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Article ; Online: T

Wang, Wen-Tao / Zhu, Shuo / Ding, Ying / Yang, Li / Chen, Cai-Zhong / Ye, Qing-Hai / Ji, Yuan / Zeng, Meng-Su / Rao, Sheng-Xiang

European journal of radiology

2018 Volume 103, Page(s) 25–31

Abstract: Purpose: Our purpose was to demonstrate the prognostic significance of T: Materials and methods ... acid-enhanced MRI were included in the study. T: Results: Reduction rate of T: Conclusions ... Reduction rate of T ...

Abstract	Purpose: Our purpose was to demonstrate the prognostic significance of T Materials and methods: One hundred and seven patients with single nodular HCC (≤3 cm) who underwent preoperative gadoxetic acid-enhanced MRI were included in the study. T Results: Reduction rate of T Conclusions: Reduction rate of T
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Contrast Media ; Female ; Gadolinium DTPA ; Hepatectomy ; Humans ; Image Enhancement/methods ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnostic imaging ; Prognosis ; Retrospective Studies ; Risk Factors ; Young Adult
Chemical Substances	Contrast Media ; gadolinium ethoxybenzyl DTPA ; Gadolinium DTPA (K2I13DR72L)
Language	English
Publishing date	2018-03-28
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2018.03.027
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Zs.A 1630: Show issues

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Article ; Online: CRISPR-Cas9 applications in T cells and adoptive T cell therapies.

Chen, Xiaoying / Zhong, Shuhan / Zhan, Yonghao / Zhang, Xuepei

Cellular & molecular biology letters

2024 Volume 29, Issue 1, Page(s) 52

Abstract: T cell immunity is central to contemporary cancer and autoimmune therapies, encompassing immune ... checkpoint blockade and adoptive T cell therapies. Their diverse characteristics can be reprogrammed ... of inflammation. T cell-based therapeutic strategies are gaining widespread adoption in oncology and treating ...

Abstract	T cell immunity is central to contemporary cancer and autoimmune therapies, encompassing immune checkpoint blockade and adoptive T cell therapies. Their diverse characteristics can be reprogrammed by different immune challenges dependent on antigen stimulation levels, metabolic conditions, and the degree of inflammation. T cell-based therapeutic strategies are gaining widespread adoption in oncology and treating inflammatory conditions. Emerging researches reveal that clustered regularly interspaced palindromic repeats-associated protein 9 (CRISPR-Cas9) genome editing has enabled T cells to be more adaptable to specific microenvironments, opening the door to advanced T cell therapies in preclinical and clinical trials. CRISPR-Cas9 can edit both primary T cells and engineered T cells, including CAR-T and TCR-T, in vivo and in vitro to regulate T cell differentiation and activation states. This review first provides a comprehensive summary of the role of CRISPR-Cas9 in T cells and its applications in preclinical and clinical studies for T cell-based therapies. We also explore the application of CRISPR screen high-throughput technology in editing T cells and anticipate the current limitations of CRISPR-Cas9, including off-target effects and delivery challenges, and envisioned improvements in related technologies for disease screening, diagnosis, and treatment.
MeSH term(s)	Humans ; CRISPR-Cas Systems/genetics ; T-Lymphocytes ; Cell Differentiation ; Inflammation ; Lymphocyte Activation
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2108724-6
ISSN	1689-1392 ; 1689-1392
ISSN (online)	1689-1392
ISSN	1689-1392
DOI	10.1186/s11658-024-00561-1
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Article ; Online: Protein ubiquitination in T cell development.

Zhong, Ting / Lei, Kang / Lin, Xiaoxi / Xie, Zhiguo / Luo, Shuoming / Zhou, Zhiguang / Zhao, Bin / Li, Xia

Frontiers in immunology

2022 Volume 13, Page(s) 941962

Abstract: ... variety of biological processes, including different aspects of T cell development and differentiation ... During T cell development, thymic seeding progenitor cells (TSPs) in the thymus undergo multistep ... in these processes. Understanding how T cell development is regulated by ubiquitination and deubiquitination will not ...

