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  1. Article ; Online: Sensing and regulation of reactive sulfur species (RSS) in bacteria.

    Giedroc, David P / Antelo, Giuliano T / Fakhoury, Joseph N / Capdevila, Daiana A

    Current opinion in chemical biology

    2023  Volume 76, Page(s) 102358

    Abstract: The infected host deploys generalized oxidative stress caused by small inorganic reactive molecules as antibacterial weapons. An emerging consensus is that hydrogen sulfide ( ... ...

    Abstract The infected host deploys generalized oxidative stress caused by small inorganic reactive molecules as antibacterial weapons. An emerging consensus is that hydrogen sulfide (H
    MeSH term(s) Hydrogen Sulfide ; Oxidative Stress ; Oxidation-Reduction ; Sulfur/chemistry ; Bacteria
    Chemical Substances Hydrogen Sulfide (YY9FVM7NSN) ; Sulfur (70FD1KFU70)
    Language English
    Publishing date 2023-07-01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1439176-4
    ISSN 1879-0402 ; 1367-5931
    ISSN (online) 1879-0402
    ISSN 1367-5931
    DOI 10.1016/j.cbpa.2023.102358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4986: Show issues Location:
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  2. Article ; Online: Protocol for using organic persulfides to measure the chemical reactivity of persulfide sensors.

    Fakhoury, Joseph N / Capdevila, Daiana A / Giedroc, David P

    STAR protocols

    2022  Volume 3, Issue 2, Page(s) 101424

    Abstract: Hydrogen sulfide ( ... ...

    Abstract Hydrogen sulfide (H
    MeSH term(s) Chromatography, Liquid ; Hydrogen Sulfide/metabolism ; Oxidation-Reduction ; Sulfides/metabolism
    Chemical Substances Sulfides ; persulfides ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A new player in bacterial sulfide-inducible transcriptional regulation.

    Giedroc, David P

    Molecular microbiology

    2017  Volume 105, Issue 3, Page(s) 347–352

    Abstract: Although hydrogen sulfide ( ... ...

    Abstract Although hydrogen sulfide (H
    MeSH term(s) Bacteria/metabolism ; Gene Expression Regulation, Bacterial/physiology ; Homeostasis ; Hydrogen Sulfide ; Oxidation-Reduction ; Sulfides/metabolism ; Sulfur/metabolism
    Chemical Substances Sulfides ; Sulfur (70FD1KFU70) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2017-08
    Publishing country England
    Document type Introductory Journal Article
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.13726
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2502: Show issues Location:
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  4. Article ; Online: Proteomics Profiling of

    Walsh, Brenna J C / Giedroc, David P

    Bio-protocol

    2021  Volume 11, Issue 9, Page(s) e4000

    Abstract: Hydrogen sulfide ( ... ...

    Abstract Hydrogen sulfide (H
    Language English
    Publishing date 2021-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4000
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  5. Article ; Online: Characterization of the Zinc Uptake Repressor (Zur) from

    Kim, Minyong / Le, My Tra / Fan, Lixin / Campbell, Courtney / Sen, Sambuddha / Capdevila, Daiana A / Stemmler, Timothy L / Giedroc, David P

    Biochemistry

    2024  Volume 63, Issue 5, Page(s) 660–670

    Abstract: Bacterial cells tightly regulate the intracellular concentrations of essential transition metal ions by deploying a panel of metal-regulated transcriptional repressors and activators that bind to operator-promoter regions upstream of regulated genes. ... ...

    Abstract Bacterial cells tightly regulate the intracellular concentrations of essential transition metal ions by deploying a panel of metal-regulated transcriptional repressors and activators that bind to operator-promoter regions upstream of regulated genes. Like other zinc uptake regulator (Zur) proteins,
    MeSH term(s) Acinetobacter baumannii/genetics ; Acinetobacter baumannii/metabolism ; Bacterial Proteins/chemistry ; Binding Sites ; Cadmium ; Protein Subunits ; Scattering, Small Angle ; Zinc/metabolism ; X-Ray Diffraction ; Repressor Proteins/metabolism ; Metals ; DNA/metabolism ; Isoquinolines ; Sulfonamides
    Chemical Substances Bacterial Proteins ; Cadmium (00BH33GNGH) ; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide (M876330O56) ; Protein Subunits ; Zinc (J41CSQ7QDS) ; Repressor Proteins ; Metals ; DNA (9007-49-2) ; Isoquinolines ; Sulfonamides
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.3c00679
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 217: Show issues Location:
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  6. Article ; Online: Coupling of zinc and GTP binding drives G-domain folding in Acinetobacter baumannii ZigA.

