combined future impacts of climate-driven vegetation changes inside African PAs and human population densities and land use in their surroundings for 2 scenarios until the end of the 21
    MeSH term(s) Humans ; Ecosystem ; Conservation of Natural Resources ; Climate Change ; Biodiversity ; Trees ; Socioeconomic Factors
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 58735-7
    ISSN 1523-1739 ; 0888-8892
    ISSN (online) 1523-1739
    ISSN 0888-8892
    DOI 10.1111/cobi.13968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4919: Show issues

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  7. Article: Entwicklung der ambulanten Ethikberatung. Verstaerkte telefonische Beratung und bessere Finanzierung gefordert

    Seifart, Carola / Simon, Alfred / Schmidt, Kurt

    Hessisches Aerzteblatt

    2020  Volume 81, Issue 3, Page(s) 174–175

    Title translation Development of outpatient ethics counselling. More telephone counselling and better funding called for
    Keywords ethics consultation ; economics ; palliative care ; organization and administration ; survey
    Subject code AN
    Language German
    Document type Article
    ZDB-ID 510015-x
    ISSN 0171-9661
    ISSN 0171-9661
    Database Ethics in Medicine (ETHMED)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1151: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Thesis: Die Interaktion von Kv7-Kaliumkanälen und der Na+- K+- ATPase in arteriellen glatten Muskelzellen

    Lux, Simon

    2021  

    Institution Universität Heidelberg
    Author's details vorgelegt von Simon Lux
    Language German
    Size 69 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität zu Heidelberg, 2021
    Note Im Titel ist "v" bei "Kv7-Kaliumkanälen" tiefgestellt und "+" bei "Na+-K+-ATPase" hochgestellt
    HBZ-ID HT021828362
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 555 order for loan Magazin

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  9. Article: Lower Respiratory Tract Infections in Pediatric Patients with Severe Neurological Impairments: Clinical Observations and Perspectives in a Palliative Care Unit.

    Mauritz, Maximilian David / Hasan, Carola / Schmidt, Pia / Simon, Arne / Knuf, Markus / Zernikow, Boris

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 6

    Abstract: Pediatric palliative care (PPC) patients with a severe neurologic impairment (SNI) suffer considerable morbidity and increased mortality from lower respiratory tract infections (LRTIs). The indication and choice of antibiotic therapy for bacterial LRTIs ... ...

    Abstract Pediatric palliative care (PPC) patients with a severe neurologic impairment (SNI) suffer considerable morbidity and increased mortality from lower respiratory tract infections (LRTIs). The indication and choice of antibiotic therapy for bacterial LRTIs are often challenging given the lack of evidence-based treatment recommendations for this vulnerable patient population. We conducted an observational study before the SARS-CoV-2 pandemic in an eight-bed pediatric palliative care inpatient unit. During two years of surveillance, we diagnosed and treated 33 cases of a bacterial LRTI in patients with an SNI; 5 patients were hospitalized with an LRTI more than once. Two patients died from complications due to LRTIs during hospitalization. Three patients (15%) were colonized with multidrug-resistant organisms. An initial antibiotic treatment failed in one-third of the cases; a successful therapy of the LRTI was achieved with broad-spectrum and extended-spectrum penicillins (
    Language English
    Publishing date 2022-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9060852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online ; Thesis: Longitudinale strukturelle MRT zur Untersuchung der Hirnatrophie von Patienten mit Morbus Parkinson und kognitiver Beeinträchtigung

    Seitz, Florian [Verfasser] / Baudrexel, Simon [Akademischer Betreuer] / Oberschmidt, Carola [Akademischer Betreuer] / Baudrexel, Simon [Gutachter] / Roeper, Jochen [Gutachter]

    2022  

    Author's details Florian David Seitz ; Gutachter: Simon Baudrexel, Jochen Roeper ; Simon Baudrexel, Carola Oberschmidt
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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