Abstract	As an important form of posttranslational modification, protein ubiquitination regulates a wide variety of biological processes, including different aspects of T cell development and differentiation. During T cell development, thymic seeding progenitor cells (TSPs) in the thymus undergo multistep maturation programs and checkpoints, which are critical to build a functional and tolerant immune system. Currently, a tremendous amount of research has focused on the transcriptional regulation of thymocyte development. However, in the past few years, compelling evidence has revealed that the ubiquitination system also plays a crucial role in the regulation of thymocyte developmental programs. In this review, we summarize recent findings on the molecular mechanisms and cellular pathways that regulate thymocyte ubiquitination and discuss the roles of E3 ligases and deubiquitinating enzymes (DUBs) involved in these processes. Understanding how T cell development is regulated by ubiquitination and deubiquitination will not only enhance our understanding of cell fate determination
MeSH term(s)	Autoimmune Diseases ; Cell Differentiation ; Humans ; T-Lymphocytes ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Chemical Substances	Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2022-08-04
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.941962
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Book ; Online: CIF-T

Zhang, Tian-Hao / Zhou, Dinghao / Zhong, Guiping / Zhou, Jiaming / Li, Baoxiang

A Novel CIF-based Transducer Architecture for Automatic Speech Recognition

2023

Abstract: RNN-T models are widely used in ASR, which rely on the RNN-T loss to achieve length alignment ... optimization target of RNN-T loss lead to computational redundancy and a reduced role for predictor network ... respectively. In this paper, we propose a novel model named CIF-Transducer (CIF-T) which incorporates ...

Abstract	RNN-T models are widely used in ASR, which rely on the RNN-T loss to achieve length alignment between input audio and target sequence. However, the implementation complexity and the alignment-based optimization target of RNN-T loss lead to computational redundancy and a reduced role for predictor network, respectively. In this paper, we propose a novel model named CIF-Transducer (CIF-T) which incorporates the Continuous Integrate-and-Fire (CIF) mechanism with the RNN-T model to achieve efficient alignment. In this way, the RNN-T loss is abandoned, thus bringing a computational reduction and allowing the predictor network a more significant role. We also introduce Funnel-CIF, Context Blocks, Unified Gating and Bilinear Pooling joint network, and auxiliary training strategy to further improve performance. Experiments on the 178-hour AISHELL-1 and 10000-hour WenetSpeech datasets show that CIF-T achieves state-of-the-art results with lower computational overhead compared to RNN-T models. Comment: Accepted by ICASSP 2024
Keywords	Computer Science - Sound ; Computer Science - Computation and Language ; Electrical Engineering and Systems Science - Audio and Speech Processing
Subject code	004
Publishing date	2023-07-26
Publishing country	us
Document type	Book ; Online
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Article ; Online: Anti-motion Ultrafast T

Zhang, Yue / Wang, Xiao / Ye, Ming / Li, Zongye / Zhuang, Yuchuan / Yang, Qinqin / Fu, Qichang / Chen, Rui / Gao, Eryuan / Ren, Yanan / Zhang, Yong / Cai, Shuhui / Chen, Zhong / Cai, Congbo / Dong, Yanbo / Bao, Jianfeng / Cheng, Jingliang

Academic radiology

2023

Abstract: ... in subacute-chronic stroke patients.: Materials and methods: 79 patients underwent 3.0 T MRI scans ... on phantoms and volunteers. Subsequently, we assessed motor dysfunction severity, ischemic lesion volume, T ... for quantitatively imaging stroke patients with involuntary movements. Additionally, T ...

Abstract	Rationale and objectives: Stroke patients commonly face challenges during magnetic resonance imaging (MRI) examinations due to involuntary movements. This study aims to overcome these challenges by utilizing multiple overlapping-echo detachment (MOLED) quantitative technology. Through this technology, we also seek to detect microstructural changes of the normal-appearing corticospinal tract (NA-CST) in subacute-chronic stroke patients. Materials and methods: 79 patients underwent 3.0 T MRI scans, including routine scans and MOLED technique. A deep learning network was utilized for image reconstruction, and the accuracy, reliability, and resistance to motion of the MOLED technique were validated on phantoms and volunteers. Subsequently, we assessed motor dysfunction severity, ischemic lesion volume, T Results: The MOLED technique showed high accuracy (P < 0.001) and excellent repeatability, with a mean coefficient of variation (CoV) of 1.11%. It provided reliable quantitative results even under head movement, with a mean difference (Mean Conclusion: The MOLED technique offers significant advantages for quantitatively imaging stroke patients with involuntary movements. Additionally, T
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1355509-1
ISSN	1878-4046 ; 1076-6332
ISSN (online)	1878-4046
ISSN	1076-6332
DOI	10.1016/j.acra.2023.11.036
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Zs.A 4594: Show issues

