LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 169

Search options

  1. Article ; Online: Mapping scientists' career trajectories in the survey of doctorate recipients using three statistical methods.

    Edwards, Kathryn Anne / Acheson-Field, Hannah / Rennane, Stephanie / Zaber, Melanie A

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 8119

    Abstract: This paper investigates to what extent there is a 'traditional' career among individuals with a Ph.D. in a science, technology, engineering, or math (STEM) discipline. We use longitudinal data that follows the first 7-9 years of post-conferral employment ...

    Abstract This paper investigates to what extent there is a 'traditional' career among individuals with a Ph.D. in a science, technology, engineering, or math (STEM) discipline. We use longitudinal data that follows the first 7-9 years of post-conferral employment among scientists who attained their degree in the U.S. between 2000 and 2008. We use three methods to identify a traditional career. The first two emphasize those most commonly observed, with two notions of commonality; the third compares the observed careers with archetypes defined by the academic pipeline. Our analysis includes the use of machine-learning methods to find patterns in careers; this paper is the first to use such methods in this setting. We find that if there is a modal, or traditional, science career, it is in non-academic employment. However, given the diversity of pathways observed, we offer the observation that traditional is a poor descriptor of science careers.
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-34809-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Assessing neuro-oncology clinical trial impact and value: Testing a novel multi-criteria decision analysis app.

    Field, Kathryn Maree / Andrew Rosenthal, Mark / Gillett, Piers / IJzerman, Maarten

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2023  Volume 118, Page(s) 70–78

    Abstract: Background: Many clinical trials are conducted globally, creating challenges in deciding which trial outcomes deserve a clinician's focus and where to direct limited resources. Determining the 'value' of a clinical trial relative to others could be ... ...

    Abstract Background: Many clinical trials are conducted globally, creating challenges in deciding which trial outcomes deserve a clinician's focus and where to direct limited resources. Determining the 'value' of a clinical trial relative to others could be useful in this context. The aim of this study was to test a novel web-based application using multi-criteria decision analysis (MCDA) to rank clinical trial value.
    Methods: The MCDA tool combines seven metrics: unmet need; target population size; access; outcomes; cost; academic impact and use of results. Clinical trials were ranked according to their calculated 'value' - meaning the importance or worth of a trial. We determined face validity of the app using a set of ten published Phase 3 neuro-oncology clinical trials. A survey of neuro-oncology clinicians asked them to rank the same ten clinical trials, and to rank the seven metrics in terms of importance.
    Results: The two highest app-ranked trials were in concordance with that of the survey respondents, and consistent with the two studies that have had the most impact on routine clinical practice in neuro-oncology. Of the seven metrics, surveyed clinicians considered patient outcomes and unmet need to be the most important when determining clinical trial value.
    Conclusions: The metrics app was able to rank and produce a numerical 'value' for existing phase 3 neuro-oncology clinical trials. In the future, a related app to prospectively rank future trials at the startup stage could be developed to help centers determine which should be prioritized to be conducted at their site.
    MeSH term(s) Humans ; Decision Support Techniques ; Mobile Applications ; Neoplasms ; Reproducibility of Results ; Clinical Trials as Topic
    Language English
    Publishing date 2023-10-25
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2023.07.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: The Utility of Oncology Information Systems for Prognostic Modelling in Head and Neck Cancer.

    Kotevski, Damian P / Smee, Robert I / Field, Matthew / Broadley, Kathryn / Vajdic, Claire M

    Journal of medical systems

    2023  Volume 47, Issue 1, Page(s) 9

    Abstract: Cancer centres rely on electronic information in oncology information systems (OIS) to guide patient care. We investigated the completeness and accuracy of routinely collected head and neck cancer (HNC) data sourced from an OIS for suitability in ... ...