    Osterberg, Maximillian K / Smith, Ally K / Campbell, Courtney / Deredge, Daniel J / Stemmler, Timothy L / Giedroc, David P

    Biophysical journal

    2024  Volume 123, Issue 8, Page(s) 979–991

    Abstract: ... class of small P-loop G3E GTPases. Multiple family members play critical roles in bacterial pathogen ...

    Abstract COG0523 proteins, also known as nucleotide-dependent metallochaperones, are a poorly understood class of small P-loop G3E GTPases. Multiple family members play critical roles in bacterial pathogen survival during an infection as part of the adaptive response to host-mediated "nutritional immunity." Our understanding of the structure, dynamics, and molecular-level function of COG0523 proteins, apart from the eukaryotic homolog, Zng1, remains in its infancy. Here, we use X-ray absorption spectroscopy to establish that Acinetobacter baumannii (Ab) ZigA coordinates Zn
    MeSH term(s) Humans ; Zinc/metabolism ; Acinetobacter baumannii/metabolism ; Nucleotides/metabolism ; Bacteria/metabolism ; Guanosine Triphosphate/metabolism ; Protein Binding ; Guanosine Diphosphate/metabolism
    Chemical Substances Zinc (J41CSQ7QDS) ; Nucleotides ; Guanosine Triphosphate (86-01-1) ; Guanosine Diphosphate (146-91-8)
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2024.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 235: Show issues Location:
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    Zs.MO 2: Show issues

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  7. Article ; Online: COG0523 proteins: a functionally diverse family of transition metal-regulated G3E P-loop GTP hydrolases from bacteria to man.

    Edmonds, Katherine A / Jordan, Matthew R / Giedroc, David P

    Metallomics : integrated biometal science

    2021  Volume 13, Issue 8

    Abstract: ... COG) COG0523 proteins. COG0523 proteins encompass a poorly understood sub-family of G3E P-loop small ...

    Abstract Transition metal homeostasis ensures that cells and organisms obtain sufficient metal to meet cellular demand while dispensing with any excess so as to avoid toxicity. In bacteria, zinc restriction induces the expression of one or more Zur (zinc-uptake repressor)-regulated Cluster of Orthologous Groups (COG) COG0523 proteins. COG0523 proteins encompass a poorly understood sub-family of G3E P-loop small GTPases, others of which are known to function as metallochaperones in the maturation of cobalamin (CoII) and NiII cofactor-containing metalloenzymes. Here, we use genomic enzymology tools to functionally analyse over 80 000 sequences that are evolutionarily related to Acinetobacter baumannii ZigA (Zur-inducible GTPase), a COG0523 protein and candidate zinc metallochaperone. These sequences segregate into distinct sequence similarity network (SSN) clusters, exemplified by the ZnII-Zur-regulated and FeIII-nitrile hydratase activator CxCC (C, Cys; X, any amino acid)-containing COG0523 proteins (SSN cluster 1), NiII-UreG (clusters 2, 8), CoII-CobW (cluster 4), and NiII-HypB (cluster 5). A total of five large clusters that comprise ≈ 25% of all sequences, including cluster 3 which harbors the only structurally characterized COG0523 protein, Escherichia coli YjiA, and many uncharacterized eukaryotic COG0523 proteins. We also establish that mycobacterial-specific protein Y (Mpy) recruitment factor (Mrf), which promotes ribosome hibernation in actinomycetes under conditions of ZnII starvation, segregates into a fifth SSN cluster (cluster 17). Mrf is a COG0523 paralog that lacks all GTP-binding determinants as well as the ZnII-coordinating Cys found in CxCC-containing COG0523 proteins. On the basis of this analysis, we discuss new perspectives on the COG0523 proteins as cellular reporters of widespread nutrient stress induced by ZnII limitation.
    MeSH term(s) Animals ; Bacteria/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biological Evolution ; GTP Phosphohydrolases/genetics ; GTP Phosphohydrolases/metabolism ; Genomics ; Humans ; Hydrolases/genetics ; Hydrolases/metabolism ; Metallochaperones/genetics ; Metallochaperones/metabolism ; Metals/metabolism ; Mice ; Transition Elements
    Chemical Substances Bacterial Proteins ; Metallochaperones ; Metals ; Transition Elements ; Hydrolases (EC 3.-) ; GTP Phosphohydrolases (EC 3.6.1.-)
    Language English
    Publishing date 2021-07-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2474317-3
    ISSN 1756-591X ; 1756-5901
    ISSN (online) 1756-591X
    ISSN 1756-5901
    DOI 10.1093/mtomcs/mfab046
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  8. Article ; Online: H