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Article ; Online: Efficient T

Cao, Xiaozhi / Wang, Kang / Liao, Congyu / Zhang, Zijing / Srinivasan Iyer, Siddharth / Chen, Zhifeng / Lo, Wei-Ching / Liu, Huafeng / He, Hongjian / Setsompop, Kawin / Zhong, Jianhui / Bilgic, Berkin

Magnetic resonance in medicine

2021 Volume 86, Issue 4, Page(s) 2064–2075

Abstract: Purpose: To rapidly obtain high isotropic-resolution T: Methods: A T: Results: In vivo ... results demonstrated that the T: Conclusion: BUDA-gSlider SE-EPI acquisition and gSlider-subspace joint ... reconstruction enabled distortion-free whole-brain T ...

Abstract	Purpose: To rapidly obtain high isotropic-resolution T Methods: A T Results: In vivo results demonstrated that the T Conclusion: BUDA-gSlider SE-EPI acquisition and gSlider-subspace joint reconstruction enabled distortion-free whole-brain T
MeSH term(s)	Brain/diagnostic imaging ; Brain Mapping ; Echo-Planar Imaging ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional
Language	English
Publishing date	2021-05-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.28872
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Zs.A 1959: Show issues

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Article ; Online: An Anti-CD7 Antibody-Drug Conjugate Target Showing Potent Antitumor Activity for T-Lymphoblastic Leukemia (T-ALL).

Wang, Shiqi / Zhang, Ruyuan / Zhong, Kunhong / Guo, Wenhao / Tong, Aiping

Biomolecules

2024 Volume 14, Issue 1

Abstract: Acute T-lymphoblastic leukemia (T-ALL) is a type of leukemia that can occur in both pediatric and ... adult populations. Compared to acute B-cell lymphoblastic leukemia (B-ALL), patients with T-cell T ... Dxd) was successfully generated and used for T-ALL treatment. Firstly, to obtain anti-CD7 mAbs ...

Abstract	Acute T-lymphoblastic leukemia (T-ALL) is a type of leukemia that can occur in both pediatric and adult populations. Compared to acute B-cell lymphoblastic leukemia (B-ALL), patients with T-cell T-ALL have a poorer therapeutic efficacy. In this study, a novel anti-CD7 antibody-drug conjugate (ADC, J87-Dxd) was successfully generated and used for T-ALL treatment. Firstly, to obtain anti-CD7 mAbs, we expressed and purified the CD7 protein extracellular domain. Utilizing hybridoma technology, we obtained three anti-CD7 mAbs (J87, G73 and A15) with a high affinity for CD7. Both the results of immunofluorescence and Biacore assay indicated that J87 (KD = 1.54 × 10
MeSH term(s)	Adult ; Animals ; Child ; Humans ; Mice ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Burkitt Lymphoma ; Immunoconjugates/pharmacology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Antigens, CD7/immunology ; Antigens, CD7/therapeutic use
Chemical Substances	Antibodies, Monoclonal ; Immunoconjugates ; Antigens, CD7
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom14010106
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Article ; Online: Determination of 3-iodothyronamine (3-T

Li, Zhong-Min / Miller, Manuel / Gachkar, Sogol / Mittag, Jens / Schriever, Sonja C / Pfluger, Paul T / Schramm, Karl-Werner / De Angelis, Meri

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2021 Volume 1165, Page(s) 122553

Abstract: 3-iodothyronamine (3-T ...