    Abstract Cancer centres rely on electronic information in oncology information systems (OIS) to guide patient care. We investigated the completeness and accuracy of routinely collected head and neck cancer (HNC) data sourced from an OIS for suitability in prognostic modelling and other research. Three hundred and fifty-three adults diagnosed from 2000 to 2017 with head and neck squamous cell carcinoma, treated with radiotherapy, were eligible. Thirteen clinically relevant variables in HNC prognosis were extracted from a single-centre OIS and compared to that compiled separately in a research dataset. These two datasets were compared for agreement using Cohen's kappa coefficient for categorical variables, and intraclass correlation coefficients for continuous variables. Research data was 96% complete compared to 84% for OIS data. Agreement was perfect for gender (κ = 1.000), high for age (κ = 0.993), site (κ = 0.992), T (κ = 0.851) and N (κ = 0.812) stage, radiotherapy dose (κ = 0.889), fractions (κ = 0.856), and duration (κ = 0.818), and chemotherapy treatment (κ = 0.871), substantial for overall stage (κ = 0.791) and vital status (κ = 0.689), moderate for grade (κ = 0.547), and poor for performance status (κ = 0.110). Thirty-one other variables were poorly captured and could not be statistically compared. Documentation of clinical information within the OIS for HNC patients is routine practice; however, OIS data was less correct and complete than data collected for research purposes. Substandard collection of routine data may hinder advancements in patient care. Improved data entry, integration with clinical activities and workflows, system usability, data dictionaries, and training are necessary for OIS data to generate robust research. Data mining from clinical documents may supplement structured data collection.
    MeSH term(s) Adult ; Humans ; Head and Neck Neoplasms/therapy ; Information Systems ; Prognosis ; Radiation Oncology ; Squamous Cell Carcinoma of Head and Neck/therapy ; Electronic Health Records ; Data Accuracy
    Language English
    Publishing date 2023-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423488-1
    ISSN 1573-689X ; 0148-5598
    ISSN (online) 1573-689X
    ISSN 0148-5598
    DOI 10.1007/s10916-023-01907-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: UK Dental Medicines Advisory Service - questions asked by dentists: part 3 - prescribing of anxiolytic medications in dental practice.

    Finn, Kathryn / Kwasnicki, Andrew / Field, E Anne / Randall, Christine

    British dental journal

    2021  Volume 231, Issue 9, Page(s) 556–561

    Abstract: The UK Dental Medicines Advisory Service (UKDMAS) provides advice to dentists and other dental healthcare professionals concerning the use of medicines and medical devices in dentistry. The commonly asked questions posed to the UKDMAS concerning the ... ...

    Abstract The UK Dental Medicines Advisory Service (UKDMAS) provides advice to dentists and other dental healthcare professionals concerning the use of medicines and medical devices in dentistry. The commonly asked questions posed to the UKDMAS concerning the prescribing, administering or dispensing of oral anxiolytic medicines in dental practice are discussed with answers supplemented by relevant information from clinicians. These include: types of oral anxiolytics available, prescribing guidelines, appropriate dosing regimens, indications and contraindications to prescribing and drug interactions.
    MeSH term(s) Anti-Anxiety Agents ; Consultants ; Dentists ; Humans ; Practice Patterns, Dentists' ; United Kingdom
    Chemical Substances Anti-Anxiety Agents
    Language English
    Publishing date 2021-11-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-021-3568-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: UK Dental Medicines Advisory Service: questions asked by dentists - part 4: prescribing of high-strength fluoride toothpastes and use of fluoride varnishes in dental practice.

    Brown, Phillip M / Fox, Kathryn / Field, E Anne / Randall, Christine

    British dental journal

    2021  Volume 231, Issue 10, Page(s) 623–628

    Abstract: The UK Dental Medicines Advisory Service (UKDMAS) provides advice to dentists and other dental healthcare professionals concerning the use of medicines and medical devices in dental prescribing, administering, or dispensing. The commonly asked questions ... ...