    Walsh, Brenna J C / Giedroc, David P

    The Journal of biological chemistry

    2020  Volume 295, Issue 38, Page(s) 13150–13168

    Abstract: Bacterial pathogens that cause invasive disease in the vertebrate host must adapt to host efforts to cripple their viability. Major host insults are reactive oxygen and reactive nitrogen species as well as cellular stress induced by antibiotics. Hydrogen ...

    Abstract Bacterial pathogens that cause invasive disease in the vertebrate host must adapt to host efforts to cripple their viability. Major host insults are reactive oxygen and reactive nitrogen species as well as cellular stress induced by antibiotics. Hydrogen sulfide (H
    MeSH term(s) Animals ; Bacteria/genetics ; Bacteria/metabolism ; Bacteria/pathogenicity ; Bacterial Infections/genetics ; Bacterial Infections/metabolism ; Bacterial Infections/pathology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Humans ; Hydrogen Sulfide/metabolism ; Microbial Viability ; Protein Processing, Post-Translational ; Signal Transduction
    Chemical Substances Bacterial Proteins ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.REV120.011304
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    Uc I Zs.108: Show issues Location:
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  9. Article: The five homologous CiaR-controlled Ccn sRNAs of

    De Lay, Nicholas R / Verma, Nidhi / Sinha, Dhriti / Garrett, Abigail / Osterberg, Maximillian K / Reiling, Spencer / Porter, Daisy / Giedroc, David P / Winkler, Malcolm E

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Zinc is a vital transition metal ... ...

    Abstract Zinc is a vital transition metal for
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.07.565944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Iron Acquisition by Bacterial Pathogens: Beyond Tris-Catecholate Complexes.

    Zhang, Yifan / Sen, Sambuddha / Giedroc, David P

    Chembiochem : a European journal of chemical biology

    2020  Volume 21, Issue 14, Page(s) 1955–1967

    Abstract: Sequestration of the essential nutrient iron from bacterial invaders that colonize the vertebrate host is a central feature of nutritional immunity and the "fight over transition metals" at the host-pathogen interface. The iron quota for many bacterial ... ...

    Abstract Sequestration of the essential nutrient iron from bacterial invaders that colonize the vertebrate host is a central feature of nutritional immunity and the "fight over transition metals" at the host-pathogen interface. The iron quota for many bacterial pathogens is large, as iron enzymes often make up a significant share of the metalloproteome. Iron enzymes play critical roles in respiration, energy metabolism, and other cellular processes by catalyzing a wide range of oxidation-reduction, electron transfer, and oxygen activation reactions. In this Concept article, we discuss recent insights into the diverse ways that bacterial pathogens acquire this essential nutrient, beyond the well-characterized tris-catecholate Fe
    MeSH term(s) Bacteria/metabolism ; Ferric Compounds/metabolism ; Host-Pathogen Interactions
    Chemical Substances Ferric Compounds
    Language English
    Publishing date 2020-04-14
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.201900778
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