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  1. Article ; Online: Denise Montell: lighting the way in border cell migration by Caitlin Sedwick.

    Montell, Denise

    The Journal of cell biology

    2011  Volume 195, Issue 4, Page(s) 540–541

    MeSH term(s) Animals ; Cell Movement ; Drosophila/cytology ; Drosophila/metabolism ; Female ; GTP Phosphohydrolases/metabolism ; History, 20th Century ; History, 21st Century ; Oogenesis/genetics
    Chemical Substances GTP Phosphohydrolases (EC 3.6.1.-)
    Language English
    Publishing date 2011-11-13
    Publishing country United States
    Document type Autobiography ; Biography ; Historical Article ; Interview ; Portrait
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.1954pi
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  2. Article ; Online: Macrophages, masters of invasion.

    Montell, Denise J

    Developmental cell

    2022  Volume 57, Issue 11, Page(s) 1314–1315

    Abstract: Macrophages are exceptionally invasive cells. In a recent article in Science, Akhmanova et al. describe a novel mechanism facilitating macrophage infiltration into a tightly packed tissue in Drosophila embryos. Ectodermal cell rounding and division ... ...

    Abstract Macrophages are exceptionally invasive cells. In a recent article in Science, Akhmanova et al. describe a novel mechanism facilitating macrophage infiltration into a tightly packed tissue in Drosophila embryos. Ectodermal cell rounding and division enhance macrophage entry by detaching the dividing cells from the underlying extracellular matrix.
    MeSH term(s) Animals ; Drosophila ; Extracellular Matrix ; Macrophages
    Language English
    Publishing date 2022-06-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2022.05.009
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  3. Article ; Online: Editorial: Special issue SCDB "Cell death and survival": Cell death and resilience in health and disease.

    Nano, Maddalena / Montell, Denise J

    Seminars in cell & developmental biology

    2023  Volume 157, Page(s) 1–2

    MeSH term(s) Resilience, Psychological ; Protein Binding
    Language English
    Publishing date 2023-12-02
    Publishing country England
    Document type Editorial
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2023.11.004
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    Zs.A 2918: Show issues Location:
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  4. Article ; Online: Apoptotic signaling: Beyond cell death.

    Nano, Maddalena / Montell, Denise J

    Seminars in cell & developmental biology

    2023  Volume 156, Page(s) 22–34

    Abstract: Apoptosis is the best described form of regulated cell death, and was, until relatively recently, considered irreversible once particular biochemical points-of-no-return were activated. In this manuscript, we examine the mechanisms cells use to escape ... ...

    Abstract Apoptosis is the best described form of regulated cell death, and was, until relatively recently, considered irreversible once particular biochemical points-of-no-return were activated. In this manuscript, we examine the mechanisms cells use to escape from a self-amplifying death signaling module. We discuss the role of feedback, dynamics, propagation, and noise in apoptotic signaling. We conclude with a revised model for the role of apoptosis in animal development, homeostasis, and disease.
    MeSH term(s) Animals ; Apoptosis/physiology ; Cell Death ; Signal Transduction
    Language English
    Publishing date 2023-11-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2023.11.002
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  5. Article ; Online: Who's really in charge: Diverse follower cell behaviors in collective cell migration.

    Campanale, Joseph P / Montell, Denise J

    Current opinion in cell biology

    2023  Volume 81, Page(s) 102160

    Abstract: Collective cell migrations drive morphogenesis, wound healing, and cancer dissemination. Cells located at the front are considered leaders while those behind them are defined topologically as followers. Leader cell behaviors, including chemotaxis and ... ...

    Abstract Collective cell migrations drive morphogenesis, wound healing, and cancer dissemination. Cells located at the front are considered leaders while those behind them are defined topologically as followers. Leader cell behaviors, including chemotaxis and their coupling to followers, have been well-studied and reviewed. However, the contributions of follower cells to collective cell migration represent an emerging area of interest. In this perspective, we highlight recent research into the broadening array of follower cell behaviors found in moving collectives. We describe examples of follower cells that possess cryptic leadership potential and followers that lack that potential but contribute in diverse and sometimes surprising ways to collective movement, even steering from behind. We highlight collectives in which all cells both lead and follow, and a few passive passengers. The molecular mechanisms controlling follower cell function and behavior are just emerging and represent an exciting frontier in collective cell migration research.
    MeSH term(s) Cell Movement ; Morphogenesis ; Wound Healing
    Language English
    Publishing date 2023-04-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2023.102160
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  6. Article ; Online: The molecular mechanisms of diapause and diapause-like reversible arrest.

    Easwaran, Sreesankar / Montell, Denise J

    Biochemical Society transactions

    2023  Volume 51, Issue 5, Page(s) 1847–1856

    Abstract: Diapause is a protective mechanism that many organisms deploy to overcome environmental adversities. Diapause extends lifespan and fertility to enhance the reproductive success and survival of the species. Although diapause states have been known and ... ...