    Abstract The UK Dental Medicines Advisory Service (UKDMAS) provides advice to dentists and other dental healthcare professionals concerning the use of medicines and medical devices in dental prescribing, administering, or dispensing. The commonly asked questions posed to the UKDMAS concerning the prescribing of high-strength fluoride toothpastes and use of fluoride varnishes in dental practice are discussed with answers, supplemented by relevant information from clinicians. These include: the prescribing of high-strength fluoride toothpastes and application of fluoride varnish in particular patient groups; issues concerning the amounts of fluoride toothpaste that can be prescribed; regulations related to the supply of fluoride toothpastes by dental hygienists and therapists; and the constituents and selection of fluoride varnishes.
    MeSH term(s) Cariostatic Agents ; Consultants ; Dental Caries/prevention & control ; Dentists ; Fluorides ; Fluorides, Topical ; Humans ; Toothpastes ; United Kingdom
    Chemical Substances Cariostatic Agents ; Fluorides, Topical ; Toothpastes ; Fluorides (Q80VPU408O)
    Language English
    Publishing date 2021-11-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-021-3664-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Leak or link? the overrepresentation of women in non-tenure-track academic positions in STEM.

    Rennane, Stephanie / Acheson-Field, Hannah / Edwards, Kathryn A / Gahlon, Grace / Zaber, Melanie A

    PloS one

    2022  Volume 17, Issue 6, Page(s) e0267561

    Abstract: ... job satisfaction and lower salaries among men and women. Explanations including differences in field ...

    Abstract This paper examines gender variation in departures from the tenure-track science, technology, engineering, and math (STEM) academic career pathway to non-tenure-track academic careers. We integrate multiple data sources including the Survey of Earned Doctorates and the Survey of Doctorate Recipients to examine longitudinal career outcomes of STEM doctorate women. We consider three types of careers after receipt of a PhD: academic, academic non-tenure-track, and non-academic positions. We find that STEM women are more likely to hold academic non-tenure-track positions, which are associated with lower job satisfaction and lower salaries among men and women. Explanations including differences in field of study, preparation in graduate school, and family structure only explain 35 percent of the gender gap in non-tenure-track academic positions.
    MeSH term(s) Career Mobility ; Engineering ; Female ; Humans ; Job Satisfaction ; Male ; Mathematics ; Science ; Sexism/trends ; Surveys and Questionnaires ; Technology
    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0267561
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Evaluation of an automated Presidio anonymisation model for unstructured radiation oncology electronic medical records in an Australian setting.

    Kotevski, Damian P / Smee, Robert I / Field, Matthew / Nemes, Yvonne N / Broadley, Kathryn / Vajdic, Claire M

    International journal of medical informatics

    2022  Volume 168, Page(s) 104880

    Abstract: Background: Electronic medical records (EMRs) contain valuable information for clinical research, however, the presence of personally identifying information (PII) restricts their use. Anonymisation of PII from EMRs enables clinical information to be ... ...

    Abstract Background: Electronic medical records (EMRs) contain valuable information for clinical research, however, the presence of personally identifying information (PII) restricts their use. Anonymisation of PII from EMRs enables clinical information to be shared for research purposes. Since there is limited research relating to the anonymisation of Australian EMRs, the performance of Microsoft Presidio with customisation on clinical documents from an Australian radiation oncology information system (OIS) was evaluated.
    Methods: A random sample of 300 unstructured free-text clinical documents were extracted from the Prince of Wales Cancer Centre OIS on patients diagnosed with cancer of the head and neck between 2000 and 2017. Anonymisation of clinical text was performed using Microsoft Presidio, implemented in Python programming language. Each clinical document was manually compared pre- and post-anonymisation for the identification and redaction of 13 PII. Model performance was evaluated using three classification criteria; correct, partial, and missed classification, to determine recall, precision, and F1-score. These three metrics were performed under relaxed conditions, where partial classifications were considered correct, and under strict conditions, where only correct classifications were considered correct.
    Results: A total of 8,713 PII were identified, of which 7,026 (81%) were classified as correct, 850 (10%) as partial, and 837 (9%) as missed. There were 245 instances of incorrect classifications. Evaluation of the model demonstrated an average precision of 0.8921, recall (strict) of 0.8064, F1-score (strict) of 0.8471, recall (relaxed) of 0.9039, and F1-score (relaxed) of 0.8980.
    Conclusion: This is the first example of an open-source anonymisation model to be customised and tested on clinical documents from an Australian radiation oncology EMR. These findings support the use of Presidio for the safe use and sharing of cancer data within Australia for certain PII, however, additional checks are required to ensure person names are successfully anonymised.
    MeSH term(s) Humans ; Electronic Health Records ; Radiation Oncology ; Australia ; Natural Language Processing
    Language English
    Publishing date 2022-10-12
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1466296-6
    ISSN 1872-8243 ; 1386-5056
    ISSN (online) 1872-8243
    ISSN 1386-5056
    DOI 10.1016/j.ijmedinf.2022.104880
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Challenges of Estimating Accurate Prevalence of Arm Weakness Early After Stroke.