Abstract	3-iodothyronamine (3-T
MeSH term(s)	Animals ; Chromatography, High Pressure Liquid/methods ; Female ; Limit of Detection ; Linear Models ; Liver/chemistry ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Reproducibility of Results ; Tandem Mass Spectrometry/methods ; Thyronines/analysis ; Thyronines/pharmacokinetics
Chemical Substances	3-iodothyronamine ; Thyronines
Language	English
Publishing date	2021-01-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1180823-8
ISSN	1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
ISSN (online)	1873-376X
ISSN	0378-4347 ; 1570-0232 ; 1387-2273
DOI	10.1016/j.jchromb.2021.122553
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Article ; Online: Single-shot T

Ouyang, Binyu / Yang, Qizhi / Wang, Xiaoyin / He, Hongjian / Ma, Lingceng / Yang, Qinqin / Zhou, Zihan / Cai, Shuhui / Chen, Zhong / Wu, Zhigang / Zhong, Jianhui / Cai, Congbo

Medical physics

2022 Volume 49, Issue 11, Page(s) 7095–7107

Abstract: ... In this context, a single-shot T: Purpose: In this work we proposed a novel single-shot method, Multi-Echo ... Train Multiple OverLapping-Echo Detachment (METMOLED) planar imaging, to accommodate a large range of T ... information. Maps of T: Results: Experimental results on the digital brain (structural similarity (SSIM ...

Abstract	Background: Quantitative magnetic resonance imaging provides robust biomarkers in clinics. Nevertheless, the lengthy scan time reduces imaging throughput and increases the susceptibility of imaging results to motion. In this context, a single-shot T Purpose: In this work we proposed a novel single-shot method, Multi-Echo-Train Multiple OverLapping-Echo Detachment (METMOLED) planar imaging, to accommodate a large range of T Methods: Multiple echo-train techniques were integrated into the MOLED sequence to capture larger TE information. Maps of T Results: Experimental results on the digital brain (structural similarity (SSIM) index = 0.975/0.991/0.988 for MOLED/METMOLED-2/METMOLED-3, hyphenated number denotes the number of echo-trains), physical phantom (the slope of linear fitting with reference T Conclusions: METMOLED breaks the restriction of echo-train length to TE and implements unbiased T
MeSH term(s)	Humans ; Deep Learning
Language	English
Publishing date	2022-07-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1002/mp.15820
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Zs.A 1210: Show issues

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Article ; Online: Single-cell clonal tracing of glandular and circulating T cells identifies a population of CD9+ CD8+ T cells in primary Sjogren's syndrome.

Chang, Ling / Zheng, Zihan / Xiao, Fan / Zhou, Yingbo / Zhong, Bing / Ni, Qingshan / Qian, Can / Chen, Chengshun / Che, Tiantian / Zhou, Yiwen / Zhao, Zihua / Zou, Qinghua / Li, Jingyi / Lu, Liwei / Zou, Liyun / Wu, Yuzhang

Journal of leukocyte biology

2023 Volume 115, Issue 5, Page(s) 804–818

Abstract: Primary Sjogren's syndrome (pSS) is a complex chronic autoimmune disease in which local tissue damage in exocrine glands is combined with broader systemic involvement across the body in tissues including the skin. These combined manifestations negatively ...

Abstract	Primary Sjogren's syndrome (pSS) is a complex chronic autoimmune disease in which local tissue damage in exocrine glands is combined with broader systemic involvement across the body in tissues including the skin. These combined manifestations negatively impact patient health and quality of life. While studies have previously reported differences in immune cell composition in the peripheral blood of pSS patients relative to healthy control subjects, a detailed immune cell landscape of the damaged exocrine glands of these patients remains lacking. Through single-cell transcriptomics and repertoire sequencing of immune cells in paired peripheral blood samples and salivary gland biopsies, we present here a preliminary picture of adaptive immune response in pSS. We characterize a number of points of divergence between circulating and glandular immune responses that have been hitherto underappreciated, and identify a novel population of CD8+ CD9+ cells with tissue-residential properties that are highly enriched in the salivary glands of pSS patients. Through comparative analyses with other sequencing data, we also observe a potential connection between these cells and the tissue-resident memory cells found in cutaneous vasculitis lesions. Together, these results indicate a potential role for CD8+ CD9+ cells in mediating glandular and systemic effects associated with pSS and other autoimmune disorders.
MeSH term(s)	Humans ; Sjogren's Syndrome/immunology ; Sjogren's Syndrome/pathology ; Sjogren's Syndrome/blood ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/pathology ; Single-Cell Analysis ; Female ; Salivary Glands/pathology ; Salivary Glands/immunology ; Tetraspanin 29/metabolism ; Middle Aged ; Male ; Adult ; Aged
Chemical Substances	Tetraspanin 29
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1093/jleuko/qiad071
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