    Abstract Diapause is a protective mechanism that many organisms deploy to overcome environmental adversities. Diapause extends lifespan and fertility to enhance the reproductive success and survival of the species. Although diapause states have been known and employed for commercial purposes, for example in the silk industry, detailed molecular and cell biological studies are an exciting frontier. Understanding diapause-like protective mechanisms will shed light on pathways that steer organisms through adverse conditions. One hope is that an understanding of the mechanisms that support diapause might be leveraged to extend the lifespan and/or health span of humans as well as species threatened by climate change. In addition, recent findings suggest that cancer cells that persist after treatment mimic diapause-like states, implying that these programs may facilitate cancer cell survival from chemotherapy and cause relapse. Here, we review the molecular mechanisms underlying diapause programs in a variety of organisms, and we discuss pathways supporting diapause-like states in tumor persister cells.
    MeSH term(s) Animals ; Humans ; Diapause ; Reproduction ; Longevity
    Language English
    Publishing date 2023-10-06
    Publishing country England
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 184237-7
    ISSN 1470-8752 ; 0300-5127
    ISSN (online) 1470-8752
    ISSN 0300-5127
    DOI 10.1042/BST20221431
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    Zs.A 944: Show issues Location:
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  7. Article ; Online: Nuclear lamin facilitates collective border cell invasion into confined spaces in vivo.

    Penfield, Lauren / Montell, Denise J

    The Journal of cell biology

    2023  Volume 222, Issue 11

    Abstract: Cells migrate collectively through confined environments during development and cancer metastasis. The nucleus, a stiff organelle, impedes single cells from squeezing into narrow channels within artificial environments. However, how nuclei affect ... ...

    Abstract Cells migrate collectively through confined environments during development and cancer metastasis. The nucleus, a stiff organelle, impedes single cells from squeezing into narrow channels within artificial environments. However, how nuclei affect collective migration into compact tissues is unknown. Here, we use border cells in the fly ovary to study nuclear dynamics in collective, confined in vivo migration. Border cells delaminate from the follicular epithelium and squeeze into tiny spaces between cells called nurse cells. The lead cell nucleus transiently deforms within the lead cell protrusion, which then widens. The nuclei of follower cells deform less. Depletion of the Drosophila B-type lamin, Lam, compromises nuclear integrity, hinders expansion of leading protrusions, and impedes border cell movement. In wildtype, cortical myosin II accumulates behind the nucleus and pushes it into the protrusion, whereas in Lam-depleted cells, myosin accumulates but does not move the nucleus. These data suggest that the nucleus stabilizes lead cell protrusions, helping to wedge open spaces between nurse cells.
    MeSH term(s) Animals ; Female ; Cell Nucleus ; Drosophila ; Intermediate Filaments ; Lamin Type B/genetics ; Nuclear Lamina ; Ovary/cytology ; Cell Movement
    Chemical Substances Lamin Type B
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202212101
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  8. Article ; Online: EMT, One of Many Morphological Transitions in Cellular Phase Space.

    Montell, Denise J

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2179, Page(s) 13–18

    Abstract: The epithelial to mesenchymal transition (EMT) is an enticingly simple mechanism that converts stationary epithelial cells into migratory mesenchymal cells. EMT is meant to provide a unified explanation for phenomena as complex as gastrulation and ... ...

    Abstract The epithelial to mesenchymal transition (EMT) is an enticingly simple mechanism that converts stationary epithelial cells into migratory mesenchymal cells. EMT is meant to provide a unified explanation for phenomena as complex as gastrulation and metastasis. However, cell movements turn out to be diverse, and many are collective. Cells commonly migrate in clusters, strands, sheets, elongating tubes, or in fluid-like masses. Moreover, plenty of cells move without activating the EMT program. Here I propose that EMT can be understood as one of many types of transitions in a broader landscape-or phase space-of cell morphologies and behaviors. Throughout biology, and at multiple scales, complexity arises from the combinatorial deployment of simple, modular components. I propose that diversity of cell shapes and behaviors similarly arises from combinatorial use of modular biomechanical properties.
    MeSH term(s) Cell Movement/genetics ; Cell Shape/genetics ; Epithelial Cells/cytology ; Epithelial-Mesenchymal Transition/genetics ; Gastrulation/genetics ; Humans ; Neoplasms/genetics ; Neoplasms/pathology
    Language English
    Publishing date 2020-09-17
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0779-4_3
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  9. Article ; Online: TRIMing Neural Connections with Ubiquitin.

    Montell, Denise J

    Developmental cell

    2019  Volume 48, Issue 1, Page(s) 5–6

    Abstract: During evolution, ubiquitin ligases increased in number with increasing nervous system complexity. Recent work shows that proper brain development, cognitive ability, and social behavior in mice require the ubiquitin ligase TRIM67. The work illuminates ... ...

    Abstract During evolution, ubiquitin ligases increased in number with increasing nervous system complexity. Recent work shows that proper brain development, cognitive ability, and social behavior in mice require the ubiquitin ligase TRIM67. The work illuminates how general regulators like ubiquitin promote specific functions such as nervous system wiring during development.
    MeSH term(s) Animals ; Brain ; Mammals ; Mice ; Nervous System ; Ubiquitin ; Ubiquitin-Protein Ligases
    Chemical Substances Ubiquitin ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2019-01-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2018.12.012
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  10. Article ; Online: A thermogenetics protocol for detecting gap junction channels in

    Miao, Guangxia / Montell, Denise

    STAR protocols

    2021  Volume 2, Issue 1, Page(s) 100269

    Abstract: In this protocol, we took a "thermogenetics" approach to detect functional gap junction channels between cells ... ...

    Abstract In this protocol, we took a "thermogenetics" approach to detect functional gap junction channels between cells in
    MeSH term(s) Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Female ; Fluorescent Dyes/chemistry ; Gap Junctions/genetics ; Gap Junctions/metabolism ; Ion Channels/genetics ; Ion Channels/metabolism ; Oocytes/metabolism ; Oogenesis
    Chemical Substances Drosophila Proteins ; Fluorescent Dyes ; Ion Channels ; TrpA1 protein, Drosophila
    Language English
    Publishing date 2021-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2020.100269
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