    Simpson, Lisa A / Hayward, Kathryn S / McPeake, Moira / Field, Thalia S / Eng, Janice J

    Neurorehabilitation and neural repair

    2021  Volume 35, Issue 10, Page(s) 871–879

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Muscle Weakness/epidemiology ; Muscle Weakness/etiology ; Muscle Weakness/physiopathology ; Prevalence ; Recovery of Function/physiology ; Stroke/complications ; Stroke/physiopathology ; Stroke Rehabilitation ; Upper Extremity/physiopathology
    Language English
    Publishing date 2021-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491637-x
    ISSN 1552-6844 ; 1545-9683 ; 0888-4390
    ISSN (online) 1552-6844
    ISSN 1545-9683 ; 0888-4390
    DOI 10.1177/15459683211028240
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: "She Gets Me": Forming a Friendship from a Place of Vulnerability.

    Field-Springer, Kimberly / Stephens, Kathryn

    Health communication

    2017  Volume 32, Issue 3, Page(s) 386–388

    Abstract: ... into the field for the first time, anxieties arise. Sometimes, in reflection, we come to learn that others ... a practitioner and a researcher and how these reflections enable friendships to form beyond the field. ...

    Abstract Becoming familiar with strange, new surroundings is an overwhelming process. Every time we enter into the field for the first time, anxieties arise. Sometimes, in reflection, we come to learn that others whom we view as our participants experience similar feelings of uncertainty. From the perspective of the researcher, we continually reflect upon co-constructed meanings we create with others from lived experiences in an effort to produce knowledge during the research process. Even though the outside observer is welcomed in, practitioners fear the presence of another who is there to critique their work, unaware that the researcher, herself, shares this fear. This essay aims to expose how we live and share meanings of vulnerability between a practitioner and a researcher and how these reflections enable friendships to form beyond the field.
    MeSH term(s) Adaptation, Psychological ; Anthropology, Cultural ; Emotions ; Female ; Friends/psychology ; Humans
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article
    ZDB-ID 1038723-7
    ISSN 1532-7027 ; 1041-0236
    ISSN (online) 1532-7027
    ISSN 1041-0236
    DOI 10.1080/10410236.2016.1138387
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Leak or link? the overrepresentation of women in non-tenure-track academic positions in STEM

    Stephanie Rennane / Hannah Acheson-Field / Kathryn A. Edwards / Grace Gahlon / Melanie A. Zaber

    PLoS ONE, Vol 17, Iss

    2022  Volume 6

    Abstract: ... job satisfaction and lower salaries among men and women. Explanations including differences in field ...

    Abstract This paper examines gender variation in departures from the tenure-track science, technology, engineering, and math (STEM) academic career pathway to non-tenure-track academic careers. We integrate multiple data sources including the Survey of Earned Doctorates and the Survey of Doctorate Recipients to examine longitudinal career outcomes of STEM doctorate women. We consider three types of careers after receipt of a PhD: academic, academic non-tenure-track, and non-academic positions. We find that STEM women are more likely to hold academic non-tenure-track positions, which are associated with lower job satisfaction and lower salaries among men and women. Explanations including differences in field of study, preparation in graduate school, and family structure only explain 35 percent of the gender gap in non-tenure-track academic positions.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top