Article ; Online: Effect of Si-Miao-Yong-An decoction on the differentiation of monocytes, macrophages, and regulatory T cells in ApoE
2021 Volume 276, Page(s) 114178
Abstract: Ethnopharmacological relevance: Si-Miao-Yong-An decoction (SMYAD) is a renowned ...
| Abstract | Ethnopharmacological relevance: Si-Miao-Yong-An decoction (SMYAD) is a renowned traditional Chinese medicinal formula. SMYAD was originally recorded in the "Shi Shi Mi Lu", which was edited by medical scientist Chen Shi'duo during the Qing Dynasty. SMYAD has been traditionally used to treat thromboangiitis obliterans. At present, it is mainly used in clinical applications and research of cardiovascular diseases. Aim of the study: To explore the effects of SMYAD on the pathological changes of atherosclerosis (AS) and the differentiation of monocytes, macrophages, and regulatory T (Treg) cells in apolipoprotein E knockout (ApoE Materials and methods: Eight C57BL/6J mice, which were fed with normal diet for 16 weeks, were used as control group. Forty ApoE Results: Compared with the model group, the level of serum TC and LDL-C decreased in the SMYAD group, the pathological changes of aortic sinus decreased, and lipid infiltration of aorta and aortic sinus also decreased. These decreases were accompanied by a significant downregulation of CD36, SRA1, and LOX-1. Furthermore, the proportions of Ly6C Conclusions: SMYAD can improve the pathological changes associated with AS and can inhibit lipid deposition in ApoE |
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| MeSH term(s) | Animals ; Aorta/metabolism ; Aorta/pathology ; Apolipoproteins E/genetics ; CD36 Antigens/metabolism ; Calcium-Binding Proteins/metabolism ; Carrier Proteins/metabolism ; Cell Differentiation/drug effects ; Cholesterol/blood ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Cytokines/blood ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Forkhead Transcription Factors/metabolism ; Lipoproteins, LDL/blood ; Macrophages/drug effects ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Monocytes/drug effects ; Plaque, Atherosclerotic/drug therapy ; Plaque, Atherosclerotic/metabolism ; Plaque, Atherosclerotic/pathology ; Receptors, G-Protein-Coupled/metabolism ; Scavenger Receptors, Class E/metabolism ; Spleen/drug effects ; Spleen/metabolism ; T-Lymphocytes, Regulatory/drug effects ; Triglycerides/blood ; Mice |
| Chemical Substances | Adgre1 protein, mouse ; Apolipoproteins E ; CD36 Antigens ; Calcium-Binding Proteins ; Carrier Proteins ; Cd36 protein, mouse ; Cholesterol, HDL ; Cholesterol, LDL ; Cytokines ; Drugs, Chinese Herbal ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; Lipoproteins, LDL ; Olr1 protein, mouse ; Receptors, G-Protein-Coupled ; Scavenger Receptors, Class E ; Triglycerides ; oxidized low density lipoprotein ; si-miao-yong-an decoction ; Cholesterol (97C5T2UQ7J) |
| Language | English |
| Publishing date | 2021-05-02 |
| Publishing country | Ireland |
| Document type | Journal Article |
| ZDB-ID | 134511-4 |
| ISSN | 1872-7573 ; 0378-8741 |
| ISSN (online) | 1872-7573 |
| ISSN | 0378-8741 |
| DOI | 10.1016/j.jep.2021.114178 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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